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Background: There is no consensus about effective systemic therapy for salivary gland carcinomas (sgcs). Our aim was summarized the clinical trials assessing the systemic therapies (ST) on sgcs. Material and Methods: Electronic searches were carried out through MEDLINE/pubmed, EMBASE, Scopus, Web of Science, and the Cochrane Library databases, and gray literature. Results: Seventeen different drugs were evaluated, and the most frequent histological subtype was adenoid cystic carcinoma (n=195, 45.5%). Stable disease, observed in 11 ST, achieved the highest rate in adenoid cystic carcinoma treated with sunitinib. The highest complete (11.1%) and partial response (30.5%) rates were seen in androgen receptor-positive tumors treated with leuprorelin acetate. Conclusions: Despite all the advances in this field, there is yet no effective evidence-based regimen of ST, with all the clinical trials identified showing low rates of complete and partial responses. Further, translational studies are urgently required to characterize molecular targets and effective ST. [ABSTRACT FROM AUTHOR]

Researchers at the University of Tunis El Manar conducted a study on primary tracheo-bronchial adenoid cystic carcinoma (TBACC), a rare disease primarily treated through surgery. The study analyzed eight patients operated on between 1994 and 2022, with bronchoscopy revealing specific characteristics of the disease. Surgical resections achieved promising outcomes, with an overall 5-year survival rate of 72% for patients with primary adenoid cystic carcinoma. The research emphasizes the importance of selecting appropriate surgical procedures to improve prognosis for this rare and low-to-moderate grade malignant tumor. [Extracted from the article]

Researchers at Tokat Gaziosmanpasa University conducted a study to investigate whether the monocyte/HDL ratio could predict ear effusion in patients with adenoid vegetation. The study included patients undergoing surgery for adenoid vegetation with or without otitis media with effusion (OME). While reduced MHR ratios may indicate elevated inflammatory levels, the study found no significant difference in predicting OME in children with adenoid vegetation. The research highlights the need for a simple, low-cost marker to predict middle ear effusion in children. [Extracted from the article]

A recent study conducted by the Department of Ultrasound focused on the diagnosis of pulmonary adenoid cystic carcinoma (PACC) using multimodal ultrasound imaging technology. The study presented a case of primary PACC in a 48-year-old male patient with multiple lung metastases, highlighting the potential of ultrasound imaging for diagnosing lung tumors. The diagnosis involved grayscale ultrasound, shear wave elastography, contrast-enhanced ultrasound, and ultrasound-guided percutaneous lung biopsy, leading to a confirmed diagnosis through pathological examination. Treatment was recommended but not accepted by the patient, who ultimately survived with telephone follow-up. [Extracted from the article]

The article discusses new findings on Adenoid Cystic Carcinoma (ACC) of the larynx, a rare malignant tumor that accounts for less than 1% of laryngeal malignancies. The research highlights two cases, one involving a 42-year-old woman and the other a 32-year-old man, both of whom underwent total laryngectomy with neck dissection and adjuvant radiotherapy. The study emphasizes the importance of long-term follow-up to assess the benefit and survival outcomes for patients with ACC. [Extracted from the article]

A recent study conducted at the King Hussein Cancer Center in Amman, Jordan, focused on personalized treatment strategies for breast adenoid cystic carcinoma (BACC), a rare subtype of breast cancer. The study analyzed data from 1212 patients using Machine Learning algorithms to predict 5-year survival rates and identified key prognostic indicators such as age, lymph node metastasis, and estrogen receptor status. The research concluded that while postoperative radiotherapy improved survival rates, the benefits of adjuvant chemotherapy were uncertain, emphasizing the importance of personalized treatment decisions. The study also introduced a web-based tool to aid in treatment optimization and prognostication. [Extracted from the article]

Researchers at Oslo University Hospital conducted a study on adenoid cystic carcinoma, comparing outcomes of patients treated with carbon-ion radiotherapy and photon radiotherapy. The study found that patients treated with carbon-ion radiotherapy had a higher incidence of osteoradionecrosis and worse prognosis compared to those treated with photon radiotherapy. The research highlights the importance of close follow-up and collaboration between treating centers to manage toxicity and improve quality of life for patients with adenoid cystic carcinoma. [Extracted from the article]

