36 results on '"Koning, F."'
Search Results
2. De impact van seksueel grensoverschrijdend gedrag op het lichaamsbeeld van studenten
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Koning, F. de, Koning, F. de, Koning, F. de, and Koning, F. de
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- 2022
3. Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity
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Jong, S.E. de, Unen, V. van, Manurung, M.D., Stam, K.A., Goeman, J.J., Jochems, S.P., Höllt, T., Pezzotti, N., Mouwenda, Y.D., Ongwe, M.E. Betouke, Lorenz, Freia-Raphaella, Kruize, Y.C., Azimi, S., König, M.H., Vilanova, A., Eisemann, E., Lelieveldt, B.P., Roestenberg, M., Sim, B.K., Reinders, M.J.T., Fendel, R., Hoffman, S.L., Kremsner, P.G., Koning, F., Mordmüller, B.G., Lell, B., Yazdanbakhsh, M., Jong, S.E. de, Unen, V. van, Manurung, M.D., Stam, K.A., Goeman, J.J., Jochems, S.P., Höllt, T., Pezzotti, N., Mouwenda, Y.D., Ongwe, M.E. Betouke, Lorenz, Freia-Raphaella, Kruize, Y.C., Azimi, S., König, M.H., Vilanova, A., Eisemann, E., Lelieveldt, B.P., Roestenberg, M., Sim, B.K., Reinders, M.J.T., Fendel, R., Hoffman, S.L., Kremsner, P.G., Koning, F., Mordmüller, B.G., Lell, B., and Yazdanbakhsh, M.
- Abstract
Item does not contain fulltext, Controlled human infections provide opportunities to study the interaction between the immune system and malaria parasites, which is essential for vaccine development. Here, we compared immune signatures of malaria-naive Europeans and of Africans with lifelong malaria exposure using mass cytometry, RNA sequencing and data integration, before and 5 and 11 days after venous inoculation with Plasmodium falciparum sporozoites. We observed differences in immune cell populations, antigen-specific responses and gene expression profiles between Europeans and Africans and among Africans with differing degrees of immunity. Before inoculation, an activated/differentiated state of both innate and adaptive cells, including elevated CD161(+)CD4(+) T cells and interferon-γ production, predicted Africans capable of controlling parasitemia. After inoculation, the rapidity of the transcriptional response and clusters of CD4(+) T cells, plasmacytoid dendritic cells and innate T cells were among the features distinguishing Africans capable of controlling parasitemia from susceptible individuals. These findings can guide the development of a vaccine effective in malaria-endemic regions.
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- 2021
4. The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases
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Alenius, H., Sinkko, H., Moitinho-Silva, L., Rodriguez, E., Broderick, C., Alexander, H., Reiger, M., Hjelmsø, M.H., Fyhrquist, N., Olah, P., Bryce, P., Smith, C., Koning, F., Eyerich, K., Greco, D., Bogaard, E.H.J. van den, Neumann, A.U., Traidl-Hoffmann, C., Homey, B., Flohr, C., Bønnelykke, K., Stokholm, J., Weidinger, S., Alenius, H., Sinkko, H., Moitinho-Silva, L., Rodriguez, E., Broderick, C., Alexander, H., Reiger, M., Hjelmsø, M.H., Fyhrquist, N., Olah, P., Bryce, P., Smith, C., Koning, F., Eyerich, K., Greco, D., Bogaard, E.H.J. van den, Neumann, A.U., Traidl-Hoffmann, C., Homey, B., Flohr, C., Bønnelykke, K., Stokholm, J., and Weidinger, S.
- Abstract
Contains fulltext : 237768.pdf (Publisher’s version ) (Open Access), The two most common chronic inflammatory skin diseases are atopic dermatitis (AD) and psoriasis. The underpinnings of the remarkable degree of clinical heterogeneity of AD and psoriasis are poorly understood and, as a consequence, disease onset and progression are unpredictable and the optimal type and time point for intervention are as yet unknown. The BIOMAP project is the first IMI (Innovative Medicines Initiative) project dedicated to investigating the causes and mechanisms of AD and psoriasis and to identify potential biomarkers responsible for the variation in disease outcome. The consortium includes 7 large pharmaceutical companies and 25 non-industry partners including academia. Since there is mounting evidence supporting an important role for microbial exposures and our microbiota as factors mediating immune polarization and AD and psoriasis pathogenesis, an entire work package is dedicated to the investigation of skin and gut microbiome linked to AD or psoriasis. The large collaborative BIOMAP project will enable the integration of patient cohorts, data and knowledge in unprecedented proportions. The project has a unique opportunity with a potential to bridge and fill the gaps between current problems and solutions. This review highlights the power and potential of the BIOMAP project in the investigation of microbe-host interplay in AD and psoriasis.
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- 2021
5. The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases
- Author
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Alenius, H., Sinkko, H., Moitinho-Silva, L., Rodriguez, E., Broderick, C., Alexander, H., Reiger, M., Hjelmsø, M.H., Fyhrquist, N., Olah, P., Bryce, P., Smith, C., Koning, F., Eyerich, K., Greco, D., Bogaard, E.H.J. van den, Neumann, A.U., Traidl-Hoffmann, C., Homey, B., Flohr, C., Bønnelykke, K., Stokholm, J., Weidinger, S., Alenius, H., Sinkko, H., Moitinho-Silva, L., Rodriguez, E., Broderick, C., Alexander, H., Reiger, M., Hjelmsø, M.H., Fyhrquist, N., Olah, P., Bryce, P., Smith, C., Koning, F., Eyerich, K., Greco, D., Bogaard, E.H.J. van den, Neumann, A.U., Traidl-Hoffmann, C., Homey, B., Flohr, C., Bønnelykke, K., Stokholm, J., and Weidinger, S.
- Abstract
Contains fulltext : 237768.pdf (Publisher’s version ) (Open Access), The two most common chronic inflammatory skin diseases are atopic dermatitis (AD) and psoriasis. The underpinnings of the remarkable degree of clinical heterogeneity of AD and psoriasis are poorly understood and, as a consequence, disease onset and progression are unpredictable and the optimal type and time point for intervention are as yet unknown. The BIOMAP project is the first IMI (Innovative Medicines Initiative) project dedicated to investigating the causes and mechanisms of AD and psoriasis and to identify potential biomarkers responsible for the variation in disease outcome. The consortium includes 7 large pharmaceutical companies and 25 non-industry partners including academia. Since there is mounting evidence supporting an important role for microbial exposures and our microbiota as factors mediating immune polarization and AD and psoriasis pathogenesis, an entire work package is dedicated to the investigation of skin and gut microbiome linked to AD or psoriasis. The large collaborative BIOMAP project will enable the integration of patient cohorts, data and knowledge in unprecedented proportions. The project has a unique opportunity with a potential to bridge and fill the gaps between current problems and solutions. This review highlights the power and potential of the BIOMAP project in the investigation of microbe-host interplay in AD and psoriasis.
- Published
- 2021
6. Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease
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Graaf, A. de, Zorro, M.M., Claringbould, A., Võsa, U., Aguirre-Gamboa, R., Li, C., Mooiweer, J., Ricaño-Ponce, I., Borek, Z., Koning, F., Kooy-Winkelaar, Y., Sollid, L.M., Qiao, S.W., Kumar, V., Li, Y., Franke, L., Withoff, S., Wijmenga, C., Sanna, S., Jonkers, I., Graaf, A. de, Zorro, M.M., Claringbould, A., Võsa, U., Aguirre-Gamboa, R., Li, C., Mooiweer, J., Ricaño-Ponce, I., Borek, Z., Koning, F., Kooy-Winkelaar, Y., Sollid, L.M., Qiao, S.W., Kumar, V., Li, Y., Franke, L., Withoff, S., Wijmenga, C., Sanna, S., and Jonkers, I.
