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Non-alcoholic fatty liver disease (NAFLD), with a global prevalence of 25%, continues to escalate, creating noteworthy concerns towards the global health burden. NAFLD causes triglycerides and free fatty acids to build up in the liver. The excessive fat build-up causes inflammation and damages the healthy hepatocytes, leading to non-alcoholic steatohepatitis (NASH). Dietary habits, obesity, insulin resistance, type 2 diabetes, and dyslipidemia influence NAFLD progression. The disease burden is complicated due to the paucity of therapeutic interventions. Obeticholic acid is the only approved therapeutic agent for NAFLD. With more scientific enterprise being directed towards the understanding of the underlying mechanisms of NAFLD, novel targets like lipid synthase, farnesoid X receptor signalling, peroxisome proliferator-activated receptors associated with inflammatory signalling, and hepatocellular injury have played a crucial role in the progression of NAFLD to NASH. Phytocompounds have shown promising results in modulating hepatic lipid metabolism and de novo lipogenesis, suggesting their possible role in managing NAFLD. This review discusses the ameliorative role of different classes of phytochemicals with molecular mechanisms in different cell lines and established animal models. These compounds may lead to the development of novel therapeutic strategies for NAFLD progression to NASH. This review also deliberates on phytomolecules undergoing clinical trials for effective management of NAFLD. [ABSTRACT FROM AUTHOR]

The article focuses on disruptions in glucose and lipid metabolism, which are often consequences of an unhealthy lifestyle. It discusses how environmental toxins, such as endocrine disruptors, also play a role in contributing to persistent metabolic impairment, leading to chronic diseases that may require medication. The use of medications, particularly statins has been highlighted as potentially creating a cycle of significant side effects on metabolism.

Alcoholic liver disease is one of the leading causes of liver-related morbidity and mortality worldwide, but effective treatments are still lacking. Honokiol, a lignin-type natural compound isolated from the leaves and bark of Magnolia plants, has been widely studied for its beneficial effects on several chronic diseases. Accumulating studies have revealed that honokiol displays a potential therapeutic effect on alcoholic liver disease. In this study, the protective activity of honokiol on alcoholic liver disease was confirmed due to its significant inhibitory activity on the expression levels of inflammatory cytokines (such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1 β) in EtOH-fed mice and in EtOH-induced AML-12 cells. Meanwhile, the expression of the lipid metabolic parameter sterol regulatory element-binding protein-1c was also reduced. However, peroxisome proliferator-activated receptor α was increased in animal and cell experiments, which indicates that the activity of honokiol was related to its regulated activity on lipid metabolism. The result showed that honokiol significantly inhibited the expression level of p38 α in vivo and in vitro. Blocking p38 α inhibited the expression levels of tumor necrosis factor-alpha, interleukin-6, interleukin-1 β , and sterol regulatory element-binding protein-1c but promoted the expression level of peroxisome proliferator-activated receptor α compared with the honokiol-treated group. Moreover, the forced expression level of p38 α further produced the opposite effect on inflammatory cytokines and lipid metabolism indicators. Furthermore, p38 α has been related to the activation of the nuclear factor kappa B signaling pathway. In our study, honokiol significantly inhibited the activation of the nuclear factor kappa B signaling pathway mediated by p38 α. In conclusion, the results suggest that honokiol might be an effective regulator of p38 α by downregulating the nuclear factor kappa B signaling pathway, thereby reducing the inflammatory response and lipid metabolism disorder in alcoholic liver disease. [ABSTRACT FROM AUTHOR]

A recent study from University Indonesia explores the health benefits of consuming vegetable salads, highlighting their positive effects on lipid and glucose metabolism, as well as the absorption of specific nutrients in vegetables. The research emphasizes the convenience and nutritional value of salads as a way to increase vegetable intake and improve overall health. For more information, readers can access the full article published in Foods journal by MDPI AG, with contact details for the authors provided for further inquiries. [Extracted from the article]

