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Objective: To explore the clinical value of echocardiography parameters combine with serum N-terminal B-type brain natriuretic peptide (NT-pro BNP), soluble urokinase type plasminogen activator receptor (suPAR), and pentraxin-3 (PTX-3) in predicting the prognosis of patients with chronic heart failure (CHF). Methods: 122 patients with CHF who were admitted to the 909th Hospital of the Joint Logistics Support Force from January 2019 to October 2021 were selected as the CHF group, while 50 healthy individuals were selected as the control group during the same period. The echocardiographic parameters and serum NT-pro BNP, suPAR, and PTX-3 levels were compared between the two groups. Patients with CHF were followed up for 12 months after discharge, and they were divided into poor prognosis group and good prognosis group based on the prognosis, and the echocardiographic parameters and serum NT-pro BNP, suPAR, and PTX-3 levels were compared between the two groups. The predictive value of receiver operating characteristic (ROC) curve analysis of echocardiography parameters combined with serum NT pro BNP, suPAR, and PTX-3 for poor prognosis of patients with CHF. Results: Compared with the control group, left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), NT-pro BNP, suPAR, and PTX-3 of the CHF group were significantly increased (P<0.05), while left ventricular ejection fraction (LVEF) was significantly decreased (P<0.05). 122 patients with CHF were followed up for 12 months after discharge, including 35 patients with poor prognosis and 83 patients with good prognosis. Compared with the good prognosis group, LVEDD, LVESD, NT-pro BNP, suPAR, and PTX-3 of the poor prognosis group significantly increased (P<0.05), while LVEF significantly decreased (P<0.05). ROC curve analysis results showed that LVEDD, LVESD, and LVEF combined with NT-pro BNP, suPAR, and PTX-3 had the highest efficacy in predicting poor prognosis of CHF, significantly superior to the individual predictin of various indicators. Conclusion: Echocardiographic parameters LVEDD, LVESD, and LVEF combine with serum NT-pro BNP, suPAR, and PTX-3 have a high value in predicting poor prognosis of patients with CHF, which can serve as an auxiliary indicator for predicting the prognosis of patients with CHF. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between body surface ECG qrs-t angle and serum levels of N-terminal pro-B-type natriuretic peptide (NT proBNP), melatonin, and galectin-3 in predicting outcomes in patients with heart failure with preserved ejection fraction (HFPEF). Methods: 156 cases of patients with HFpEF who were admitted to the Wuhan Third Hospital from January 2020 to January 2022 were selected. Surface electrocardiogram examinations were performed on admission day, QRS-T Angle was recorded, serum NT-proBNP, Melatonin and galectin-3 levels were detected, and follow-up was conducted after discharge until June 2022. They were divided into poor prognosis group and good prognosis group according to the occurrence of adverse cardiovascular events. Multiple Logistic regression was used to analyze the prognostic factors of patients with HFpEF, and receiver operating characteristic curve (ROC) was used to analyze the value of QRS-T Angle combined with serum NT-proBNP, galectin-3 in predicting the prognosis of patients with HFpEF. Results: The QRS-T Angle in the poor prognosis group was larger than that in the good prognosis group, the serum NT-proBNP and galectin-3 levels were higher than those in the good prognosis group, and serum Melatonin level was lower than that in the good prognosis group (P＜0.05). Enlarged QRS-T Angle, elevated NT-proBNP, galectin-3 were risk factors for poor prognosis in patients with HFpEF (P＜0.05), and elevated Melatonin was a protective factor (P＜0.05). The area under curve of combining the four indicators to predict poor prognosis of patients with HFpEF was 0.899, which was higher than that predicted by alone. Conclusion: Enlarged QRS-T Angle, elevated serum NT-proBNP and galectin-3 levels, and decreased serum Melatonin level are associated with poor prognosis of HFpEF, and the combination of four indicators can help predict prognosis of HFpEF. [ABSTRACT FROM AUTHOR]

