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1. BIOBADABRASIL: SAFETY PROFILE OF THE FIRST BIOLOGICAL AGENT OR JAK INHIBITOR FOR THE TREATMENT OF RA

Author

Ivanio Alves Pereira, Jose Roberto Prevenza, Manoel Barros Bertolo, Claiton Viegas Brenol, Adriana Maria Kakehasi, Hellen M.S. Carvalho, Jose Carlos Amaral, Barbara Standler Kahlow, Laurindo Ferreira da Rocha, José Caetano Macieira, David C. Titton, Roberto Ranza, Rina Dalva Neubarth Giorgi, Aline Ranzolin, Geraldo da Rocha Castelar Pinheiro, Flavio Sztajnbok, Paulo Lozada, Deborah Negrão Gonçalo Dias, Morton Scheinberg, Reginaldo Botelho Teodoro, Markus Bredmeir, André Luiz Shinji Hayata, Helena Lúcia Alves Pereira, Angela Luzia Branco Pinto Duarte, Vander Fernandes, Ieda Maria Magalhães Laurindo, Ana Cristina de Medeiros Ribeiro, José Roberto Silva Miranda, Morgana Ohira Gazzeta, Marcelo De Medeiro Pinheiro, Maria de Fátima Lobato da Cunha Sauma, Cristiano Michelini Lupo, S. Studart, Valéria Valim Cristo, Inês Guimarães da Silveira, Gláucio Ricardo Werner de Castro, and Sergio Kowalski

Subjects
Safety profile, business.industry, Medicine, Pharmacology, business
Published
2021
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2. CHRONIC USE OF HYDROXYCHLOROQUINE DID NOT PROTECT AGAINST COVID-19 IN A LARGE COHORT OF PATIENTS WITH RHEUMATIC DISEASES IN BRAZIL

Author

Gilda Aparecida Ferreira, Ângela Luzia Branco Pinto Duarte, Licia Maria Henrique Mota, Vanderson Souza Sampaio, Marcelo de Medeiros Pinheiro, Paula Reale Fernandes, Ana Paula Monteiro Gomides Reis, Ricardo Machado Xavier, José Roberto Provenza, Mirhelen Mendes de Abreu, Emília Inoue Sato, Mariana Peixoto Guimarães, Blanca Elena Rios Gomes Bica, Danielle Christinne Soares Egypto de Brito, Viviane Angelina de Souza, Kirla Wagner Poti Gomes, Gabriela Araújo Munhoz, Ana Beatriz Santos Bacchiega, Marcus Lacerda, Cleandro Pires de Albuquerque, Claudia Diniz Lopes Marques, Rafaela Cavalheiro do Espírito Santo, Eduardo Ferreira Borba, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, Laurindo Ferreira da Rocha Junior, Valeria Valim, Nafice Costa Araújo, Evandro Mendes Klumb, Edgard Torres Reis-Neto, Gecilmara Salviato Pileggi, Eloisa Bonfa, Dante Valdetaro Bianchi, Eduardo dos Santos Paiva, Adriana Maria Kakehasi, Cristina Costa Duarte Lanna, Odirlei André Monticielo, Thelma Skare, and Camila Santana Justo Cintra Sampaio

Subjects
Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Medicine, Hydroxychloroquine, business, medicine.drug, Large cohort
Published
2021
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3. MENTAL HEALTH EVALUATION OF MEDICINE GRADUATE STUDENTS THROUGH DASS-21 DURING THEIR PARTICIPATION AT MARIO PINOTTI II STUDY AND THE COVID-19 PANDEMIC

