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A recent study conducted at Shanghai University of Engineering Science focused on the solubilities of (R,S)- and (S)-sulpiride in various solvents, including chiral ionic liquids and methanol mixtures. The research involved the synthesis of four chiral ionic liquids and the determination of solubilities through experimental and thermodynamic modeling methods. The study also utilized molecular simulation to predict hydrogen bonding sites and clarify solubility phenomena in mixed solvents. This peer-reviewed research provides valuable insights into the dissolution processes and solid-state characterization of sulpiride compounds. [Extracted from the article]

Researchers from the Department of Chemistry in Delhi, India, have explored the potential of 1,3-benzodioxole-based ionic liquids as effective tools in cancer treatment. These compounds show promise in providing anticancer activities while minimizing harm to healthy tissues, offering a potentially transformative strategy to address the limitations of conventional drugs. The study includes a detailed synthesis protocol, computational studies, and various spectroscopic approaches, highlighting an emerging research domain with significant implications for the future of oncology. This research has been peer-reviewed and offers a comprehensive overview of recent progress in the development of 1,3-benzodioxole-based ionic liquids. [Extracted from the article]

Researchers from the University of Alexandria in Egypt have explored the use of ionic liquids (ILs) as innovative platforms in drug delivery systems. ILs offer advantages such as low volatility, chemical stability, and thermal stability, making them promising components in drug delivery. The research suggests that ILs have great potential for use in the production of pharmaceutical products, offering benefits such as enhanced permeation and solubilization of active pharmaceutical ingredients. This study has been peer-reviewed and provides valuable insights into the application of ILs in drug delivery systems. [Extracted from the article]

A study conducted at Bahauddin Zakariya University in Punjab, Pakistan, focused on the efficient extraction and analysis of drug residues in animal-derived food products using a polyoxometalate-based ionic liquid composite. The research utilized magnetic solid-phase extraction (MSPE) and HPLC analysis to quantify drug residues such as amoxicillin, paracetamol, levofloxacin, and cefixime in samples like milk, meat, and water. The study demonstrated high efficiency in extracting drug residues, with excellent linearity ranges and low limits of detection, addressing concerns over food safety and environmental pollution. The research was peer-reviewed and offers a powerful analytical strategy for sensitive and rapid quantification of drug residues in food products. [Extracted from the article]

Researchers from Beijing University of Chemical Technology have explored the design principles and applications of ionic liquids for transdermal drug delivery. Ionic liquids, salts with low melting points, have shown promise in pharmacological research as solubilizers, absorption enhancers, antibacterial agents, and stabilizers of pharmaceutical ingredients. The study highlights the importance of understanding the physicochemical characteristics of ionic liquids in improving skin permeability and provides a comprehensive assessment of their synthesis and application in transdermal drug administration. This research was supported by the National Key Research and Development Program of China and can be accessed through Advanced Science. [Extracted from the article]

A report from Shiraz University of Technology in Iran discusses the design, synthesis, and evaluation of novel 8-piperazinylcaffeine carboxylate ionic liquids. These salts were created by combining 8-piperazinyl caffeine with various carboxylic acids, some of which are commonly used nonsteroidal anti-inflammatory drugs (NSAIDs). In vivo experiments on female mice showed that these salts exhibited significant analgesic activity, particularly when compared to a standard reference drug. Additionally, the synthesized salts displayed antibacterial activity against certain bacteria and showed strong binding to the active site of the COX-2 enzyme. The research provides insights into the potential of these ionic liquids for analgesic and antibacterial therapies. [Extracted from the article]

A study conducted by researchers at Payame Noor University in Tehran, Iran, has focused on the use of carbon nanotubes to determine the presence of the cardiac drug isoproterenol in the presence of acetaminophen. Isoproterenol is commonly used to treat heart attacks, bronchitis, and allergic emergencies, but excessive use can lead to adverse effects such as decreased blood pressure and heart failure. The researchers developed a sensitive electrochemical sensor using a modified electrode with multiwall carbon nanotubes and ionic liquid, which showed promising results in detecting isoproterenol in serum and urine samples. The study was peer-reviewed and received financial support from Payame Noor University. [Extracted from the article]

