1. Water-Promoted Carbon-Carbon Bond Cleavage Employing a Reusable Fe Single-Atom Catalyst.
- Author
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Qi H, Mao S, Rabeah J, Qu R, Yang N, Chen Z, Bourriquen F, Yang J, Li J, Junge K, and Beller M
- Abstract
The development of methods for selective cleavage reactions of thermodynamically stable C-C/C=C bonds in a green manner is a challenging research field which is largely unexplored. Herein, we present a heterogeneous Fe-N-C catalyst with highly dispersed iron centers that allows for the oxidative C-C/C=C bond cleavage of amines, secondary alcohols, ketones, and olefins in the presence of air (O
2 ) and water (H2 O). Mechanistic studies reveal the presence of water to be essential for the performance of the Fe-N-C system, boosting the product yield from <1 % to >90 %. Combined spectroscopic characterizations and control experiments suggest the singlet1 O2 and hydroxide species generated from O2 and H2 O, respectively, take selectively part in the C-C bond cleavage. The broad applicability (>40 examples) even for complex drugs as well as high activity, selectivity, and durability under comparably mild conditions highlight this unique catalytic system., (© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)- Published
- 2023
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