Objective: To explore the value of serum procalcitonin (PCT), leukocyte differentiation antigen 14 subtype (presepsin) and growth arrest specific gene product 6 (Gas6) in evaluating the condition and prognosis of senile patients with chronic heart failure (CHF) complicated with pulmonary infection. Methods: 412 senile patients with CHF who were divided into pulmonary infection group (n=176) and non-pulmonary infection group (n=236) according to whether they were complicated with pulmonary infection. Another 40 healthy patients during the same period were selected as healthy control group. The serum PCT, presepsin and Gas6 levels of the three groups were compared. The prognosis of senile patients with CHF complicated with pulmonary infection within 28d of hospitalization was counted, and they were divided into death group (n=37) and survival group (n=139) according to different prognosis. Multivariate Logistic regression models were used to analyze the risk factors of death in senile patients with CHF complicated with pulmonary infection. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum PCT, presepsin combined with Gas6 for mortality in senile patients with CHF complicated with pulmonary infection. Results; The serum PCT, presepsin and Gas6 levels in the pulmonary infection group and the non-pulmonary infection group were higher than those in the healthy control group, and the pulmonary infection group was higher than the non-pulmonary infection group (P<0.05). Multivariate Logistic regression analysis showed that higher age, cardiac function grade Ⅳ, elevated PCT, elevated presepsin and elevated Gas6 were independent risk factors for death of senile patients with CHF complicated with pulmonary infection (P<0.05). The ROC results showed that the AUC of serum PCT, presepsin, and Gas6 alone and in combination to predict the risk of death in senile patients with CHF complicated with pulmonary infection were 0.663, 0.731, 0.751 and 0.855, respectively. The predictive efficacy of the combined detection of three indicators was better than that of individual detection of each indicator. Conclusion: Serum PCT, presepsin and Gas6 levels increased in senile patients with CHF complicated with pulmonary infection, and are independent risk factors for poor short-term prognosis. Detecting the levels of PCT, presepsin, and Gas6 has certain evaluation value for the condition and prognosis of senile patients with CHF complicated with pulmonary infection. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between serum thioredoxin 1 (Trx1), fibrinogen like protein 2 (FGL2) and the prognosis of patients with heart failure after acute myocardial infarction. Methods: 158 patients with heart failure after acute myocardial infarction who were admitted to our hospital from October 2019 to may 2020 were selected as the observation group, and they were divided into 54 patients in grade II group, 57 patients in grade III group and 47 patients in grade IV group according to Killip classification of cardiac function. In addition, 102 patients with acute myocardial infarction who were admitted to our hospital in the same period were selected as the control group. After admission, serum Trx1 and FGL2 levels were detected by enzyme-linked immunosorbent assay (ELISA). Patients in the observation group were followed up for 2 years after discharge, and they were divided into poor prognosis group and good prognosis group according to whether there were major adverse cardiovascular events (MACE). Multivariate Logistic regression was used to analyze the relevant factors affecting the prognosis of patients with heart failure after acute myocardial infarction, and the predictive value of serum Trx1 and FGL2 on the prognosis of patients with heart failure after acute myocardial infarction was evaluated using the receiver operating characteristi (ROC) curve. Results: The serum FGL2 level in the observation group was significantly higher than that in the control group, and the serum Trx1 level was significantly lower than that in the control group (P<0.05). The serum Trx1 level in the Killip grade IV group was significantly lower than that in grade II group and grade III group (P<0.05), and the serum FGL2 level was significantly higher than that in the grade II group and grade III group (P<0.05). The serum Trx1 and LVEF in the poor prognosis group were significantly lower than those in the good prognosis group, while the age, serum FGL2, serum uric acid, serum creatinine and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were significantly higher than those in the good prognosis group (P<0.05). There was a statistically significant difference between the two groups in the proportion of Killip grading of cardiac function (P<0.05). Multivariate Logistic regression analysis showed that age (higher), Killip grade IV of cardiac function, decrease of Trx1 and increase of FGL2 were all risk factors affecting the prognosis of patients with heart failure after acute myocardial infarction (P<0.05). ROC curve results showed that the areas under curve of serum Trx1 and FGL2 predicting the prognosis of patients with heart failure after acute myocardial infarction were 0.807 and 0.811 respectively, and the areas under curve of combined detection of the two predicting the prognosis of patients with heart failure after acute myocardial infarction were 0.889. Conclusion: The serum Trx1 level in patients with heart failure after acute myocardial infarction decrease, and FGL2 level increase, and the serum Trx1 and FGL2 levels are closely related to the classification of cardiac function and prognosis of patients, which can be used as auxiliary indicators to evaluate the prognosis of patients with heart failure after acute myocardial infarction. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between serum Sirtuin 1 (SIRT1) level and inflammatory factors and oxidative stress in patients with heart failure with preserved ejection fraction (HFpEF), and to analyze the prognostic value of SIRT1 in patients with HFpEF. Methods: 190 patients with HFpEF who were admitted to Qingdao Fuwai Cardiovascular Hospital from October 2019 to June 2021 were selected as HFpEF group, and 92 healthy examination volunteers with normal cardiac function were selected as control group. The patients with HFpEF were followed up for 12 months after discharge. The incidence of adverse cardiovascular events during the follow-up period was statistically analyzed. Multivariate Logistic regression analysis was used to analyze the influencing factors of poor prognosis in patients with HFpEF. Results: The serum SIRT1 level in the HFpEF group was lower than that in the control group (P<0.05), and the interleukin (IL) -6, tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), malondialdehyde (MDA) and advanced oxidation protein product (AOPP) levels were higher than those in control group (P<0.05). Serum SIRT1 level in patients with HFpEF were negatively correlated with IL-6, TNF-α, CRP, MDA and AOPP(r=-0.496, -0.502, -0.419, -0.533, -0.542, P<0.05). 2 cases of the 190 patients were lost to follow-up. Among the remaining 188 patients with HFpEF, 41 had poor prognosis, and 147 had good prognosis. New York Heart Association (NYHA) grade Ⅳ ratio, IL-6, TNF-α, CRP, MDA, AOPP, N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, left ventricular end-systolic diameter (LVEDS), left ventricular end-diastolic diameter (LVEDD), mitral valve early diastolic Peak Flow (E) and Late diastolic Peak Flow (A) (E/A) in the poor prognosis group were higher than those in the good prognosis group (P<0.05), and the serum SIRT1 level and left ventricular ejection fraction (LVEF) were lower than those in the good prognosis group (P<0.05). High IL-6, high MDA and high NT-proBNP were risk factors for poor prognosis in patients with HFpEF (P<0.05), and SIRT1 was a protective factor for poor prognosis in patients with HFpEF (P<0.05). Conclusion: The decrease serum SIRT1 level in patients with HFpEF is related to the occurrence of inflammatory reaction, oxidative stress and poor prognosis in patients with HFpEF, which can be used as an auxiliary indicator for the prognosis evaluation of patients with HFpEF. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between serum Sirtuin 1 (SIRT1) level and inflammatory factors and oxidative stress in patients with heart failure with preserved ejection fraction (HFpEF), and to analyze the prognostic value of SIRT1 in patients with HFpEF. Methods: 190 patients with HFpEF who were admitted to Qingdao Fuwai Cardiovascular Hospital from October 2019 to June 2021 were selected as HFpEF group, and 92 healthy examination volunteers with normal cardiac function were selected as control group. The patients with HFpEF were followed up for 12 months after discharge. The incidence of adverse cardiovascular events during the follow-up period was statistically analyzed. Multivariate Logistic regression analysis was used to analyze the influencing factors of poor prognosis in patients with HFpEF. Results: The serum SIRT1 level in the HFpEF group was lower than that in the control group (P＜0.05), and the interleukin (IL) -6, tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), malondialdehyde (MDA) and advanced oxidation protein product (AOPP) levels were higher than those in control group (P＜0.05) . Serum SIRT1 level in patients with HFp EF were negatively correlated with IL-6, TNF-α, CRP, MDA and AOPP (r=-0.496,-0.502,-0.419,-0.533,-0.542, P＜0.05) . 