A study conducted by researchers at Sichuan University in Chengdu, China, has developed a new method for extracting bioactive substances from Periplaneta americana (PA) using a low-voltage electric field and an ionic liquid (IL). This new extraction mode reduced extraction time by 75% and energy consumption by 40% compared to traditional methods. The study found that the new method had a higher extraction efficiency and produced products with antioxidant, antibacterial, wound healing, and enzyme inhibition activities. Additionally, the new extraction process demonstrated superior environmental benefits compared to traditional water and ethanol extraction methods. [Extracted from the article]

A study conducted by the Chinese Academy of Sciences has found that certain ionic liquids (ILs) derived from carbon dots have enhanced antibacterial activity and can effectively inhibit the growth of Staphylococcus aureus (S. aureus) biofilms. The IL-derived carbon dots demonstrated selective antibacterial action against methicillin-resistant Staphylococcus aureus (MRSA) and outperformed vancomycin in terms of efficacy. In vivo experiments on MRSA-infected mice models showed that the IL-derived carbon dots alleviated inflammation, facilitated wound healing, and had potential as therapeutic candidates for MRSA infection-like conditions. This research offers new insights into the application prospects of IL-derived materials for developing effective antibacterials. [Extracted from the article]

Researchers at the University of Novi Sad in Serbia have developed a rapid and straightforward electrochemical approach for quantifying the anticonvulsant drug carbamazepine (CBZ). They modified a carbon paste electrode with graphitic carbon nitride (g-C3N4) and an ionic liquid tetrabutylammonium chloride (TBACl) to create an advanced electrochemical sensor for CBZ. The sensor showed improved electrochemical response and selectivity for CBZ, and was successfully used to detect CBZ in pharmaceuticals and spiked human urine samples. This research provides a promising method for monitoring CBZ in different matrices. [Extracted from the article]

Researchers from Jaume I University in Castellon de la Plana, Spain have synthesized a set of fourteen imidazolium ionic liquids derived from L-amino acids. These liquids were characterized and found to have transition temperatures below 100 degrees C. The researchers investigated the effects of these liquids on cancer cell lines and non-cancerous cells, and found that by adjusting the molecular structure of the liquids, they were able to design potent and selective chemotherapeutic agents. This study provides evidence for the potential of tailored amino acid-derived ionic liquids as precision chemotherapy for tumors. [Extracted from the article]

A recent report from Ningxia Medical University in Yinchuan, China discusses the importance of early diagnosis of Helicobacter pylori (H. pylori), a bacterium that can cause various gastric diseases, including gastric cancer. The researchers developed a biosensing platform using chitosan@ionic liquid and graphitic carbon nitride modified glassy carbon microspheres ionic liquid paste electrode to detect H. pylori antibodies in serum samples. The immunosensor demonstrated good immunoreactivity, sensitivity, specificity, and stability, making it a potential tool for the development of label-free electrochemical H. pylori immunosensors. The research was supported by the Natural Science Foundation of Ningxia, China. [Extracted from the article]

A recent study conducted by researchers at the Harbin Institute of Technology in Shenzhen, China, has focused on the potential use of metformin and paclitaxel (PTX) in cancer therapy. The researchers successfully loaded PTX into metformin oleate ionic liquid micelles, which exhibited good particle size and stability. In vitro and in vivo experiments showed that the PTX-IL/T-80 micelle had significant antitumor efficacy, with a high inhibition rate on cancer cells and a greater tumor inhibition rate in mice compared to the PTX prodrug group. The study suggests that the PTX-IL/T-80 micelle has potential for application in cancer therapy due to its synergistic antitumor effect. [Extracted from the article]

Researchers from Bam University of Medical Sciences in Iran have developed a new electrochemical sensor for the determination of methotrexate (MTX), a widely used anti-cancer drug. The sensor, which is based on ionic liquid (IL)/Ni-Co layered double hydroxide nanosheets (Ni-Co-LDH), exhibited good performance and a linear relationship between the peak current and MTX concentrations. The sensor has a detection limit of 0.006 M and showed precision in recovery tests on real samples. The researchers believe that this cost-effective sensor could be valuable for therapeutic drug monitoring and clinical diagnostics. [Extracted from the article]

