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Ibuprofen (IBU) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties used to treat rheumatoid arthritis, osteoarthritis, and mild to moderate pain. However, it has extremely low aqueous solubility, rapid biotransformation with a half-life of nearly 2 h and poor tissue absorption resulting in poor bioavailability. One of the most important strategies for avoiding NSAID-related toxicity is modified release polymeric systems. Cross-linked polyphosphazene microspheres are attractive systems in drug delivery, as they are biocompatible and biodegradable. In the current work, novel cross-linked inorganic hybrid polyphosphazene microspheres were synthesized by self-assembly precipitation polymerization between hexachlorocyclotriphosphazene (trimer)/octachlorocyclotetraphosphazene (tetramer) as a cross-linker and 4,7-dihydroxyisoflavone (4.7 DHF) as a monomer. The structure of synthesized microspheres was identified several techniques in detail. IBU was successfully incorporated into the trimeric and tetrameric polyphosphazene microspheres. Particle size, zeta potential, drug loading, morphology, thermal, FT-IR, and XRD analyses, and IBU quantification using UPLC method were carried out to evaluate the microspheres. Considering the higher drug loading values and smaller particle size, trimer-based microspheres (4.7 DHF-TRI-IBU) were selected for further studies. In vitro release studies from 4.7 DHF-TRI-IBU demonstrated modified release pattern which followed zero-order kinetic model. Characteristics of 4.7 DHF-TRI-IBU were found to remain stable at 4 °C ± 1 °C, 25 °C ± 1 °C and 40 °C ± 1 °C during the storage period of 3 months. In vitro characterization analyses showed that spherical, micron-sized 4.7 DHF-TRI-IBU microspheres with prolonged release pattern has the potential of enhancing analgesic and anti-inflammatory activity.

Inorganic–organic hybrid and highly cross-linked poly(cyclotriphosphazene-co-dopamine) microspheres (PCTD) were successfully synthesized by a one-step precipitation polymerization technique. In the...

WOS: 000442645700002, In this study, novel cross-linked inorganic-organic hybrid polyphosphazene nanospheres were synthesized via self-assembly precipitation polymerization between hexachlorocyclotriphosphazene (HCCP) as a crosslinker molecule and anticancer featured quercetin (QCT). The technique used for synthesizing QCT nanospheres is quite simple and rapid, and has some advantages like using just ultrasonic power. Furthermore, it does not require any surfactant or stabilizer. Growth of nanospheres and reaction time effect on the formation of QCT nanospheres were investigated. Quercetin and 4',7-dihydroxyflavone were compared for the formation of nanospheres. The particle size of the spheres was determined to be approximately 434 nm by DLS (dynamic light scattering) measurements in 3 hours reaction time. The structure and morphology of synthesized QCT nanospheres were investigated by SEM-EDX (scanning electron microscope) and XRD (X-ray diffractometer). The spectroscopic and thermal properties of cyclomatrix polyphosphazene QCT nanospheres were investigated by FTIR (Fourier transform infrared spectroscopy), UV-vis (ultraviolet-visible), fluorescence, and TGA (thermogravimetric analysis). Moreover, QCT nanospheres were used for controlled release of acriflavine which had been chosen as a model drug., Anadolu University, Scientific Research Unit [1506F536], The authors acknowledge to the "Anadolu University, Scientific Research Unit" Grant No. 1506F536 for their financial support.

In this article, highly cross-linked inorganic and organic hybrid polyphosphazene microspheres including amino groups on the surface have been successfully obtained via self-assembly polycondensation approach using 4,4ʹ-diaminodiphenylmethane and octachlorocyclotetraphosphazene which is a new crosslinker. Experiments were performed without adding a surfactant or stabilizer, using only an ultrasonic bath. Otherwise, effect of different molar ratios of the reactants, reaction time and ultrasonic power were investigated on preparing morphologically good spheres. The reactivity of octachlorocyclotetraphosphazene was investigated comparing with hexachlorocyclotriphosphazene which is the most popular crosslinker cyclic phosphazene molecule. The size of acquired microspheres were approximately same, and 1.00μm. The novel microspheres were characterized by SEM, FTIR, ZETA, UV, Fluorescense, XRD and TGA.

WOS: 000456491500085, In this study, the novel compounds (2,5-dimethoxy-methanimine propyltriethoxysilane; S1 and 3-ethoxy-salicylaldimine propyltriethoxysilane; S2) derived from aminopropyltriethoxysilane (APTES) were synthesized by a simple and facile approach in order to modify mesoporous silica (MS) surface. Characterization of S1 and S2 was experimentally performed by FTIR, H-1-C-13 NMR spectroscopic methods and elemental analysis. The IR frequencies, H-1 and C-13 NMR chemical shift values for the optimized molecular geometries of S1 and S2 were calculated by using Density Functional Theory (DFT with B3LYP/6-311 + G (d, p) basis set), and the theoretical results were compared to the obtained experimental data. The experimental and theoretical results confirmed the proposed molecular structures of the synthesized S1 and S2 compounds. After that, the mesoporous silica material (MS) was synthesized according to the Stober procedure, and characterized by the elemental analysis, and the experimental and theoretical IR spectra. The surface of MS was successfully functionalized with S1 and S2 to produce more selective and effective adsorbent materials, and the structures of functionalized MSs (S1-MS and S2-MS) were investigated with FTIR spectroscopy and elemental analysis. The theoretical optimized molecular geometries, IR frequencies and H-1-C-13 NMR chemical shift values were calculated to execute the structural analysis of S1-MS and S2-MS. In addition, the calculations of the sum of electronic and thermal free energy (SETFE), dipole moment, the HOMO-LUMO energies, the molecular electrostatic potential (MEP), the solvent accessible surface (SAS) and atomic charge for the synthesized S1, S2, MS, S1-MS and S2-MS were accomplished by using DFT/B3LYP/6-311 + G (d, p) level of theory, Anadolu University [1306F256, 1102F027, 1304F064], This study was supported by Anadolu University Scientific Research Projects (1306F256). The authors also gratefully thank to Anadolu University for supporting Gaussian 09 and Gauss View 5.0 programs with the projects (1102F027 and 1304F064).

