Search

A double whammy of coronavirus and the resulting economic stagnation cause the risk of stimulating policy of the survival and failure of strategic planning. At the same time, it is in an era of change that we must first adhere to a stable system of values and pre-defined goals and plans. This will allow you not only to stay on the right course, not to go astray, but also to work ahead of the situation. The paper presents the results of a comparative assessment of the rate of change in quantitative indicators that characterize the state of regional socioeconomic systems in 2009, 2014 and 2018, depending on the use of strategic planning in the subjects of the Russian Federation.

With the rapid development of single‐cell sequencing technology, the Langendorff perfusion system has emerged as a common approach to decompose cardiac tissue and obtain living cardiomyocytes to study cardiovascular disease with the mechanism of cardiomyocyte biology. However, the traditional Langendorff perfusion system is difficult to master, and further, the viability and purity of cardiomyocytes are frequently unable to meet sequencing requirements due to complicated devices and manipulate processes. Here, we provide an optimized Langendorff perfusion system with a simplified and standardized operating protocol which utilizes gravity as the perfusion pressure, includes a novel method for bubbles removing and standardizes the criteria for termination of digestion. We obtained stable cardiomyocyte with high viability and purity after multiple natural gravity sedimentation. The combination of the optimized Langendorff perfusion system and the multiple natural gravity sedimentation provides a stable system for isolating adult mouse heart, which will provide higher‐quality cardiomyocytes for further experiments.

The research featured relationship between self-regulation and psychological competence of future specialists. The study involved an analysis of theoretical approaches to this problem in domestic and foreign psychology. Psychological competence presupposes developed psychological knowledge and communicative abilities and skills, as well as a stable system of self-regulation that allows for effective management of one's behavior during professional interaction. The author established the features of psychological and communicative competences in students, as well as such regulatory qualities as self-regulation, self-control, and self-efficacy. The research revealed statistically significant relationships between the level of development of psychological and communicative competences and the characteristics of regulatory qualities. A cluster analysis showed three groups of students with different levels of communicative competence and regulatory qualities. The regulatory and communicative components of psychological competence appeared closely interrelated. Self-regulation, self-control, self-efficacy, and communicative skills of future psychologists were the instrumental basis for the development of psychological competence. A well-developed self-regulation helped students understand and control their behavioral reactions. It enabled them to carry out conscious and focused interaction with people in problematic professional situations, as well as contributed to the development of psychological competence during vocational training.

The stable and metastable phase diagrams between the sinister and the rectus ibuprofen enantiomers were established by means of thermal analysis and X-ray powder diffraction experiments as a function of temperature. The results obtained allow proving for the first time the existence, for the stable system, of a solid solution by mixing the racemic ibuprofen with one of its enantiomers for low concentration of the enantiomer. Since the rectus ibuprofen is a non-active pharmaceutical agent which can be partially bio-converted into the sinister enantiomer, the present work offers a new approach for scalemic mixtures preparation in order to improve the benefit/risk ratio related to ibuprofen solid dosage form administration.

Epilepsy is a global epidemic and 30% of the 60 million patients do not respond to medication treatment. The only treatment options for patients with medically refractory epilepsy are surgical removal or electrical stimulation of the epileptogenic zone (EZ) i.e. the source of their seizures. Despite extensive evaluations with neuroimaging, visual EEG analysis and clinical testing, surgical success rates vary between 30-70%. Currently, no computational methods have been translated into the clinic to assist in localizing the EZ. Here, we applied a dynamical network model that quantifies the fragility of nodes within a patient9s intracranial EEG (iEEG) brain network. Fragility is quantified as the minimal amount of perturbation that must to be applied to a node9s influence on a "balanced" network to cause imbalance. Here, a balanced network is one in which the connectivity between excitatory and inhibitory nodes render a stable system, and an imbalanced network is unstable and hence can generate seizures. Using iEEG data from 91 patients treated across 5 epilepsy centers (44 successes, 47 failures), we demonstrated that nodal fragility is greater in electrodes within the EZ. In addition, we compared fragility of iEEG nodes to 7 frequency-based and 14 graph theoretic features of the EZ in both seizure (n=91) and non-seizure data (n=54). We calculated a confidence statistic, defined as the ratio of the value of a given feature averaged across electrodes in the clinically annotated seizure onset zone to its average across all other electrodes. Fragility has a significantly greater effect size difference between surgical outcomes when compared to other features. This novel feature, outperformed the most popular iEEG features when comparing across surgical outcomes, possibly defining a superior network-based EEG fingerprint for the EZ.

