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A recent study conducted at Sichuan University in China has explored the role of Sirtuins in intervertebral disc degeneration (IDD). IDD is a major cause of low back pain and has limited treatment options. Sirtuins are a family of enzymes involved in various metabolic processes and have been found to play a regulatory role in IDD. The study reviews the molecular pathways of Sirtuins in IDD and discusses the therapeutic potential of targeting Sirtuins with activators or micro-RNA. The research aims to provide possible solutions for the treatment of IDD. [Extracted from the article]

Researchers from Bharathidasan University in Tamil Nadu, India, have conducted a study on imidazole therapy and its potential as a sirtuin inhibitor. Sirtuins are a family of enzymes that regulate cellular processes by removing acetyl groups from proteins. The researchers used in-silico and in-vitro methods to evaluate the inhibitory effects of imidazole derivatives on sirtuins, specifically in non-small cell lung cancer (NSCLC) cell lines. The results suggest that Ethyl 2-[5-(4-chlorophenyl)-2-methyl-1-H-Imidazole-4-yl) acetate has a strong inhibitory effect on nuclear sirtuins in NSCLC cell lines. This research contributes to the emerging strategy of targeting sirtuins to combat carcinogenesis. [Extracted from the article]

Keywords: ADP Ribose Transferases; Amidohydrolases; Dermatology; Enzymes and Coenzymes; Genetics; Glycosyltransferases; Group III Histone Deacetylases; Health and Medicine; Intracellular Signaling Peptides and Proteins; Papulosquamous Skin Diseases and Conditions; Psoriasis; Sirtuins; Skin Diseases and Conditions EN ADP Ribose Transferases Amidohydrolases Dermatology Enzymes and Coenzymes Genetics Glycosyltransferases Group III Histone Deacetylases Health and Medicine Intracellular Signaling Peptides and Proteins Papulosquamous Skin Diseases and Conditions Psoriasis Sirtuins Skin Diseases and Conditions 1104 1104 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- New study results on psoriasis have been published. Amidohydrolases, Dermatology, Enzymes and Coenzymes, Genetics, Glycosyltransferases, Group III Histone Deacetylases, ADP Ribose Transferases, Health and Medicine, Intracellular Signaling Peptides and Proteins, Papulosquamous Skin Diseases and Conditions, Psoriasis, Sirtuins, Skin Diseases and Conditions. [Extracted from the article]

Keywords: ADP Ribose Transferases; Amidohydrolases; Amino Acids; Arginine; Basic Amino Acids; Cell Nucleus Structures; Chromatin; Chromosome Structures; Chromosomes; Diamino Amino Acids; Enzymes and Coenzymes; Essential Amino Acids; Genetics; Glycosyltransferases; Group III Histone Deacetylases; Histones; Intracellular Signaling Peptides and Proteins; Intranuclear Space; Nuclear Proteins; Nucleoproteins; Nucleosomes; Penn State; Proteins; Sirtuins EN ADP Ribose Transferases Amidohydrolases Amino Acids Arginine Basic Amino Acids Cell Nucleus Structures Chromatin Chromosome Structures Chromosomes Diamino Amino Acids Enzymes and Coenzymes Essential Amino Acids Genetics Glycosyltransferases Group III Histone Deacetylases Histones Intracellular Signaling Peptides and Proteins Intranuclear Space Nuclear Proteins Nucleoproteins Nucleosomes Penn State Proteins Sirtuins 421 421 1 05/02/23 20230505 NES 230505 2023 MAY 5 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- UNIVERSITY PARK, Pa. - New research provides insight into how an enzyme that helps regulate aging and other metabolic processes accesses our genetic material to modulate gene expression within the cell. According to Tan, the nucleosome is a hundred times larger than typical histone peptides used in these studies and are consequently much more complicated to work with. "The arginine anchor is a common paradigm for how many chromatin proteins interact with the nucleosome", said Tan. [Extracted from the article]