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Evaluation of kinetic parameters of natural phytoalexin in resveratrol orally administered in wine to rats

Evaluation of kinetic parameters of natural phytoalexin in resveratrol orally administered in wine to rats

Authors :
A A, Bertelli
L, Giovannini
R, Stradi
S, Urien
J P, Tillement
A, Bertelli
Source :
Drugs under experimental and clinical research. 24(1)
Publication Year :
1998

Abstract

In view of the increasing interest in the biological activity of resveratrol, one of the components of red wine which is considered to be one of the main ingredients responsible for the beneficial effect of wine on human health, we have studied plasma kinetics and tissue bioavailability of this compound after red wine oral administration in rats. Plasma pharmacokinetics after oral administration of resveratrol could be described by an open one- or two-compartment model. Tissue concentrations show a significant cardiac bioavailability, and a strong affinity for the liver and kidneys.

Details

ISSN :
03786501
Volume :
24
Issue :
1
Database :
OpenAIRE
Journal :
Drugs under experimental and clinical research
Accession number :
edsair.pmid..........5232c48d80c0cda22e4205035e12d949