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Polysaccharide from fermented Momordica charantia L. with Lactobacillus plantarum NCU116 ameliorates type 2 diabetes in rats
Polysaccharide from fermented Momordica charantia L. with Lactobacillus plantarum NCU116 ameliorates type 2 diabetes in rats
- Source :
- Carbohydrate polymers. 201
- Publication Year :
- 2018
-
Abstract
- The influence of Lactobacillus plantarum-fermentation on the structure and anti-diabetic effects of Momordica charantia polysaccharides were evaluated. High-fat diet and streptozotocin-induced type 2 diabetic rats were administrated with polysaccharides from fermented and non-fermented Momordica charantia (FP and NFP) for 4 weeks. Fermentation affected the physicochemical characterization, monosaccharide composition, molecular weight, and viscosity of Momordica charantia polysaccharides. Treatment with FP significantly ameliorated hyperglycemia, hyperinsulinemia, hyperlipidemia, and oxidative stress in diabetic rats compared with NFP. Moreover, the diversity and abundance of gut microbiota (Lactococcus laudensis and Prevotella loescheii) in diabetic rats were notably increased by treatment with FP in comparison to NFP. Meanwhile, FP-treated diabetic rats exhibited more colonic short-chain fatty acids (SCFAs) and lower pH values than that in NFP-treated rats. Overall, Lactobacillus plantarum-fermentation could enhance the anti-diabetes effects of Momordica charantia polysaccharides in rats by modifying the structure of polysaccharides to optimize gut microbiota and heighten the production of SCFAs.
- Subjects :
- 0301 basic medicine
Male
Polymers and Plastics
Momordica charantia
Gut flora
medicine.disease_cause
Polysaccharide
Diabetes Mellitus, Experimental
03 medical and health sciences
Polysaccharides
Lactobacillus
Hyperlipidemia
Materials Chemistry
medicine
Monosaccharide
Animals
Hypoglycemic Agents
Food science
Rats, Wistar
chemistry.chemical_classification
030109 nutrition & dietetics
Momordica
biology
Organic Chemistry
food and beverages
biology.organism_classification
medicine.disease
Rats
030104 developmental biology
chemistry
Diabetes Mellitus, Type 2
Oxidative stress
Lactobacillus plantarum
Subjects
Details
- ISSN :
- 18791344
- Volume :
- 201
- Database :
- OpenAIRE
- Journal :
- Carbohydrate polymers
- Accession number :
- edsair.doi.dedup.....cd69ddbf6f44d6494acb15aacea88adc