A complete understanding of the plant microbiome has not yet been achieved due to its complexity and temporal shifts in the community structure. To overcome these issues, we created a synthetic bacterial community of the aquatic plant, duckweed. The synthetic community established with six bacterial strains showed a stable composition for 50 days, which may have been because duckweed maintains a similar physiological status through its clonal reproduction. Additionally, the synthetic community reflected the taxonomic structure of the natural duckweed microbiome at the family level. These results suggest the potential of a duckweed-based synthetic community as a useful model system for examining the community assembly mechanisms of the plant microbiome.

Pickering emulsion, which is an emulsion stabilized by solid particles, offers a wide range of potential applications because it generally provides a more stable system than surfactant-stabilized emulsion. Among various solid stabilizers, nanocellulose may open up new opportunities for future Pickering emulsions owing to its unique nanosizes, amphiphilicity, and other favorable properties (e.g. chemical stability, biodegradability, biocompatibility, and renewability). In this review, the preparation and properties of nanocellulose-stabilized Pickering emulsions are summarized. We also provide future perspectives on their applications, such as drug delivery, food, and composite materials.

The contractile apparatus of cardiomyocytes is considered to be a stable system. However, it undergoes strong rearrangements during heart development as cells progress from their non-muscle precursors. Long-term culturing of mature cardiomyocytes is also accompanied by the reorganization of their contractile apparatus with the conversion of typical myofibrils into structures of non-muscle type. Processes of heart development as well as cell adaptation to culture conditions in cardiomyocytes both involve extracellular matrix changes, which appear to be crucial for the maturation of contractile apparatus. The aim of this review is to analyze the role of extracellular matrix in the regulation of contractile system dynamics in cardiomyocytes. Here, the remodeling of actin contractile structures and the expression of actin isoforms in cardiomyocytes during differentiation and adaptation to the culture system are described along with the extracellular matrix alterations. The data supporting the regulation of actin dynamics by extracellular matrix are highlighted and the possible mechanisms of such regulation are discussed.

An algorithm of consistent implicit discretization for locally homogeneous finite-time stable system having discontinuity only at the origin is developed. It preserves finite-time stability property in the discrete-time models. The homogeneous domination approach is utilized for analysis of the discretized model. The scheme is demonstrated for a simplified model of a quadrotor control system.

Single-parameter single-electron pumps (SEPs) based on a quantum dot have been suggested as promising devices to realize the new definition of the unit of current, the ampere, where quantized current produced from the SEP device is only defined by the elementary charge e and applied external radiofrequency (rf), f, i.e., I = ef. The conventional method to eliminate offset signals in the precision current measurement of pump current has been to measure the current difference between the pump-on and pump-off states. To date, the rf-on and rf-off method has been used to pump between its on and off states. However, this method inevitably induces alternating rf-heating effects and varying temperatures of the device environment, possibly leading to a thermal drift of the offset current. In the current work, we developed a new gate-switching technique that can alternate the pump on and off states while maintaining a constant rf-on state, resulting in a more stable system temperature. Using the gate-switching technique, we achieved a temperature-stabilized environment and performed a precision current measurement with sub-parts per million uncertainty.

Based on a new model of a possible origin of life, we propose an efficient and stable system undergoing structural reproduction, self-optimization, and molecular evolution. This system is being formed under realistic conditions by the interaction of two cyclic processes, one of which offers vesicles as the structural environment, with the other supplying peptides from a variety of amino acids as versatile building blocks. We demonstrate that structures growing in a combination of both cycles have the potential to support their own existence, to undergo chemical and structural evolution, and to develop unpredicted functional properties. The key mechanism is the mutual stabilization of the peptides by the vesicles and of the vesicles by the peptides together with a constant production and selection of both. The development of the proposed system over time would not only represent one of the principles of life, but could also be a model for the formation of self-evolving structures ultimately leading to the first living cell. The experiment yields clear evidence for a vesicle-induced accumulation of membrane-interacting peptide which could be identified by liquid chromatography combined with high-resolution mass spectroscopy. We found that the selected peptide has an immediate effect on the vesicles, leading to (i) reduced vesicle size, (ii) increased vesicle membrane permeability, and (iii) improved thermal vesicle stability. CA Mayer C.

