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Protein provision and lower mortality in critically ill patients with COVID-19
- Source :
- Clinical Nutrition Espen
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Summary Background and aims Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severely impacted the management of critically ill patients, including nutritional therapy. This study aimed to verify an association between mortality and the energy and protein provided to critically ill patients affected by the SARS-CoV-2 and receiving enteral nutrition support. Methods Patients with confirmed COVID-19, with >7 days of stay in the ICU, on enteral nutrition were followed from the moment of hospitalization until discharge from the ICU or death. Data about age, gender, Simplified Acute Physiology Score III (SAPS3), intensive care unit (ICU) length of stay, days on mechanical ventilation (MV), clinical endpoint outcome (discharge or death), and daily energy and protein provision were collected from electronic medical records. Cox regression analyses and Kaplan-Meyer curves were used in statistical analysis. Results Fifty-two patients (66.2 ± 13.1 years; 53.8% women) were enrolled in the present study. The mean length of hospitalizations and SAPS3 score were 17.8 ± 9.8 days and 78.7 ± 14.7, respectively; all patients needed mechanical ventilation (mean of days was 16.42 ± 9.1). For most patients (73.1%) the endpoint was death. Twenty-five percent of patients had protein supply >0.8 g/IBW/day. Survival during COVID-19 hospitalization at ICU was significantly different among patients according to protein supply (p = 0.005). Hazard Ratios (HR) for protein supply showed that a protein intake >0.8 g/IBW/day was associated with significantly lower mortality (HR 0.322, p = 0.049). Conclusion Our study suggests that a protein supply at least > 0.8 g/IBW/day could be related to reduced mortality in ICU patients with COVID-19.
- Subjects :
- Male
medicine.medical_specialty
Short Communication
Critical Illness
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Protein supply
law.invention
Nutritional therapy
Enteral Nutrition
law
Internal medicine
Clinical endpoint
medicine
Humans
Medical nutrition therapy
Mortality
Simplified Acute Physiology Score
Mechanical ventilation
Nutrition and Dietetics
SARS-CoV-2
Proportional hazards model
business.industry
Hazard ratio
COVID-19
Tube feeding
Intensive care unit
Critical care
Intensive Care Units
Parenteral nutrition
Female
business
Subjects
Details
- ISSN :
- 24054577
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Clinical Nutrition ESPEN
- Accession number :
- edsair.doi.dedup.....a24c6e6eab9911c436e1265a3b38de93