1. Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.
- Author
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Kirst, H A, Willard-Gallo, Karen, Debono, M, Toth, J E, Truedell, B A, Leeds, J P, Ott, J L, Felty-Duckworth, A M, Counter, F T, Ose, E E, Kirst, H A, Willard-Gallo, Karen, Debono, M, Toth, J E, Truedell, B A, Leeds, J P, Ott, J L, Felty-Duckworth, A M, Counter, F T, and Ose, E E
- Abstract
Reductive amination of the C-20 aldehyde group of tylosin and related macrolides yielded a large series of derivatives with potentially useful antibiotic properties. Evaluation of these new compounds was conducted on the basis of: 1) Broad antimicrobial spectrum in vitro, with particular emphasis on inhibition of Pasteurella multocida and Pasteurella haemolytica; 2) in vivo efficacy, especially when given orally, against P. multocida in experimental infections in chicks; and 3) bioavailability after oral administration to laboratory animals. The most useful activity was found within a series of derivatives produced by reductive amination of desmycosin with secondary amines., info:eu-repo/semantics/published
- Published
- 1989