WOS: 000457024800003, Inorganic-organic hybrid cyclomatrix type polyphosphazene microspheres (poly[cyclotriphosphazene-co-(4,4 '-diaminodiphenylmethane)]) (HDMS) and poly[cyclotetraphosphazene-co-4,4 '-diaminodiphenylmethane)] (ODMS) were prepared to investigate their possible use as alternative adsorbents for the comparative study on Pb(II) ions removal from aqueous solutions. The structures of the microspheres were elucidated by Fourier Transform Infrared (FTIR) spectroscopy and Dynamic Light Scattering (DLS) measurements, and the surface morphologies were also observed by Scanning Electron Microscopy (SEM). The adsorption of Pb(II) ions onto HDMS and ODMS from aqueous solutions was examined by means of pH, temperature, contact time and concentration. Furthermore, adsorption kinetics and isotherm models were applied and the experimental data fitted well with Langmuir isotherm and pseudo-second-order kinetic models. The maximum adsorption capacities of HDMS and ODMS for Pb(II) ions were obtained as 157.8 and 308.0 mg g(-1) at 20 degrees C and pH 5.5, respectively.

WOS: 000392648000022, The Schiff bases 4,4'-di(2-hydroxybenzyl imino) diphenylmethane (S1), 4,4'-di(2-hydroxy-5-chloro benzyl imino) diphenylmethane (S2) and 4,4'-di(2-hydroxy-5-bromo benzyl imino) diphenylmethane (S3) were synthesized from the condensation reactions of salicyl-aldehyde, 5-chlorosalicylaldehyde and 5-bromosalicylaldehyde, respectively, with 4,4-diaminodiphenylmethane and reduced with NaBH4 in dry MeOH to obtain N/O-donor type ligands 4,4'-di(2-hydroxy benzyl amino) diphenylmethane (L1), 4,4'-di(2-hydroxy-5-chloro benzyl amino) diphenylmethane (L2) and 4,4'-di(2-hydroxy-5-bromo benzyl amino) diphenylmethane (L3). The novel spiro-bino-spiro-cyclotriphosphazene derivatives 1 - 3 were obtained from the reactions of L1-L3 with trimer (N3P3Cl6). The identities of these compounds were elucidated by P-31-, H-1-, C-13-NMR, FT-IR spectroscopy and elemental analysis. The solid state structures of compounds 1 and 2 were determined by single crystal X-ray diffraction. Experimental results on the molecular structures of compounds 1 and 2 were supported by computational studies using Density Functional Theory (DFT) methods with Becke-3-Lee-Yang-Parr (B3LYP) functional and 6-31+G(2d,p) basis set. The experimentally determined values of the bond angles and bond lengths in the compounds are in accord with to those predicted theoretically.

This work describes the syntheses and characterizations of double-armed benzo-15-crown-5 containing nitro (1), amine (2), and imine (3–5) groups, and their sodium complexes (1a–5a). Structures of the ligands (1–5) and sodium complexes (1a–5a) were identified via elemental analyses, and infrared, 1H- nuclear magnetic resonance (NMR), 13C-NMR, and mass spectrometry. The metal extractions were examined by using ultravoilet–visible spectrophotometry. Single crystal for 2 was successfully obtained, and its X-ray crystal structure was resolved. The compound 2 crystallizes in triclinic, space group p-1 with a = 9.1420(3), b = 14.9580(4), c = 20.4110(5), and Z = 4.

WOS: 000323468500036, Three new cyano-bridged tetracyanonickelate(II) complexes with 1-ethylimidazole (etim) ligand, [Ni(etim)(4)Ni(mu-CN)(2)(CN)(2)](n) (1), [Zn(etim)(4)Ni(mu-CN)(2)(CN)(2)](n) (2) and {[Cd(etim)(4)Ni(mu-CN)(2)(CN)(2)](2)center dot 2H(2)O}(n) (3) have been synthesized and characterized by spectroscopic (IR and Raman) and X-ray diffraction techniques. According to the crystallographic data, it was understood that the complexes with the chain 2,2-TT structures belong to P-1 space group of triclinic crystal system. In the complexes, it was observed that Ni(II), Zn(II) and Cd(II) ions have distorted octahedral geometries. In the [Ni(mu-CN)(2)(CN)(2)](2-) anion, the Ni(II) ion is coordinated by the four carbon atoms of the four cyano ligands, and exhibits square-planar coordination geometry. The crystallographic analyses reveal that the crystal structures of complexes 1-3 are one dimensional linear chain polymers and these chains are held together by the C-H center dot center dot center dot pi, C-H center dot center dot center dot Ni and hydrogen bonding interactions, forming three-dimensional networks, Research Fund of Eskisehir Osmangazi University [201219019], This work was supported by the Research Fund of Eskisehir Osmangazi University. Project Number: 201219019. Raman spectra were recorded at Anadolu University, Department of Physics. The authors thank Prof. Dr. Mustafa Senyel and Tulay Tiras for support during the Raman spectra. The authors wish to thank Plant, Drug and Scientific Research Centre at Anadolu University for the use of X-ray diffractometer.

