Search

Your search keyword '"Yasuhiro Kurumiya"' showing total 4 results
Start Over Author "Yasuhiro Kurumiya" Journal plos one
4 results on '"Yasuhiro Kurumiya"'

1. A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study: MUC3 is a novel prognostic factor.

Author

Hiroaki Shibahara, Michiyo Higashi, Seiya Yokoyama, Karine Rousseau, Iwao Kitazono, Masahiko Osako, Hiroshi Shirahama, Yukie Tashiro, Yasuhiro Kurumiya, Michihiko Narita, Shingo Kuze, Hiroshi Hasagawa, Takehito Kato, Hitoshi Kubota, Hideaki Suzuki, Toshiyuki Arai, Yu Sakai, Norihiro Yuasa, Masahiko Fujino, Shinji Kondo, Yoshichika Okamoto, Tatsuyoshi Yamamoto, Takashi Hiromatsu, Eiji Sasaki, Kazuhisa Shirai, Satoru Kawai, Koutarou Hattori, Hideki Tsuji, Osamu Okochi, Masaki Sakamoto, Akinobu Kondo, Naomi Konishi, Surinder K Batra, and Suguru Yonezawa

Subjects
Medicine, Science
Abstract

Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma.Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma.The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p = 0.036); MUC2 with histological type (mucinous carcinoma, p

Published
2014
Full Text
View/download PDF

2. Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer.

Author

Hiroaki Shibahara, Michiyo Higashi, Chihaya Koriyama, Seiya Yokoyama, Iwao Kitazono, Yasuhiro Kurumiya, Michihiko Narita, Shingo Kuze, Takanori Kyokane, Saburo Mita, Toshiyuki Arai, Takehito Kato, Norihiro Yuasa, Ryuzo Yamaguchi, Hitoshi Kubota, Hideaki Suzuki, Satoshi Baba, Karine Rousseau, Surinder K Batra, and Suguru Yonezawa

Subjects
Medicine, Science
Abstract

Mucins have been associated with survival in various cancer patients, but there have been no studies of mucins in small bowel carcinoma (SBC). In this study, we investigated the relationships between mucin expression and clinicopathologic factors in 60 SBC cases, in which expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6 and MUC16 in cancer and normal tissues were examined by immunohistochemistry. MUC1, MUC5AC and MUC16 expression was increased in SBC lesions compared to the normal epithelium, and expression of these mucins was related to clinicopathologic factors, as follows: MUC1 [tumor location (p = 0.019), depth (p = 0.017) and curability (p = 0.007)], MUC5AC [tumor location (p = 0.063) and lymph node metastasis (p = 0.059)], and MUC16 [venous invasion (p = 0.016) and curability (p = 0.016)]. Analysis of 58 cases with survival data revealed five factors associated with a poor prognosis: poorly-differentiated or neuroendocrine histological type (p

Published
2014
Full Text
View/download PDF

3. A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor

Author

Hideki Tsuji, Satoru Kawai, Toshiyuki Arai, Koutarou Hattori, Yukie Tashiro, Takashi Hiromatsu, Michihiko Narita, Shingo Kuze, Yasuhiro Kurumiya, Iwao Kitazono, Karine Rousseau, Hitoshi Kubota, Masahiko Osako, Eiji Sasaki, Norihiro Yuasa, Osamu Okochi, Masaki Sakamoto, Masahiko Fujino, Naomi Konishi, Hiroshi Hasagawa, Hiroaki Shibahara, Hiroshi Shirahama, Akinobu Kondo, Shinji Kondo, Michiyo Higashi, Yoshichika Okamoto, Suguru Yonezawa, Tatsuyoshi Yamamoto, Hideaki Suzuki, Surinder K. Batra, Seiya Yokoyama, Yu Sakai, Kazuhisa Shirai, and Takehito Kato

