1. [Disorders of cardiac contractile function in ischemic shock; the protective effect of antioxidants and liposomes made from egg phospholipids].
- Author
-
Bilenko MV, Morgunov AA, Churakova TD, Bulgakov VG, and Komarov PG
- Subjects
- Animals, Coronary Disease complications, Coronary Disease drug therapy, Coronary Disease mortality, Drug Carriers, Drug Evaluation, Preclinical, Female, Lipid Peroxidation drug effects, Lipid Peroxidation physiology, Liposomes, Myocardial Contraction drug effects, Rats, Rats, Inbred Strains, Shock, Cardiogenic drug therapy, Shock, Cardiogenic etiology, Shock, Cardiogenic mortality, Time Factors, Antioxidants therapeutic use, Coronary Disease physiopathology, Myocardial Contraction physiology, Phospholipids administration & dosage, Shock, Cardiogenic physiopathology
- Abstract
Experiments were made on Wistar rats with 6h tourniqueting of the hind limbs to study animal survival rate, myocardial contractile function and protective action of antioxidants and egg phospholipid liposomes during ischemic shock. It has been shown that reperfusion of the limbs leads to a high animal lethality, make lower myocardial contractile function and coronary flow of the hearts isolated from rats following a 6h reperfusion of the limbs. Well-known antioxidant butylated hydroxytoluene and a new antioxidant tetramethylpiperidine derivative bring animal lethality down and improve coronary flow and contractile function of the isolated heart. Phospholipid liposomes increase survival rate moderately but have no any effect on the heart contractile function. It has been deduced that lipid peroxidation takes part in the disturbance of heart contractile function and genesis of the death within ischemic shock.
- Published
- 1989