2 cases of the 190patients were lost to follow-up. Among the remaining 188 patients with HFpEF, 41 had poor prognosis, and 147 had good prognosis. New York Heart Association (NYHA) grade Ⅳ ratio, IL-6, TNF-α, CRP, MDA, AOPP, N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, left ventricular end-systolic diameter (LVEDS), left ventricular end-diastolic diameter (LVEDD), mitral valve early diastolic Peak Flow (E) and Late diastolic Peak Flow (A) (E/A) in the poor prognosis group were higher than those in the good prognosis group (P＜0.05), and the serum SIRT1 level and left ventricular ejection fraction (LVEF) were lower than those in the good prognosis group (P＜0.05) . High IL-6, high MDA and high NT-proBNP were risk factors for poor prognosis in patients with HFpEF (P＜0.05), and SIRT1 was a protective factor for poor prognosis in patients with HFpEF (P＜0.05) . Conclusion: The decrease serum SIRT1 level in patients with HFpEF is related to the occurrence of inflammatory reaction, oxidative stress and poor prognosis in patients with HFpEF,which can be used as an auxiliary indicator for the prognosis evaluation of patients with HFpEF. [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinical value of cardiac color Doppler ultrasound examination combined with serum B-type natriuretic peptide (BNP), albumin (ALB) and cystatin C (CysC) in the prognosis assessment of patients with chronic heart failure (CHF). Methods: 123 patients with CHF who were treated in our hospital from June 2017 to May 2018 were selected. Left ventricular ejection fraction (LVEF), left atrial diameter (LAD) and left ventricular diameter (LVD) were examined by cardiac color Doppler ultrasound, and the levels of serum BNP, ALB and Cys C were detected in the laboratory. According to whether the patients died after 3-year follow-up, they were divided into 35 cases in the death group and 88 cases in the survival group. The clinical data were collected, and the influencing factors of the prognosis of patients with CHF were analyzed by multivariate Logistic regression. The receiver operating characteristic (ROC) curve was used to analyze the prognostic value of cardiac color Doppler ultrasound examination combined with serum BNP, ALB and CysC in patients with CHF. Results:The levels of LAD, LVD, serum BNP and CysC in the death group patients were higher than those in the survival group patients, while the levels of LVEF and serum ALB were lower than those in the survival group patients (P<0.05). Cardiac color Doppler index LVEF, LAD, LVD, serum BNP, ALB and CysC were significant prognostic factors in patients with CHF (P<0.05). The area under ROC curve (AUC) (0.95CI) of cardiac color Doppler ultrasound indexes LVEF, LAD, LVD combined with serum BNP, ALB and CysC was 0.857(0.771~0.938), and the sensitivity and specificity were 0.914 (32/35) and 0.795(70/88), respectively, which were significantly higher than the above indexes. Conclusion: Cardiac color Doppler index LVEF, LAD, LVD and serum BNP, ALB, CysC are all factors influencing the prognosis of patients with CHF, and the combined detection has high prognostic value for patients, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective The random forest and Logistic regression method were used to analyze the prognostic factors of cardiogenic death in patients with chronic heart failure complicated by atrial fibrillation. Methods Using the method of the cohort study, we selected patients with chronic heart failure complicated by atrial fibrillation in six traditional Chinese medicine (TCM) hospitals in Shandong Province (Affiliated Hospital of Shandong University of TCM, Weifang Hospital of TCM, Rizhao Hospital of TCM, Zibo Hospital of TCM, Qingdao Hospital of TCM, and Jinan Hospital of TCM) as the research object. We collected a total of 72 original data samples during hospitalization, including baseline data, complications, TCM pattern factors, cardiac color Doppler ultrasound, laboratory examination, and Chinese and Western medicinal treatment. After discharge, we followed up with the patients every six months to obtain the incidence of cardiac death. According to the occurrence of cardiac death, the included cases were divided into the endpoint group and the non-endpoint group. The statistically significant variables between the groups were selected by single factor analysis and successively included in the random forest model. The variable set with the smallest estimation error rate outside the bag was taken as the pre-treatment factor of cardiac death, and the importance of prognostic factors was ranked according to the reduction in the average Gini index. Multivariate logistic regression was further used to analyze the nature of prognostic factors. Results A total of 723 cases were included in the study, including 99 cases of cardiogenic death; 25 of 72 variables were screened out by single-factor analysis. Results of the stepwise random forest model showed that when the number of included variables was 11, estimation error rate outside the bag of the model was the smallest. Finally, the top 11 variables of the mean Gini index reduction were selected as the prognostic factors of cardiac death. Cardiac function