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• Bionic hierarchical scaffold fabricated by 3D-printing and surface mineralization. • The obtained biomimetic multi-structured scaffolds facilitate bone regeneration. • Regulation of cell fate in activated PI3K/AKT/mTOR signaling were confirmed. • Hydroxyapatite coating accelerates osseointegration and enhance bone-augmentation. • A two-step method enriches and guides the design of modified bone graft materials. The architecture and surface modifications have been regarded as effective methods to enhance the biological response of biomaterials in bone tissue engineering. The porous architecture of the implantation was essential conditions for bone regeneration. Meanwhile, the design of biomimetic hydroxyapatite (HAp) coating on porous scaffolds was demonstrated to strengthen the bioactivity and stimulate osteogenesis. However, bioactive bio-ceramics such as β-tricalcium phosphate (β-TCP) and calcium silicate (CS) with superior apatite-forming ability were reported to present better osteogenic activity than that of HAp. Hence in this study, 3D-printed interconnected porous bioactive ceramics β-TCP/CS scaffold was fabricated and the biomimetic HAp apatite coating were constructed in situ via hydrothermal reaction, and the effects of HAp apatite layer on the fate of mouse bone mesenchymal stem cells (mBMSCs) and the potential mechanisms were explored. The results indicated that HAp apatite coating enhanced cell proliferation, alkaline phosphatase (ALP) activity, and osteogenic gene expression. Furthermore, PI3K/AKT/mTOR signaling pathway is proved to have an important impact on cellular functions. The present results demonstrated that the key molecules of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT) and mammalian target of rapamycin (mTOR) were activated after the biomimetic hydroxyapatite coating were constructed on the 3D-printed ceramic scaffolds. Besides, the activated influence on the protein expression of Runx2 and BMP2 could be suppressed after the treatment of inhibitor HY-10358. In vivo studies showed that the constructed HAp coating promoted bone formation and strengthen the bone quality. These results suggest that biomimetic HAp coating constructed on the 3D-printed bioactive composite scaffolds could strengthen the bioactivity and the obtained biomimetic multi-structured scaffolds might be a potential alternative bone graft for bone regeneration. [ABSTRACT FROM AUTHOR]

Researchers from Kyung Hee University in Seoul, South Korea, conducted a study on the effects of Diosgenin (DIOS) in alleviating obesity-induced insulin resistance in mice fed a high-fat diet. The study found that DIOS significantly suppressed weight gain, improved glucose and insulin levels, and reduced inflammation in adipose tissue. The research concluded that DIOS improves insulin resistance and obesity-associated inflammation through the PI3K/Akt signaling pathway. The study was supported by the Korea Health Industry Development Institute and has been peer-reviewed. [Extracted from the article]

A study conducted in Henan, China, focused on the effects of silver nanoparticles on human periodontal ligament fibroblasts (hPDLFs) and their impact on orthodontic tooth movement. The research found that silver nanoparticles enhanced the biological functions of the periodontal ligament, promoting tissue repair and regeneration, suggesting potential clinical value in orthodontic treatments. The study involved morphological changes in periodontal tissues and the evaluation of cell proliferation, calcification, and osteogenic differentiation in hPDLFs treated with different concentrations of silver nanoparticles. The findings were published in Cell Biochemistry and Biophysics and have been peer-reviewed. [Extracted from the article]

A study conducted at Shanghai University of Traditional Chinese Medicine explored the effects and mechanisms of the Jiawei Pentongling formula in treating endometriosis-related pain. The research involved network pharmacology study and experimental validation, identifying core targets and pathways of the formula against pain associated with endometriosis. The study suggested that the formula may inhibit the release of inflammatory factors and reverse pain associated with endometriosis by downregulating the PI3K/Akt signaling pathway. The research was supported by the National Natural Science Foundation of China and has been peer-reviewed. [Extracted from the article]

A recent study conducted at the University of Louisville explored the potential of Mahanine, an alkaloid from Murraya koenigii, in treating drug-sensitive and drug-resistant non-small cell lung cancer (NSCLC). The research found that Mahanine effectively reduced the proliferation of lung cancer cells and inhibited tumor growth in mice by targeting various molecular pathways. This study provides new insights into Mahanine's therapeutic potential against NSCLC, offering promising avenues for further research and treatment development. [Extracted from the article]

Researchers at the Affiliated Hospital of Guizhou Medical University in China have explored the role of a long non-coding RNA (lncRNA) called ANRIL in cell proliferation and apoptosis in acute myeloid leukemia (AML) cells. Their study found that ANRIL upregulation promoted cell proliferation and inhibited apoptosis in Kasumi-1 cells by activating the PI3K/AKT/BCL-2 pathway. The research suggests that the GRK2 protein mediates the effects of ANRIL on cell behavior. This study provides new insights into the molecular mechanisms underlying apoptosis regulation in AML cells. [Extracted from the article]

A study conducted at Zhejiang Chinese Medicine University in China explored the use of Guizhi Fuling Decoction (GZFL) in treating hyperlipidemia through network pharmacology and experimental methods. The research identified key targets and active components of GZFL, highlighting its potential to influence lipid metabolism. Results showed that GZFL significantly reduced cholesterol levels and influenced key proteins involved in lipid signaling pathways. The study concluded that GZFL may regulate proteins like AKT, TP53, IL-6, and PPAR gamma to impact lipid and atherosclerosis signaling pathways. [Extracted from the article]

A study conducted in Anhui, People's Republic of China, explored the mechanism of action of Bidens pilosa L. in treating liver fibrosis using network pharmacology and molecular docking methods. The research identified core targets such as PIK3R1, HSP90AA1, SRC, TP53, AKT1, RELA, and highlighted pathways like PI3K-AKT and MAPK signaling pathways. The study suggests that the active components of Bidens pilosa L. may induce apoptosis in activated HSC cells to reverse and improve liver fibrosis. Financial support for the research came from the Natural Science Key Project of Bengbu Medical College. [Extracted from the article]

A recent study conducted by the Department of Central Laboratory explored the inhibitory effect of berberine on contrast-induced nephropathy (CIN) in rats and human kidney cells. The research found that berberine treatment reduced renal injury and cell apoptosis through regulating the Akt-Foxo3a-Nrf2 axis in a p-Akt dependent manner. This study provides valuable insights into potential therapeutic approaches for CIN. [Extracted from the article]

A recent study conducted at Xinjiang Medical University in the People's Republic of China focused on using bioinformatics to predict targets and pathways for treating myocardial ischemia with Apocynum venetum L. The research utilized network pharmacology, gene analysis, and molecular docking to identify potential interactions and mechanisms of action. The study concluded that Apocynum venetum L. therapy has the potential to alleviate myocardial ischemia symptoms by reducing oxidative stress and modulating the expression of key proteins like PI3K and Akt1. This research has been peer-reviewed and provides valuable insights into potential treatments for cardiovascular diseases. [Extracted from the article]

A recent study conducted at Shanghai Jiao Tong University explored the activation of the platelet mTORC2/Akt pathway by anti-β2GP1 antibodies in patients with Antiphospholipid Syndrome (APS). The research found that the antibodies promoted thrombosis by enhancing platelet activation through the mTORC2/Akt pathway. The study suggests that SIN1 may be a potential therapeutic target for treating APS. This research was peer-reviewed and published in Arteriosclerosis Thrombosis and Vascular Biology. [Extracted from the article]

Researchers from the Korea Institute of Oriental Medicine conducted a study on the immunostimulatory effects of Gamisoyosan (GSS) on macrophages through TLR4-mediated signaling pathways. The study found that GSS increased the production of immune-related molecules and improved macrophage immune function without causing cytotoxicity. Mechanistic studies revealed that GSS activated specific signaling pathways in macrophages, suggesting its potential as an immunity-enhancing agent. This research provides valuable insights into the potential benefits of GSS in enhancing immune responses. [Extracted from the article]

Researchers at Skidmore College conducted a study on the impact of aging on body composition and glucose metabolism in male C57BL/6J mice. The study found that the oldest mice had greater lean body mass and AKT protein levels in skeletal muscle compared to younger mice. Despite increased glucose tolerance, the oldest mice appeared to be resistant to AMPK-mediated glucose uptake. This research sheds light on the possible role of skeletal muscle protein kinase B expression in protecting against sarcopenic obesity in aging mice. [Extracted from the article]

Researchers from Laurentian University in Canada have published a study on sepsis, focusing on the role of the complement anaphylatoxin C5a in cellular dysfunction during sepsis. The study used the PC12 cell model to investigate the effects of C5a on adrenal cell function, revealing an increase in apoptosis and changes in inflammatory protein expression. The research suggests that high levels of C5a may contribute to C5aR-dependent apoptosis of adrenal medullary cells in sepsis. The findings were published in the International Journal of Molecular Sciences. [Extracted from the article]

Researchers at Jiangxi University conducted a study on the anti-inflammatory properties of Hosta plantaginea flowers, a traditional Chinese herbal medicine. Through network pharmacology and molecular docking, they identified key phytochemicals and targets involved in the anti-inflammatory mechanism. The study highlighted the potential of Hosta plantaginea flowers in treating inflammation-related diseases and provided valuable insights into their pharmacodynamics. The research was peer-reviewed and published in the European Journal of Integrative Medicine. [Extracted from the article]

A study conducted at Yancheng Institute of Technology in the People's Republic of China focused on the use of porous starch microspheres loaded with luteolin to exhibit hypoglycemic activities and alter gut microbial communities in type 2 diabetes mellitus mice. The research found that the porous starch microspheres enhanced the stability and bioavailability of luteolin, leading to improvements in various indicators related to diabetes, liver health, and gut microbiota. The study concluded that this approach could potentially advance luteolin's application in the functional food industry and further explore its hypoglycemic potential. [Extracted from the article]

A recent study conducted at Sun Yat-sen University Cancer Center in Guangzhou, China, focused on the role of KRAS mutation in impairing the interferon response in colorectal cancer. The research found that KRAS accelerates double-stranded RNA degradation, leading to immunosuppression by down-regulating DDX60. Overexpressing DDX60 increased colorectal cancer sensitivity to immune checkpoint inhibition therapy, suggesting potential strategies to overcome resistance in CRC with KRAS mutations. The study was published in Science Immunology and provides insights into potential therapeutic approaches for improving treatment outcomes in colorectal cancer patients. [Extracted from the article]

A study conducted by researchers at Nanchang University explores the role of exosomal-related genes (ERGs) in hepatic ischemia-reperfusion injury (HIRI) and aims to identify diagnostic markers for HIRI. The study used bioinformatics to analyze gene expression data and identified differentially expressed genes (DEGs) associated with HIRI. Functional annotations and enrichment pathways of these genes were determined, and diagnostic models for HIRI were developed. Five key genes (ANXA1, HNRNPA2B1, ICAM1, PTEN, and THBS1) were identified as potential diagnostic markers. The study provides insights into the molecular mechanisms and potential diagnostic tools for HIRI. [Extracted from the article]

Researchers from the Korea Food Research Institute have conducted a study on the potential therapeutic effects of licochalcone D (LicoD) derived from Glycyrrhiza uralensis in improving glucose metabolism and insulin resistance in hepatocytes. The study found that LicoD enhanced glucose consumption and uptake, as well as increased the expression of Glut2 mRNA in hepatocytes with high-glucose-induced insulin resistance. Additionally, LicoD and GUE (Glycyrrhiza uralensis extract) promoted glycogen synthesis and improved mitochondrial function. These findings suggest that LicoD and GUE could be potential therapeutic options for alleviating insulin resistance-induced metabolic disorders. [Extracted from the article]

A recent study conducted by researchers at Chiang Mai University in Thailand focused on the effectiveness of a compound called oxyresveratrol (OXY) in combination with cisplatin, a chemotherapy drug, against epithelial ovarian cancer. The study found that OXY enhanced cisplatin's ability to reduce cell viability, induce apoptosis, and arrest the cell cycle in ovarian cancer cell lines. OXY was also found to inhibit the PI3K/AKT/mTOR signaling pathway, which is involved in cancer cell growth and survival. These findings suggest that OXY could be developed as a pharmaceutical adjunct for combination therapies in the treatment of ovarian cancer. [Extracted from the article]