- Abstract
Contains fulltext : 232566.pdf (Publisher’s version ) (Open Access), Celiac disease (CeD) is a complex T cell-mediated enteropathy induced by gluten. Although genome-wide association studies have identified numerous genomic regions associated with CeD, it is difficult to accurately pinpoint which genes in these loci are most likely to cause CeD. We used four different in silico approaches-Mendelian randomization inverse variance weighting, COLOC, LD overlap, and DEPICT-to integrate information gathered from a large transcriptomics dataset. This identified 118 prioritized genes across 50 CeD-associated regions. Co-expression and pathway analysis of these genes indicated an association with adaptive and innate cytokine signaling and T cell activation pathways. Fifty-one of these genes are targets of known drug compounds or likely druggable genes, suggesting that our methods can be used to pinpoint potential therapeutic targets. In addition, we detected 172 gene combinations that were affected by our CeD-prioritized genes in trans. Notably, 41 of these trans-mediated genes appear to be under control of one master regulator, TRAF-type zinc finger domain containing 1 (TRAFD1), and were found to be involved in interferon (IFN)γ signaling and MHC I antigen processing/presentation. Finally, we performed in vitro experiments in a human monocytic cell line that validated the role of TRAFD1 as an immune regulator acting in trans. Our strategy confirmed the role of adaptive immunity in CeD and revealed a genetic link between CeD and IFNγ signaling as well as with MHC I antigen processing, both major players of immune activation and CeD pathogenesis.
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- 2020
7. Reducing Computational Cost in District Heating Network Simulations
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de Koning, F. and de Koning, F.
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- 2020
8. Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4+ T cells.
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Sollid, LM, Tye-Din, JA, Qiao, S-W, Anderson, RP, Gianfrani, C, Koning, F, Sollid, LM, Tye-Din, JA, Qiao, S-W, Anderson, RP, Gianfrani, C, and Koning, F
- Abstract
Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4+ T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.
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- 2020
9. Reducing Computational Cost in District Heating Network Simulations
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de Koning, F. and de Koning, F.
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- 2020
10. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel, G, Claverie, C, Labreuche, J, Renaudin, J-M, Dorkenoo, A, Eb, M, Moneret-Vautrin, A, Deschildre, A, Leteurtre, S, Grabenhenrich, L, Worm, M, Dölle, S, Scherer, K, Hutteger, I, Christensen, M, Bindslev-Jensen, C, Mortz, C, Eller, E, Kjaer, HF, Carneiro-Leão, L, Badas, J, Coimbra, A, Levy, DP, Ben-Shoshan, M, Rimon, A, Benor, S, Arends, NJT, Edelbroek, N, de Groot, H, Emons, JAM, Brand, HKA, Verhoeven, D, van Veen, LN, de Jong, NW, Noh, G, Jang, EH, Pascal, M, Dominguez, O, Piquer, M, Alvaro, M, Jimenez-Feijoo, R, Lozano, J, Machinena, A, del Mar Folqué, M, Giner, MT, Plaza, AM, Turner, P, Patel, N, Vazquez-Ortiz, M, Lindsley, S, Walker, L, Rosenberg, S, Mari, A, Alessandri, C, Giangrieco, I, Tuppo, L, Rafaiani, C, Mitterer, G, Ciancamerla, M, Ferrara, R, Bernardi, ML, Zennaro, D, Tamburrini, M, Ciardiello, MA, Harwanegg, C, Fernandez, A, Selb, R, Egenmann, P, Epstein, M, Hoffmann-Sommergruber, K, Koning, F, Lovik, M, Clare Mills, EN, Moreno, J, van Loveren, H, Wal, J-M, Diesner, S, Bergmayr, C, Pfitzner, B, Assmann, VE, Starkl, P, Endesfelder, D, Eiwegger, T, Szepfalusi, Z, Fehrenbach, H, Jensen-Jarolim, E, Hartmann, A, Pali-Schöll, I, Untersmayr, E, Wille, S, Meyer, P, Klingebiel, C, Lidholm, J, Ehrenberg, A, Östling, J, Cleach, I, Mège, J-L, Vitte, J, Aina, R, Dubiela, P, Pfeifer, S, Bublin, M, Radauer, C, Humeniuk, P, Kabasser, S, Asero, R, Bogas, G, Gomez, F, Campo, P, Salas, M, Doña, I, Barrionuevo, E, Guerrero, MA, Mayorga, C, Prieto, A, Barber, D, Torres, MJ, Jamin, A, Wangorsch, A, Ballmer, B, Vieths, S, Scheurer, S, Apostolovic, D, Mihailovic, J, Krstic, M, Starkhammar, M, Velickovic, TC, Hamsten, C, van Hage, M, van Erp, FC, Knol, EF, Kansen, HM, Pontoppidan, B, Meijer, Y, van der Ent, CK, Knulst, AC, Sayers, R, Brown, H, Custovic, A, Simpson, A, Mills, C, Schulz, J, Akkerdaas, J, Totis, M, Capt, A, Herouet-Guicheney, C, van Ree, R, Banerjee, T, Banerjee, A, Claude, M, Bouchaud, G, Lupi, R, Castan, L, Tranquet, O, Denery-Papini, S, Bodinier, M, Brossard, C, De Poi, R, Gritti, E, De Dominicis, E, Popping, B, de Laureto, PP, Palosuo, K, Kukkonen, AK, Pelkonen, A, Mäkelä, M, Lee, NA, Rost, J, Muralidharan, S, Campbell, D, Mehr, S, Nock, C, Baumert, J, Taylor, S, Mastrorilli, C, Tripodi, S, Caffarelli, C, Perna, S, Di Rienzo Businco, A, Sfika, I, Dondi, A, Bianchi, A, Dascola, CP, Ricci, G, Cipriani, F, Maiello, N, del Giudice, MM, Frediani, T, Frediani, S, Macrì, F, Pistoletti, C, Iacono, ID, Patria, MF, Varin, E, Peroni, D, Comberiati, P, Chini, L, Moschese, V, Lucarelli, S, Bernardini, R, Pingitore, G, Pelosi, U, Olcese, R, Moretti, M, Cirisano, A, Faggian, D, Travaglini, A, Plebani, M, Verga, MC, Calvani, M, Giordani, P, Matricardi, PM, Ontiveros, N, Cabrera-Chavez, F, Galand, J, Beaudouin, E, Pineau, F, Sakai, S, Matsunaga, K, Teshima, R, Larré, C, Denery, S, Tschirner, S, Trendelenburg, V, Schulz, G, Niggemann, B, Beyer, K, Bouferkas, Y, Belabbas, Y, Saidi, D, Kheroua, O, Mecherfi, KEE, Guendouz, M, Haddi, A, Kaddouri, H, Amaral, L, Pereira, A, Rodrigues, S, Datema, M, Jongejan, L, Clausen, M, Knulst, A, Papadopoulos, N, Kowalski, M, de Blay, F, Zwinderman, A, Hoffman-Sommergruber, K, Ballmer-Weber, B, Fernandez-Rivas, M, Deng, S, Yin, J, Eisenmann, C, Nassiri, M, Reinert, R, van der Valk, JPM, van Wijk, RG, Vergouwe, Y, Steyerberg, EW, Reitsma, M, Wichers, HJ, Savelkoul, HFJ, Vlieg-Boerstra, B, Dubois, AEJ, Carolino, F, Rodolfo, A, Cernadas, J, Roa-Medellín, D, Rodriguez-Fernandez, A, Navarro, J, Albendiz, V, Baeza, ML, Intente-Herrero, S, Mikkelsen, A, Mehlig, K, Lissner, L, Verrill, L, Luccioli, S, van Bilsen, J, Kuper, F, Wolterbeek, A, Rankouhi, TR, Verschuren, L, Cnossen, H, Jeurink, P, Garssen, J, Knippels, L, Garthoff, J, Houben, G, Leeman, W, Eleonore Pettersson, M, Schins, AMM, Koppelman, GH, Kollen, BJ, Zubchenko, S, Kuntz, S, Mérida, P, Álvaro, M, Riggioni, C, Castellanos, JH, Jimenez, R, Cap, M, Drumez, E, Lejeune, S, Thumerelle, C, Mordacq, C, Nève, V, Ricò, S, Varini, M, Nocerino, R, Cosenza, L, Amoroso, A, Di Costanzo, M, Di Scala, C, Bedogni, G, Canani, RB, Turner, PJ, Poza-Guedes, P, González-Pérez, R, Sánchez-Machín, I, Matheu-Delgado, V, Wambre, E, Ballegaard, A-S, Madsen, C, Gregersen, J, Bøgh, KL, Aubert, P, Neunlist, M, Magnan, A, Lozano-Ojalvo, D, Pablos-Tanarro, A, Pérez-Rodríguez, L, Molina, E, López-Fandiño, R, Rekima, A, Macchiaverni, P, Turfkruyer, M, Holvoet, S, Dupuis, L, Baiz, N, Annesi-Maesano, I, Mercenier, A, Nutten, S, Verhasselt, V, Mrakovcic-Sutic, I, Banac, S, Sutic, I, Baricev-Novakovic, Z, Pavisic, V, Muñoz-Cano, R, Jiménez-Rodríguez, T, Corbacho, D, Roca-Ferrer, J, Bartra, J, Bulog, A, Micovic, V, Markiewicz, L, Szymkiewicz, A, Szyc, A, Wróblewska, B, Harvey, BM, Harthoorn, LF, Wesley Burks, A, Rentzos, G, Björk, A-LB, Bengtsson, U, Barber, C, Kalicinsky, C, Breynaert, C, Coorevits, L, Jansen, C, Van Hoeyveld, E, Verbeke, K, Kochuyt, A-M, Schrijvers, R, Deleanu, D, Muntean, A, Konstantakopoulou, M, Pasioti, M, Papadopoulou, A, Iliopoulou, A, Mikos, N, Kompoti, E, de Castro, ED, Bartalomé, B, Ue, KL, Griffiths, E, Till, S, Grimshaw, K, Roberts, G, Selby, A, Butiene, I, Larco, JI, Dubakiene, R, Fiandor, A, Fiocchi, A, Sigurdardottir, S, Sprikkelman, A, Schoemaker, A-F, Xepapadaki, P, Keil, T, Cojocariu, Z, Barbado, BS, Iancu, V, Arroabarren, E, Esarte, MG, Arteaga, M, Andrade, MC, Borges, D, Kalil, J, Bianchi, PG, Agondi, RC, Gupta, RK, Sharma, A, Gupta, K, Das, M, Dwivedi, P, Karseladze, R, Jorjoliani, L, Saginadze, L, Tskhakaia, M, Basello, K, Piuri, G, Speciani, AF, Speciani, MC, Camerotto, C, Zinno, F, Pakholchuk, O, Nedelska, S, Pattini, S, Costantino, MT, Peveri, S, Villalta, D, Savi, E, Costanzi, A, Revyakina, VA, Kiseleva, MA, Kuvshinova, ED, Larkova, IA, Shekhetov, AA, Silva, D, Moreira, A, Plácido, J, van der Kleij, H, van Twuijver, E, Sutorius, R, de Kam, P-J, van Odijk, J, Lindqvist, H, Lustig, E, Jácome, AAA, Aguilar, KLB, Domínguez, MG, Hernández, DAM, Caruso, C, Casale, C, Rapaccini, GL, Romano, A, De Vitis, I, Cocco, RR, Aranda, C, Mallozi, MC, Motta, JF, Moraes, L, Pastorino, A, Rosario, N, Goudouris, E, Porto, A, Wandalsen, NF, Sarinho, E, Sano, F, Solé, D, Pitsios, C, Petrodimopoulou, M, Papadopoulou, E, Passioti, M, Kontogianni, M, Adamia, N, Khaleva, E, del Prado, AP, Du Toit, G, Krzych, E, Samolinska-Zawisza, U, Furmanczyk, K, Tomaszewska, A, Raciborski, F, Lipiec, A, Samel-Kowalik, P, Walkiewicz, A, Borowicz, J, Samolinski, B, Nano, AL, Recto, M, Somoza, ML, López, NB, Alzate, DP, Ruano, FJ, Garcimartín, MI, Haroun, E, de la Torre, MV, Rojas, A, Onieva, ML, Canto, G, Rodrigues, A, Forno, A, Cabral, AJ, Gonçalves, R, Vorozhko, I, Sentsova, T, Chernyak, O, Denisova, S, Ilènko, L, Muhortnich, V, Zimmermann, C, Rohrbach, A, Bakhsh, FR, Boudewijn, K, Oomkes-Pilon, A-M, Van Ginkle, D, Šilar, M, Jeverica, A, Vesel, T, Avčin, T, Korošec, P, van der Valk, J, Berends, I, Arends, N, van Maaren, M, Wichers, H, Emons, J, Dubois, A, de Jong, N, Matsyura, O, Besh, L, Huang, C-H, Jan, T-R, Stiefel, G, Tratt, J, Kirk, K, Arasi, S, Caminiti, L, Crisafulli, G, Fiamingo, C, Fresta, J, Pajno, G, Remington, B, Kruizinga, A, Marty Blom, W, Westerhout, J, Bijlsma, S, Blankestijn, M, Otten, H, Klemans, R, Michelsen-Huisman, AD, van Os-Medendorp, H, Kruizinga, AG, Versluis, A, van Duijn, G, de Zeeuw-Brouwer, HM-L, Castenmiller, JJM, Noteborn, HPJM, Houben, GF, Bravin, K, Luyt, D, Javed, B, Couch, P, Munro, C, Padfield, P, Sperrin, M, Byrne, A, Oosthuizen, L, Kelleher, C, Ward, F, Brosnan, N, King, G, Corbet, E, Guzmán, JAH, García, MB, Asensio, O, Navarrete, LV, Larramona, H, Miró, XD, Pyrz, K, Austin, M, Boloh, Y, Galloway, D, Hernandez, P, Hourihane, JOB, Kenna, F, Majkowska-Wojciechowska, B, Regent, L, Themisb, M, Schnadt, S, Semic-Jusufagic, A, Galvin, AD, Kauppila, T, Kuitunen, M, Kitsioulis, NA, Douladiris, N, Kostoudi, S, Manolaraki, I, Mitsias, D, Manousakis, E, Papadopoulos, NG, Knibb, R, Hammond, J, Cooke, R, Yrjänä, J, Hanni, A-M, Vähäsarja, P, Mustonen, O, Dunder, T, Kulmala, P, Lasa, E, D’Amelio, C, Martínez, S, Joral, A, Gastaminza, G, Goikoetxea, MJ, Candy, DCA, Van Ampting, MTJ, Oude