A recent study conducted by Johns Hopkins University School of Medicine focused on the spatially heterogeneous lipid dysregulation in pediatric tuberculous meningitis, the deadliest form of extrapulmonary tuberculosis that primarily affects children and immunocompromised individuals. The research utilized mass spectrometry techniques to analyze brain lipidome alterations in a young rabbit model of TB meningitis, revealing downregulation of various lipids and cholesterol intermediates due to Mycobacterium tuberculosis infection. The study concluded that there is significant spatially regulated brain lipidome dysregulation in pediatric TB meningitis, highlighting the potential vulnerability of the developing brain to lipid composition alterations. [Extracted from the article]

Researchers at the Carnegie Institute of Science have developed a high-cholesterol diet protocol for zebrafish to study lipid metabolism and human lipid-associated disorders. The diet led to hypercholesterolemia and fasting-associated liver steatosis in zebrafish, providing insights into fatty liver disease mechanisms. This study offers an effective approach to investigate the physiological and biochemical responses to high dietary cholesterol levels. The research was supported by the National Institutes of Health, G. Harold and Leila Y. Mathers Foundation, and Research Council of Norway. [Extracted from the article]

Researchers at the University of Campania in Naples, Italy, have conducted a study on the dynamic changes of brain lipids, lipid rafts, and lipid droplets in aging and Alzheimer's disease. The study found that aging induces complex changes in lipid profiles in the brain, which can impact brain cell function and potentially contribute to neurodegenerative diseases like Alzheimer's. The research highlights the role of lipid rafts in maintaining membrane integrity and cellular signaling, as well as the impact of lipid droplets on cellular energy metabolism. The interplay between lipid metabolism, oxidative stress, and inflammation is crucial in understanding the processes involved in aging and Alzheimer's disease. [Extracted from the article]

The article discusses the impact of lipid disbalance on neuronal dendrite growth and maintenance in a human ceramide synthase disease model, specifically Progressive Myoclonic Epilepsy Type 8 (PME8). The study conducted in Drosophila sensory neurons revealed developmental and degenerative dendrite loss in cerS mutants, with a reduction in ceramides and an increase in bioactive signaling lipids. By restoring specific long-chain ceramides and decreasing (dh)Sphingosine-1-P, researchers were able to fully rescue the cerS mutant phenotype, offering insights into the metabolic origin of PME8 and potential therapeutic implications. [Extracted from the article]

A study conducted at Chengdu University in China explored the effects of short-term zinc supplementation on lipid metabolism in mice. The research found that zinc supplementation led to a decrease in visceral adipose tissue weight and adipocyte size, as well as an increase in serum insulin levels and lipolysis. The study suggests that short-term zinc supplementation may help reduce fat deposition by enhancing lipolysis in mice, with potential implications for future research on fat reduction in both animal models and humans. [Extracted from the article]

The article discusses the impact of BCL2L13 on autophagy and ceramide metabolism in glioblastoma, specifically in relation to Temozolomide (TMZ) resistance. The study found that TMZ-resistant cells exhibited inhibited autophagy flux and altered ceramide profiles compared to non-resistant cells. The research suggests that targeting BCL2L13 and ceramide metabolism could be potential therapeutic strategies to overcome TMZ resistance in glioblastoma. The findings are based on a preprint and have not been peer-reviewed. [Extracted from the article]

Researchers from Northeast Agricultural University in Harbin, China, conducted a study on the effects of the herbicide atrazine (ATZ) on mitochondrial function and lipid metabolism in the liver. They found that melatonin (MLT) can combat these effects by restoring Rab8a levels, which regulate fatty acid utilization in mitochondria. The study concluded that targeting Rab8a can prevent ATZ-induced lipid metabolism disorders in hepatocytes. This research was supported by various funding sources and has been peer-reviewed. [Extracted from the article]

