1. Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers.
- Author
-
Herbeuval, Jean-Philippe, Smith, Nikaïa, and Thèze, Jacques
- Subjects
HIV-positive persons ,AIDS ,DENDRITIC cells ,CD4 antigen ,T cells ,IMMUNE response - Abstract
Despite variability, the majority of HIV-1-infected individuals progress to AIDS characterized by high viral load andmassive CD4+ T-cell depletion. However, there is a subset of HIV-1-positive individuals that does not progress and spontaneously maintains an undetectable viral load. This infrequent patient population is defined as HIV-1 controllers (HIV controllers), and represents less than 1% of HIV-1-infected patients. HIV-1-specific CD4+ T cells and the pool of central memory CD4+ T cells are also preserved despite immune activation due to HIV-1 infection. The majority of HIV controllers are also defined by the absence of massive CD4+ T-cell depletion, even after 10 years of infection. However, the mechanisms involved in protection against HIV-1 disease progression have not been elucidated yet. Controllers represent a heterogeneous population; we describe in this paper some common characteristics concerning innate immune response and CD4+ T cells of HIV controllers. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF