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A study conducted by researchers at Hannover Medical School in Germany explores the potential benefits of a ketogenic diet (KD) as an alternative treatment for drug-resistant epilepsy. The study investigates the impact of C8 and C10 fatty acids, which are found in the KD, on sirtuins, enzymes involved in energy metabolism, in neuronal cells. The findings suggest that C8 and C10 fatty acids may play a role in the antiepileptic effect of the KD, and nutritional supplements of these fatty acids could potentially replace the diet. Further research is needed to fully understand the mechanisms underlying the therapeutic effects of the KD. [Extracted from the article]

A recent study conducted by researchers at the State University of Campinas (UNICAMP) has provided new insights into Aspergillus fumigatus, a human pathogenic fungus that poses a public health problem. The study focused on the role of sirtuins, NAD+-dependent lysine deacetylases, in A. fumigatus. The researchers found that the deletion of a specific sirtuin gene, SirE, resulted in significant changes in gene expression and protein acetylation, as well as a decrease in virulence. These findings suggest that sirtuin inhibitors could be potential therapeutic strategies for combating A. fumigatus infections, either alone or in combination with existing antifungal drugs. [Extracted from the article]

A recent study conducted by researchers at the University of Messina in Italy explores the role of sirtuins in the regulation of epigenetic processes. Sirtuins are a type of enzyme involved in various physiological and pathological processes, including cardiovascular and neurodegenerative diseases, obesity and diabetes, age-related disorders, and cancer. The study specifically focuses on the potential of Citrus flavonoids, found in Mediterranean diet, to modulate sirtuins and their signaling pathways. The findings suggest that Citrus flavonoids may have promising therapeutic applications in the future. [Extracted from the article]

We also elucidate the biological function of Sirtuins across diverse cardiovascular diseases and further discuss the development of novel drugs that regulate Sirtuin-mediated autophagy." Keywords: ADP Ribose Transferases; Amidohydrolases; Cardiology; Cardiovascular; Cardiovascular Diseases and Conditions; Cardiovascular Research; Drugs and Therapies; Enzymes and Coenzymes; Glycosyltransferases; Group III Histone Deacetylases; Health and Medicine; Intracellular Signaling Peptides and Proteins; Pharmaceuticals; Sirtuins EN ADP Ribose Transferases Amidohydrolases Cardiology Cardiovascular Cardiovascular Diseases and Conditions Cardiovascular Research Drugs and Therapies Enzymes and Coenzymes Glycosyltransferases Group III Histone Deacetylases Health and Medicine Intracellular Signaling Peptides and Proteins Pharmaceuticals Sirtuins 879 879 1 09/25/23 20230929 NES 230929 2023 SEP 25 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Research findings on cardiovascular diseases and conditions are discussed in a new report. [Extracted from the article]

ADP Ribose Transferases, Amidohydrolases, Cerebrovascular Diseases and Conditions, Drugs and Therapies, Enzymes and Coenzymes, Glycosyltransferases, Group III Histone Deacetylases, Health and Medicine, Intracellular Signaling Peptides and Proteins, Sirtuins, Stroke Keywords: ADP Ribose Transferases; Amidohydrolases; Cerebrovascular Diseases and Conditions; Drugs and Therapies; Enzymes and Coenzymes; Glycosyltransferases; Group III Histone Deacetylases; Health and Medicine; Intracellular Signaling Peptides and Proteins; Sirtuins; Stroke EN ADP Ribose Transferases Amidohydrolases Cerebrovascular Diseases and Conditions Drugs and Therapies Enzymes and Coenzymes Glycosyltransferases Group III Histone Deacetylases Health and Medicine Intracellular Signaling Peptides and Proteins Sirtuins Stroke 1773 1773 1 08/21/23 20230825 NES 230825 2023 AUG 25 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on stroke have been published. [Extracted from the article]

Fibrosis and neurodegenerative diseases (NDs) often occur with aging, imposing large burdens on public health worldwide, and there are currently no effective treatment strategies for these diseases." Keywords: Xi'an; People's Republic of China; Asia; ADP Ribose Transferases; Amidohydrolases; Drugs and Therapies; Enzymes and Coenzymes; Glycosyltransferases; Group III Histone Deacetylases; Intracellular Signaling Peptides and Proteins; Neurodegenerative Diseases and Conditions; Sirtuins EN Xi'an People's Republic of China Asia ADP Ribose Transferases Amidohydrolases Drugs and Therapies Enzymes and Coenzymes Glycosyltransferases Group III Histone Deacetylases Intracellular Signaling Peptides and Proteins Neurodegenerative Diseases and Conditions Sirtuins 1724 1724 1 04/03/23 20230407 NES 230407 2023 APR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New research on Neurodegenerative Diseases and Conditions is the subject of a report. [Extracted from the article]