A recent study conducted by researchers at the University of Nevada School of Medicine explores the role of estrogen in protecting against insulin-resistant type 2 diabetes (T2D) in female mice. The study found that estrogen deficiency in female mice led to a prompt onset of T2D, characterized by dysregulation of insulin and insulin receptor levels. The researchers identified the miR-10a/b-5p-NCOR2 pathway as a potential mechanism through which estrogen protects against insulin resistance. These findings suggest that restoring miR-10a/b-5p levels may have therapeutic benefits for managing T2D in females. [Extracted from the article]

Researchers from Martin Luther-University Halle-Wittenberg in Germany have conducted a study on the effects of combining the chemotherapeutic agent vincristine with the calcium antagonist nimodipine. The study found that nimodipine enhanced the cell death effects of vincristine in tumor cells, while protecting neuronal cells. The protein levels in tumor cells and neuronal cells also showed opposite changes. This research suggests that combining nimodipine with vincristine may improve tumor response to chemotherapy and reduce side effects such as neuropathy. [Extracted from the article]

A recent report from Hainan Medical University in Haikou, China discusses new findings on ovarian cancer. Researchers isolated four compounds from a mangrove endophytic fungus, including a copper(II)-based complex that showed inhibitory effects on the growth of ovarian cancer cells in vitro. The compound was found to induce mitochondrial membrane potential collapse in the cancer cells and activate key signaling molecules in the VEGF pathway. The research suggests that this copper-based compound could be a promising candidate for anticancer and antiangiogenic therapies. [Extracted from the article]

According to a preprint abstract from biorxiv.org, researchers have characterized a genetic mouse model lacking phosphorylation sites on the TSC2 protein, which is involved in mTORC1 signaling. The study found that these mice exhibited reduced body weight and organ weight, such as the brain and skeletal muscle, due to decreased growth factor-stimulated mTORC1 signaling. The findings suggest that TSC2 phosphorylation is a primary mechanism for mTORC1 activation in certain tissues. However, further research is needed to understand how these molecular mechanisms function in physiological states. This information is based on a preprint and has not yet undergone peer review. [Extracted from the article]

Researchers from Nanjing University of Chinese Medicine have conducted a study on hyperthyroidism, specifically focusing on the pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decoction (HYD) in treating the condition. The study utilized network pharmacology, molecular docking, and non-targeted serum metabolomics to identify therapeutic targets and hub genes associated with hyperthyroidism. Through their analysis, the researchers identified 214 common targets between HYD compounds and therapeutic targets of hyperthyroidism, which were mainly enriched in biological processes related to gene expression, MAPK cascade, and protein phosphorylation. The study concluded that HYD exerts its pharmacological effect on hyperthyroidism by inhibiting pathological angiogenesis in the thyroid and rebalancing immunity. [Extracted from the article]

A recent study conducted by researchers at Southern Medical University in Guangdong, China, has explored a new treatment approach for rheumatoid arthritis (RA). The study focused on the use of a nanoparticle formulation containing saponin and dexamethasone, which showed promising results in inhibiting the excessive proliferation of fibroblast-like synoviocytes (FLSs) in inflamed joints. The treatment was found to alleviate RA-induced inflammatory response and joint damage in animal models. The researchers believe that this nanomedicine holds potential for the synergistic treatment of RA. [Extracted from the article]

A recent research article from Universitas Sumatera Utara explores the role of microRNAs (miRNAs) in the development, progression, and treatment resistance of pancreatic cancer (PC). The study highlights the potential therapeutic benefits of flavonoids, a group of phytochemicals found in fruits and vegetables, in regulating miRNA expression and inhibiting PC cell proliferation. The review also emphasizes the significance of certain miRNAs as targets of flavonoid action, as well as the use of flavonoid nanoformulations to enhance stability and maximize anti-PC activity. The researchers call for further research to optimize the use of flavonoid nanoformulations in clinical trials for more effective treatment strategies. [Extracted from the article]

A recent study conducted at the Chinese Academy of Agricultural Sciences focused on Streptococcus suis, an important bacterial pathogen that affects the global pig industry. The researchers aimed to uncover the role of pyroptosis, a form of cellular necrosis, in thymic cells of S. suis-infected mice. They found that S. suis activated the M1 phenotype and induced pyroptosis in macrophages, leading to inflammation and the involvement of specific signaling pathways. The study concluded that pyroptosis contributes to necrotic cells and thymocyte reduction in the atrophied thymus of mice. [Extracted from the article]

A recent study conducted at Gangneung-Wonju National University in South Korea explored the anti-inflammatory effects of a lipocalin-like protein called OJlipo1, derived from Oenanthe javanica. The researchers cloned and expressed OJlipo1 in E. coli and conducted rigorous characterization to evaluate its potential against inflammation. The study found that OJlipo1 has significant anti-inflammatory potential, particularly in diseases associated with toll-like receptor 4 dysregulation. These findings validate the traditional use of O. javanica in treating inflammation and suggest new therapeutic possibilities. The research has been peer-reviewed and published in the journal Food Science and Biotechnology. [Extracted from the article]

A research report from the First Affiliated Hospital in Jinan, People's Republic of China, discusses the role of oxytocin in stabilizing cardiac mast cells and improving sympathetic innervation in rats after myocardial infarction (heart attack). The study found that oxytocin reduced the number of degranulated cardiac mast cells and attenuated sympathetic hyperinnervation. Oxytocin was shown to stabilize mast cells through the PI3K/Akt signaling pathway. The research suggests that oxytocin may have potential therapeutic benefits in preventing fatal ventricular arrhythmias after a heart attack. [Extracted from the article]

A recent study conducted by researchers at Peking University in Beijing, China, explores the potential of intermedin (IMD) in alleviating diabetic cardiomyopathy (DCM). The study found that IMD, a bioactive small molecule peptide, can mitigate cardiac hypertrophy, fibrosis, dysfunction, and lipid accumulation in DCM rats and mice. The researchers also discovered that IMD up-regulates the levels of carnitine palmitoyltransferase-1b (CPT-1b), an enzyme responsible for the oxidation of long-chain fatty acids, through the activation of the phosphatidyl inositol 3 kinase/protein kinase B (PI3K/Akt) signaling pathway. These findings suggest that IMD may serve as a potential therapeutic target for the treatment of DCM. [Extracted from the article]

The article presents research from Zhejiang University on the role of ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 (ACAP3) and histone deacetylase 2 (HDAC2) in papillary thyroid carcinoma (PTC), highlighting how HDAC2 negatively regulates ACAP3 to inhibit PTC cell malignancy. Topics include the impact of ACAP3 on PTC cell proliferation, migration, and apoptosis, the interaction between ACAP3 and HDAC2, and the potential therapeutic implications of targeting these molecular pathways.

A recent report from University Hospital RWTH Aachen in Germany explores the potential of different types of stem cells in regenerative medicine and orthodontic treatment. The researchers focused on the adaptability of various stem cell types to mechanical forces and observed distinct morphological and proliferation changes in response to compression. They also found that the secretion of certain growth factors and proteins was reduced under mechanical stress, with variations depending on the cell type. These findings provide valuable insights into the behavior of mesenchymal stem cells and their potential roles in bone remodeling, wound healing, and tissue regeneration. However, further research is needed to fully understand the mechanisms behind stem cell-based periodontal therapies. [Extracted from the article]

A researcher from Ewha Womans University in Seoul, South Korea, has published a study on overcoming drug resistance in cancer using nanoparticle strategies for key protein inhibition. The study highlights how drug resistance hinders the effectiveness of cancer therapies and discusses the limitations of current inhibitors. Nanoparticle-based drug delivery systems are proposed as a promising solution to improve drug solubility, stability, and targeted delivery, thereby reducing off-target toxicity and increasing therapeutic efficacy. The research aims to enhance treatment outcomes and develop more effective cancer therapies. [Extracted from the article]

A recent study conducted by researchers at Guangzhou University of Chinese Medicine in China has found that oligosaccharides of Ophiopogon japonicus (OOJ), a bioactive component of Ophiopogonis radix, have significant hypoglycemic and hypolipidemic effects. The study examined the effects of OOJ on insulin resistance and glucolipid metabolism in both in vivo and in vitro models of type 2 diabetes mellitus. The results showed that OOJ improved various parameters related to type 2 diabetes, such as blood glucose levels, lipid profile, insulin sensitivity, and glucose tolerance. The researchers concluded that OOJ has the potential to be used as a functional food ingredient and therapeutic agent for treating metabolic syndrome and type 2 diabetes. [Extracted from the article]

A study conducted by the Affiliated Hospital of Nanjing University of Chinese Medicine has explored the therapeutic effects of Yinqiaosan decoction (YQSD) against influenza A virus infection. YQSD, a traditional Chinese medicinal recipe used for 300 years in China, was found to suppress viral multiplication and inflammatory response by modulating T cell immunity. The study utilized UHPLC-Q-TOF-MS/MS to examine the substances of YQSD and identified 97 compounds. Network pharmacology analysis revealed that the therapeutic effect of YQSD against influenza may be associated with the regulation of T cell receptors (TCR) and Phosphoinositide 3-Kinase (PI3K)-protein kinase B (Akt) signaling pathways. In vivo experiments showed that YQSD significantly prolonged the mean survival time of mice and reduced lung injury caused by the influenza A virus. The study concludes that YQSD's capacity to modulate T cell immunity may explain its effect against influenza viral pneumonia. [Extracted from the article]

Researchers at Tianjin Medical University in China have conducted a study on the effects of tetrahedral framework nucleic acids (tFNAs) on bone marrow mesenchymal stem cells (BMSCs) in diabetic rats. The study found that tFNAs can promote the proliferation, migration, and osteogenic differentiation of BMSCs, while also inhibiting cell senescence and apoptosis. Additionally, tFNAs were found to scavenge reactive oxygen species and activate the protein kinase B (Akt) signaling pathway. This research provides a potential strategy for endogenous bone regeneration in diabetes and highlights the potential of DNA-based nanomaterials in regenerative medicine. [Extracted from the article]

A recent study conducted at the Second Affiliated Hospital of Chongqing Medical University in China explored the impact of leptin on chondrocytes and osteoarthritis (OA). The researchers collected cartilage tissue from OA patients for in vitro experiments and established an OA rat model for in vivo experiments. They found that leptin protects chondrocytes by inhibiting autophagy through the phosphoinositide 3 kinase/protein kinase B/mammalian target of rapamycin signaling pathway. This research provides valuable insights into the role of leptin in OA development and potential therapeutic strategies. [Extracted from the article]

A study conducted by researchers from Zhejiang University in China explores the role of cellular retinoic acid binding protein 2 (CRABP2) in prostate cancer (PCa). The study found that CRABP2 promotes cell migration and invasion in PCa by activating the PI3K/AKT and MAPK signaling pathways through upregulating LAMB3. However, the effect of CRABP2 on cell proliferation varied among different PCa cell lines. The research suggests that CRABP2 may be a potential target for therapeutic interventions in PCa. [Extracted from the article]

A recent study conducted at the Medical University of Lodz in Poland explored the effects of the mycotoxin zearalenone (ZEN) and its metabolites on prostate cancer cells. The researchers found that the metabolites, alpha-zearalenol (alpha-ZEL) and beta-zearalenol (beta-ZEL), reduced cell viability, induced oxidative stress, cell cycle arrest, and apoptosis in the prostate cancer cells. The study also revealed that the FOXO3a and PI3K/Akt signaling pathway played a role in the toxicity induced by the metabolites. These findings suggest that this signaling pathway may be involved in mycotoxin-induced toxicity more broadly. [Extracted from the article]