Researchers at Fudan University in Shanghai, China, have conducted a study on the circadian regulation of lipid metabolism during pregnancy. The study highlights the importance of circadian rhythms in metabolic disorders and lipid homeostasis during gestation, potentially impacting adverse pregnancy outcomes. By analyzing circadian clock genes, researchers aim to understand how circadian rhythms influence lipid metabolism and explore the possibility of resynchronizing these rhythms to improve pregnancy outcomes. For more information, the full report can be accessed in the International Journal of Molecular Sciences. [Extracted from the article]

Researchers at the Massachusetts General Hospital Research Institute conducted a study on the loss of CLN3 in microglia, which leads to impaired lipid metabolism and myelin turnover. The study focused on the impact of CLN3 deficiency on microglial function, revealing abnormalities in lysosomal storage, lipid metabolism, and myelin turnover. The findings suggest potential implications for targeted therapies in addressing CLN3 disease. The research was funded by Ncl Stiftung and published in Communications Biology. [Extracted from the article]

A study conducted at the University of Colorado focused on the role of glial-neuronal metabolic crosstalk and horizontal lipid flux in the brain's fatty acid sensing. The research highlighted the importance of non-neuronal glial cells in regulating systemic metabolism and energy homeostasis. By understanding glial lipid metabolism, future studies may target lipid processing in the brain to reduce the risk of obesity and metabolic diseases. The study was supported by the NIH National Institute of Neurological Disorders & Stroke and was published in the journal Biochimie. [Extracted from the article]

Researchers at Yale University conducted a study on the role of hepatic miR-33 in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). The study found that deletion of miR-33 in hepatocytes improved various aspects of the disease, including steatosis and inflammation, reducing the progression to MASH, fibrosis, and HCC. The results suggest that suppressing hepatic miR-33 could be an effective therapeutic approach to mitigate the development of MASLD, MASH, and HCC in obesity. Funding for the research was provided by the National Institutes of Health (NIH) - USA, American Heart Association, American Diabetes Association, and the Spanish Government. [Extracted from the article]

A study conducted at Shandong Provincial Qianfoshan Hospital in China explored the relationship between dietary habits, liposomes, and osteoporosis risk using genetic variations as instrumental variables. The research found significant causal links between specific dietary components like white rice, cereal, and non-oily fish, and osteoporosis risk mediated through changes in liposome levels. The study emphasizes the importance of considering lipidomic profiles in dietary guidance to prevent osteoporosis through nutritional interventions. [Extracted from the article]

A recent study conducted at Harbin Medical University Cancer Hospital in China explored the relationship between lipid metabolism and immune interactions in breast cancer. By integrating transcriptomics and machine learning, researchers identified 259 genes related to lipid metabolism and developed a 21-gene prognostic model. The study revealed differences in immune responses and treatment outcomes between high and low-scoring patient groups, highlighting potential therapeutic targets for personalized breast cancer treatment. This research offers new insights into the mechanisms and treatment strategies for breast cancer. [Extracted from the article]

Researchers at Peking University conducted a study to investigate the role of DNA methylation age in mediating the effects of metabolic profiles on cardiovascular and general aging. The study, which utilized data from the China Kadoorie Biobank, found that different mechanisms underlie the first and second generations of DNA methylation age in cardiovascular and general aging. The research suggests that epigenomic mechanisms may play a significant role in the associations between circulating metabolites and the aging process. [Extracted from the article]

A recent study conducted at the University of Milan focused on the impact of PCSK9 and LDLR on the lipidome of mice with altered lipoprotein metabolism under different dietary conditions. The research identified specific lipid species in the atherosclerotic aorta of mice fed a Western-type diet, which could potentially serve as biomarkers or therapeutic targets. Financial support for the study was provided by various organizations including Fondazione Cariplo and the European Union. The findings suggest potential implications for cardiovascular research and lipid metabolism. [Extracted from the article]

Researchers from Fudan University in Shanghai, China, have conducted a study on age-related macular degeneration (AMD), a leading cause of vision loss globally. The study focuses on the role of lipid metabolism in AMD pathogenesis, highlighting the need for further research to develop targeted therapies. This research provides valuable insights into the mechanisms underlying AMD and potential future treatment options. [Extracted from the article]