A patent has been issued for wearable biosensors with a room temperature ionic liquid buffer. Biosensor systems are devices that can detect and estimate the concentration of specific substances in biological fluids. The patent describes the development of highly functional wearable biosensors that can provide meaningful diagnostics for monitoring body functions. The use of room temperature ionic liquids is proposed to enhance the stability and reliability of the biosensors, allowing for continuous and dynamic monitoring of multiple analytes. The biosensors can be used for non-invasive point-of-care diagnostic devices and have the potential to manage diseases, provide customized therapies, and reduce costs for consumers. [Extracted from the article]

A report from China Agricultural University discusses the use of surface-active ionic liquids (SAILs) in drug delivery systems. SAILs are a type of ionic liquid with long hydrophobic alkyl chains. The report explores the structures, characterization techniques, safety aspects, and self-assembly behaviors of SAILs for drug delivery applications. It also summarizes and discusses 38 drugs that have been studied in relation to SAILs. The research has been peer-reviewed and can be found in the Journal of Molecular Liquids. [Extracted from the article]

A recent study from Technical University in St. Petersburg, Russia, explores the applications and properties of protic alkanolammonium ionic liquids (PAAILs). PAAILs are formed through proton transfer from a Brønsted acid to a Brønsted base and have a wide range of uses, including as gas adsorbents, solvents, catalysts, and corrosion inhibitors. The study also discusses the structural features of PAAILs and their impact on physicochemical properties. Additionally, the researchers suggest that converting active pharmaceutical ingredients into PAAILs could enhance their biopharmaceutical properties. The study has been peer-reviewed and provides valuable insights into the field of ionic liquids. [Extracted from the article]

A report from Southwest University in Chongqing, People's Republic of China, discusses the importance of food safety and the need for effective detection methods. The researchers developed multifunctional stationary phases for liquid chromatography to detect various food additives. They synthesized dicationic ionic liquid silanes and bonded them onto silica gel, resulting in satisfactory separation performance for different analytes. The study concludes that using mixed-mode stationary phases can improve food safety inspection and potentially reduce costs and the need for frequent column changes. [Extracted from the article]

• Ionic liquid of BMIMPF 6 is utilized for the first time as dual bulk and interface modifier for fabricating inorganic perovskite solar cells in ambient air. • The proposed strategy enables effective protection of CsPbI 3 perovskite structure and enhancement of charge carrier transport/extraction. • Dramatically improved efficiency and stability of ambient-processed inverted CsPbI 3 perovskite solar cells are achieved. All-inorganic cesium lead iodide (CsPbI 3) perovskites with superior thermal stability are attractive candidates for perovskite solar cells (PSCs). Fabricating such inorganic PSCs in the ambient atmosphere is desirable for practical production, however, the challenge remains in inhibiting the phase transition of CsPbI 3 in ambient air. Herein, we demonstrate a dual bulk and interface engineering using ionic liquid to stabilize CsPbI 3 perovskite structure, thus enhancing the performance of ambient-processed inverted CsPbI 3 PSCs. Such dual bulk and interface engineering is found effective not only in suppressing the bulk and interfacial charge carrier recombination and enhancing charge carrier transport and extraction, but also in protecting CsPbI 3 crystal structure by leaving hydrophobic alkyl chains coverage at the boundary and surface to prevent phase transition caused by moisture from ambient air. The optimized device fully processed in the open air with relative humidity up to 55% exhibits remarkably enhanced efficiency and stability over the control device, with the efficiency increasing from 8.6% to 13.21%, and 92% efficiency maintaining after storage for 1680 h, which outperforms the control device with only 82% retaining after 648 h storage. We thus believe this work can provide an efficient alternative for the low-cost fabrication of ambient-processible PSCs. [ABSTRACT FROM AUTHOR]

Researchers from Changchun University of Technology in China have developed a composite hydrogel called DM 16 CHA that can effectively remove organic pollutants from wastewater. The hydrogel was found to have high adsorption capacities for cationic and anionic dyes, as well as nitrobenzene compounds. It also demonstrated excellent catalytic performance and recyclability. The researchers believe that DM 16 CHA could be a cost-effective and environmentally friendly solution for industrial wastewater treatment. [Extracted from the article]