Nijhuis, MM, Butt, AM, Peroni, DG, Fox, AT, Knol, J, Michaelis, LJ, Padua, I, Padrao, P, Moreira, P, Barros, R, Sharif, H, Ahmed, M, Gomaa, N, Mens, J, Smit, K, Timmermans, F, Poredoš, T, Jeverica, AK, Sedmak, M, Benedik, E, Accetto, M, Zupančič, M, Yonamine, G, Soldateli, G, Aquilante, B, Pastorino, AC, de Moraes Beck, CL, Gushken, AK, de Barros Dorna, M, dos Santos, CN, Castro, APM, Al-Qahtani, A, Arnaout, R, Khaliq, AR, Amin, R, Sheikh, F, Alvarez, J, Anda, M, Palacios, M, De Prada, M, Ponce, C, Balbino, B, Sibilano, R, Marichal, T, Gaudenzio, N, Karasuyama, H, Bruhns, P, Tsai, M, Reber, LL, Galli, SJ, Ferreira, AR, Cernadas, JR, del Campo García, A, Fernández, SP, Carrera, NS, Sánchez-Cruz, FB, Lorenzo, JRF, Claus, S, Pföhler, C, Ruëff, F, Treudler, R, Jaume, ME, Madroñero, A, Perez, MTG, Julia, JC, Plovdiv, CH, Gethings, L, Langridge, J, Adel-Patient, K, Bernard, H, Barcievic-Jones, I, Sokolova, R, Yankova, R, Ivanovska, M, Murdjeva, M, Popova, T, Dermendzhiev, S, Karjalainen, M, Lehnigk, U, Brown, D, Locklear, JC, Locklear, J, Maris, I, Hourihane, J, Ornelas, C, Caiado, J, Ferreira, MB, Pereira-Barbosa, M, Puente, Y, Daza, JC, Monteseirin, FJ, Ukleja-Sokolowska, N, Gawronska-Ukleja, E, Zbikowska-Gotz, M, Bartuzi, Z, Sokolowski, L, Adams, A, Mahon, B, English, K, Gourdon-Dubois, N, Sellam, L, Pereira, B, Michaud, E, Messaoudi, K, Evrard, B, Fauquert, J-L, Palomares, F, Gomez, G, Rodriguez, MJ, Galindo, L, Molina, A, Paparo, L, Mennini, M, Aitoro, R, Wawrzeńczyk, A, Przybyszewski, M, Sarıcoban, HE, Ugras, M, Yalvac, Z, Flokstra-de Blok, BMJ, van der Velde, JL, Vereda, A, Ippolito, C, Traversa, A, Adriano, D, Bianchi, DM, Gallina, S, Decastelli, L, Makatsori, M, Miles, A, Devetak, SP, Devetak, I, Tabet, SA, Trandbohus, JF, Winther, P, Malling, H-J, Hansen, KS, Garvey, LH, Wang, C-C, Cheng, Y-H, Tung, C-W, Dietrich, M, Marenholz, I, Kalb, B, Grosche, S, Blümchen, K, Schlags, R, Price, M, Rietz, S, Esparza-Gordillo, J, Lau, S, Lee, Y-A, Almontasheri, A, Bahkali, MA, Elshorbagi, S, Alfhaid, A, Altamimi, M, Madbouly, E, Al-Dhekri, H, Arnaout, RK, Basagaña, M, Miquel, S, Bartolomé, B, Brix, B, Rohwer, S, Brandhoff, S, Berger, A, Suer, W, Weimann, A, Bueno, C, Martín-Pedraza, L, Abián, S, Segundo-Acosta, PS, López-Rodríguez, JC, Barderas, R, Batanero, E, Cuesta-Herranz, J, Villalba, MT, Correia, M, Benito-Garcia, F, Arêde, C, Piedade, S, Morais-Almeida, M, Hindley, J, Yarham, R, Kuklinska-Pijanka, A, Gillick, D, Patient, K, Chapman, MD, Miranda, A, Matos, E, Sokolova, A, Rao, H, Baricevic-Jones, I, Smith, F, Xue, W, Magnusdottir, H, Vidarsdottir, AG, Lund, S, Jensen, AB, Ludviksson, BR, Simon, R, Elfont, R, Bennett, S, Voyksner, R, de Lurdes Torre, M, Yürek, S, Faber, MA, Bastiaensen, A, Mangodt, E, van Gasse, A, Decuyper, I, Sabato, V, Hagendorens, MM, Bridts, CH, De Clerck, LS, Ebo, D, Schwarz, S, Ziegert, M, Albroscheit, 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MG, Hernández, DAM, Caruso, C, Casale, C, Rapaccini, GL, Romano, A, De Vitis, I, Cocco, RR, Aranda, C, Mallozi, MC, Motta, JF, Moraes, L, Pastorino, A, Rosario, N, Goudouris, E, Porto, A, Wandalsen, NF, Sarinho, E, Sano, F, Solé, D, Pitsios, C, Petrodimopoulou, M, Papadopoulou, E, Passioti, M, Kontogianni, M, Adamia, N, Khaleva, E, del Prado, AP, Du Toit, G, Krzych, E, Samolinska-Zawisza, U, Furmanczyk, K, Tomaszewska, A, Raciborski, F, Lipiec, A, Samel-Kowalik, P, Walkiewicz, A, Borowicz, J, Samolinski, B, Nano, AL, Recto, M, Somoza, ML, López, NB, Alzate, DP, Ruano, FJ, Garcimartín, MI, Haroun, E, de la Torre, MV, Rojas, A, Onieva, ML, Canto, G, Rodrigues, A, Forno, A, Cabral, AJ, Gonçalves, R, Vorozhko, I, Sentsova, T, Chernyak, O, Denisova, S, Ilènko, L, Muhortnich, V, Zimmermann, C, Rohrbach, A, Bakhsh, FR, Boudewijn, K, Oomkes-Pilon, A-M, Van Ginkle, D, Šilar, M, Jeverica, A, Vesel, T, Avčin, T, Korošec, P, van der Valk, J, Berends, I, Arends, N, van Maaren, M, Wichers, H, Emons, J, Dubois, A, de Jong, N, Matsyura, O, Besh, L, Huang, C-H, Jan, T-R, Stiefel, G, Tratt, J, Kirk, K, Arasi, S, Caminiti, L, Crisafulli, G, Fiamingo, C, Fresta, J, Pajno, G, Remington, B, Kruizinga, A, Marty Blom, W, Westerhout, J, Bijlsma, S, Blankestijn, M, Otten, H, Klemans, R, Michelsen-Huisman, AD, van Os-Medendorp, H, Kruizinga, AG, Versluis, A, van Duijn, G, de Zeeuw-Brouwer, HM-L, Castenmiller, JJM, Noteborn, HPJM, Houben, GF, Bravin, K, Luyt, D, Javed, B, Couch, P, Munro, C, Padfield, P, Sperrin, M, Byrne, A, Oosthuizen, L, Kelleher, C, Ward, F, Brosnan, N, King, G, Corbet, E, Guzmán, JAH, García, MB, Asensio, O, Navarrete, LV, Larramona, H, Miró, XD, Pyrz, K, Austin, M, Boloh, Y, Galloway, D, Hernandez, P, Hourihane, JOB, Kenna, F, Majkowska-Wojciechowska, B, Regent, L, Themisb, M, Schnadt, S, Semic-Jusufagic, A, Galvin, AD, Kauppila, T, Kuitunen, M, Kitsioulis, NA, Douladiris, N, Kostoudi, S, Manolaraki, I, Mitsias, D, Manousakis, E, Papadopoulos, NG, Knibb, R, Hammond, J, Cooke, R, Yrjänä, J, Hanni, A-M, Vähäsarja, P, Mustonen, O, Dunder, T, Kulmala, P, Lasa, E, D’Amelio, C, Martínez, S, Joral, A, Gastaminza, G, Goikoetxea, MJ, Candy, DCA, Van Ampting, MTJ, Oude Nijhuis, MM, Butt, AM, Peroni, DG, Fox, AT, Knol, J, Michaelis, LJ, Padua, I, Padrao, P, Moreira, P, Barros, R, Sharif, H, Ahmed, M, Gomaa, N, Mens, J, Smit, K, Timmermans, F, Poredoš, T, Jeverica, AK, Sedmak, M, Benedik, E, Accetto, M, Zupančič, M, Yonamine, G, Soldateli, G, Aquilante, B, Pastorino, AC, de Moraes