The heteronuclear complex, [Cd(NH3)2(μ-ampy)Pd(μ-CN)2(CN)2] n (1) (ampy = 4-aminomethylpyridine), was synthesized and characterized by vibrational (FT-IR and Raman) spectroscopy, elemental and thermal analyses and single crystal X-ray diffraction techniques. The complex crystallizes in the triclinic system, space group P-1. The Cd(II) ion exhibits a distorted octahedral coordination by two different N-atoms from two symmetrically equivalent ampy ligands, two ammine ligands and two bridging cyano groups, whereas the Pd(II) ion has square planar coordination and is coordinated by four cyano ligands. The tetracyanopalladate(II) anion is coordinated to the adjacent two Cd(II) ions to generate a one-dimensional chain. The adjacent 1D chains are connected by the μ-ampy bridging ligands to form a 2D network. The 2D layers are further linked by Pd···π and hydrogen bonding interactions to generate a 3D supramolecular network. The decomposition reaction takes places in the temperature range of 40–900 °C in the static air atmosphere.

Cross-linked cyclomatrix polyphosphazene microspheres have been successfully synthesized via self-assembly polycondensation reaction between hexachlorocyclotriphosphazene (HCCP) and 4,4¢-diaminodiphenylmethane (DADPM) in acetonitrile. The absence of any stabilizing agent or surfactant and usage of only an ultrasonic bath have been the advantages for this reaction. HCCP and DADPM ratios have been attempted to obtain the best morphology by SEM-EDX. The size of microspheres were ranging from 4.46 to 4.74 μm. The inorganic-organic hybrid microspheres were characterized by FTIR, TGA, UV, Fluorescence and XRD.

WOS: 000361863200018, The new water-soluble and air stable compounds (H(2)ppz)[Co(dipic)(2)]center dot 6H(2)O (1), (H(2)ppz)[Ni(dipic)(2)]center dot 6H(2)O (2) and (H(2)ppz)[Zn(dipic)(2)]center dot 6H(2)O (3) were prepared by the reaction of corresponding metal(II) acetates and a proton transfer salt, (H(2)ppz) (Hdipic)(2), (4) of pyridine-2,6-dicarboxylic acid (H(2)clipic) and 2-(piperazin-1-yl)ethanol (ppz). The compounds 1-3 were characterized by elemental, IR, UV-vis. thermal analyses, magnetic measurement and single crystal X-ray diffraction studies. The molecular structures of the title compounds consist of one 1-(2-hydroxyethyl)piperazine-1,4-diium (H(2)ppz(+2)) cation, one bis(pyridine-2,6-dicarboxylate)metal(II) [M(dipic)(2)](2-) anion, and six uncoordinated water molecules. In compounds 1-3 the metal ions coordinate to two oxygen and one nitrogen atoms of two pyridine-2,6-dicarboxylate molecules forming an octahedral environment. Antimicrobial activities against Gram (-) wild type (Escherichia coli and Pseudomonas aeruginosa), Gram (+) wild type (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus cereus and Bacillus subtilis) and clinical isolate (Morganella morganii, Proteus vulgaris and Enterobacter aeruginosa) were also studied. The results were reported, discussed and compared with the corresponding starting materials ((H(2)ppz) (Hdipic)(2) (4), H(2)dipic and ppz). MIC (Minimal Inhibition Concentration) values of the newly synthesized compounds were determined as 4000 mu g/ml (except B. subtilis and clinical isolate E. aeruginosa, >4000 mu g/ml)., Dumlupinar University Research Foundation [2011-13], This study was supported by a grant (Grant No: 2011-13) received from Dumlupinar University Research Foundation and was carried out at the Department of Chemistry of Dumlupinar University. The authors would like to express their gratitude to the "Medicinal Plants and Medicine Research Center of Anadolu University, Eskisehir" for having received the permission to use the X-ray facility.