Researchers at National Jewish Health in Denver, Colorado, have conducted a study on the role of lipids in skin barrier function, specifically focusing on ceramides in the stratum corneum. The research highlights how keratinocyte terminal differentiation leads to unique ceramides and lamellae formation, which protect the skin from water loss and allergens. The study suggests that testing skin components for lipid and protein biomarkers could help predict the onset of allergic skin diseases. This peer-reviewed research provides valuable insights into skin health and barrier function. [Extracted from the article]

The article discusses the Mechanism of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD), highlighting its prevalence and impact on public health globally. It emphasizes the role of lipid metabolism in MASLD development and progression, with disturbances in fatty acid uptake, cholesterol metabolism, and bile acid synthesis identified as key factors. Therapeutic approaches targeting lipid metabolism, including GLP-1 agonists, PPAR agonists, and Chinese proprietary medicines (CPMs), are explored as potential treatments for MASLD. The study underscores the importance of understanding lipid metabolism in developing effective therapeutic strategies for MASLD. [Extracted from the article]

Researchers from Kyung Hee University in Seoul, South Korea, have conducted a study on targeting lipid metabolism in cancer stem cells (CSCs) for anticancer treatment. CSCs are small subpopulations of cancer cells crucial for cancer relapse and therapy resistance. The study explores the impact of metabolic reprogramming, particularly in lipids, on drug efficacy and the development of chemoresistance in various cancers. Understanding the interplay between autophagy and lipid reprogramming in CSCs could lead to the development of new approaches for enhancing therapies and reducing tumorigenicity. [Extracted from the article]

Researchers at Tongji University in Shanghai, China, have conducted a study on cervical cancer, focusing on the role of the AUP1 protein in promoting the malignant progression of the disease. Through various experiments, they found that AUP1 could be transcriptionally activated by KDM5B to reprogram lipid metabolism, thereby facilitating the growth of cervical cancer. The study suggests potential therapeutic strategies targeting metabolic pathways to combat cervical cancer. This research was supported by the National Natural Science Foundation of China and has been peer-reviewed. [Extracted from the article]

A recent study conducted at Mansoura University in Egypt explored the expression of Apolipoprotein C1 (APOC1) in different molecular subtypes of breast cancer. The research found that high APOC1 expression was associated with triple-negative basal-like breast cancer and was linked to shorter overall survival and disease-free interval. APOC1 was identified as an independent predictor of mortality, suggesting its potential role in breast cancer progression and therapeutic implications. The study highlights the importance of identifying new prognostic markers for breast cancer treatment. [Extracted from the article]

A report from Cambridge University Hospitals NHS Foundation Trust discusses the impact of subclinical hypothyroidism on lipid metabolism and cardiovascular health. The research highlights the complex relationship between thyroid hormones and lipid profiles, emphasizing the need for further studies to clarify the implications for cardiovascular health. The review calls for more comprehensive research to guide future interventions and treatment strategies in addressing lipid profile pitfalls in subclinical hypothyroidism. [Extracted from the article]

A recent study conducted at the Medical University of Warsaw focused on the impact of Atorvastatin treatment on the distribution of low-density lipoprotein subfractions and the level of Vitamin D in patients after acute myocardial infarction. The research found that Atorvastatin primarily reduced strongly atherogenic small, dense LDL and decreased less atherogenic large LDL subfractions, along with a reduction in VLDL cholesterol and IDL fractions. The study highlighted the importance of analyzing LDL subfractions for a more detailed understanding of lipid metabolism and potential targets for lipid-lowering therapy. Vitamin D deficiency was also noted to be associated with atherogenic dyslipidemia, particularly high levels of small, dense LDL. [Extracted from the article]