Beck, CL, Gushken, AK, de Barros Dorna, M, dos Santos, CN, Castro, APM, Al-Qahtani, A, Arnaout, R, Khaliq, AR, Amin, R, Sheikh, F, Alvarez, J, Anda, M, Palacios, M, De Prada, M, Ponce, C, Balbino, B, Sibilano, R, Marichal, T, Gaudenzio, N, Karasuyama, H, Bruhns, P, Tsai, M, Reber, LL, Galli, SJ, Ferreira, AR, Cernadas, JR, del Campo García, A, Fernández, SP, Carrera, NS, Sánchez-Cruz, FB, Lorenzo, JRF, Claus, S, Pföhler, C, Ruëff, F, Treudler, R, Jaume, ME, Madroñero, A, Perez, MTG, Julia, JC, Plovdiv, CH, Gethings, L, Langridge, J, Adel-Patient, K, Bernard, H, Barcievic-Jones, I, Sokolova, R, Yankova, R, Ivanovska, M, Murdjeva, M, Popova, T, Dermendzhiev, S, Karjalainen, M, Lehnigk, U, Brown, D, Locklear, JC, Locklear, J, Maris, I, Hourihane, J, Ornelas, C, Caiado, J, Ferreira, MB, Pereira-Barbosa, M, Puente, Y, Daza, JC, Monteseirin, FJ, Ukleja-Sokolowska, N, Gawronska-Ukleja, E, Zbikowska-Gotz, M, Bartuzi, Z, Sokolowski, L, Adams, A, Mahon, B, English, K, Gourdon-Dubois, N, Sellam, L, Pereira, B, Michaud, E, Messaoudi, K, Evrard, B, Fauquert, J-L, Palomares, F, Gomez, G, Rodriguez, MJ, Galindo, L, Molina, A, Paparo, L, Mennini, M, Aitoro, R, Wawrzeńczyk, A, Przybyszewski, M, Sarıcoban, HE, Ugras, M, Yalvac, Z, Flokstra-de Blok, BMJ, van der Velde, JL, Vereda, A, Ippolito, C, Traversa, A, Adriano, D, Bianchi, DM, Gallina, S, Decastelli, L, Makatsori, M, Miles, A, Devetak, SP, Devetak, I, Tabet, SA, Trandbohus, JF, Winther, P, Malling, H-J, Hansen, KS, Garvey, LH, Wang, C-C, Cheng, Y-H, Tung, C-W, Dietrich, M, Marenholz, I, Kalb, B, Grosche, S, Blümchen, K, Schlags, R, Price, M, Rietz, S, Esparza-Gordillo, J, Lau, S, Lee, Y-A, Almontasheri, A, Bahkali, MA, Elshorbagi, S, Alfhaid, A, Altamimi, M, Madbouly, E, Al-Dhekri, H, Arnaout, RK, Basagaña, M, Miquel, S, Bartolomé, B, Brix, B, Rohwer, S, Brandhoff, S, Berger, A, Suer, W, Weimann, A, Bueno, C, Martín-Pedraza, L, Abián, S, Segundo-Acosta, PS, López-Rodríguez, JC, Barderas, R, Batanero, E, Cuesta-Herranz, J, Villalba, MT, Correia, M, Benito-Garcia, F, Arêde, C, Piedade, S, Morais-Almeida, M, Hindley, J, Yarham, R, Kuklinska-Pijanka, A, Gillick, D, Patient, K, Chapman, MD, Miranda, A, Matos, E, Sokolova, A, Rao, H, Baricevic-Jones, I, Smith, F, Xue, W, Magnusdottir, H, Vidarsdottir, AG, Lund, S, Jensen, AB, Ludviksson, BR, Simon, R, Elfont, R, Bennett, S, Voyksner, R, de Lurdes Torre, M, Yürek, S, Faber, MA, Bastiaensen, A, Mangodt, E, van Gasse, A, Decuyper, I, Sabato, V, Hagendorens, MM, Bridts, CH, De Clerck, LS, Ebo, D, Schwarz, S, Ziegert, M, Albroscheit, S, Schwager, C, Kull, S, Behrends, J, Röckendorf, N, Schocker, F, Frey, A, Homann, A, Becker, W-M, Jappe, U, Zaabat, N, Osscini, S, Agabriel, C, Sterling, B, Carsin, A, Liabeuf, V, Maćków, M, Zbróg, A, Bronkowska, M, Courtois, J, Gadisseur, R, Bertholet, C, Lukas, P, Cavalier, E, Delahaut, P, Quinting, B, Gertmo, MB, Hasseus, ET, Barzylovych, V, Oliveira, J, Ensina, LF, Aranda, CS, Dopazo, L, Lopez, R, Perez, R, Santos-Diez, L, Bilbao, A, Garcia, JM, Núñez, IG, Mármol, MÁA, Villarejo, MJB, Martos, JAB, Vergara, MS, García, JMI, Michalska, A, Sergiejko, G, Zacniewski, R, Ghiordanescu, I-M, Deaconu, C, Popescu, M, Bumbacea, RS, Ibranji, A, Nikolla, E, Loloci, G, Juel-Berg, N, Larsen, LF, Poulsen, LK, Marcelino, J, Prata, R, Costa, AC, Duarte, F, Neto, M, Santos, J, Pestana, LC, Sampaio, D, Minale, P, Dignetti, P, Bignardi, D, Nedelea, I, Popescu, F-D, Vieru, M, Secureanu, F-A, Ganea, CS, Vieira, M, Silva, JPM, Watts, T, Watts, S, Lomikovska, M, Peredelskaya, M, Nenasheva, N, Filipovic, I, Zivkovic, Z, Filipovic, D, Higgs, J, Warner, A, and Jones, C
- Published
- 2017
11. Triticinae alpha-gliadin storage protein gene, partial cds
- Author
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van Herpen, T.W.J.M., Goryunova-Svetlana, V., van der Schoot, J., Mitreva, M., Salentijn, E.M.J., Vorst, O.F.J., Schenk, M.F., van Veelen, P., de Koning, F., van Soest, L.J.M., Vosman, B.J., Bosch, H.J., Gilissen, L.J.W.J., Smulders, M.J.M., van Herpen, T.W.J.M., Goryunova-Svetlana, V., van der Schoot, J., Mitreva, M., Salentijn, E.M.J., Vorst, O.F.J., Schenk, M.F., van Veelen, P., de Koning, F., van Soest, L.J.M., Vosman, B.J., Bosch, H.J., Gilissen, L.J.W.J., and Smulders, M.J.M.
- Published
- 2016
12. Randomized feeding intervention in infants at high risk for celiac disease
- Author
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Vriezinga, S. L., Auricchio, R., Bravi, E., Castillejo, G., Chmielewska, A., Crespo Escobar, P., Kolaček, S., Koletzko, S., Korponay-Szabo, I. R., Mummert, E., Polanco, I., Putter, H., Ribes-Koninckx, C., Shamir, R., Szajewska, H., Werkstetter, K., Greco, L., Gyimesi, J., Hartman, C., Esch, C. Hogen, Hopman, E., Ivarsson, Anneli, Koltai, T., Koning, F., Martinez-Ojinaga, E., te Marvelde, C., Pavic, A. Mocic, Romanos, J., Stoopman, E., Villanacci, V., Wijmenga, C., Troncone, R., Mearin, M. L., Vriezinga, S. L., Auricchio, R., Bravi, E., Castillejo, G., Chmielewska, A., Crespo Escobar, P., Kolaček, S., Koletzko, S., Korponay-Szabo, I. R., Mummert, E., Polanco, I., Putter, H., Ribes-Koninckx, C., Shamir, R., Szajewska, H., Werkstetter, K., Greco, L., Gyimesi, J., Hartman, C., Esch, C. Hogen, Hopman, E., Ivarsson, Anneli, Koltai, T., Koning, F., Martinez-Ojinaga, E., te Marvelde, C., Pavic, A. Mocic, Romanos, J., Stoopman, E., Villanacci, V., Wijmenga, C., Troncone, R., and Mearin, M. L.