WOS: 000365469900018, New cadmium complexes of 4-methoxyphenyl dithiophosphinic acids, H3CO-C-6 H (4)-(R)PS2H were prepared. The five dithiophosphinato ligands (L) involved were of the general structure H3CO-C-6 H (4)-(R)PS with R = 3-methylbutyl, (L1); n-butyl, (L2); 2-methylpropyl, (L3); 1-methylpropyl, (L4) and 2-propyl, (L5). To the best of our knowledge, this is the first report on the preparation and characterization of the n-butyl- derivative. The acid forms of the ligands were obtained by treatment of the Lawesson reagent, (LR) [2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide] with the corresponding Grignard reagent in dry diethylether. The acids formed were transformed into easily crystallizable ammonium salts (NH4L) for purification. These salts were treated with CdCl2 in ethanol at room temperature to produce the bis-dithiophosphinato cadmium complexes ([Cd(L)(2)](2)) exclusively. The structures of the complexes were elucidated by elemental analysis, MS, FTIR and Raman spectroscopy techniques as well as H-1-, C-13- and P-31- NMR. The crystal structures of [Cd(L1)(2)](2) and [Cd(L2)(2)](2) were also studied as examples. X-ray studies confirmed the nonplanar, four-coordination geometry of the complexes and indicate that electron delocalization prevails in the PS moiety of the dithiophosphinato groups., Technical Research Council of Turkey [TBAG 114Z091, TUBITAK]; Research and Application Centers of Bozok University [BAP2015 FEF/A153], We gratefully acknowledge the financial assistance of Technical Research Council of Turkey (grant nos. TBAG 114Z091, TUBITAK) and Research and Application Centers of Bozok University (BAP2015 FEF/A153). Our thanks also go to the tutors of the Zurich School of Crystallography, for assistance and guidance with the data collection and structure determination of compound [Cd(L1)2]2 and Prof. Davit Zargarian, Chemistry Department of the Universite de Montreal for their support with the X-ray facility for [Cd(L2)2]2.

The title compound, C14H14Cl4N5OP3, is a phosphazene derivative with a bulky substituent attached through a spiro junction. The C3NPO ring at the spiro junction has a twist–boat conformation, while the phosphazene ring has a flattened-boat conformation. The Pspiro atom is likely to be stereogenic.

WOS: 000342056900013, PubMed ID: 24148087, A novel proton transfer compound (HMeOABT) (+) (HDPC)(-) (1) and its Fe(III), Co(II), Ni(II) and Cu(II) complexes (2-5) have been prepared and characterized by spectroscopic techniques. Complex 4 has distorted octahedral conformation revealed by single crystal X-ray diffraction method. Structures of the other complexes might be proposed as octahedral according to experimental data. All compounds were also evaluated for their in vitro inhibition effects on hCA I and II for their hydratase and esterase activities. Although there is no inhibition for hydratase activities, all compounds have inhibited the esterase activities of hCA I and II. Data have been analyzed by using a one-way analysis of variance. The comparison of the inhibition studies of 1-5 to parent compounds indicates that 1-5 have superior inhibitory effects. The inhibition effects of 2-5 are also compared to inhibitory properties of the metal complexes of MeOABT and H2DPC, revealing an improved transfection profile., Dumlupinar University Research Fund [2012/16], The authors acknowledge the support provided by Dumlupinar University Research Fund (grant No. 2012/16). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

WOS: 000322938100008, A novel proton transfer compound (HMeABT)(+)(HDPC)(-)center dot H2O (1) obtained from 2-amino-6-methylbenzothiazole (MeABT) and dipicolinic acid (H2DPC) and its Fe(III), Fe(II), Co(II), Ni(II) and Cu(II) complexes (2-6) have been prepared and characterized by elemental, spectral (H-1 NMR, IR and UV-Vis) and thermal analyses, magnetic measurement and molar conductivity. Additionally, single crystal X-ray diffraction techniques were applied to all complexes. All compounds, including acetazolamide (AAZ) as the control compound, were also evaluated for their in vitro inhibition effects on human carbonic anhydrase isoenzymes (hCA I and hCA II) for their hydratase and esterase activities. Although there is no inhibition for hydratase activities, all compounds have inhibited the esterase activities of hCA land II. The comparison of the inhibition studies of 1-6 to parent compounds, MeABT and H2DPC, indicates that 1-6 have more inhibitory effects. The inhibition effects of 2-6 are also compared to the simple metal complexes of MeABT and H2DPC, and the complexes from proton transfer salt (2-6) have shown better inhibition effects. Nevertheless, all the studied compounds have less inhibition effects than AAZ, Dumlupinar University Research Fund [2010/2], The authors acknowledge the support provided by Dumlupinar University Research Fund (grant No. 2010/2). In addition, the authors would like to thank the Medicinal Plants and Medicine Research Center of Anadolu University Eskisehir for allowing to use the X-ray facility.