We propose a novel algorithm to decompose a 3D object into an atlas of disk-like charts. Decomposition into charts with controlled shape and topology is relevant in many engineering areas, such as spline fitting, compression and re-meshing. We produce our chartifications by jointly exploiting the Reeb graph of a guiding function and its gradient aligned flow paths. The key advancements of our method with respect to similar approaches are: (i) a novel strategy to provably remove all T-junctions; (ii) a stable system to trace flow paths starting far from critical points; (iii) the exploitation of the regularity of certain functions under isometries (e.g., harmonic ones) to produce structurally equivalent chartifications for families of objects posed differently. The charts produced by our system can be of two types: topological quads and topological octagons. Both of them can be easily gridded to produce full quadrilateral meshes, as we demonstrate in the second part of the article.

In this work, nonlinear pollution absorption, emission rate, and effectiveness of abatement technology are incorporated into the classic overlapping generation model. Within this framework, we analyze the macroeconomic effects of pollution emission and abatement technology on the economy. Our findings reveal that different levels of pollution emission rates from per capita income and the effectiveness of abatement technology could induce complex dynamical behavior, including the occurrence of a stable equilibrium, cycles, and chaos. Our analysis shows that either the pollution emission rate per capita income should be controlled to be small enough or the effectiveness of abatement technology should be large enough to maintain a stable system yielding high level of per capita income. A high level of pollution emission rate per capita income and a low level of effectiveness of abatement technology can lead to a stable economy, but with a low level of per capita income. In the case that the pollution emission rate and the effectiveness of abatement technology vary in a certain range, the economy would become unstable, and cycles and chaos would emerge.

We study the stability of a certain class of switched systems where discontinuous jumps (resets) on some of the state components are allowed, at the switching instants. It is known that, if all components of the state are available for reset, the system can be stabilisable by an adequate choice of resets. However, this question may have negative answer if there are forbidden state components for reset. We give a sufficient condition for the stabilisability of a switched system, under arbitrary switching, by partial state reset in terms of a block simultaneous triangularisability condition. Based on this sufficient condition, we show that the particular class of systems with partially commuting stable system matrices is stabilisable by partial state reset. We also provide an algorithm that allows testing whether a switched system belongs to this particular class of systems.

Paulo Freire and Ivan Illich are prominent figures in contemporary education, who broke the stable system of education. Paulo Freire suggests to stop bank style education and to promote andragogy education, which views both teacher and students equally. Education should be actualized through facing problems and should be able to omit naïve and magic awareness replaced with critical and transformative awareness. Different from Freire, Illich offers to free the society from formal schools. Education should be run in an open learning network. Technical skills can be taught by drilling. In addition, social transformation will happen only if there are epimethean people that are minority in existence.

Horses are often stabled in individual boxes, a method that does not meet their natural needs and may cause psychical and musculoskeletal diseases. This problem is particularly evident in Iceland, where horses often spend the long winter periods in cramped boxes. The aim of this study was to analyze the suitability of a group housing system in Iceland, but the results are also applicable to horses of other regions. Eight Icelandic horses were observed in an active stable system, and their behavior and time budget were recorded. Movement and lying behavior were studied with ALT (Activity, Lying, Temperature detection) pedometers. The effect of an automatic concentrate feeding station (CFS) on the horses’ behavior was examined. In the first period of investigation, the horses were fed concentrates manually, and in the second period, they were fed with the CFS. Additional behavioral observations and a determination of social hierarchy occurred directly or by video surveillance. The physical condition of the horses was recorded by body weight (BW) measurement and body condition scoring (BCS). The results showed a significant increase between the first and second trial periods in both the activity (P < 0.001) and the lying time (P = 0.003) of the horses with use of the CFS. However, there was no significant change in BW during the first period without the CFS (P = 0.884) or during the second period with the CFS (P = 0.540). The BCS of the horses was constant at a very good level during both trial periods, and the horses showed a low level of aggression, a firm social hierarchy and behavioral synchronization. This study concludes that group housing according to the active stable principle is a welfare-friendly option for keeping horses and is a suitable alternative to conventional individual boxes.

This paper makes a case for a stronger cultural and narrative approach to economic history. It shows that an analysis of the discourse strategies used to construct and present the narratives of crises can be used to reach a better understanding of economic crises. Starting from the observation that economic crises are frequently portrayed as serious illnesses which undergo different courses and progressions, the author argues that crises should also be viewed as phenomena of communication and perception. These should be examined in order to reveal either repeatedly used or changing linguistic patterns, metaphors and abstract concepts. The analysis therefore focuses on the relationship between economic crises and crisis discourses. Whether the crisis is described as an “imbalance” (in an otherwise fundamentally stable system) or a multi-layered disease (that culminates in death) is not only based on different metaphors and interpretation patterns. It also has an effect on the assessment of the causes and the progression of the crises, and it presents different courses of possible action.