- Abstract
BACKGROUND A window of opportunity has been suggested for reducing the risk of celiac disease by introducing gluten to infants at 4 to 6 months of age. METHODS We performed a multicenter, randomized, double-blind, placebo-controlled dietary-intervention study involving 944 children who were positive for HLA-DQ2 or HLA-DQ8 and had at least one first-degree relative with celiac disease. From 16 to 24 weeks of age, 475 participants received 100 mg of immunologically active gluten daily, and 469 received placebo. Anti-transglutaminase type 2 and antigliadin antibodies were periodically measured. The primary outcome was the frequency of biopsy-confirmed celiac disease at 3 years of age. RESULTS Celiac disease was confirmed by means of biopsies in 77 children. To avoid underestimation of the frequency of celiac disease, 3 additional children who received a diagnosis of celiac disease according to the 2012 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition diagnostic criteria (without having undergone biopsies) were included in the analyses (80 children; median age, 2.8 years; 59% were girls). The cumulative incidence of celiac disease among patients 3 years of age was 5.2% (95% confidence interval [CI], 3.6 to 6.8), with similar rates in the gluten group and the placebo group (5.9% [95% CI, 3.7 to 8.1] and 4.5% [95% CI, 2.5 to 6.5], respectively; hazard ratio in the gluten group, 1.23; 95% CI, 0.79 to 1.91). Rates of elevated levels of anti-transglutaminase type 2 and antigliadin antibodies were also similar in the two study groups (7.0% [95% CI, 4.7 to 9.4] in the gluten group and 5.7% [95% CI, 3.5 to 7.9] in the placebo group; hazard ratio, 1.14; 95% CI, 0.76 to 1.73). Breast-feeding, regardless of whether it was exclusive or whether it was ongoing during gluten introduction, did not significantly influence the development of celiac disease or the effect of the intervention. CONCLUSIONS As compared with placebo, the introduction of small quantiti
- Published
- 2014
- Full Text
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13. Bacterial immune modulation of the cytokine response elicited by gliadin in an in vitro model ofceliac disease
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Pozo Rubio, Tamara, Marcos, Ascensión, Koning, F., Mujico, Jorge R., Sanz Herranz, Yolanda, Nova, Esther, Pozo Rubio, Tamara, Marcos, Ascensión, Koning, F., Mujico, Jorge R., Sanz Herranz, Yolanda, and Nova, Esther
- Abstract
Gluten peptides have been shown to induce cytotoxicity and IL-15 production even in in vitro studies with cell lines and biopsies of healthy subjects(1,2). We hypothesized that the inflammatory milieu caused by gluten antigens might be counteracted by certain species or strains of the commensal intestinal microbiota in interaction with the immune system. The aim of the present study was to evaluate the effect of different bacterialstrains from breastfed (BF) and formula-fed (FF) infants at risk ofceliac disease on cytokine production and T cell proliferationin vitro. Two combinations of predominant bacteria from fecal samples ofBF (Escheriquia coli (51.6%), Lactobacillus casei (19.4%), and Bifidobacterium breve (29%)) and FF (Klebsiella pneumoniae (44.1%), Lactobacillus rhamnosus (29.4%), and Bifidobacterium longum (26.5%)) infants were used. Caco-2 monolayers grown in a transwell cell-culture system (12mm inserts (Millipore)) were challenged by apical addition of 2 · 106cfu/insert ofbacteria. PBMCs (1 · 106 cells/well) and gluten specific T cell clones (1 · 105 cells/well) from HLA-DQ2 patients were added in the basal compartment of the culture well for a 12-hour incubation.Gliadin (7.5 mg/mL) was also added at the same time in the basal or apical compartment. Thereafter, further 36 hours incubation was allowed after disassembly of the system in order to measure the cytokine production by the sensitized Caco-2, and cytokine production and proliferation by T cell clones separately.TNF-a, IL-6, IL-1b, and IL-8 cytokines were measured in Caco-2 cells basolateral medium, and TNF-a, IL-6, IL-1b, and IL-10 cytokines were measured in T cells supernatant by Cytometric Bead Array Flex sets (BD Biosciences) and analyzed by flow cytometry. T cell proliferation was measured by quantification of H3-thymidine incorporation. Gliadin in the apical compartment did not show any effect on T cell proliferation and cytokine production. In the basal compartment Gliadin plus breastfed mi
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- 2013
14. Aegilops markgrafii gamma-gliadin gene, partial cds
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Salentijn, E.M.J., Mitea, D.C., Goryunova, S.V., van der Meer, I.M., Padioleau, I., Gilissen, L.J.W.J., de Koning, F., Smulders, M.J.M., Salentijn, E.M.J., Mitea, D.C., Goryunova, S.V., van der Meer, I.M., Padioleau, I., Gilissen, L.J.W.J., de Koning, F., and Smulders, M.J.M.
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- 2012
15. Food-related strategies towards reduction of gluten intolerance and gluten sensitivity
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Gilissen, L.J.W.J., van den Broeck, H.C., Londono, D.M., Salentijn, E.M.J., Koning, F., van der Meer, I.M., Smulders, M.J.M., Gilissen, L.J.W.J., van den Broeck, H.C., Londono, D.M., Salentijn, E.M.J., Koning, F., van der Meer, I.M., and Smulders, M.J.M.
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- 2012
16. Triticinae gamma-gliadin gene, partial cds
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Salentijn, E.M.J., Mitea, D.C., Goryunova, S.V., van der Meer, I.M., Padioleau, I., Gilissen, L.J.W.J., de Koning, F., Smulders, M.J.M., Salentijn, E.M.J., Mitea, D.C., Goryunova, S.V., van der Meer, I.M., Padioleau, I., Gilissen, L.J.W.J., de Koning, F., and Smulders, M.J.M.
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- 2012
17. Celiac disease T cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation
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Salentijn, E.M.J., Mitea, D.C., Goryunova, S.V., van der Meer, I.M., Padioleau, I., Gilissen, L.J.W.J., de Koning, F., Smulders, M.J.M., Salentijn, E.M.J., Mitea, D.C., Goryunova, S.V., van der Meer, I.M., Padioleau, I., Gilissen, L.J.W.J., de Koning, F., and Smulders, M.J.M.