WOS: 000318914700035, The condensation reactions of the tetrachloro mono (1 and 2) and bisferrocenylspirocyclotriphosphazenes (3-5) with 1,4-dioxa-8-azaspiro[4,5]decane (DASD) resulted in the formation of the partly and fully DASD-substituted phosphazenes. The reactions of equal amounts of 1-5 and DASD produced the mono-DASD-substituted ferrocenylphosphazenes (1a-5a), as the major product. When the reactions were carried out with 1 equiv of 1-5 and 2 equiv of DASD, corresponding geminal-phosphazenes (1b-5b) were isolated. Moreover, the reactions of 1 equiv of 1-5 and 3 equiv of DASD gave the tri-(1c-4c) and tetra-substituted (1d-5d) phosphazenes. When the excess DASD was used, the fully-substituted phosphazenes (1d-5d) were obtained. The chirality of 3a was evaluated using chiral HPLC column. The structures of all the phosphazenes were verified by FTIR, MS, H-1, C-13 and P-31 NMR, and HSQC spectral data. The crystal structures of 4a, 2b, 5b, and 1d were determined by X-ray diffraction techniques. The 10 phosphazene derivatives were screened for antimicrobial activity. Meanwhile, interactions between the compounds and pBR322 plasmid DNA were presented by agarose gel electrophoresis. The compounds 2b, 1d, 2d, and 4d were tested against HeLa cancer cell lines. Among these compounds, 4d had cytotoxic effect on HeLa cell after 24 h treatment, Ankara University, Scientific Researchs Unit [12B4240004]; Hacettepe University, Scientific Research Unit [02 02 602 002]; State Planing Organization [1998K121480], The authors acknowledge the "Ankara University, Scientific Researchs Unit" Grant No. 12B4240004 and also thank "Medicinal Plants and Medicine Research Center of Anadolu University, Eskisehir" for using the X-ray facility. T. H. is indebted to "Hacettepe University, Scientific Research Unit" (Grant No. 02 02 602 002) for their financial support. L. A. thanks "State Planing Organization" (Grant No. 1998K121480).

WOS: 000330554400025, PubMed ID: 24161706, A number of partly (7-9) and fully (10a-12d. Scheme 1) substituted mono(4-fluorobenzyl)spiro cyclotriphosphazenes was prepared. The structures of the compounds were determined by MS, FTIR, 1D and 2D NMR techniques. The crystal structures of 9, llb and 12b were verified by X-ray diffraction analysis. In vitro cytotoxic activity of the phosphazenes (10a-12d) against HeLa cervical cancer cell lines was evaluated. Compound 12c was found to be the most effective, as it is a cytotoxic reagent that might activate apoptosis by altering mitochondrial membrane potential. Compounds 10b, lib and 12b showed very good activity against yeast strains Candida tropicalis and Candida albicans. BamHI and HindIII digestion results demonstrate that the compounds (10a-12a, 10b-12b, 10d-12d), and (9,10c-12c) bind with GIG and A/A nucleotides, respectively, Ankara University Scientific Research Unit [09B4240006]; Hacettepe University, Scientific Research Unit [02 02 602 002]; State Planning Organization [1998K121480], The authors acknowledge the "Ankara University Scientific Research Unit" Grant No. 09B4240006, "Hacettepe University, Scientific Research Unit" Grant No. 02 02 602 002 and "The State Planning Organization" Grant No. 1998K121480 for financial supports. One of the authors, Y.S., thanks the "Anadolu University, Medicinal Plants and Medicine Research Center" for using the X-ray facility.

WOS: 000324325200010, In this study, six new complexes (3ampyH)(2)[Ni(CN)(4)] (1), (3ampyH)(2)[Pd(CN)(4)] (2), (3ampyH)(2)[Pt(CN)(4)] (3), (4ampyH)(2)[Ni(CN)(4)] (4), (4ampyH)(2)[Pd(CN)(4)] (5) and (4ampyH)(2)[Pt(CN)(4)] (6) (3ampy = 3-aminomethylpyridine and 4ampy = 4-aminomethylpyridine) have been synthesized and characterized by spectroscopic, elemental and thermal analyses, and single crystal X-ray diffraction techniques. Complexes 1, 2 and 3 crystallize in the monoclinic system, space groups P2(1)/c, C2 and C2, respectively, whereas complexes 4, 5 and 6 crystallize in the triclinic system, space groups P (1) over bar. The asymmetric units contain one halves of the [M(CN)(4)](2) anions and the 3ampyH or the 4ampyH cations, where M is Ni(II), Pd(II) or Pt(II), respectively. The metal atoms are located on inversion centres and each metal atom is coordinated in a distorted square planar geometry by the four symmetry related C atoms from four cyano ligands, Eskisehir Osmangazi University [201219A202], This work was supported by the Research Fund of Eskisehir Osmangazi University. Project number: 201219A202. Raman spectra were recorded at Anadolu University, Department of Physics. The authors wish to thank Prof. Dr. Mustafa Senyel and Mrs. Tulay Tiras for the Raman measurements.

WOS: 000304796800003, Eight new copper(II)-thiophene-2,5-dicarboxylate (tdc) complexes with N-methylethylenediamine (nmen), [Cu(H2O)(2)(nmen)(2)](tdc) (1), N,N-dimethylethylenediamine (nnen), [Cu(tdc)(nnen)(2)]center dot H2O (2), N,N'-dimethylethylenediamine (dmen), [Cu(mu-tdc)(H2O)(dmen)](n) (3), N,N,N',N'-tetramethylethylenediamine (tmen), {[Cu(mu-tdc)(tmen)(2)]center dot H2O}(n) (4), N-ethylethylenediamine (neten), trans-[Cu(H2O)(2)(neten)(2)](tdc)center dot 2H(2)O (5), N,N'-diethylethylenediamine (deten), trans-[Cu(H2O)(2)(deten)(2)](tdc) (6), N,N-diethylethylenediamine (eten), [Cu(mu-tdc)(eten)](n), (7), and N-methyl-1,3-propanediamine (nmpen), [Cu(tdc)(nmpen)(2)] (8), have been synthesized and characterized by elemental analyses, magnetic moments, thermal analyses (TG, DTG and DTA), UV-Vis and IR spectra. The crystal structures of 2, 3, 5 and 7 were determined by single crystal X-ray diffraction studies. In 1, 5 and 6, the Cu(II) ions are coordinated by two aqua ligands and four nitrogen atoms of nmen, neten and deten, respectively and thiophene-2,5-dicarboxylate (tdc) acts as a counterion. In 2, 4 and 8, tdc coordinates to the Cu(II) ions through the oxygen atom of the carboxylate group as a monodentate ligand, and the distorted square pyramidal geometries of the Cu(II) ions of 2, 4 and 8 are completed by the nnen, tmen and nmpen ligands, respectively, which act as bidentate ligands. In 3 and 7, the tdc ligand exhibits tridentate-mu(2) and tetradentate-mu(2) bridging modes, being coordinated through three and four carboxylate oxygens atoms, respectively. The crystal packing of the complexes is a composite of intermolecular hydrogen bonding interactions. Furthermore, in vitro antimicrobial activities of these complexes were tested against selected wild type microorganisms using MIC methods, Eskisehir Osmangazi University [200819042], This work was supported by the Eskisehir Osmangazi University by project No 200819042.