Author

Valeria Valim, Kirla Wagner Poti Gomes, Lilian David de Azevedo Valadares, Danielle Christinne Soares Egypto de Brito, Ana Karla Guedes, Henrique de Ataíde Mariz, Nafice Costa Araújo, Ângela Luzia Branco Pinto Duarte, Adriana Maria Kakehasi, João Vitor Ziroldo Lopes, Ana Beatriz Santos Bacchiega, Eduardo dos Santos Paiva, Thelma Skare, Gilda Aparecida Ferreira, Mirhelen Mendes de Abreu, Emília Inoue Sato, Aline Rizzo Borges, Blanca Elena Rios Gomes Bica, Viviane Angelina de Souza, Ana Paula Monteiro Gomides, Paula Reale Fernandes, Licia Maria Henrique Mota, José Roberto Provenza, Samuel Elias Basualto Dias, Bárbara Stadler Kalow, Claudia Diniz Lopes Marques, Débora Cerqueira Calderaro, Marcelo de Medeiros Pinheiro, Cleandro Pires de Albuquerque, Gecilmara Salviato Pileggi, Evandro Mendes Klumb, Maycoln Leôni Martins Teodoro, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, Gabriela Araújo Munhoz, and Edgard Torres Reis-Neto

Subjects
Medical education, Graduate students, DASS, Coronavirus disease 2019 (COVID-19), Pandemic, Psychology, Mental health
Published
2021
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4. EXPERIENCE REPORT OF THE INCLUSION OF PATIENTS WITH IMRD IN THE MÁRIO PINOTTI II PROJECT IN MANAUS-AMAZONAS

Author

Joelma Moreira Belas Torres, Bruna Borges Santos, Raissa Pires Medeiros, Cecília Tizatto Barroso, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, Micaella Oliveira Costa, Isabela de Araújo Seffair, Gabriela Alarcón Alcântara, Douglas Ferreira dos Santos, Samuel Elias Basualto Dias, Andrezza Mendes Franco, Gabriella Bacellar Marques, Heitor Torres Garrido, Gabriel Pacífico Seabra Nunes, Matheus Diniz Araújo Teixeira, Henrique Euzébio Guedes de Freitas, Laura Ribeiro Aref Kzam, Juliana Bühring, Vitória Miki Pang Takatani, Clara Pinheiro Martins, Davi Queiroz Rêgo, Roland Guilherme Ferreira Vermehren, Bárbara Letícia Costa Corrêa, Marianna Maisonnette de Attayde Silva, Tayana Evelling Uchôa da Silva, Gustavo Lopes de Castro, Gabriel Antônio de Lima Cerqueira, Victória Pereira Ferreira, Yane Melo Santana, Bárbara Seabra Carneiro, Bruna Guimarães Dutra, Thais de Arruda Reinehr, Ranna Simôes e Souza, Fernanda Maria Da Silva Bezerra, and Giordana Farnese

Subjects
medicine.medical_specialty, Family medicine, medicine, Experience report, Sociology, Inclusion (education)
Published
2021
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6. DRUG PROFILE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN TIMES OF COVID-19 PANDEMIC IN AMAZONAS

Author

Samuel Elias Basualto Dias, Laura Ribeiro Aref Kzam, Bruna Borges Santos, Bárbara Seabra Carneiro, Gabriella Bacellar Marques, Gabriel Antônio de Lima Cerqueira, Andrezza Mendes Franco, Vitóri Miki Pang Takatani, Clara Pinheiro Martins, Bruna Guimarães Dutra, Bárbara Letícia Costa Corrêa, Cecília Tizatto Barroso, Joelma Moreira Belas Torres, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, and Gabriela Alarcón Alcântara

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Drug profile, Pandemic, Medicine, business, Dermatology
Published
2021
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7. IMPACT OF THE COVID-19 PANDEMIC ON THE TREATMENT OF PATIENTS WITH IMMUNOMEDIATED RHEUMATIC DISEASES USING ANTIMALARIALS IN THE CITY OF MANAUS/AMAZONAS

Author

Bruna Borges Santos, Bruna Guimarães Dutra, Gabriel Antônio de Lima Cerqueira, Joelma Moreira Belas Torres, Bárbara Letícia Costa Corrêa, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, Gabriella Bacellar Marques, Laura Ribeiro Aref Kzam, Clara Pinheiro Martins, Vitória Miki Pang Takatani, Andrezza Mendes Franco, Gabriela Alarcón Alcântara, Cecília Tizatto Barroso, and Samuel Elias Basualto Dias

