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Subarachnoid hemorrhage (SAH) leads to ferroptosis with clinical evidence like iron metabolism deregulation, increased lipid peroxitation(LPO) and the inhibition of glutathione/glutathione peroxides 4(GSH/GPX4). Ferroptosis mediated early brain injury (EBI) may occur in the 72-hour period following SAH (EBI-SAH) leads to the poor prognosis of SAH. Pharmacological targeting at ferroptosis mitigate EBI-SAH, provides a new target for future treatment and prevention of EBI-SAH through targeting at ferroptosis.

Recently, mounting evidences have suggested the therapeutic potential of Nrf2/ARE activators for treating Ischemic stroke. Moreover, several Nrf2 activators attenuate ischemic stroke-induced brain injury in several transient focal cerebral ischemia (tMCAO) in experimental animal models.

Based on the characteristics and laws of coal spontaneous combustion in Yanzhou Mining Area, this paper studies the construction of accurate prevention and control system of coal spontaneous combustion, including the research on accurate fire prevention and control of coal spontaneous combustion prediction, monitoring and early warning and advanced disposal. Through the establishment of a 15 t large-scale coal spontaneous combustion testbed to study the characteristics of coal spontaneous combustion, the research and development of infrared thermal imaging technology to determine hidden fire sources, and the development of a series of new fire-fighting materials, technologies and equipment, the three leaps of forward development of “effective management, early prediction and early control, and ahead of time prevention” of coal fire disasters has been realized, and a scientific coal spontaneous combustion technology and management system has been formed in terms of management, equipment and technology; the research results promote the three major changes of coal seam fire from “passive control to advanced prevention and control, from traditional technology to high-tech, and from decentralized practical technology to complete set of applicable technologies”, and build three lines of defense for natural fire disaster “advanced prediction, early prevention, and rapid emergency control”, so as to achieve accurate prevention and control of coal spontaneous combustion in Yanzhou Mining Area.

As a special application of image completion technology,face image completion has an irreplaceable role in the occlusion of face recognition,portrait restoration and other issues.The existing face completion algorithm only aims at complementing the authenticity of the image without considering its identity consistency after completion.A face complement algorithm based on improved generative confrontation network was designed.By introducing SN-GAN algorithm,the stability of model training was improved.At the same time,the identity recognition constraint was added to the generated image using the face recognition model.Experiments have shown that the proposed method can effectively maintain the identity of the complementary image when generating high-authenticity images.

In order to improve the side impact safety of a domestic production car model, the side impact sub-models for side airbag, human abdomen and hip are built with MADYMO based on the vehicle side impact test and components tests of the car. By applying the theoretical model for side impact, the dummy injury mechanism and the correlation between various parameters of car body are studied. The side airbag and the structures in related locations of door-trim are modified through computer simulation and verified by component tests. The results show that by means of components tests dummy injury can be effectively reduced with the side impact safety of vehicle improved. [ABSTRACT FROM AUTHOR]

Interleukin-2 (IL-2) is one of the most important regulators in immune system, as it plays an essential part both in immune activation and suppression. However, as the first immunotherapy drug approved for the treatment of cancer, IL-2 is limited in clinical application by the serious adverse reactions. The long-felt needs in clinical practice, including prolonged half-lives, T cell subset specificity, and toxicity reduction can be achieved by polyethylene glycol (PEG) modification, Fc fusing, or protein mutation of IL-2. NKTR-214, the most advanced IL-2 pathway-targeted agent in clinical development for oncology, shows exciting results in treatment of melanoma in combination with nivolumab. At the same time, many more other modified molecules against cancer and autoimmune diseases are being tested in clinical research, an exciting future lying ahead for IL-2 therapeutics.