1. A surface molecularly imprinted polymer as chiral stationary phase for chiral separation of 1,1′-binaphthalene-2-naphthol racemates.
- Author
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Dong, Hongxing, Zhang, Danxia, Lin, Hailong, Wang, Yudan, Liu, Lijia, Zheng, Meixia, Li, Xiaobo, Zhang, Chunhong, Li, Junqing, Zhang, Peng, and So, Juhyok
- Subjects
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ACRYLAMIDE , *ETHYLENE glycol , *NAPHTHOL , *SILICA gel , *FREE radical reactions , *HIGH performance liquid chromatography - Abstract
Acrylamide (AM) was copolymerized with ethylene glycol dimethacrylate (EGDMA) in the presence of ( R)-1,1′-binaphthalene-2-naphthol (BINOL) as the template molecules on the surface of silica gel by a free radical polymerization to produce a chiral stationary phase based on the surface molecularly imprinted polymer (SMIP-CSP). The SMIP-CSP showed a much better separation factor ( α = 4.28) than the CSP based on the molecularly imprinted polymer (MIP-CSP) without coating on the silica gel ( α = 1.96) during the chiral separation of BINOL enantiomers by high-performance liquid chromatography. The influence of the pretreatment temperature and the content of the template molecule (( R)-BINOL) of the SMIP-CSP, and the mobile phase composition on the separation of the racemic BINOL were systematically investigated. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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