The ever increasing demand to analyse substrates means that an improved theoretical understanding is necessary for atomic force microscope cantilevers. In this study, we utilize fundamental mathematical modelling, comprising the Lennard-Jones potential and techniques involving the calculus of variations, to obtain the energy equations arising from the probe and the substrate, leading to the deflection equations of the cantilever. Here we assume a silicon tip and the substrate surface is assumed to be a graphene sheet. Based on an energy calculation, the most stable system occurs where the probe is 0.206 nm away from the substrate, and this value exists independently of the size and tilt angle of the probe. For the deflection of the cantilever, we apply the calculus of variations to the separate domains, considering derivatives up to third order at the connection point. The deflection behaviour of a V shaped plate depends primarily on its length, and the spring constants of various cantilevers are calibrated from the deflection equations. In comparison to the zeroth order method of previous studies, our method predicts a 30-50% difference in the value of their spring constants. Moreover, we observe the bending behaviour of cantilever systems by considering the energy between the probe and the substrate together with the bending energy in the cantilever, and we find that the maximum bending distance at the tip is in the range between 0.09 nm and 0.2 nm. Refereed/Peer-reviewed

Received 11 October 2014, Available online 26 January 2016 In deciding whether to join a coalition or not, an agent must consider both i) the expected power of the coalition and ii) her position in the vertical structure within the coalition. We establish the existence of a positive relationship between the degree of inequality in remuneration within coalitions and the number of coalitions to be formed endogenously in stable systems. We show that such coalitions can be mixed and balanced, rather than segregated, in terms of members' ability levels. In any stable system each coalition is of an efficient size and every agent is paid her marginal contribution. Article is version of EUI WP ECO; 2011/20

The size of the basin of attraction in ecosystems with alternative stable states is often referred to as "ecological resilience." Ecosystems with a low ecological resilience may easily be tipped into an alternative basin of attraction by a stochastic event. Unfortunately, it is very difficult to measure ecological resilience in practice. Here we show that the rate of recovery from small perturbations (sometimes called "engineering resilience") is a remarkably good indicator of ecological resilience. Such recovery rates decrease as a catastrophic regime shift is approached, a phenomenon known in physics as "critical slowing down." We demonstrate the robust occurrence of critical slowing down in six ecological models and outline a possible experimental approach to quantify differences in recovery rates. In all the models we analyzed, critical slowing down becomes apparent quite far from a threshold point, suggesting that it may indeed be of practical use as an early warning signal. Despite the fact that critical slowing down could also indicate other critical transitions, such as a stable system becoming oscillatory, the robustness of the phenomenon makes it a promising indicator of loss of resilience and the risk of upcoming regime shifts in a system.

We discuss the equations describing the motion of ferrofluids subject to an external magnetic field. We concentrate on the model proposed by Rosensweig, provide an appropriate definition for the effective magnetizing field, and explain the simplifications behind this definition. We show that this system is formally energy stable, and devise a numerical scheme that mimics the same stability estimate. We prove that solutions of the numerical scheme always exist and, under further simplifying assumptions, that the discrete solutions converge. We also discuss alternative formulations proposed in pre-existing work, primarily involving a regularization of the magnetization equation and supply boundary conditions which lead to an energy stable system. We present a series of numerical experiments which illustrate the potential of the scheme in the context of real applications.

In this paper we present a right inversion scheme based on the essential concept of reachability. This scheme inverts a Hurwitz stable system one step ahead. We illustrate our procedure with the simulation of an ideal inverted pendulum.

Combination of relay feedback experiment and control synthesis is usually a part of autotuning principles. This contribution deals with the relay based identification of continuous time plants because the knowledge of the controlled system parameters is important for the quality of control. The feedback relay schemes can use different types of relays. This paper is focused on biased relay with hysteresis. The controlled system is identified as a first order transfer function because most of industrial plants can be sufficiently approximated by a first order linear stable system with time delay term. The main aim is to analyze the precision of controlled system parameters identification when the feedback relay parameters will vary. Matlab program environment is used for all simulations conducted in this paper. © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.