A report from Zhejiang University of Technology in Hangzhou, China, discusses the potential use of ammonia (NH3) as a hydrogen energy vector and the importance of separating and storing NH3 for safe transportation and effective utilization. The researchers propose the use of thiocyanate-based pseudo ionic liquids (PILs) as innovative NH3 absorbents. They experimentally evaluate the NH3 absorption performance of five PILs and find that NH4SCN demonstrates a robust and outstanding reversible absorption capacity. The NH3 absorption mechanism and liquefaction process are comprehensively elucidated using spectroscopy, calculations, and simulations. The researchers conclude that these novel PILs have excellent renewability for ammonia absorption and storage. [Extracted from the article]

The article presents new research on carboxylate ionic liquids, focusing on their physicochemical properties and antimicrobial activity. Topics discussed include the synthesis and characterization of ionic liquids with various carboxylate anions, their enhanced antimicrobial effects against specific bacteria and fungi, and the comparison of their properties through experimental and in silico methods.

Researchers at Isfahan University of Medical Sciences in Iran have developed novel nano-composites for the co-delivery of curcumin and polyarsenotungstate (POM) to triple-negative breast cancer cells. The nano-composites showed better anticancer activity than free POM without cytotoxicity against normal cells. The optimized nano-composites had a particle size of around 200 nm and a zeta potential of +22.4 mV. Further pre-clinical studies are warranted based on these promising results. [Extracted from the article]

A study conducted by researchers at the Birla Institute of Technology and Science in Pilani, India, explores the potential of ionic liquids (ILs) in drug delivery systems. ILs are seen as promising solutions due to their unique properties, such as chemical diversity and thermal stability. However, challenges such as side reactions, impurity effects, and biocompatibility concerns need to be addressed. The study suggests innovative methods to overcome these challenges and improve the efficacy of transdermal drug delivery. For more information, the full article can be accessed through the provided link. [Extracted from the article]

A recent study conducted by researchers at the University of Tabriz explored the solubility of acetaminophen (ACP) in three protic ionic liquids (PILs) based on ethanolamines. The study used the shake flask method at various temperatures and atmospheric pressure to measure the solubility of ACP. The researchers also employed empirical and thermodynamic models to correlate the experimental solubility data. The study concluded that the Van't Hoff and Gibbs equations were used to determine the thermodynamic properties of dissolution in the studied systems. This research provides valuable insights into the potential applications of PILs in drug solubility and delivery. [Extracted from the article]

A recent report from investigators at the University of Delhi in India discusses the use of designer solvents, specifically ionic liquids (ILs) and deep eutectic solvents (DESs), in the pharmaceutical industry. These solvents have shown promise in improving the bioavailability, solubility, and stability of biologic and synthetic drugs. They have also demonstrated solubilizing effects for synthetic drugs and are considered eco-friendly. The report highlights the potential applications of designer solvents in pharmaceuticals and emphasizes the need for further research in this area. [Extracted from the article]

A recent study conducted at Mayo Clinic in Scottsdale, Arizona, has developed an injectable compound called prostate ablation and drug delivery agent (PADA) for the treatment of benign prostatic hyperplasia and prostate cancer. PADA is an ionic liquid that can be injected into the prostate to ablate tissue and deliver therapeutic agents. The study found that PADA decreased the number of viable cells in the treated area and supported the delivery of nivolumab, a cancer drug. The researchers concluded that PADA shows promise as a therapeutic strategy for treating lower urinary tract symptoms associated with prostate conditions. [Extracted from the article]

A recent study conducted at the University of Tabriz in Iran explored the use of ionic liquids (ILs) as solvents in various industries, including pharmaceuticals and chemicals. Ionic liquids are considered "green solvents" due to their low vapor pressure. The researchers focused on choline-based ILs, which are known for their low toxicity and high biodegradability. They synthesized and characterized an ionic liquid called choline lactate and examined its interactions with amino acids glycine, L-alanine, and L-phenylalanine. The study found that the interactions between the ionic liquid and amino acids were influenced by temperature. This research provides valuable insights into the thermodynamic and transport properties of amino acids in the presence of ionic liquids. [Extracted from the article]