- Abstract
Background - Celiac disease (CD) is caused by an uncontrolled immune response to gluten, a heterogeneous mixture of wheat storage proteins. The CD-toxicity of these proteins and their derived peptides is depending on the presence of specific T-cell epitopes (9-mer peptides; CD epitopes) that mediate the stimulation of HLA-DQ2/8 restricted T-cells. Next to the thoroughly characterized major T-cell epitopes derived from the alpha-gliadin fraction of gluten, gamma-gliadin peptides are also known to stimulate T-cells of celiac disease patients. To pinpoint CD-toxic gamma-gliadins in hexaploid bread wheat, we examined the variation of T-cell epitopes involved in CD in gamma-gliadin transcripts of developing bread wheat grains. Results - A detailed analysis of the genetic variation present in gamma-gliadin transcripts of bread wheat (T. aestivum, allo-hexaploid, carrying the A, B and D genome), together with genomic gamma-gliadin sequences from ancestrally related diploid wheat species, enabled the assignment of sequence variants to one of the three genomic gamma-gliadin loci, Gli-A1, Gli-B1 or Gli-D1. Almost half of the gamma-gliadin transcripts of bread wheat (49%) was assigned to locus Gli-D1. Transcripts from each locus differed in CD epitope content and composition. The Gli-D1 transcripts contained the highest frequency of canonical CD epitope cores (on average 10.1 per transcript) followed by the Gli-A1 transcripts (8.6) and the Gli-B1 transcripts (5.4). The natural variants of the major CD epitope from gamma-gliadins, DQ2-gamma-I, showed variation in their capacity to induce in vitro proliferation of a DQ2-gamma-I specific and HLA-DQ2 restricted T-cell clone. Conclusions - Evaluating the CD epitopes derived from gamma-gliadins in their natural context of flanking protein variation, genome specificity and transcript frequency is a significant step towards accurate quantification of the CD toxicity of bread wheat. This approach can be used to predict relative levels
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- 2012
18. Gluten toxicity, how to get rid of it?
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Koning, F., Smulders, M.J.M., Koning, F., and Smulders, M.J.M.
- Published
- 2011
19. Successful treatment of coeliac disease by allogeneic haematopoietic stem cell transplantation.
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Hoekstra, J.H., Groot-Loonen, J.J., Weij, A.M. van der, Hoogerbrugge, P.M., Kooy, Y., Koning, F., Hoekstra, J.H., Groot-Loonen, J.J., Weij, A.M. van der, Hoogerbrugge, P.M., Kooy, Y., and Koning, F.
- Abstract
1 december 2010, Contains fulltext : 89150.pdf (publisher's version ) (Closed access)
- Published
- 2010
20. Successful treatment of coeliac disease by allogeneic haematopoietic stem cell transplantation.
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Hoekstra, J.H., Groot-Loonen, J.J., Weij, A.M. van der, Hoogerbrugge, P.M., Kooy, Y., Koning, F., Hoekstra, J.H., Groot-Loonen, J.J., Weij, A.M. van der, Hoogerbrugge, P.M., Kooy, Y., and Koning, F.
- Abstract
01 december 2010, Contains fulltext : 89150.pdf (publisher's version ) (Closed access)
- Published
- 2010
21. Successful treatment of coeliac disease by allogeneic haematopoietic stem cell transplantation.
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Hoekstra, J.H., Groot-Loonen, J.J., Weij, A.M. van der, Hoogerbrugge, P.M., Kooy, Y., Koning, F., Hoekstra, J.H., Groot-Loonen, J.J., Weij, A.M. van der, Hoogerbrugge, P.M., Kooy, Y., and Koning, F.
- Abstract
01 december 2010, Contains fulltext : 89150.pdf (publisher's version ) (Closed access)
- Published
- 2010
22. Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation.
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Risk Assessment of Toxic and Immunomodulatory Agents, Strategic Infection Biology, Dep Infectieziekten Immunologie, Kel, J.M., de Geus, E.D., van Stipdonk, M.J., Drijfhout, J.W., Koning, F., Nagelkerken, L., Risk Assessment of Toxic and Immunomodulatory Agents, Strategic Infection Biology, Dep Infectieziekten Immunologie, Kel, J.M., de Geus, E.D., van Stipdonk, M.J., Drijfhout, J.W., Koning, F., and Nagelkerken, L.
- Published
- 2008
23. Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation.
- Author
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Risk Assessment of Toxic and Immunomodulatory Agents, Strategic Infection Biology, Dep Infectieziekten Immunologie, Kel, J.M., de Geus, E.D., van Stipdonk, M.J., Drijfhout, J.W., Koning, F., Nagelkerken, L., Risk Assessment of Toxic and Immunomodulatory Agents, Strategic Infection Biology, Dep Infectieziekten Immunologie, Kel, J.M., de Geus, E.D., van Stipdonk, M.J., Drijfhout, J.W., Koning, F., and Nagelkerken, L.
- Published
- 2008
24. Triticinae alpha-gliadin storage protein pseudogene, partial sequence
- Author
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van Herpen, T.W.J.M., Goryunova-Svetlana, V., van der Schoot, J., Mitreva, M., Salentijn, E.M.J., Vorst, O.F.J., Schenk, M.F., van Veelen, P., de Koning, F., van Soest, L.J.M., Vosman, B.J., Bosch, H.J., Gilissen, L.J.W.J., Smulders, M.J.M., van Herpen, T.W.J.M., Goryunova-Svetlana, V., van der Schoot, J., Mitreva, M., Salentijn, E.M.J., Vorst, O.F.J., Schenk, M.F., van Veelen, P., de Koning, F., van Soest, L.J.M., Vosman, B.J., Bosch, H.J., Gilissen, L.J.W.J., and Smulders, M.J.M.
- Published
- 2006
25. Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes
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van Herpen, T.W.J.M., Goryunova-Svetlana, V., van der Schoot, J., Mitreva, M., Salentijn, E.M.J., Vorst, O.F.J., Schenk, M.F., van Veelen, P., de Koning, F., van Soest, L.J.M., Vosman, B.J., Bosch, H.J., Gilissen, L.J.W.J., Smulders, M.J.M., van Herpen, T.W.J.M., Goryunova-Svetlana, V., van der Schoot, J., Mitreva, M., Salentijn, E.M.J., Vorst, O.F.J., Schenk, M.F., van Veelen, P., de Koning, F., van Soest, L.J.M., Vosman, B.J., Bosch, H.J., Gilissen, L.J.W.J., and Smulders, M.J.M.
- Abstract
Background - Bread wheat (Triticum aestivum) is an important staple food. However, wheat gluten proteins cause celiac disease (CD) in 0.5 to 1% of the general population. Among these proteins, the a-gliadins contain several peptides that are associated to the disease. Results - We obtained 230 distinct a-gliadin gene sequences from severaldiploid wheat species representing the ancestral A, B, and D genomes of the hexaploid bread wheat. The large majority of these sequences (87%) contained an internal stop codon. All a-gliadin sequences could be distinguished according to the genome of origin on the basis of sequence similarity, of the average length of the polyglutamine repeats, and of the differences in the presence of four peptides that have been identified as T cell stimulatory epitopes in CD patients through binding to HLA-DQ2/8. By sequence similarity, a-gliadins from the public database of hexaploid T. aestivum could be assigned directly to chromosome 6A, 6B, or 6D. T. monococcum (A genome) sequences, as well as those from chromosome 6A of bread wheat, almost invariably contained epitope glia-a9 and glia-a20, but never the intact epitopes glia-a and glia-a2. A number of sequences from T. speltoides, as well as a number of sequences fromchromosome 6B of bread wheat, did not contain any of the four T cell epitopes screened for. The sequences from T. tauschii (D genome), as well as those from chromosome 6D of bread wheat, were found to contain all of these T cell epitopes in variable combinations per gene. The differences in epitope composition resulted mainly from point mutations. These substitutions appeared to be genome specific. Conclusion - Our analysis shows that a-gliadin sequences from the three genomes of bread wheat form distinct groups. The four known T cell stimulatory epitopes are distributed non-randomly across the sequences, indicating that the three genomes contribute differently to epitope content. A systematic analysis of all known epitopes in g
- Published
- 2006
26. Evaluation of the CO2 sequestration potential of afforestation projects and secondary forests in two different climate zones of South America
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de Koning, F., Olschewski, R., Veldkamp, E., Benìtez-Ponce, P.C., Laclau, P., Lopez, M., de Urquiza, M., Schlichter, T., de Koning, F., Olschewski, R., Veldkamp, E., Benìtez-Ponce, P.C., Laclau, P., Lopez, M., de Urquiza, M., and Schlichter, T.