grading, aortic valve stenosis, anticoagulant drugs, Yiqi TCM injection, heart rate, bilirubin, diastolic pressure, yang deficiency pattern, peripheral vascular disease, hypolipidemia drugs, and NT-ProBNP were ranked from high to low. Multivariate Logistic regression analysis showed that factors such as increased cardiac function grading (OR = 2.204) combined with aortic stenosis (OR = 12.852), increased heart rate (OR = 1.008), increased bilirubin (OR = 1.025), as well as increased diastolic blood pressure (OR = 1.029) combined with peripheral vascular disease (OR = 8.751) and an increase of NT-ProBNP (OR = 1.922), were risk factors for cardiac death in Western medicine. Taking anticoagulants (OR = 0.437) and hypolipidemics (OR = 0.366) were both protective factors for cardiac death in Western medicine. The yang deficiency pattern (OR = 1.127) was a TCM risk factor for cardiogenic death in patients, while the use of Yiqi TCM injections (OR = 0.261) was a TCM protective factor of cardiogenic death in patients. Conclusion Cardiac function grading, aortic valve stenosis, anticoagulants, Yiqi TCM injection, heart rate, bilirubin, diastolic pressure, yang deficiency pattern, peripheral vascular disease, hypolipidemics, and NT-ProBNP are prognostic factors of cardiogenic death in patients with chronic heart failure complicated by atrial fibrillation. The data analysis method combined with random forest and Logistic regression can realize complementary advantages and is suitable for high-dimensional and complex prognostic factor analysis of Chinese and Western medicine, which has clinical promotion value. [ABSTRACT FROM AUTHOR]

Objective: To study Analysis of the Relationship between serum miRNA-21, Myoglobin (MYO), myocardial creatine kinase isoenzyme (CK-MB) and cardiac function and prognosis in patients with acute heart failure. Methods: 95 patients with acute heart failure admitted to our hospital from February 2018 to February 2019 were selected as the research subjects (case group). In addition, 80 healthy patients who underwent examination in our hospital during the same period were selected as the control group, and the changes of serum miRNA-21, MYO, CK-MB, left ventricular ejection fraction (LVEF), left atrial diameter (LAD), and left ventricular end-diastolic diameter (LVED) levels and their correlation with prognosis were analyzed in 2 groups. Results: The levels of serum miRNA-21, MYO and CK-MB in case group were significantly higher than those in control group, and the differences were significant (P<0.05). LAD and LVED levels in case group were significantly higher than those in control group, and LVEF levels were significantly lower than those in control group (P<0.05). The serum miRNA-21, MYO, CK-MB levels in grade II patients were significantly lower than those in grade III and IV patients, and the serum miRNA-21, MYO, CK-MB levels in grade III patients were significantly lower than those in grade IV patients, the difference was significant (P<0.05). The levels of serum miRNA-21, MYO and CK-MB in the good prognosis group were significantly lower than those in the poor prognosis group, with significant differences (P<0.05). Spearman correlation analysis showed that serum miRNA-21, MYO, CK-MB and LVEF were negatively correlated, while serum miRNA-21, MYO, CK-MB and LAD and LVEF were positively correlated (P<0.05). Logistic regression analysis showed that serum miRNA-21, MYO, CK-MB, LVEF, LAD, LVED were the prognostic factors in patients with acute heart failure (P<0.05). Conclusion: The expression of miRNA-21, MYO and CK-MB in patients with acute heart failure is increased, which is closely related to cardiac function and prognosis. [ABSTRACT FROM AUTHOR]

Objective: To study Analysis of the Relationship between serum miRNA-21, Myoglobin (MYO), myocardial creatine kinase isoenzyme (CK-MB) and cardiac function and prognosis in patients with acute heart failure. Methods: 95 patients with acute heart failure admitted to our hospital from February 2018 to February 2019 were selected as the research subjects (case group). In addition, 80 healthy patients who underwent examination in our hospital during the same period were selected as the control group, and the changes of serum miRNA-21, MYO, CK-MB, left ventricular ejection fraction (LVEF), left atrial diameter (LAD), and left ventricular end-diastolic diameter (LVED) levels and their correlation with prognosis were analyzed in 2 groups. Results: The levels of serum miRNA-21, MYO and CK-MB in case group were significantly higher than those in control group, and the differences were significant (P<0.05). LAD and LVED levels in case group were significantly higher than those in control group, and LVEF levels were significantly lower than those in control group (P<0.05). The serum miRNA-21, MYO, CK-MB levels in grade II patients were significantly lower than those in grade III and IV patients, and the serum miRNA-21, MYO, CK-MB levels in grade III patients were significantly lower than those in grade IV patients, the difference was significant (P<0.05). The levels of serum miRNA-21, MYO and CK-MB in the good prognosis group were significantly lower than those in the poor prognosis group, with significant differences (P<0.05). Spearman correlation analysis showed that serum miRNA-21, MYO, CK-MB and LVEF were negatively correlated, while serum miRNA-21, MYO, CK-MB and LAD and LVEF were positively correlated (P<0.05). Logistic regression analysis showed that serum miRNA-21, MYO, CK-MB, LVEF, LAD, LVED were the prognostic factors in patients with acute heart failure (P<0.05). Conclusion: The expression of miRNA-21, MYO and CK-MB in patients with acute heart failure is increased, which is closely related to cardiac function and prognosis. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of sacubitril/valsartan on ventricular remodeling and prognosis of patients with refractory heart failure. Methods: 150 patients with refractory heart failure who were treated in the department of Cardiology, Minhang Hospital, Fudan University from September 2017 to December 2017 were divided into two groups. The control group(n=75) was given guidelines guide drug treatment(GDMT), and the treatment group(n=75) was given sacubitril/valsartan on the basis of control group,with a starting dose of 50 mg/time and 2 times/d, doubling every 2-4 weeks until the dose reached the maintenance dose of 200 mg/time and 2 times/d. All patients were treated for 4 weeks. The changes of left ventricular structure and function, serum neurohormones and NT-pro BNP levels were analyzed before and after treatment, between two groups. At the same time, the incidence of adverse effects during treatment and the prognosis during follow-up were observed and compared. Results: After treatment, the left ventricular end systolic diameter(LVESD), left ventricular end-diastolic diameter(LVEDD) of treatment group were significantly lower than those before treatment, the left ventricular ejection fraction(LVEF) was significantly higher than before treatment, and these indicators in the treatment group were superior to those of the control group(P <0.05). After treatment, the levels of serum renin activity(RA), renin nervous element(Ang Ⅱ) and NT-pro BNP of both groups were all significantly lower than those before treatment, which were also lower in the treatment group than those of the control group(P <0.05). No significant difference was found in the incidence of complications between two groups(P >0.05). The rehospitalization rate and cardiogenic mortality rate of treatment group were significantly lower than those in control group(P<0.05). Conclusions: Sacubitril/valsartan can effectively improve the cardiac function,reverse the cardiac remodeling and reduce the hospitalization rate and mortality rate without increasing adverse reactions in the treatment of refractory heart failure. [ABSTRACT FROM AUTHOR]

Objective: To explore the evaluation value of red blood cell distribution width(RDW) on severity and prognosis of patients with heart failure. Methods: According to the severity of disease, 110 cases of heart failure patients(research group) who admitted in the department of cardiology of our hospital were divided into different grades, including 30 patients of NYHA Ⅱ, 46 patients of NYHA Ⅲ, 34 patients of NYHA Ⅳ. At the same time, 110 cases of physical examination were selected as the control group. All the patients were also divided into the survival group(n=91) and the death group(n=19) according to the prognosis within 6 months. The RDW and mortality were compared among the groups, univariate analysis and multivariate logistic analysis were performed to assess the influencing factors of heart failure. Results: The RDW level in NYHA Ⅲ~Ⅳ of research group were significantly lower than that of the control group, and with the increase of NYHA classification, the RDW level was significantly increased(P<0.05). Compared with the death group, the age in survival group was obviously younger, the levels of Hcy, CRP, GLU, RDW, NT-pro BNP on admission were significantly decreased, the LVEF level was significantly increased(P<0.05). Logistic regression analysis showed that age, NT-pro BNP,RDW on admission were independent risk factors of heart failure, and LVEF was independent protection factor(P<0.05). Conclusions:RDW can reflect the severity of heart failure, it has important guiding meaning for the prognosis evaluation of patients with heart failure. [ABSTRACT FROM AUTHOR]