Researchers at the University of Wurzburg in Germany have highlighted the role of lipid metabolism in promoting vulnerabilities in cancer cells, particularly in breast tumors with poor prognosis. The studies published in EMBO Molecular Medicine emphasize the importance of understanding metabolic adaptations in cancer progression and therapy resistance to develop targeted therapies. The findings suggest that lipid unsaturation can lead to selenium dependency and sensitivity to ferroptosis, providing potential avenues for therapeutic interventions. [Extracted from the article]

A study conducted at Harran University in Sanliurfa, Turkey, examined the effects of vigorous-intensity bodybuilding exercise on atherosclerosis biomarkers and lipid profiles in male bodybuilders. The research compared bodybuilders to individuals engaged in moderate-intensity aerobic exercise, overweight/obese sedentary individuals, and normal-weight sedentary individuals. The study found that while bodybuilding exercise improved certain lipid parameters compared to sedentary obese individuals, it did not significantly enhance antioxidant enzyme activities or further improve lipid profiles beyond those observed in normal-weight sedentary men. The research suggests that moderate-intensity aerobic exercise may offer superior cardiovascular benefits by enhancing antioxidant defenses and improving lipid profiles. [Extracted from the article]

A study conducted at China Jiliang University in Hangzhou, People's Republic of China, focused on the effects of Compound Oolong tea on lipid metabolism and gut microbiota in a mouse obesity model. The research found that WLT reduced body weight, liver index, and fat index, while also improving glucose tolerance and hepatic lipid metabolism through the AMPK-PPAR pathway. The study suggests that WLT could potentially be used as a functional food ingredient for preventing obesity. The research was supported by various science and technology projects in China. [Extracted from the article]

Researchers at Tabriz University of Medical Sciences conducted a systematic review and meta-analysis on the effects of B-hydroxy-b-methylbutyrate (HMB) supplementation on lipid profiles in adults. The study included 10 randomized controlled trials with 421 participants and found that HMB supplementation did not significantly alter total cholesterol, triglycerides, low-density lipoprotein cholesterol, or high-density lipoprotein cholesterol levels. The quality of evidence was rated as moderate to low, suggesting that further research is needed to confirm these results and explore the potential mechanisms of action of HMB. [Extracted from the article]

A recent study from Princeton University explores the role of lipid metabolism in cancer progression, specifically focusing on how lipids impact CD8+ T-cell-mediated antitumor immunity. The research suggests that targeting lipid metabolism to enhance CD8+ T-cell effector functions could improve immunotherapy outcomes in solid tumors. By understanding the interplay between lipid metabolism and CD8+ T cells, promising therapeutic opportunities for cancer treatment may be developed. [Extracted from the article]

A study conducted by researchers at the University of Belgrade focused on hypertension, specifically preeclampsia in pregnant women. The study examined changes in advanced lipid status parameters and the dominant diameter of LDL and HDL particles in pregnant women at high risk for complications. The research found that pregnant women with preeclampsia exhibit atherogenic changes in lipid status parameters, potentially leading to a loss of HDL's protective effect. This study provides valuable insights into the impact of preeclampsia on lipid metabolism during pregnancy. [Extracted from the article]

Researchers at the University of Belgrade-Faculty of Chemistry conducted a study on schizophrenia patients in Serbia, aiming to identify lipid biomarkers for early diagnosis and therapy. The study analyzed serum samples from 30 schizophrenia patients and 31 non-psychiatric individuals, revealing altered lipid metabolism in patients compared to controls. The research highlighted the importance of metabolic pathways in the pathogenesis of schizophrenia, emphasizing the need for reliable biomarkers in mental health diagnostics. [Extracted from the article]

A study conducted at Henan Agricultural University in China explored the role of lncLLM in lipid metabolism in chicken LMH cells. The research found that lncLLM promotes lipid deposition by facilitating the ubiquitination of MYH9 protein, leading to increased intracellular triglyceride and cholesterol content. This discovery may offer new insights into improving egg-laying performance in hens and treating fatty liver disease in humans. For more information, the full article can be accessed in the International Journal of Molecular Sciences. [Extracted from the article]