In the title complex, [Co(C8H7O3)2(C6H6N2O)(H2O)2], the CoII atom is coordinated by three O atoms from two 4-methoxybenzoate ligands, which act in different modes, viz. monodentate and bidentate, two water molecules and one N atom of the isonicotinamide ligand in a distorted octahedral geometry. The monodentate-coordinated carboxylate group is involved in an intramolecular O—H...O hydrogen bond with the coordinated water molecule. In the crystal structure, intermolecular O—H...O and N—H...O hydrogen bonds link the molecules into layers parallel to the ab plane. The crystal packing is further stabilized by weak C—H...O hydrogen bonds and π–π interactions indicated by the short distance of 3.6181 (8) Å between the centroids of the benzene and pyridine rings of neighbouring molecules.

In the centrosymmetric dimeric CdII title compound, [Cd2(C9H10NO2)4(C6H6N2O)2(H2O)2], each seven-coordinated CdII atom is chelated by the carboxylate groups of the two 4-(dimethylamino)benzoate (DMAB) anions; the two monomeric units are bridged through the two O atoms of the two carboxyl groups. In the crystal structure, intermolecular O—H...O, N—H...O and C—H...O hydrogen bonds link the molecules into a three-dimensional network. π–π contacts between the pyridine rings [centroid–centroid distance = 3.974 (1) Å] may further stabilize the structure. Weak C—H...π interactions are also observed.

The asymmetric unit of the centrosymmetric dinuclear title compound, [Cu2(C8H7O3)4(C6H6N2O)2(H2O)2], contains one half of the complex molecule. Each CuII atom is five-coordinated by one N atom from one bridging nicotinamide ligand and one O atom from another symmetry-related bridging nicotinamide ligand, two O atoms from two 4-methoxybenzoate ligands, and one water molecule, forming a distorted square-pyramidal geometry. Intermolecular O—H...O and N—H...O hydrogen bonds link the molecules into layers parallel to (overline{1}01). π–π interactions, indicated by short intermolecular distances of 3.801 (1) Å between the centroids of the benzene rings and 3.653 (1) Å between the centroids of the pyridine rings, further stabilize the structure.

The asymmetric unit of the centrosymmetric dinuclear title compound, [Cu(2)(C(8)H(7)O(3))(4)(C(6)H(6)N(2)O)(2)(H(2)O)(2)], contains one half of the complex mol-ecule. Each Cu(II) atom is five-coordinated by one N atom from one bridging nicotinamide ligand and one O atom from another symmetry-related bridging nicotinamide ligand, two O atoms from two 4-meth-oxy-benzoate ligands, and one water mol-ecule, forming a distorted square-pyramidal geometry. Inter-molecular O-H⋯O and N-H⋯O hydrogen bonds link the mol-ecules into layers parallel to (01). π-π inter-actions, indicated by short inter-molecular distances of 3.801 (1) Å between the centroids of the benzene rings and 3.653 (1) Å between the centroids of the pyridine rings, further stabilize the structure.

In the title complex, [Co(C(8)H(7)O(3))(2)(C(6)H(6)N(2)O)(H(2)O)(2)], the Co(II) atom is coordinated by three O atoms from two 4-meth-oxy-benzoate ligands, which act in different modes, viz. monodentate and bidentate, two water mol-ecules and one N atom of the isonicotinamide ligand in a distorted octa-hedral geometry. The monodentate-coordinated carboxyl-ate group is involved in an intra-molecular O-H⋯O hydrogen bond with the coordinated water mol-ecule. In the crystal structure, inter-molecular O-H⋯O and N-H⋯O hydrogen bonds link the mol-ecules into layers parallel to the ab plane. The crystal packing is further stabilized by weak C-H⋯O hydrogen bonds and π-π inter-actions indicated by the short distance of 3.6181 (8) Å between the centroids of the benzene and pyridine rings of neighbouring mol-ecules.

