1. Hearing loss and renal syndromes.
- Author
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Phelan, Paul J. and Rheault, Michelle N.
- Subjects
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HEARING disorder diagnosis , *KIDNEY abnormalities , *KIDNEY disease diagnosis , *EAR abnormalities , *DIFFERENTIAL diagnosis , *MEMBRANE proteins , *GENETIC mutation , *TRANSCRIPTION factors , *NEPHRITIS , *GENETICS - Abstract
The association between ear and kidney abnormalities has long been recognized; however, the connection between these two disparate organs is not always straightforward. Although Alport syndrome is the most well-known, there are over 20 disorders that need to be considered in the differential diagnosis of patients with both ear and kidney abnormalities. Commonalities are present between the kidney and ear in a number of structural proteins, developmentally important transcription factors, ciliary proteins, and channel proteins, and mutations in these pathways can lead to disease in both organ systems. This manuscript reviews the congenital disorders with both hearing and kidney manifestations. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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