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Clinical Pathology, Colorectal cancer, Lymphovascular invasion, lcsh:Medicine, Pathology and Laboratory Medicine, Metastasis, Young Adult, Diagnostic Medicine, Pancreatic cancer, Gastrointestinal Tumors, Carcinoma, medicine, Medicine and Health Sciences, Mucinous carcinoma, Humans, lcsh:Science, Survival analysis, Aged, Aged, 80 and over, Multidisciplinary, business.industry, Cancer Risk Factors, Gene Expression Profiling, lcsh:R, Mucins, Cancer, Cancers and Neoplasms, Middle Aged, medicine.disease, Prognosis, Survival Analysis, 3. Good health, Oncology, Appendiceal Neoplasms, Multivariate Analysis, lcsh:Q, Female, business, Research Article
Abstract

Background Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma. Methods Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma. Results The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p = 0.036); MUC2 with histological type (mucinous carcinoma, p

Published
2014

4. Pathobiological Implications of Mucin (MUC) Expression in the Outcome of Small Bowel Cancer

Author

Takanori Kyokane, Shingo Kuze, Michihiko Narita, Iwao Kitazono, Hideaki Suzuki, Norihiro Yuasa, Hitoshi Kubota, Toshiyuki Arai, Satoshi Baba, Hiroaki Shibahara, Takehito Kato, Michiyo Higashi, Yasuhiro Kurumiya, Suguru Yonezawa, Chihaya Koriyama, Saburo Mita, Karine Rousseau, Ryuzo Yamaguchi, Seiya Yokoyama, and Surinder K. Batra

Subjects
Male, Pathology, Colorectal cancer, Lymphovascular invasion, Glycobiology, lcsh:Medicine, Mucin 5AC, Pathology and Laboratory Medicine, Gastroenterology, Biochemistry, Metastasis, 0302 clinical medicine, Intestine, Small, Medicine and Health Sciences, Neoplasm Metastasis, lcsh:Science, MUC1, Aged, 80 and over, 0303 health sciences, Multidisciplinary, Hazard ratio, Middle Aged, Prognosis, Immunohistochemistry, 3. Good health, Gene Expression Regulation, Neoplastic, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Female, Anatomy, Immunohistochemical Analysis, Research Article, Adult, medicine.medical_specialty, Histology, Immunology, Immunopathology, Biology, Research and Analysis Methods, 03 medical and health sciences, Diagnostic Medicine, Antigens, Neoplasm, Internal medicine, Gastrointestinal Tumors, Intestinal Neoplasms, medicine, Biomarkers, Tumor, Humans, Neoplasm Invasiveness, Immunohistochemistry Techniques, 030304 developmental biology, Glycoproteins, Aged, Proportional Hazards Models, Proportional hazards model, Mucin, lcsh:R, Mucin-1, Cancer, Biology and Life Sciences, Cancers and Neoplasms, Membrane Proteins, medicine.disease, Histochemistry and Cytochemistry Techniques, CA-125 Antigen, Immunologic Techniques, lcsh:Q, Clinical Immunology, Biomarkers
Abstract

Mucins have been associated with survival in various cancer patients, but there have been no studies of mucins in small bowel carcinoma (SBC). In this study, we investigated the relationships between mucin expression and clinicopathologic factors in 60 SBC cases, in which expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6 and MUC16 in cancer and normal tissues were examined by immunohistochemistry. MUC1, MUC5AC and MUC16 expression was increased in SBC lesions compared to the normal epithelium, and expression of these mucins was related to clinicopathologic factors, as follows: MUC1 [tumor location (p = 0.019), depth (p = 0.017) and curability (p = 0.007)], MUC5AC [tumor location (p = 0.063) and lymph node metastasis (p = 0.059)], and MUC16 [venous invasion (p = 0.016) and curability (p = 0.016)]. Analysis of 58 cases with survival data revealed five factors associated with a poor prognosis: poorly-differentiated or neuroendocrine histological type (p

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results