A recent study conducted at Seoul National University explored the effects of environmental noise stress on mouse metabolism. The research found that exposure to construction noise led to increased locomotor activity and reduced anxiety in mice, along with initial weight loss followed by an increase in fat mass and adipocyte hypertrophy. These findings suggest that environmental noise-induced stress may impact behavior, neurotransmitter modulation, and lipid metabolism, potentially increasing the risk of obesity. The study highlights the complex relationship between environmental factors and metabolic health. [Extracted from the article]

A study conducted in Taiwan by the Ministry of Agriculture examined the impact of storage time and temperature on the aroma quality and color of vanilla beans. The research found that storing the beans at -20 °C or 4 °C maintained stability, with the highest vanillin levels observed at -20 °C for 6 months. However, storage at 35 °C led to the detection of oxidative metabolites after 18 months, resulting in significant color and odor changes. The study suggests that storing vanilla beans at -20 °C can extend their shelf life by 12 months. [Extracted from the article]

A study conducted by the Max-Planck-Institute for Psychiatry in Munich, Germany, examined the effects of mirtazapine, a commonly prescribed antidepressant, on lipid metabolism in healthy men. The research found that a seven-day administration of mirtazapine led to an increase in triglyceride levels and unfavorable changes in lipid metabolism, despite a decrease in weight. These findings suggest that mirtazapine may have direct pharmacological effects on lipid metabolism. The study was conducted under highly standardized conditions and has been peer-reviewed. [Extracted from the article]

A recent study conducted at Hunan Cancer Hospital in the People's Republic of China explored the metabolic reprogramming in nasopharyngeal carcinoma (NPC) and its potential therapeutic targets. The research highlighted the role of Epstein-Barr virus (EBV) infection, hypoxia, and tumor microenvironment in modulating metabolic changes in NPC, leading to resistance to standard therapies. The study also discussed current therapeutic strategies targeting these metabolic changes and evaluated the successes and failures of clinical trials in addressing resistance mechanisms, providing insights for future therapeutic avenues in NPC. [Extracted from the article]

Researchers at the Institute of Physiology of the Czech Academy of Sciences conducted a proteomic analysis of the fasting heart to understand the molecular basis of fasting-induced cardioprotection. They identified 4,652 proteins, with significant changes in processes such as lipid metabolism, the peroxisome pathway, and reactive oxygen species metabolism. The study highlighted the complex regulation of the cardioprotective HIF-1 signaling pathway during fasting, with insights into differential responses of HIF-1 targets. The research findings were published in Frontiers in Physiology and provide valuable insights into the effects of fasting on heart health. [Extracted from the article]

A study conducted at Nanjing Medical University in China explored the role of Hedgehog signaling in promoting autophagy and lipid degradation in hepatocytes. The research found that Hedgehog activates AMPK via Smoothened, leading to increased autophagy and lipid degradation. This study was supported by the National Natural Science Foundation of China and has been peer-reviewed. For more information, readers can refer to the article "Hedgehog Signal Activates Ampk Via Smoothened To Promote Autophagy and Lipid Degradation In Hepatocytes" in the journal Biochemistry and Cell Biology. [Extracted from the article]

Researchers from Tongji University School of Medicine in Shanghai, China, conducted a study on the association between serum Metrnl levels and high-density lipoprotein cholesterol (HDL-C) in patients with type 2 diabetes mellitus (T2DM). The study found that higher serum Metrnl levels were positively correlated with higher HDL-C levels in T2DM patients, suggesting that increasing Metrnl levels could potentially improve lipid metabolism and prevent cardiovascular events in this population. The study was registered in the Chinese clinical trial registry (ChiCTR-2100047148) and was published in PeerJ. [Extracted from the article]