A patent has been issued for a halloysite nanotube (HNT)-encapsulated ionic liquid (IL) microcapsule, self-lubricating fiber textile composite, and its preparation method and use. The invention aims to improve the wear resistance of self-lubricating fiber textile materials without increasing the friction coefficient. The HNT-encapsulated IL microcapsule acts as a lubricant additive in the composite, allowing for stable friction while reducing wear. This technology has potential applications in aviation, particularly in key aircraft components such as transmission systems and control systems. [Extracted from the article]

A report from Soochow University in Suzhou, China, discusses the development of a biological hydrogen therapy for diabetic wound dressing. The researchers created a sustainable hydrogel patch loaded with an imidazolium-based poly(ionic liquid) (PIL) flocculated live Chlorella, which continuously produces hydrogen for 24 hours. The hydrogel was found to have antibacterial and antioxidant properties, promoting the healing of chronic wounds by killing bacteria, reducing inflammation, and promoting collagen deposition and angiogenesis. This research provides a new strategy for constructing hydrogen-producing hydrogels with potential applications in wound dressing. [Extracted from the article]

A recent study conducted by the University of Minho in Braga, Portugal, explores the use of an ionic liquid called cholinium oleate as a solvent for extracting b-carotene from Dunaliella salina, a microalga commonly used in the food industry. The researchers found that the use of the ionic liquid significantly improved b-carotene recovery, with an efficiency of over 84%. Additionally, the ionic liquid was used as an emulsifier in the production of nanoemulsions, which showed high stability and entrapment efficiency. The study suggests that this sequential application of the ionic liquid as a solvent and emulsifier has potential applications in the food industry. [Extracted from the article]

A recent report from the University of Baghdad discusses the use of kinase inhibitors in the treatment of cutaneous melanoma. The researchers aimed to develop a vemurafenib microemulsion using ionic liquids as a substitute for conventional oil phases. Multiple tests were conducted to assess the physical stability and in vitro release of the microemulsions. The results showed that four formulations successfully met all criteria and were used to create microemulsion-based hydrogels. The study concluded that topical delivery of vemurafenib using ionic liquids is a promising route for treating melanoma. [Extracted from the article]

Researchers from the University of Tabriz in Iran have conducted a study on the use of novel surfactant protic ethanolamine-based ionic liquids (ILs) to improve the solubility of acetaminophen (ACP), a commonly used analgesic and antipyretic drug. The study explores the potential applications of ILs in pharmaceutical formulations and investigates the impact of different combinations of hydroxyethyl groups on the solubility profile of ACP. The experimental results show that these ILs have a significant ability to enhance the solubility of ACP, making them promising candidates for pharmaceutical formulations. The study also discusses the mechanisms underlying this enhancement and considers the potential implications for the bioavailability and formulation versatility of ACP. The research concludes that the dissolution process in the co-solvents used is characterized by an endothermic nature and driven by enthalpy. This research has been peer-reviewed and published in the Journal of Molecular Liquids. [Extracted from the article]

A report from the Institute of Plant Genetics - Polish Academy of Sciences in Poznan, Poland, discusses the need for sustainable agriculture and the environmental impact of widespread fertilizer use. The study focuses on improving the efficiency of nanofertilizers by controlling the release of copper ions through bioionic liquids. The research found that certain bioionic liquids led to significantly higher dissolution of copper ions compared to others, and that nanoformulations with lower concentrations of copper ions exhibited superior outcomes in terms of plant growth and carbon dioxide sequestration. The study emphasizes the importance of dissolution kinetics in determining the effectiveness of bioionic liquid-based nanoformulations for sustainable agriculture. [Extracted from the article]

A report from researchers at the University of Technology Sydney discusses the cytotoxicity of acridinium-based ionic liquids (ILs) and their potential as novel anticancer agents. The study found that acridinium-based ILs containing large cations were potent cytotoxic agents, reducing the viability of breast cancer cells. Unlike a pyridinium-based analogue, the acridinium-based ILs did not inhibit oxidative phosphorylation or induce reactive oxygen species formation, suggesting they may target other mitochondrial processes or components. This research provides insights into the structural features that promote IL cytotoxicity and opens up possibilities for the development of new anticancer treatments. [Extracted from the article]

