1. [Review about mechanisms of anti-cancer of Solanum nigrum].
- Author
-
An L, Tang JT, Liu XM, and Gao NN
- Subjects
- Alkaloids isolation & purification, Animals, Antineoplastic Agents, Phytogenic isolation & purification, Caspase 3 metabolism, Cell Line, Tumor, Cell Membrane Permeability drug effects, DNA, Neoplasm biosynthesis, Drugs, Chinese Herbal isolation & purification, Glycoproteins isolation & purification, Humans, NF-kappa B metabolism, Nitric Oxide metabolism, Plants, Medicinal chemistry, RNA, Neoplasm biosynthesis, Sialic Acids metabolism, Alkaloids pharmacology, Antineoplastic Agents, Phytogenic pharmacology, Apoptosis drug effects, Drugs, Chinese Herbal pharmacology, Glycoproteins pharmacology, Solanum nigrum chemistry
- Abstract
This paper gave a brief introduction of the effect of Solanum nigrum on anti-cancer. The experimental results showed that the total alkaloid isolated from S. nigrum interfered structure and function of tumor cell membrane, disturbed the synthesis of DNA and RNA, changed the cell cycle distribution, so that total alkaloids could play in inhibabition to tumor cells, while the glycoprotein (150 x 10(3)) isolated from S. nigrum might have shown anti-cancer abilities by blocking the anti-apoptotic pathway of NF-kappaB, activating caspase cascades reaction and increasing the production of nitric oxide.
- Published
- 2006