Subjects
Coronavirus disease 2019 (COVID-19), business.industry, Environmental health, Pandemic, Medicine, business
Published
2021
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8. FREQUENCY OF FLU-LIKE SYMPTOMS AND THE CONCERNS ON THE COVID-19 PANDEMIC IN GRADUATE MEDICAL STUDENTS FROM ALL BRAZILIAN REGIONS - A REAL LIFE STUDY

Author

João Vitor Ziroldo Lopes, Helena Lúcia Alves Pereira, Viviane Angelina de Souza, Sandra Lúcia Euzébio Ribeiro, Kirla Wagner Poti Gomes, Lilian David de Azevedo Valadares, Egypt Brito, Maycoln Leôni Martins Teodoro, José Roberto Provenza, Edgard Torres Reis-Neto, Ana Karla Guedes, Marcelo de Medeiros Pinheiro, Mirhelen Mendes de Abreu, Gabriela Araújo Munhoz, Emília Inoue Sato, Henrique de Ataíde Mariz, Ângela Luzia Branco Pinto Duarte, Valeria Valim, Ana Beatriz Santos Bacchiega, Nafice Costa Araújo, Licia Maria Henrique Mota, Ana Paula Monteiro Gomides, Claudia Diniz Lopes Marques, Adriana Maria Kakehasi, Danielle Christinne Soares, Gecilmara Salviato Pileggi, Débora Cerqueira Calderaro, Bárbara Stadler Kalow, Thelma Skare, Cleandro Pires de Albuquerque, Samuel Elias Basualto Dias, Paula Reale Fernandes, Aline Rizzo Borges, Gilda Aparecida Ferreira, Evandro Mendes Klumb, Eduardo dos Santos Paiva, and Blanca Elena Rios Gomes Bica

Subjects
Flu-like symptoms, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Family medicine, Pandemic, medicine, Life study, business
Published
2021
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9. ANALYSIS OF THE LOW PERFORMANCE OF TESTS FOR DIAGNOSIS AMONG IMMUNOMEDIATED RHEUMATIC DISEASES PATIENTS WITH SUSPECTED CASE OF COVID-19 IN MANAUS/AMAZONAS

Author

Bruna Borges Santos, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, Bárbara Letícia Costa Corrêa, Cecília Tizatto Barroso, Vitória Miki Pang Takatani, Samuel Elias Basualto Dias, Laura Ribeiro Aref Kzam, Joelma Moreira Belas Torres, Clara Pinheiro Martins, Gabriela Alarcón Alcântara, Bruna Guimarães Dutra, Gabriella Bacellar Marques, Andrezza Mendes Franco, and Gabriel Antônio de Lima Cerqueira

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Medicine, business, Dermatology
Published
2021
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10. EPIDEMIOLOGICAL DESCRIPTION OF RHEUMATOLOGICAL PATIENTS IN CHRONIC USE OF ANTIMALARIALS FROM THE MÁRIO PINOTTI II PROJECT IN MANAUS-AMAZONAS

Author

Gabriella Bacellar Marques, Laura Ribeiro Aref Kzam, Andrezza Mendes Franco, Bárbara Letícia Costa Corrêa, Cecília Tizatto Barroso, Bruna Borges Santos, Gabriel Antônio de Lima Cerqueira, Bruna Guimarães Dutra, Samuel Elias Basualto Dias, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, Joelma Moreira Belas Torres, Clara Pinheiro Martins, Vitória Miki Pang Takatani, and Gabriela Alarcón Alcântara

Subjects
medicine.medical_specialty, business.industry, Family medicine, Epidemiology, Medicine, business
Published
2021
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11. HOSPITALIZATION AND MORTALITY RATE RELATED TO COVID-19 IN PATIENTS WITH RHEUMATIC DISEASES ON CHRONIC USE OF HYDROXYCHLOROQUINE: 16-WEEK PRELIMINARY DATA FROM THE MARIO PINOTTI STUDY

