6 results
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2. Morphologic Features of Extrahepatic Manifestations of Hepatitis C Virus Infection.
- Author
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Ko, Huaibin M., Hernandez-Prera, Juan C., Zhu, Hongfa, Dikman, Steven H., Sidhu, Harleen K., Ward, Stephen C., and Thung, Swan N.
- Subjects
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IMMUNOLOGY , *VIRUS diseases , *AUTOIMMUNE thyroiditis , *LYMPHOPROLIFERATIVE disorders , *HEPATITIS C virus , *GLOMERULONEPHRITIS , *B cells - Abstract
Cirrhosis and hepatocellular carcinoma are the prototypic complications of chronic hepatitis C virus infection in the liver. However, hepatitis C virus also affects a variety of other organs that may lead to significant morbidity and mortality. Extrahepatic manifestations of hepatitis C infection include a multitude of disease processes affecting the small vessels, skin, kidneys, salivary gland, eyes, thyroid, and immunologic system. The majority of these conditions are thought to be immune mediated. The most documented of these entities is mixed cryoglobulinemia. Morphologically, immune complex depositions can be identified in small vessels and glomerular capillary walls, leading to leukoclastic vasculitis in the skin and membranoproliferative glomerulonephritis in the kidney. Other HCV-associated entities include porphyria cutanea tarda, lichen planus, necrolytic acral erythema, membranous glomerulonephritis, diabetic nephropathy, B-cell non-Hodgkin lymphomas, insulin resistance, sialadenitis, sicca syndrome, and autoimmune thyroiditis. This paper highlights the histomorphologic features of these processes, which are typically characterized by chronic inflammation, immune complex deposition, and immunoproliferative disease in the affected organ. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
3. HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type IIMixed Cryoglobulinemia: A Concurrent Pathogenetic Role.
- Author
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Sautto, Giuseppe, Mancini, Nicasio, Solforosi, Laura, Diotti, Roberta A., Clementi, Massimo, and Burioni, Roberto
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HEPATITIS C virus , *IMMUNOGLOBULINS , *CRYOGLOBULINEMIA , *IMMUNE response , *RHEUMATOID factor , *B cells - Abstract
The association between hepatitis C virus (HCV) infection and type II mixed cryoglobulinemia (MCII) is well established, but the role played by distinct HCV proteins and by specific components of the anti-HCV humoral immune response remains to be clearly defined. It is widely accepted that HCV drives the expansion of few B-cell clones expressing a restricted pool of selected immunoglobulin variable (IgV) gene subfamilies frequently endowed with rheumatoid factor (RF) activity. Moreover, the same IgV subfamilies are frequently observed in HCV-transformed malignant B-cell clones occasionally complicating MCII. In this paper, we analyze both the humoral and viral counterparts at the basis of cryoglobulins production in HCV-induced MCII, with particular attention reserved to the single IgV subfamilies most frequently involved. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
4. Indolent B-Cell Lymphomas Associated with HCV Infection: Clinical and Virological Features and Role of Antiviral Therapy.
- Author
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Arcaini, Luca, Merli, Michele, Volpetti, Stefano, Rattotti, Sara, Gotti, Manuel, and Zaja, Francesco
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HEPATITIS C virus , *B cells , *HODGKIN'S disease , *EPIDEMIOLOGY , *ANTIVIRAL agents - Abstract
The association between hepatitis C virus (HCV) infection and B-cell non-Hodgkin's lymphomas (NHL) has been demonstrated by epidemiological studies, in particular in highly endemic geographical areas such as Italy, Japan, and southern parts of United States. In these countries, together with diffuse large B-cell lymphomas, marginal zone lymphomas are the histotypes most frequently associated with HCV infection; in Italy around 20-30% cases of marginal zone lymphomas are HCV positive. Recently, antiviral treatment with interferon with or without ribavirin has been proved to be effective in the treatment of HCV-positive patients affected by indolent lymphoma, prevalently of marginal zone origin. An increasing number of experiences confirmed the validity of this approach in marginal zone lymphomas and in other indolent NHL subtypes like lymphoplasmacytic lymphoma. Across different studies, overall response rate was approximately 75%. Hematological responses resulted significantly associated with the eradication of the virus. This is the strongest evidence of a causative link between HCV and lymphomas. The aim of this paper is to illustrate the relationship between HCV infection and different subtypes of indolent B-cell lymphomas and to systematically summarize the data from the therapeutic studies that reported the use of antiviral treatment as hematological therapy in patients with HCV-associated indolent lymphomas. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
5. RP105-Negative B Cells in Systemic Lupus Erythematosus.
- Author
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Koarada, Syuichi and Tada, Yoshifumi
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B cells , *SYSTEMIC lupus erythematosus , *AUTOANTIBODIES , *NUCLEAR proteins , *TOLL-like receptors , *IMMUNOLOGY - Abstract
Systemic lupus erythematosus (SLE) is a multisystem disease characterized by B cells producing autoantibodies against nuclear proteins and DNA, especially anti-double-strand DNA (dsDNA) antibodies. RP105 (CD180), the toll-like receptor- (TLR-) associated molecule, is expressed on normal B cells. However, RP105-negative B cells increase in peripheral blood from patients with active SLE. RP105 may regulate B-cell activation, and RP105-negative B cells produce autoantibodies and take part in pathophysiology of SLE. It is possible that targeting RP105-negative B cells is one of the treatments of SLE. In this paper, we discuss the RP105 biology and clinical significance in SLE. [ABSTRACT FROM AUTHOR]
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- 2012
- Full Text
- View/download PDF
6. Mechanisms behind Functional Avidity Maturation in T Cells.
- Author
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Von Essen, Marina Rode, Kongsbak, Martin, and Geisler, Carsten
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T cells , *IMMUNE response , *ANTIBODY formation , *ANTIGENS , *B cells - Abstract
During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional aviditymaturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
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