The title complex, [Ni(C8H8NO2)2(H2O)4], is centrosymmetric with the NiII ion located on a centre of symmetry. It contains two 4-(methylamino)benzoate (PMAB) anions and four coordinated water molecules. The four O atoms in the equatorial plane around the NiII ion form a slightly distorted square-planar arrangement, while the slightly distorted octahedral coordination is completed by two O atoms of the PMAB anions in the axial positions. In the crystal structure, intermolecular O—H...O, O—H...N, N—H...O and C—H...O hydrogen bonds link the molecules into a three-dimensional network.

In the crystal structure of the title compound, [Cd(C8H7O2)2(C6H6N2O)2(H2O)]·H2O, the CdII cation is coordinated by two 4-methylbenzoate (PMB) anions, two isonicotinamide (INA) ligands and one water molecule in a distorted octahedral CdN2O4 geometry. One of PMB ions acts as a bidentate ligand while the other and the two INA are monodentate ligands. An O—H...O hydrogen bond links the uncoordinated water molecule to the carboxyl groups of the complex. The dihedral angles between the carboxyl groups and the adjacent benzene rings are 10.28 (11) and 21.24 (9)°, while the two benzene rings and the two pyridine rings are oriented at dihedral angles of 6.90 (4) and 88.64 (4)°, respectively. In the crystal structure, O—H...O and N—H...O hydrogen bonds link the molecules into a supramolecular structure. A π–π contact between the benzene rings [centroid–centroid distance = 3.911 (1) Å] may further stabilize the crystal structure. Weak C—H...π interactions involving the pyridine rings also occur in the crystal structure.

The centrosymmetric title NiII complex, [Ni(C9H10NO2)2(C10H14N2O)2(H2O)2], contains two dimethylaminobenzoate (DMAB), two diethylnicotinamide (DENA) ligands and two water molecules, all of them monodentate. The four O atoms in the equatorial plane around the NiII atom form a slightly distorted square-planar arrangement, while the slightly distorted octahedral coordination is completed by the two pyridine N atoms of the DENA ligands in axial positions. The NiII atom is displaced by 0.681 (1) Å out of the least-squares plane of the carboxylate group. The dihedral angle between the carboxylate group and the adjacent benzene ring is 5.61 (7)°, while the pyridine and benzene rings are oriented at a dihedral angle of 73.20 (4)°. An intramolecular O—H...O hydrogen bond results in the formation of a six-membered ring with a twisted conformation. In the crystal structure, intermolecular O—H...O and C—H...O hydrogen bonds link molecules into a three-dimensional network. Two weak C—H...π interactions are also present.

The centrosymmetric title Ni(II) complex, [Ni(C(9)H(10)NO(2))(2)(C(10)H(14)N(2)O)(2)(H(2)O)(2)], contains two dimethyl-amino-benzoate (DMAB), two diethyl-nicotinamide (DENA) ligands and two water mol-ecules, all of them monodentate. The four O atoms in the equatorial plane around the Ni(II) atom form a slightly distorted square-planar arrangement, while the slightly distorted octa-hedral coordination is completed by the two pyridine N atoms of the DENA ligands in axial positions. The Ni(II) atom is displaced by 0.681 (1) Å out of the least-squares plane of the carboxyl-ate group. The dihedral angle between the carboxyl-ate group and the adjacent benzene ring is 5.61 (7)°, while the pyridine and benzene rings are oriented at a dihedral angle of 73.20 (4)°. An intra-molecular O-H⋯O hydrogen bond results in the formation of a six-membered ring with a twisted conformation. In the crystal structure, inter-molecular O-H⋯O and C-H⋯O hydrogen bonds link mol-ecules into a three-dimensional network. Two weak C-H⋯π inter-actions are also present.

WOS: 000248625200036, PubMed ID: 17174146, The condensation reaction of {N-[(2-hydroxyphenylmethyl)amino]-4,6-dimethylpyridine} (2), which is a reduction product of 1, with trimer N3P3Cl6 affords partially a substituted spiro-cyclic phosphazene derivative (3). The fully substituted phosphazenes (4 and 5) have also been obtained from the reactions of 3 with the excess of pyrrolidine and morpholine. The characterizations and spectral investigations of these compounds have been made by elemental analyses, FTIR, H-1-, C-13-, P-31 NMR, correlation spectroscopy (COSY), heteronuclear chemical shift correlation (HETCOR), heteronuclear multiple-bond correlation (HMBC) and mass spectroscopy (MS). The salient features of spectral data of these compounds have been discussed

WOS: 000247452400039, PubMed ID: 17046319, Schiff bases derived from different meta-substituted salicylaldehyde and 5-methylaminopyridine have been synthesized and characterized by elemental analysis, FT-IR, NMR and UV-vis techniques. NMR assignments were made using H-1, C-13 NMR and aided by 2D HETCOR and HMBC heteronuclear correlation techniques. The UV-vis spectra of the compounds were found useful in understanding the existence of tautomeric equilibria [phenol-imine (O-H center dot center dot center dot N) and keto-amine (O center dot center dot center dot H-N) forms] in polar and non-polar solvents. In order to rationalize the stabilization of tautomer in solid state, X-ray structure of 2-[(1E)-2-aza-2-(5-methyl(2-pyridyl)ethenyl)]-4-bromobenzen-1-ol (6) was determined. According to our crystallographic result, it has enol-imine tautomeric form

The title compound, C13H12Cl4N5OP3, is a phosphazene derivative with a bulky substituted spirocyclic ring. The C3NPO spirocyclic ring has a twist-boat conformation, while the phosphazene ring has a very flattened boat conformation.