This paper describes the applicability of microwave radiometry for several potential diagnostic and therapeutic applications that can benefit from accurate non-invasive measurement of volume average temperature of tissue regions extending 4cm or more into the body. Design features are summarized for an appropriate high sensitivity long term stable system with 2.5 and 7cm diameter receive antennas and integral 1.1–1.6GHz total power radiometer electronics. Radiometer performance is characterized with electromagnetic and thermal simulations, as well as experimental measurements in realistic models of two typical diagnostic applications. Results demonstrate sufficient sensitivity to track clinically significant changes in temperature of deep tissue targets for applications like the non-invasive detection of vesicoureteral reflux into kidney, and monitoring brain “core” temperature during extended hypothermic surgery.

The corporate offensive was the main driving force in the neoliberal transformation of Mexico as it was in the United States and Canada. But in Mexico the corporate power bloc had to change the political order to achieve its hegemonic aspirations and desired policy changes. While the top bourgeoisie have been able to achieve more direct control of the state, they have not been able to establish a stable system of domination. The rise of bourgeois hegemony in Mexico is fragile. But the working class has not yet been able to find its voice and break free of the bonds of Mexico’s old state-linked unions or state system of labour repression in general. However, the on-going hardships imposed by neoliberalism, the fragile legitimacy of the new political regime, and the surviving popular traditions of revolutionary struggle point to a renewal of a class-based popular fight-back sooner rather than later. L’offensive du patronat a été la force prépondérante derrière la transformation néolibérale du Mexique, comme aux Etats-Unis et au Canada. Mais, au Mexique, le bloc du pouvoir patronal était obligé de transformer l’ordre politique afin de réaliser ses aspirations hégémoniques et la transformations politiques souhaitées. Alors que la haute bourgeoisie a réussi à renforcer son contrôle direct sur l’état, elle n’a pas réussi à établir un système stable de domination. L’ascendance de l’hégémonie bourgeoise au Mexique est fragile. Mais, la classe ouvrière n’a pas encore réussi à trouver sa voix et à briser les chaines des anciens syndicats liés à l’état mexicain ou le système étatique de répression du travail en général. Néanmoins, les difficultés de longue durée imposée par le néolibéralisme, la légitimité fragile du nouveau régime politique et les traditions populaires de lutte révolutionnaire qui persistent, suggère la renaissance d’une contre-attaque populaire basée sur les classes, plus tôt et non plus tard.

In this paper, we introduce machine-job incidence (MJI) matrix that can be obtained from Steward sequencing matrix and Kusiak machine-part incidence matrix. Methods for determination of structural properties of free-choice multiple reentrant systems (FMRF) are proposed and an explanation on how the content (number of active jobs) of those structures can be controlled. This paper gives a new method on how to determine if allocation of resources, in a form of repeatable sequences, gives stable system behavior. Although efficiency of the proposed methods have been demonstrated on examples involving manufacturing workcells, the method can be used for other discrete-event systems as well, as long as the system under study belongs to FMRF class.

Recently, there has been a growing interest in academic and commercial environments for Video-on-Demand (VoD) using Peer-to-Peer (P2P) technology. Unlike centralized solutions for VoD services, P2P technology lets the clients distribute video content among themselves. In this paper, we propose an analytical model for P2PVoD and we compare that model to a realistic P2PVoD simulator. With our model, parameters that affect the system performance can be observed, and the system stability can be investigated. Our model leads to design rules for achieving a good and stable system performance. This work is, to our knowledge, the first analytical work to model mesh-based P2PVoD.

In the framework of nonrelativistic quantum mechanics we derive a necessary condition for four Coulomb charges $(m_{1}^+, m_{2}^-, m_{3}^+, m_{4}^-)$, where all masses are assumed finite, to form the stable system. The obtained stability condition is physical and is expressed through the required minimal ratio of Jacobi masses. In particular this provides the rigorous proof that the hydrogen-antihydrogen molecule is unstable. This is the first result of this sort for four particles., Submitted to Phys.Rev.Lett

In C 60 compounds the frequencies of the phonon involved in the superconductive processes (intra-molecular modes with ω ph up to 2300 K) are comparable with the typical electronic scale ( E F =2900 K) and thus the two dynamics cannot be treated separately (breakdown of the adiabatic hypothesis). This implies a generalization of the standard theory to include nonadiabatic effects. The strong electronic correlation in the fullerenes causes the contribution of the nonadiabatic processes to be positive with consequent increase of the effective electron–phonon (el–ph) pairing λ and of T c . We show that the inclusion of nonadiabatic terms in the el–ph interaction is a key element for the high values of T c in fullerenes. In particular T c as high as 100 K are shown to be compatible with moderate values of λ ≲1. This implies that it should be possible to increase the value of λ , and so T c , and still have a stable system.