Researchers from Peking University in Beijing, China, have conducted a study on Adenoid Cystic Carcinoma (SACC), a malignant tumor that often metastasizes to the lungs. They found that inhibiting Cdh11 activates the cGAS-STING pathway by stimulating branched chain amino acid catabolism, which can help mitigate lung metastasis of SACC. The study suggests that targeting hybrid EMT cells, specifically through the use of celecoxib and its derivatives as CDH11 inhibitors, could be a promising treatment strategy for patients with SACC. This research was supported by the National Natural Science Foundation of China and the Natural Science Foundation of Beijing Municipality. [Extracted from the article]

A recent study from the University of Chicago highlights the potential of PRMT5 inhibitors in treating adenoid cystic carcinoma (ACC) of the salivary glands. ACC is a rare malignancy that often presents in advanced stages, with limited treatment options available. The research suggests that PRMT5 inhibitors show promise in inhibiting tumor growth in ACC, especially when combined with lenvatinib therapy. This study underscores the importance of identifying new therapeutic targets for ACC to improve patient outcomes. [Extracted from the article]

Researchers at Shaheed Zulfiqar Ali Bhutto Medical University conducted a study on the immunohistochemical expression of estrogen receptor-b (ERb) in adenoid cystic carcinoma of the salivary gland. The study found that 86.7% of cases showed positivity for ERb expression, suggesting a potential for hormone therapy using selective ER modulators. The research did not find a statistically significant association between gender, tumor site, histological type of adenoid cystic carcinoma, and ERb expression. This study provides valuable insights into the role of estrogen receptors in salivary gland cancers. [Extracted from the article]

Research conducted at the All India Institute of Medical Sciences (AIIMS) focused on otitis media with effusion (OME) in children, a common childhood disease characterized by fluid in the middle ear without acute infection symptoms. The study discussed the epidemiology, clinical features, and management of OME, highlighting the benefits of interventions such as nasal balloon auto-inflation, grommet insertion, and adenoidectomy. The combination of ventilation tubes and adenoidectomy was found to be beneficial for improving hearing, respiratory health, and overall development in children with OME. [Extracted from the article]

A study conducted at Bayero University in Nigeria explored the correlation between clinical symptoms and fiberoptic nasopharyngoscopy in diagnosing obstructive adenoid enlargement in children. The research found that clinical symptomatology scores were reliable in predicting the severity of adenoid enlargement as confirmed by fiberoptic endoscopic findings. This study highlights the importance of utilizing clinical symptoms as a diagnostic tool, especially in resource-constrained settings where fiberoptic nasopharyngoscopy may not be readily available. [Extracted from the article]

A study conducted at Beilun People's Hospital in Zhejiang, China, compared the outcomes of different surgical techniques for treating adenoid hypertrophy in children. The study found that nasal endoscopic transoral low-temperature adenoid ablation resulted in less bleeding, fewer postoperative residuals, and a lower recurrence rate compared to other methods. However, this technique requires skilled operation by doctors. The research was published in the International Journal of Pediatric Otorhinolaryngology and recommended nasal endoscopic transoral low-temperature adenoid ablation as the preferred method for treatment. [Extracted from the article]

A recent study conducted at the University of Miami focused on adenoid cystic carcinoma (ACC), a rare and lethal malignancy that originates in secretory glands of the head and neck. The research highlighted the overexpression of the proto-oncogene MYB as a prominent molecular feature of ACC. The study developed a quantitative polymerase chain reaction (qPCR) assay for MYB transcripts, which detected significantly elevated levels in metastatic ACC patients, potentially offering a sensitive and minimally invasive diagnostic test for early detection of metastatic disease. The findings were published in The Journal of Liquid Biopsy. [Extracted from the article]

A study conducted at the University of Brescia focused on developing a model to predict Relapse-Free Survival (RFS) in patients with Adenoid Cystic Carcinoma (AdCC) of the head and neck. The study utilized a combination of clinical and radiomic features from preoperative MRI scans to create a predictive model. The results showed that the combined clinical-radiomic model had the highest predictive accuracy and outperformed models based solely on clinical or radiomic features. This model could potentially assist clinicians in patient management and personalized treatment planning for AdCC patients. [Extracted from the article]