In the centrosymmetric dimeric Cd(II) title compound, [Cd(2)(C(9)H(10)NO(2))(4)(C(6)H(6)N(2)O)(2)(H(2)O)(2)], each seven-coordin-ated Cd(II) atom is chelated by the carboxyl-ate groups of the two 4-(dimethyl-amino)-benzoate (DMAB) anions; the two monomeric units are bridged through the two O atoms of the two carboxyl groups. In the crystal structure, inter-molecular O-H⋯O, N-H⋯O and C-H⋯O hydrogen bonds link the mol-ecules into a three-dimensional network. π-π contacts between the pyridine rings [centroid-centroid distance = 3.974 (1) Å] may further stabilize the structure. Weak C-H⋯π inter-actions are also observed.

The asymmetric unit of the centrosymmetric dinuclear title compound, [Cu2(C8H7O3)4(C6H6N2O)2(H2O)2], contains one half of the complex mol­ecule. Each CuII atom is five-coordinated by one N atom from one bridging nicotinamide ligand and one O atom from another symmetry-related bridging nicotinamide ligand, two O atoms from two 4-meth­oxy­benzoate ligands, and one water mol­ecule, forming a distorted square-pyramidal geometry. Inter­molecular O—H⋯O and N—H⋯O hydrogen bonds link the mol­ecules into layers parallel to (\overline{1}01). π–π inter­actions, indicated by short inter­molecular distances of 3.801 (1) A between the centroids of the benzene rings and 3.653 (1) A between the centroids of the pyridine rings, further stabilize the structure.

In the title complex, [Co(C8H7O3)2(C6H6N2O)(H2O)2], the CoII atom is coordinated by three O atoms from two 4-meth­oxy­benzoate ligands, which act in different modes, viz. monodentate and bidentate, two water mol­ecules and one N atom of the isonicotinamide ligand in a distorted octa­hedral geometry. The monodentate-coordinated carboxyl­ate group is involved in an intra­molecular O—H⋯O hydrogen bond with the coordinated water mol­ecule. In the crystal structure, inter­molecular O—H⋯O and N—H⋯O hydrogen bonds link the mol­ecules into layers parallel to the ab plane. The crystal packing is further stabilized by weak C—H⋯O hydrogen bonds and π–π inter­actions indicated by the short distance of 3.6181 (8) A between the centroids of the benzene and pyridine rings of neighbouring mol­ecules.

Anadolu Üniversitesi ve Bilecik Şeyh Edebali Üniversitesi tarafından ortak yürütülen program. Polifosfazenler fonksiyonel gruplarla kolaylıkla ve çeşitli yöntemlerle reaksiyon verip farklı özellikte bileşikler oluşturabilmektedir. Polifosfazenlerin kontrollü ilaç salımı, enzim aktiviteleri, cerrahi malzemeler, hidrofob-hidrofil malzemeler, sıvı kristal olarak teknolojik ürünler, sensörler, termal dayanıklı malzemeler, iyon transfer membranlar, katalizör destek vb. uygulamaları bulunmaktadır. Bundan dolayı çalışma alanları zamanla gelişen bileşiklerdir. Bu çalışmada, o-dianisidin ve 3,3'-diaminobenzidin türevli bazı polifosfazen bileşiklerinin sentezi ve yapılarının aydınlatılması amaçlanmıştır. Çöktürme polimerizasyonu yöntemine göre, o-dianisidin ve 3,3’- diaminobenzidin monomerleri ile trimer (N₃P₃Cl₆) ve tetramer’in (N₄P₄Cl₈) farklı oranlarda reaksiyonlarından siklomatriks yapıda polifosfazen mikro/nanoküreler elde edilmeye çalışılmıştır. Bunlardan o-dianisidin-trimer (ters oran) denemesi ve 3,3’- diaminobenzidin-tetramer (düz oran) denemeleri dışındaki diğer denemelerden mikro/nanoküreler sentezlenmiştir. Oluşan ürünlerin yapıları SEM, FT-IR ve XRD spektral yöntemleri ile analiz edilerek karakterizasyonları yapılmıştır Polyphosphazenes can react with functional groups easily and by various methods to form compounds of different properties. Controlled drug release of polyphosphazenes, enzyme activities, surgical materials, hydrophobic-hydrophilic materials, technological products as liquid crystals, sensors, thermal resistant materials, ion transfer membranes, catalyst support etc. applications. Therefore, the fields of study are compounds that develop over time. In this study, the synthesis and structure of some polyphosphazene compounds derived from o-dianisidine and 3,3’-diaminobenzidine are aimed. According to the precipitation polymerization method, it was tried to obtain cyclomatrix polyphosphazene micro/nano spheres in different ratios from the reactions of o-dianisidine and 3,3’-diaminobenzidine monomers and trimer (N₃P₃Cl₆) and tetramer (N₄P₄Cl₈). Of these, microspheres were synthesized from the other experiments except o-dianisidine-trimer (reverse ratio) and 3,3’-diaminobenzidine-tetramer (straight ratio). The structures of the products were analyzed by SEM, FT-IR and XRD spectral methods and their characterizations were made.