Author

José Roberto Provenza, Eduardo Ferreira Borba, Ana Karla Guedes, Marcus Lacerda, Ângela Luzia Branco Pinto Duarte, Claudia Diniz Lopes Marques, Dante Valdetaro Bianchi, Vanderson Souza Sampaio, Viviane Angelina de Souza, Gilda Aparecida Ferreira, Evandro Mendes Klumb, Kirla Wagner Poti Gomes, Valeria Valim, Thelma Skare, Ana Paula Monteiro Gomides Reis, Marcelo Medeiros Pinheiro, Adriana Maria Kakehasi, Eduardo dos Santos Paiva, Mirhelen Mendes de Abreu, Emília Inoue Sato, Odirlei André Monticielo, Danielle Christinne Soares Egypto de Brito, Nafice Costa Araújo, Gabriela Gimenez Faustino, Mariana Peixoto Guimarães, Ricardo Machado Xavier, Camila Santana Justo Cintra Sampaio, Blanca Elena Rios Gomes Bica, Paula Reale Fernandes, Gabriela Araújo Munhoz, Licia Maria Henrique Mota, Cleandro Pires de Albuquerque, Gecilmara Salviato Pillegi, Ana Beatriz Santos Bacchiega, Laurindo Ferreira da Rocha Junior, Edgard Torres Reis-Neto, Rafaela Cavalheiro do Espírito Santo, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, and Eloisa Bonfa

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Internal medicine, Mortality rate, Medicine, Hydroxychloroquine, In patient, business, medicine.drug
Published
2021
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12. SYMPTOMS SUGGESTIVE OF COVID-19 IN RHEUMATIC PATIENTS USING ANTIMALARIALS OF MÁRIO PINOTTI PROJECT II IN MANAUS/ AMAZONAS

Author

Bruna Borges Santos, Bruna Guimarães Dutra, Gabriella Bacellar Marques, Andrezza Mendes Franco, Joelma Moreira Belas Torres, Laura Ribeiro Aref Kzam, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, Gabriel Antônio de Lima Cerqueira, Clara Pinheiro Martins, Cecília Tizatto Barroso, Bárbara Letícia Costa Corrêa, Samuel Elias Basualto Dias, Vitória Miki Pang Takatani, and Gabriela Alarcón Alcântara

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Medicine, business, Dermatology
Published
2020
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13. Poliarterite nodosa cutânea: apresentação atípica com gangrena

Author

Helena Lúcia Alves Pereira, Mariana Pereira Ferreira, Rachel Pereira Ferreira, and Victória Pereira Ferreira

Subjects
General Medicine
Abstract

Objetivo: Discutir sobre essa doença rara que demanda alta suspeição clínica, mostrando uma apresentação grave, comparação com outros casos na literatura, forma de tratamento e seguimento clínico. Detalhamento do caso: Mulher de 60 anos, previamente hígida, apresentou livedo reticular, úlcera cutânea e gangrena de membros inferiores. Recebeu tratamento com esteróides, sem resolução. Evoluiu com sepse de foco cutâneo, contraindicando imunossupressor. Submetida a plasmaférese e imunoglobulina, com estabilização da doença. Porém evoluiu com amputação de membros inferiores. Esse relato mostra apresentação rara e grave de CPAN, com rápida progressão para gangrena de membros inferiores. Inicialmente, necessário manejo clínico agressivo, com corticoterapia, sem resposta. Administrado terapia alternativa com imunoglobulina e plasmaférese, também adequados no contexto de sepse associada. Tratamento efetivo para controle clínico, entretanto fora inevitável amputação de membros inferiores. Considerações Finais: Tratamento envolveu inicialmente corticoterapia, porém paciente evoluiu com sepse de foco cutâneo e progressão da isquemia. Nesse contexto, inviabilizou-se imunossupressão com ciclofosfamida. Indicado plasmaférese e imunoglobulina, terapias alternativas relatadas na literatura, seguras no cenário infeccioso. Paciente apresentou estabilização do quadro clínico, seguiu imunossupressão com prednisona e uso de Azatioprina por 01 ano, sem recorrência.

Published
2020
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14. Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis

Author

Helena Lúcia Alves Pereira, Juliana Brandão Pinto Carneiro, Sandra Lúcia Euzébio Ribeiro, Taíssa Pinto de Souza, Felipe Augusto Silva Gama, and Mauro Martins Lippi

Subjects
medicine.medical_specialty, Pyomyositis, biology, Klebsiella pneumoniae, business.industry, Internal medicine, Rheumatoid arthritis, medicine, MEDLINE, Images in Rheumatology, medicine.disease, biology.organism_classification, business
Published
2018
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15. Long-term persistence of anti-β2 glycoprotein I in treated leprosy patients

Author

E I Sato, Helena Lúcia Alves Pereira, Luiz Fernando de Souza Passos, Sandra Lúcia Euzébio Ribeiro, Nataliê Silva, and Maria Cristina Dos-Santos

Subjects
Adult, Male, Enzyme-Linked Immunosorbent Assay, Rheumatology, Antiphospholipid syndrome, Prednisone, Leprosy, Humans, Medicine, Autoantibodies, Autoimmune disease, biology, business.industry, Middle Aged, medicine.disease, Thalidomide, Titer, Coagulation, beta 2-Glycoprotein I, Antibodies, Anticardiolipin, Immunology, biology.protein, Female, Antibody, business, medicine.drug
Abstract

β2 glycoprotein I (β2GPI) is a phospholipid binding protein that plays an important role in endothelial stability, blood coagulation, clearance of apoptotic debris and other physiologic processes. Anti-β2GPI antibodies occur in normal individuals and transiently during the course of infections, but are also associated with thrombotic events in autoimmune disease: the antiphospholipid syndrome (APS). A total of 31 out of 37 treated leprosy patients previously found to present high titers of IgM anti-β2GPI and/or anticardiolipin antibodies (aCL) remained positive for IgM antiphospholipid antibodies (aPL), and exhibited high titers of anti-β2GPI. The 37 patients were part of the 77 aPL-positive patients from a previous study that evaluated 158 leprosy patients. The median time elapsed between the first and second sample was 66 months. None of the 37 patients had any thrombotic event and 24 had a reactional state and were still requiring the use of prednisone, thalidomide or both. None of them fulfilled World Health Organization criteria for leprosy recurrence.

Published
2014
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16. Vasculite na hanseníase mimetizando doenças reumáticas

Author

Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, Lucilene Sales de Souza, and Erilane Leite Guedes

Subjects
Gynecology, medicine.medical_specialty, Rheumatology, business.industry, Medicine, business
Abstract

Os autores alertam para o multiplo espectro de apresentacao clinica da hanseniase, destacando as lesoes cutâneas necrosantes e manifestacoes articulares simulando doencas reumaticas, confundindo o diagnostico e o tratamento correto. Nesses aspectos, sao relatados dois casos do sexo feminino com hanseniase virchowiana e dimorfa cujas manifestacoes iniciais foram de lesoes eritemato-violaceas, necroticas e ulceradas, livedo reticular, oligoartrite, poliartralgias, mialgias e edema de membros inferiores, que mimetizaram algumas doencas reumaticas como o lupus eritematoso sistemico e a vasculite sistemica (poliarterite nodosa).

Published
2007
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17. Tratamento com antiinflamatórios tópicos na osteoartrite de joelho

Author

Sandra Lúcia Euzébio Ribeiro, Helena Lúcia Alves Pereira, and Rozana Mesquita Ciconelli

Subjects
Gynecology, medicine.medical_specialty, Rheumatology, business.industry, Medicine, business
Abstract

Os antiinflamatorios nao-esteroidais (AINEs) orais sao eficazes no alivio da dor na osteoartrite (OA), porem tem o risco de efeitos adversos sistemicos. Para diminuir a toxicidade e necessario reduzir a concentracao plasmatica uma vez que os efeitos adversos sao dose-dependentes. Os AINEs de uso topico, em teoria, alcancam altas concentracoes nos tecidos-alvo com concentracoes plasmaticas baixas, sendo portanto uma alternativa terapeutica, especialmente para pacientes de risco. Nossa revisao dos ensaios clinicos randomizados mostrou que os AINEs topicos foram mais efetivos que o placebo e tao eficazes quanto os AINEs orais. Porem, o pequeno numero de ensaios e falhas na metodologia nos impossibilita de fazer conclusoes definitivas, sendo necessarios estudos bem desenhados e de maior duracao.

Published
2006
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18. Systemic manifestations and ulcerative skin lesions in leprosy: differential diagnosis with rheumatic diseases

Author

Erilane Leite Guedes, Lucilene Sales de Souza, Sandra Lúcia Euzébio Ribeiro, and Helena Lúcia Alves Pereira

Subjects
Systemic disease, Pathology, medicine.medical_specialty, Borderline leprosy, business.industry, Rheumatic disease, lesões cutâneas ulceradas, medicine.disease, polyarthritis, Cutaneous Involvement, Rheumatology, hanseníase, poliartrite, Female patient, medicine, Polyarthritis, Leprosy, Differential diagnosis, business, leprosy, cutaneous ulcerative lesions
Abstract

A hanseníase apresenta acometimento cutâneo e neurológico característicos; entretanto, as manifestações reumáticas são relativamente comuns sendo, em alguns pacientes, a queixa inicial. O presente relato de caso descreve uma paciente do sexo feminino, com hanseníase borderline, cuja manifestação inicial foi poliartrite simétrica, lesões cutâneas ulceradas em membros inferiores e manifestações sistêmicas simulando doença reumática. Os autores enfatizam a importância do diagnóstico diferencial do comprometimento sistêmico, articular e cutâneo na hanseníase com as doenças reumáticas. Leprosy is a systemic disease with predominant involvement of skin and nerves; articular manifestations are common and, in some cases, represent the initial complaint. We describe the case of a female patient with borderline leprosy, which manifested, initially, with symmetric polyarthritis, cutaneous ulcerative lesions on the lower limbs, and systemic manifestations mimicking rheumatic disease. The authors emphasize the importance of the differential diagnosis of the systemic, joint and, cutaneous involvement of leprosy with rheumatic diseases.

Published
2009
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19. Autoanticorpos em pacientes com hanseníase, com e sem comprometimento articular, no Estado do Amazonas

Author

Emília Inoue Sato, Sandra Lúcia Euzébio Ribeiro, Helena Lúcia Alves Pereira, and Neusa Pereira da Silva

Subjects
medicine.medical_specialty, Lepromatous leprosy, biology, Anti-nuclear antibody, business.industry, Autoantibody, medicine.disease, Gastroenterology, Latex fixation test, Rheumatology, Internal medicine, Immunology, medicine, biology.protein, Rheumatoid factor, Leprosy, Antibody, skin and connective tissue diseases, business, Anti-neutrophil cytoplasmic antibody
Abstract

OBJECTIVE: Determine the frequency of rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP), antinuclear antibodies (ANA), antineutrophil cytoplasmic antibodies (ANCA), anticardiolipin antibodies (aCL), and anti-β2 glycoprotein I antibodies (anti-β2GPI) in leprosy patients, with and without joint involvement, and to evaluate the possible association among those antibodies and articular manifestations, clinical type, reactional episodes, polychemotherapic treatment (PCT), and discharge from PCT. PATIENTS AND METHODS: One hundred and fifty-eight leprosy patients were divided in two groups of 73 patients (Group I) and 82 patients (Group II). Group III was composed of 129 healthy individuals. Methods: Semi-quantitative latex agglutination test for IgM-RF, indirect immunofluorescence for ANA and ANCA, and ELISA for anti-CCP, aCL, and anti-β2GPI. RESULTS: Fifty-six (35.4%) of 158 leprosy patients had lepromatous leprosy (LL). The frequency of anti-CCP, RF, and ANA antibodies in Groups I and II was similar to that of Group III. Antineutrophil cytoplasmic antibodies were not detected in any patient. Anticardiolipin antibodies were more frequent in leprosy patients (Groups I and II) than in control group (15.8% vs. 3.1%; P < 0.001), and differences between Groups I and II (P = 0.67) were not observed. Anti-β2GPI antibodies were also more common in leprosy patients than in control group (46.2% vs. 9.4%; P < 0.001), without differences between Groups I and II. A predominance of IgM isotype over IgG isotype was observed both for aCL (88% vs. 16%; P = 0.001) and anti-β2GPI (97.3% vs. 12.3%; P < 0.001). Patients did not present manifestations suggestive of vascular thrombosis. CONCLUSION: The frequency of aCL and anti-β2GPI antibodies was significantly increased in leprosy patients than in healthy individuals. However, positivity to other autoantibodies was similar to that observed in the control group. An association between autoantibodies and joint involvement, reactional episodes, polychemotherapic treatment, discharge, and clinical type of leprosy was not observed, except for aCL antibodies, which were more frequent in lepromatous leprosy.

Published
2009
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20. Avaliação por imagem do comprometimento osteoarticular e de nervos periféricos na hanseníase

Author

Rozana Mesquita Ciconelli, Sandra Lúcia Euzébio Ribeiro, Artur da Rocha Corrêa Fernandes, and Helena Lúcia Alves Pereira

Subjects
Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Neuritis, Magnetic resonance imaging, medicine.disease, Scleroderma, Rheumatology, Bone lesion, Diabetes mellitus, medicine, Leprosy, Differential diagnosis, Abscess, business
Abstract

In leprosy, bone lesions due direct invasion of bacilli are low in incidence and these lesions exhibit radiologic findings of acute and chronic osteomyelitis similar to those of other granulomatous infectious agents. The more common bone lesions are those due to injurious effects of trauma and infection imposed upon denervated tissues. Radiographycally are seen various degrees of reabsorption of the extremities involving hands and feet with the loss of digits and disorganizing arthropathies in small joints. The radiologic appearance are similar to other conditions in which there is sensory impairment like scleroderma, syringomielia and diabetes mellitus. The ultrasonography and magnetic resonance imaging (MRI) can be helpful in evaluation of the involvement of the peripheral nerves helping in the diagnosis of the neuritis, abscess and differential diagnosis in compressive syndromes.

Published
2006
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21. The development of arthritis and antinuclear antibodies correlate with serum 25-hydroxyvitamin D levels in patients with leprosy

Author

Carlos Eduardo Ferreira, Eliane Aparecida Rosseto, Cristóvão Luis Pitangueira Mangueira, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro, and Morton Scheinberg

Subjects
Arthritis, Infectious, Endemic Diseases, Anti-nuclear antibody, business.industry, Immunology, Arthritis, Disease, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Natural history, Immune system, Rheumatology, Antibodies, Antinuclear, Leprosy, Vitamin D and neurology, medicine, Humans, Immunology and Allergy, Vitamin D, Serum 25 hydroxyvitamin d, business, Brazil
Abstract

Leprosy, a chronic granulomatous infection, presents with cutaneous and neurological manifestations. Musculoskeletal involvement, though the third most common manifestation, is underdiagnosed.1 ,2 In its natural history, other immune manifestations besides articular manifestations may be present, such as the presence of autoantibodies.3 ,4 There is evidence that vitamin D influences the activity of immune-mediated diseases, particularly autoimmune diseases.5 ,6 Amazon is a state in the northern part of Brazil where the disease is endemic. It has a high level of sunshine, so a low prevalence of vitamin D insufficiency would be expected. In this study we looked at the serum vitamin D …

Published
2012
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