- Published
- 2002
27. Clue: an integrated, gis-based model to simulate the dynamics of land use in developing countries
- Author
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Verburg, P.H., Kok, K., de Koning, F., Soepboer, W., Veldkamp, A., Verburg, P.H., Kok, K., de Koning, F., Soepboer, W., and Veldkamp, A.
- Published
- 2000
28. Spatially explicit analysis of land use change : a case study for Ecuador
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Fresco, L.O., Veldkamp, A., de Koning, F., Fresco, L.O., Veldkamp, A., and de Koning, F.
- Abstract
Introduction and objectivesWithin agricultural research increasing attention is paid to the integrated study of agro-ecosystems in order to address issues related to sustainable food production at the eco-regional level. This has been stimulated by the awareness that the world-wide demand for food will continue to increase while at the same there is high pressure on natural resources needed for food production, such as suitable soils and available water. Human-driven land use change is also relevant for global change because of its influence on greenhouse gas emissions, water and energy balances, and biodiversity.These issues have confronted research with substantive methodological challenges, such as the integration of biophysical and socio-economic disciplines over various spatio-temporal scales, and the development of modelling approaches for the exploration of future changes in land use and their effects.The general objective of this thesis is the analysis of spatial variation and temporal dynamics of agricultural land use systems in order to quantitatively assess the interaction between land use and the natural resource base. This is addressed through three derived objectives. Firstly, the spatial analysis of land use systems with the aim to detect the main biophysical and socio-economic drivers of actual land use at different spatial scales. Secondly, the spatially explicit modelling of near-future land use change dynamics, taking into account the multi-scale structure of actual land use and its drivers. Thirdly, the quantification of possible effects of future land use change on the natural resource base and agricultural production.The study areaThe study area is the South-American country of Ecuador. Agriculture is important in Ecuador, both for the production of subsistence crops as well as export crops. The country is characterised by a high agro-ecological diversity. A wide variety of climate and soil conditions exist and land use is diverse, with respect
- Published
- 1999
29. Spuiten met spuitmast kan beter
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Koning, F. and Koning, F.
- Abstract
In een tomatengewas komt bij hoogvolume-bespuitingen met een spuitmast een derde van de dosering op de grond terecht. Door de mast aan te passen kan deze hoeveelheid met 50 procent worden teruggebracht
- Published
- 1995
30. Beperking van zinkemissie voor bestaande tuinbouwkassen : eindrapportage fase 1, project 7406
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Heemskerk, M.J., Koning, F., Heemskerk, M.J., and Koning, F.
- Published
- 1995
31. High expression of V gamma 8 is a shared feature of human gamma delta T cells in the epithelium of the gut and in the inflamed synovial tissue.
- Author
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Söderström, K, Bucht, A, Halapi, E, Lundqvist, C, Grönberg, A, Nilsson, E, Orsini, D L, van de Wal, Y, Koning, F, Hammarström, Marie-Louise, Söderström, K, Bucht, A, Halapi, E, Lundqvist, C, Grönberg, A, Nilsson, E, Orsini, D L, van de Wal, Y, Koning, F, and Hammarström, Marie-Louise
- Abstract
We have analyzed the V-gene usage in gamma delta T cells of the human gut and joint by using a new mAb (B18) specific for V gamma 8 of human TCR-gamma delta+ T cells. The B18+ population constituted a minor subset of the gamma delta T cells in peripheral blood (PB) of healthy persons (6 +/- 5%) and only 1 of 35 gamma delta T cell clones analyzed was positive. In contrast, the B18+ subset was a dominant gamma delta T cell population among intraepithelial lymphocytes (IEL) derived from the human intestine (74 +/- 29, p < 0.002), and two of three IEL clones from patients with coeliac disease were B18+. Interestingly, a higher proportion of B18+ gamma delta T cells was found in the synovial fluid of patients with rheumatoid arthritis (RA) (21 +/- 18%, 0.02 < p < 0.05) compared with normal PB. Furthermore, the B18+ subset was more frequent among IL-2-expanded gamma delta T cells (42 +/- 20%) derived from synovial tissue than among IL-2-expanded cells derived from synovial fluid (p < 0.002) and PB from RA patients (p < 0.02) as well as normal PB (p < 0.002). The V-gene usage of 13 gamma delta T cell clones from the synovial fluid of arthritic patients was analyzed. All B18+ clones (n = 7) expressed mRNA for V gamma 8 together with mRNA for V delta 1 (n = 5) or mRNA for V delta 3 (n = 2). None of the B18- clones expressed V gamma 8 (n = 6). We conclude that the gamma delta T cell that expresses V gamma 8, together with mainly V delta 1, is a major gamma delta T cell subset among the IEL of the gut and a highly frequent subset in the synovial tissue of patients with RA. This subset may correspond to the mouse V gamma 7+ IEL, which has a high degree of amino acid sequence homology with the human V gamma 8 protein.
- Published
- 1994
32. Emissie en toedieningstechnieken van bestrijdingsmiddelen in de glastuinbouw : een literatuuronderzoek voor het onderzoeksprogramma Emissie-beperkende toedieningstechnieken
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van der Knaap, R., Koning, F., van der Knaap, R., and Koning, F.
- Published
- 1992
33. Proef met roterende sproeier voor mogelijke toepassing bij wortelbesproeiïng
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Heemskerk, M.J., Koning, F., Heemskerk, M.J., and Koning, F.
- Published
- 1992
34. Milieutechnologie voor materiaalverbruik in glastuinbouw-productiesystemen
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Koning, F. and Koning, F.
- Published
- 1991
35. Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer.
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Yokoyama, WM, Yokoyama, WM, Koning, F, Stingl, G, Bluestone, JA, Coligan, JE, Shevach, EM, Yokoyama, WM, Yokoyama, WM, Koning, F, Stingl, G, Bluestone, JA, Coligan, JE, and Shevach, EM
- Abstract
We have produced a T cell hybridoma line by fusion of an IL-2-dependent, long-term T cell receptor (TCR) gamma/delta+ Thy-1+, bone marrow-derived, dendritic epidermal cell line to the BW5147 tumor line. The resultant hybridoma was rapidly growing, lymphokine independent, and expressed T3 in association with the TCR gamma/delta heterodimer. Several subclones of the hybridoma line produced easily detectable levels of IL-2 after stimulation by anti-T3 or Con A. The availability of these cloned cell lines should greatly facilitate further functional, biochemical, and molecular studies of the TCR delta chain.
- Published
- 1987
36. Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer.
- Author
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Yokoyama, WM, Yokoyama, WM, Koning, F, Stingl, G, Bluestone, JA, Coligan, JE, Shevach, EM, Yokoyama, WM, Yokoyama, WM, Koning, F, Stingl, G, Bluestone, JA, Coligan, JE, and Shevach, EM
- Abstract
We have produced a T cell hybridoma line by fusion of an IL-2-dependent, long-term T cell receptor (TCR) gamma/delta+ Thy-1+, bone marrow-derived, dendritic epidermal cell line to the BW5147 tumor line. The resultant hybridoma was rapidly growing, lymphokine independent, and expressed T3 in association with the TCR gamma/delta heterodimer. Several subclones of the hybridoma line produced easily detectable levels of IL-2 after stimulation by anti-T3 or Con A. The availability of these cloned cell lines should greatly facilitate further functional, biochemical, and molecular studies of the TCR delta chain.
- Published
- 1987
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