1. Logic gate controlled theranostic nanoagents for in situ microwave thermal therapeutic efficacy evaluation.
- Author
-
Chen, Zengzhen, Guo, Wenna, Liang, Tiansong, Zheng, Yingjuan, Niu, Meng, Yang, Daoke, Tan, Longfei, Fu, Changhui, Wu, Qiong, Ren, Xiangling, Yu, Jie, Liang, Ping, Ren, Jun, and Meng, Xianwei
- Subjects
- *
TREATMENT effectiveness , *MICROWAVES , *LOGIC circuits , *CELL imaging - Abstract
In vivo monitoring of treatment response is of great significance for tumor therapy in clinical trials, but it remains a formidable challenge. Herein, we demonstrate a logic AND gate theranostic nanoagent that responds to the coexistence of endogenous and exogenous stimuli, namely HAuCl 4 @1-Tetradecanol@Gd-based metal−organic framework@SiO 2 nanocomposites (APGS NCs). Upon microwave (MW) irradiation, HAuCl 4 in the inner part of APGS NCs reacts with the tumor-associated glutathione (GSH). Subsequently, it transforms into an active luminescent form of Au@1-Tetradecanol@Gd-MOF@SiO 2 nanocomposites (AuPGS NCs). The intensity of generated fluorescence is correlated with the tumor thermal-injury status. Thus, the generation of AuPGS NCs with high intensity fluorescence under the co-activation of MW and GSH can visualize the treatment effects during MW thermal therapy and instantly modulate the irradiation time and range for optimal outcomes. Hence, this logic gate controlled APGS NCs makes MW thermal therapy eliminate tumor cells completely. This research offers an effective strategy for the design and preparation of activatable theranostic nanoagents for precise tumor imaging and therapy. A logic AND gate controlled theranostic nanoagent (APGS NCs) that responds to the stimuli of GSH and MW in the same tumor site in a simultaneous way, which can monitor the treatment process in real-time and optimize treatment outcomes. [Display omitted] • APGS NCs with endogenous/exogenous co-responsive imaging and therapy were fabricated. • Logic gate controlled APGS NCs was utilized for selective imaging of damaged cells. • Changes of fluorescence intensity/distribution in cell were used to quantify tumor damage. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF