1. Effects of palmitoyl-KVK-L-ascorbic acid on skin wrinkles and pigmentation.
- Author
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Kim HM, An HS, Bae JS, Kim JY, Choi CH, Kim JY, Lim JH, Choi JH, Song H, Moon SH, Park YJ, Chang SJ, and Choi SY
- Subjects
- Adult, Cell Line, Female, Humans, Middle Aged, Skin drug effects, Skin physiopathology, Skin Aging physiology, Ascorbic Acid analogs & derivatives, Ascorbic Acid pharmacology, Collagen biosynthesis, Oligopeptides pharmacology, Skin Aging drug effects, Skin Lightening Preparations pharmacology
- Abstract
Wrinkle formation and abnormal pigmentation are major clinical alterations associated with skin aging. As the aim of our study was to investigate the effects of palmitoyl-KVK-L-ascorbic acid on skin aging, the anti-wrinkle and depigmentation effects of palmitoyl-KVK-L-ascorbic acid were evaluated by measuring collagen expression in dermal fibroblast cells and inhibition of melanogenesis in B16F1 cells, respectively. The anti-aging effect of palmitoyl-KVK-L-ascorbic acid cream was also evaluated against a placebo cream in a clinical trial. Our results confirmed that the expression of type Ι collagen in dermal fibroblast cells treated with palmitoyl-KVK-L-ascorbic acid (0.1-4 μg/mL) increased in a dose-dependent manner. In B16F1 cells, treatment with 20 μg/mL palmitoyl-KVK-L-ascorbic acid reduced the melanin content by approximately 20% compared to alpha-melanocyte stimulating hormone treatment. In the clinical trial, application of palmitoyl-KVK-L-ascorbic acid cream led to an improvement in skin roughness and lightness in 12 and 8 weeks, respectively. Our data show that palmitoyl-KVK-L-ascorbic acid is an effective anti-aging agent that reduces wrinkles and abnormal skin pigmentation.
- Published
- 2017
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