A recent study from Saveetha University in Tamil Nadu, India, focused on adenoid cystic carcinoma (ACC), a challenging cancer due to its slow growth and resistance to traditional treatments. The research highlighted the potential of targeting the AXL receptor to inhibit tumor growth and improve patient outcomes. The study concluded that further research into AXL biology and therapeutic strategies could reshape the treatment landscape for metastatic ACC. This information may be valuable for individuals interested in precision-based treatments for this type of cancer. [Extracted from the article]

A recent study conducted at Dr. D.Y. Patil Vidyapeeth in Maharashtra, India, focused on adenoid cystic carcinoma (ACC), a rare tumor that accounts for less than 1% of head and neck malignancies. The research highlighted the characteristics of sinonasal adenoid cystic carcinoma (SNACC), emphasizing its slow growth and potential for intracranial extension, necessitating surgical and radiotherapy treatment. The study underscored the importance of histological subtype and treatment options in determining the prognosis of SNACC, presenting rare histopathological findings in a case report. For more information, readers can access the full article in the Medical Journal of Dr. D.Y. Patil Vidyapeeth. [Extracted from the article]

Researchers from Wuhan University conducted a study on the hyoid bone position and upper airway morphology in children with and without adenotonsillar hypertrophy (ATH). The study found that children with ATH may have distinct differences in hyoid bone position and upper airway morphology, potentially impacting craniofacial growth and development. The research concluded that adenotonsillar hypertrophy could be associated with these differences, with children with enlarged tonsils showing a farther hyoid bone position from the mentum compared to those with enlarged adenoids. The findings were published in BMC Oral Health. [Extracted from the article]

A recent study conducted at the Instituto Portugues de Oncologia de Lisboa Francisco Gentil in Lisbon, Portugal, focused on Adenoid Cystic Carcinoma (ACC) of the vulva and vagina. The research examined clinicopathologic, immunohistochemical, and molecular characteristics of five cases, revealing similarities with ACCs in other locations but a less common presence of the MYB::NFIB fusion in this context. The study highlighted the importance of further research in understanding this rare neoplasm in the lower female genital tract. [Extracted from the article]

A study conducted by Weill Cornell Medicine in New York City compared the microbiome of pediatric patients with and without chronic rhinosinusitis. The research found no significant difference in bacterial composition between the two groups, but noted differences in diversity among the adenoids, tonsils, and middle meatus. The study suggests that there may be colonization of the middle meatus by the adenoid in pediatric chronic rhinosinusitis patients. [Extracted from the article]

A study conducted at Peking University in Beijing, China, focused on understanding bone metastasis in Adenoid Cystic Carcinoma (AdCC) through the dysregulation of the Notch signaling pathway and the potential therapeutic target SPARC. The research, which included 144 AdCC patients, found that SPARC may serve as a prognostic biomarker and therapeutic target for AdCC. The study highlighted the role of Notch activation in promoting bone metastasis by inhibiting SPARC expression in AdCC. [Extracted from the article]

A recent study conducted by the Korea Institute of Materials Science (KIMS) focused on adenoid cystic carcinoma, an uncommon malignant neoplasm of the salivary gland known for its aggressive nature and high recurrence rates. The study presented a case of a 72-year-old female with multiple recurrences of adenoid cystic carcinoma in the submandibular salivary gland, emphasizing the importance of complete surgical resection for treatment. The research highlighted the challenges in treating adenoid cystic carcinoma due to its aggressive clinical behavior and the need for regular follow-up to monitor for recurrence and metastasis. [Extracted from the article]

A recent study conducted at the Department of Orthodontics focused on the association between adenoid/tonsillar hypertrophy and craniofacial features in different age groups. The research, funded by organizations in Xiamen, China, analyzed cephalometric measurements of 942 patients aged 6-15 years. The findings indicated that children with isolated adenoid hypertrophy showed specific growth patterns and skeletal features at different age ranges, highlighting the importance of age-specific considerations in understanding these associations. For more information, the full article can be accessed through BMC Oral Health. [Extracted from the article]

The University of Saint Joseph conducted research on adenoid cystic carcinoma of the lacrimal gland, focusing on its clinical features, genetic factors, and treatment options. Adenoid cystic carcinoma is the most common malignant epithelial tumor of the lacrimal gland, presenting symptoms such as pain, eye swelling, double vision, and eye bulging. Early detection and appropriate treatment are crucial due to the tumor's aggressive nature, with surgical procedures and neoadjuvant intra-arterial chemotherapy being primary treatment options. The research emphasizes the importance of identifying prognostic factors to enhance treatment outcomes for patients with adenoid cystic carcinoma. [Extracted from the article]