A study conducted at Ohio State University explores the role of phospholipids, sphingolipids, and cholesterol-derived lipid mediators in neurological disorders. The research highlights how these lipid mediators play a crucial role in cellular functions, inflammation, and immunity. The study emphasizes the impact of different lipid mediators, such as prostaglandins, leukotrienes, and specialized pro-resolving lipid metabolites, on neuroinflammation and cellular processes. For more information, the full report can be accessed in the International Journal of Molecular Sciences. [Extracted from the article]

Researchers at Newcastle University in Australia conducted a study on the lipidomic secretions of early equine embryos to understand cellular processes. They found that 55 lipids were released into the embryo-conditioned media, with triacylglycerols and ceramides being the most prevalent. The study highlights the importance of a defined embryo culture medium and the need to identify the lipid requirements of embryos precisely. This research sheds light on early embryo lipid metabolism and the transfer of lipids during in vitro culture. [Extracted from the article]

A recent study conducted at Fudan University in Shanghai, China, focused on the role of GPR37 in promoting colorectal cancer by reprogramming lipid metabolism to protect cancer cells from ferroptosis. The research highlighted the potential of targeting GPR37 as a therapeutic strategy for colorectal cancer. This study was supported by the National Natural Science Foundation of China and has been peer-reviewed, providing valuable insights into the mechanisms underlying CRC development. [Extracted from the article]

Researchers from the Fifth Affiliated Hospital of Wenzhou Medical University have published a study in personalized medicine focusing on the role of glycerophospholipid-driven lipid metabolic reprogramming in the progression of primary liver cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). The study utilized advanced metabolomics analysis to identify significant upregulation of lipid metabolites in patients with HCC and CCA, highlighting the potential of lipid metabolism as a therapeutic target. The findings offer new insights into addressing clinical challenges associated with these cancers, paving the way for early diagnosis and personalized treatment strategies for patients. [Extracted from the article]

A recent study conducted at Ocean University of China focused on lipid metabolism in nonsmall cell lung cancer (NSCLC) tissues, revealing alterations in ceramides, acylcarnitines, glycerolpls, and amines. The research, funded by the National Natural Science Foundation of China and Qingdao Marine Science and Technology Center, found specific lipid changes in NSCLC tissues compared to noncancerous tissues, with implications for cancer development. The study established a lipid panel model that effectively discriminated between cancerous and noncancerous tissues, providing valuable insights for future research in cancer treatment. [Extracted from the article]

A recent report from researchers at Charite - University Medicine Berlin highlights the multifaceted role of the protein CIDEB in hepatitis. Initially identified as an apoptosis-inducing protein, further research has revealed its pivotal role in lipid metabolism, including the regulation of very-low-density lipoprotein (VLDL), lipid droplets (LD), sterol response element-binding protein (SREBP), and chylomicrons. Rare germline variants in CIDEB have been found to protect against liver diseases, such as MAFLD, cirrhosis, and viral hepatitis. Additionally, CIDEB influences various steps of the hepatitis C virus (HCV) replication cycle. This review provides an overview of CIDEB's roles in apoptosis, lipid metabolism, and viral hepatitis, emphasizing its critical role in liver diseases. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of fatty acid binding proteins (FABPs) in breast cancer. The study collected surgical breast tissue samples from 96 women with different subtypes of breast cancer and analyzed the expression patterns of FABP4 and FABP5. The researchers found that FABP4, mainly expressed in breast stroma, supported tumor cell invasion, while FABP5, primarily expressed in epithelial-derived tumor cells, promoted tumor metastasis. Elevated levels of FABP4 and FABP5 could serve as poor prognostic markers for breast cancer, and inhibiting their activity may offer a novel treatment strategy. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A recent study conducted in Nigeria examined the serum lipid profile in patients with preeclampsia and eclampsia, conditions that contribute to maternal mortality. The study found that patients with preeclampsia and eclampsia had significantly lower levels of high-density lipoproteins (HDL) and triglycerides compared to normotensive pregnant women. However, there was no relationship between lipid levels and the severity of the disease. These findings provide valuable insights into the lipid metabolism in these conditions and may contribute to future research and treatment strategies. [Extracted from the article]