A study conducted by researchers at Kyushu University in Fukuoka, Japan, explores the use of nanodispersion for transdermal drug delivery. The researchers developed a transdermal patch using an ionic liquid-based solid in oil (IL-S/O) nanodispersion and a pressure-sensitive adhesive (PSA) to deliver the macromolecular antigenic protein, ovalbumin (OVA). The IL-S/O patch was found to deliver a higher amount of the drug compared to an aqueous formulation, and mice immunized with the OVA-containing patch produced a significant increase in anti-OVA IgG. These findings suggest that the IL-S/O patch may be a promising platform for transdermal delivery of antigen molecules. [Extracted from the article]

A research report from Islamic Azad University in Tehran, Iran discusses the use of a SnO2-NiO nanocomposite in the electrochemical determination of hydrochlorothiazide (HCTZ). The nanocomposite was prepared using a hydrothermal method and characterized using various techniques. The researchers found that the SnO2-NiO nanocomposite, when modified with an ionic liquid, showed good electrocatalytic behavior towards the oxidation of HCTZ. The sensor developed in this study was used to determine HCTZ in pharmaceutical formulations and biological samples. [Extracted from the article]

Researchers at Sardar Vallabhbhai National Institute of Technology in Gujarat, India have developed pH-responsive catanionic vesicles for drug delivery. These vesicles are created by combining two oppositely charged surface active ionic liquids (SAILs), resulting in vesicular nanoaggregates that are sensitive to pH changes. The researchers loaded these vesicles with the hydrophobic drug curcumin, which improved its solubility, efficacy, and bioavailability. This innovative approach holds promise for advancements in drug delivery and therapeutic applications. [Extracted from the article]

A study conducted at Forman Christian College in Lahore, Pakistan, evaluated the potential of two surface-active ionic liquids (SAILs) as drug carriers for ciprofloxacin. The researchers compared the SAILs with their conventional counterparts using spectroscopic and electrochemical techniques. The study found that the SAILs demonstrated higher solubilization powers and binding constants, as well as lower critical micelle concentrations (CMCs), indicating stronger hydrophobic forces. The research concluded that using SAILs as drug carriers could offer benefits such as improved binding and partition coefficients, lower CMCs, and favorable electrochemical results. [Extracted from the article]

A new study conducted by researchers at Huazhong University of Science and Technology in Wuhan, China, has developed a novel drug delivery system for treating androgenic alopecia (AGA), the most common type of hair loss. The researchers created a minoxidil and epigallocatechin gallate co-loaded ionic liquids drug delivery system that effectively regulated the hair follicle microenvironment and promoted hair regrowth. The system showed superior efficacy compared to commercially available minoxidil products. This study provides a potential treatment strategy for AGA with minimal side effects and optimal efficacy. [Extracted from the article]

Researchers from Rajshahi University in Bangladesh have published a report on the use of 3D printed hydrogels based on ionic liquids in tissue engineering. The hydrogels, made from ionic liquids known for their unique properties, offer improved structural integrity and adjustable characteristics. The use of 3D printing technology allows for precise control over the morphology and spatial arrangement of the hydrogels, expanding their potential applications in tissue engineering and drug delivery systems. The addition of functional components like nanoparticles and bioactive compounds further enhances the therapeutic potential of these materials. The research provides insights into the design concepts and fabrication methods of these hydrogels, advancing materials science and bioengineering for next-generation biomedical applications. [Extracted from the article]

A study conducted by the Science University of Malaysia explores the use of supported ionic liquid membranes (SILM) for removing ibuprofen from aquaculture wastewater. The researchers developed SILM using a carrier solution and a solid support, and found that the system was effective in removing ibuprofen and maintaining stability for at least five cycles of membrane reusability. The study highlights the potential of SILM in mitigating ibuprofen pollution in the aquaculture sector. Financial support for the research was provided by the Long Term Research Grant Scheme - Ministry of Higher Education in Malaysia. [Extracted from the article]

Researchers at the University of Porto in Portugal have conducted a study on the removal of amoxicillin from wastewater using choline-amino acid ionic liquids. The presence of antibiotics in wastewater can harm aquatic ecosystems and contribute to antibiotic resistance. The researchers found that less polar ionic liquids were more effective in extracting amoxicillin from the wastewater. This study suggests that choline-amino acid ionic liquids could be a more eco-friendly and cost-effective method for water purification. [Extracted from the article]