Researchers at Soochow University in Jiangsu, China, have published a study on a rare case of advanced breast adenoid cystic carcinoma (AdCC) with a solid-basaloid component. The tumor exhibited unique genetic characteristics, including a novel EWSR1-MYB fusion, which has not been previously reported in AdCC with a solid-basaloid component. This research may contribute to a better genetic understanding of AdCC and improve clinical diagnosis and treatment strategies for this rare form of cancer. [Extracted from the article]

The article discusses a study on detecting metastatic adenoid cystic carcinoma (ACC) through monitoring tumor-specific MYB expression in blood samples. The researchers developed a qPCR assay for MYB transcripts and found significantly elevated levels in the metastatic ACC cohort. This study suggests a sensitive and minimally invasive diagnostic test that could enhance early detection of metastatic ACC. The preprint has not yet been peer-reviewed, and more information can be found on medrxiv.org. [Extracted from the article]

A patent has been issued for a method of treating adenoid cystic carcinoma by administering an inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling to patients. Adenoid cystic carcinoma is a lethal form of cancer primarily affecting young and middle-aged adults, with limited treatment options currently available. The patent outlines the use of specific inverse agonists and their potential as radio-sensitizers or chemo-sensitizers in conjunction with traditional treatments like surgery and radiotherapy. This method aims to address the challenges in treating adenoid cystic carcinoma and improve patient outcomes. [Extracted from the article]

Rgenta Therapeutics has initiated a Phase 1a/b clinical trial for RGT-61159, an oral small molecule targeting MYB, in patients with adenoid cystic carcinoma (ACC) and colorectal cancer (CRC). The trial aims to evaluate the safety, tolerability, pharmacokinetics, and clinical efficacy of the drug in patients with advanced ACC or CRC. This innovative approach addresses the urgent need for effective systemic treatment options for ACC and poor outcomes in colorectal cancer patients, offering hope for improved therapeutic strategies in oncology. [Extracted from the article]

A recent study conducted by Weill Cornell Medicine researchers analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database to investigate the long-term survival outcomes of patients with adenoid cystic carcinoma (ACC) in different geographic regions of the United States. The study included 5150 patients and found that the West region exhibited the worst survival compared to the Northeast region. Factors such as age, sex, cancer type, disease stage, treatment modalities, social support, and geographic location were identified as independent predictors of late mortality in ACC patients. Further research is needed to explore the causal relationships between these factors. [Extracted from the article]

A study conducted by researchers at Van Yuzuncu Yil University Faculty of Medicine in Turkey explored the relationship between adenoid hypertrophy and childhood afebrile seizures. The researchers measured adenoid tissue volume and nasopharyngeal distance in children aged 2-8 years who presented with afebrile seizures. They found that increased adenoid tissue volume was significantly associated with a higher number of afebrile seizure episodes. This research suggests that volumetric adenoid tissue size may be a contributing factor to recurrent episodes of childhood afebrile seizure. [Extracted from the article]

A recent study conducted by researchers at Recep Tayyip Erdogan University Faculty of Medicine in Turkey explored the relationship between adenoid hypertrophy, a common cause of obstructive sleep apnea in children, and systemic immune inflammation. The study analyzed data from 29 patients who underwent adenoidectomy for obstructive sleep apnea and compared it to a control group of healthy subjects. The results showed that platelet systemic immune inflammation index (SII) and pan-immune inflammation value (PIV) were significantly higher in patients with adenoid hypertrophy. However, further research is needed to fully understand the clinical implications of these findings. [Extracted from the article]

A recent study conducted by researchers from Capital Medical University in Beijing, China, focused on optimizing surgical approaches for lacrimal gland adenoid cystic carcinoma (a type of cancer). The study examined the outcomes of eye-sparing surgery for this type of carcinoma and its impact on tumor recurrence and orbital integrity. The researchers found that preserving intact orbital bone tissue is crucial for minimizing cross-organ metastasis of lacrimal gland adenoid cystic carcinoma. They recommend avoiding the lateral orbitotomy approach with no or limited invasion of the orbital bone wall. [Extracted from the article]

A recent study conducted at the University of Baghdad examined the cephalometric differences between grades II and IV adenoid hypertrophy. The study involved 120 patients aged 6-12 years old and used cephalometric radiographs to measure various points and angles in the craniofacial region. The results showed significant differences between the two grades of adenoid hypertrophy, suggesting that craniofacial changes occur as the adenoids enlarge. The researchers concluded that urgent medical intervention and orthodontic treatment may be necessary to establish nasal breathing in severe cases of adenoid hypertrophy. [Extracted from the article]

A recent study conducted by researchers at Fudan University Shanghai Cancer Center has explored the expression of Trichorhinophalangeal syndrome type 1 (TRPS1) in different types of breast carcinoma. The study found that TRPS1 is a highly sensitive marker for most special types of breast carcinoma, including mucinous carcinoma, adenoid cystic carcinoma, tubular carcinoma, secretory carcinoma, invasive lobular carcinoma, invasive micropapillary carcinoma, ER-positive neuroendocrine tumors, metaplastic breast carcinomas, and apocrine carcinomas. The study also revealed an inverse correlation between TRPS1 and androgen receptor (AR) expression in triple-negative breast cancer (TNBC). These findings contribute to a better understanding of adenoid cystic carcinoma and provide potential diagnostic markers for breast cancer. [Extracted from the article]

This article discusses the challenges in treating adenoid cystic carcinoma (ACC), a rare and lethal cancer, due to its low response rates to systemic therapies. The study aimed to understand the poor response rates to immune-checkpoint inhibitors (ICIs) by characterizing the ACC immune landscape. The researchers found that ACC tumors have low expression of HLA/B2M class I, which may explain their lack of response to ICIs. However, they also discovered that this low expression can be reversed through treatment with interferon-gamma or a STING agonist, suggesting a potential path for effective immunotherapies. [Extracted from the article]

A recent study conducted at Teerthanker Mahaveer University in Uttar Pradesh, India compared conventional adenoidectomy with power-assisted adenoidectomy. The study found that power-assisted adenoidectomy was a better surgical procedure, with improved surgical clearance and nasal symptom scores compared to conventional adenoidectomy. Additionally, patients who underwent power-assisted adenoidectomy experienced less postoperative pain and had a shorter recovery time. The findings suggest that power-assisted adenoidectomy may be a more effective and efficient treatment option for patients. [Extracted from the article]

A recent study conducted in China focused on adenoid cystic carcinoma, an extremely rare form of breast cancer that accounts for less than 0.1% of all breast cancers. The study presented a case of a 71-year-old woman with a large non-metastatic adenoid cystic carcinoma of the left breast and discussed the diagnosis and treatment of the case. The patient underwent neoadjuvant chemotherapy and radical mastectomy, and the tumor size was successfully reduced. The study emphasized the rarity of such a large tumor and the importance of early diagnosis in breast malignancies, particularly in older individuals. [Extracted from the article]

A study conducted by researchers at the Faculty of Medicine in Mashhad, Iran, focuses on adenoid cystic carcinoma (ACC) of the breast, which belongs to the basal-like subgroup of breast carcinomas. ACC is characterized by being triple negative, meaning it is negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (Her2). However, ACC has a good prognosis compared to other types of triple negative breast tumors. The study presents a case of a 43-year-old woman with ACC and describes the histopathological features of the tumor. ACC tumors are distinguished by their triple-negative appearance, basal-like features, and positivity for CD117 or cytokeratins 14 or 17 expression, which is important for distinguishing ACC from other tumors with worse prognoses. [Extracted from the article]

A recent study conducted at Wuhan University in China examined the relationship between adenotonsillar hypertrophy and dentofacial characteristics in children seeking orthodontic treatment. The study included a sample of 598 orthodontic patients aged 6-12, and compared the dentofacial characteristics of children with and without adenoid and/or tonsillar hypertrophy. The results showed that children with adenoid hypertrophy tended to have skeletal Class II malocclusion, while those with tonsillar hypertrophy tended to have skeletal Class III malocclusion. The study concluded that over 80% of children seeking orthodontic treatment had either adenoid or tonsillar hypertrophy. [Extracted from the article]