A recent study conducted at Peking University Shenzhen Hospital has revealed new findings on cardiovascular and cerebrovascular diseases. The research focused on the role of inositol 1,4,5-trisphosphate receptors (IP3Rs) in regulating vascular smooth muscle cell (VSMC) proliferation and neointima formation. The study found that genetic ablation of IP3Rs reduced VSMC proliferation and migration, and smooth muscle-specific deletion of IP3Rs in mice attenuated neointima formation. The researchers concluded that IP3R-mediated calcium release from the endoplasmic reticulum plays an essential role in regulating VSMC proliferation and neointima formation in mouse arteries. [Extracted from the article]

The article offers information on the effects of microRNA-515-5p on the biological behavior of colorectal cancer cells through the phosphoinositide 3-kinase/protein kinase B signaling pathway. Topics discussed include the impact of microRNA-515-5p on cell proliferation and migration; its influence on apoptosis-related proteins; and its role in modulating signaling pathways associated with colorectal cancer progression.

The article focuses on a new report on oncology that explores the mechanism of ITGB4 in tumor migration and invasion, with topics including the role of ITGB4 in cell adhesion, migration, and signaling, as well as its involvement in epithelial-mesenchymal transition and phosphorylation of associated molecules. It study found that ITGB4 plays a critical role in tumor migration and invasion, and its mechanisms involve pathways involving focal adhesion kinase.

A study conducted by researchers at the General Hospital of Ningxia Medical University in China explores the anti-angiogenic effects of a fusion protein called BDS-hEA on hepatocellular carcinoma (HCC), a highly vascularized liver cancer. The researchers found that BDS-hEA induced autophagy in vascular endothelial cells, leading to a decrease in angiogenesis. They also discovered that BDS-hEA modulated the AMPK/AKT/mTOR signaling pathway, resulting in cytotoxic effects against HCC. These findings suggest that BDS-hEA has potential as a therapeutic approach for inhibiting angiogenesis in liver cancer. [Extracted from the article]

The article explores Zhejiang University's study on liraglutide's impact on myocardial injury in rats with acute myocardial infarction, focusing on its regulation of the phosphoinositide 3 kinase/protein kinase B pathway. Topics include liraglutide's effects on cardiac function, myocardial damage, and its comparative impact with or without a phosphoinositide 3 kinase inhibitor.

A recent study conducted by researchers at East China Normal University explores the effects of the water extract of Phyllanthus emblica L. fruit on glucose utilization and insulin resistance in skeletal muscle. The study found that the extract stimulated glucose uptake and translocation of GLUT4 to the plasma membrane, accompanied by an increase in AMPK phosphorylation. Additionally, the extract prevented palmitate-induced insulin resistance and restored insulin-mediated translocation of GLUT4. The researchers concluded that the extract activates the CaMKKb/AMPK pathway and ameliorates insulin resistance in C2C12 myotubes. [Extracted from the article]

A recent study conducted by researchers at Alpert Medical School of Brown University explored the potential benefits of hypoxia-conditioned extracellular vesicles in a large animal model of coronary artery disease. The study involved injecting these vesicles into Yorkshire swine with induced coronary artery disease. The results showed that the injection of hypoxia-conditioned extracellular vesicles led to increased myocardial perfusion without a change in vessel density, suggesting that this improvement may be due to changes in nitric oxide signaling. These findings indicate that hypoxia-conditioned extracellular vesicles could be a potential therapeutic strategy for increasing myocardial perfusion in patients with advanced coronary artery disease. [Extracted from the article]

Researchers at Changchun University of Chinese Medicine have conducted a study on the effects of electroacupuncture on glycolipid metabolism disorders in mice with non-alcoholic fatty liver disease (NAFLD). The study focused on the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling pathway and its role in improving glycolipid metabolism. The results showed that electroacupuncture treatment reduced triglyceride, LDL cholesterol, and cholesterol levels, while increasing HDL cholesterol levels in the mice. Additionally, the treatment improved liver histopathologic changes and hepatic glycogen synthesis. The study suggests that electroacupuncture may be effective in improving glucose-lipid metabolism disorders in NAFLD mice through the AMPK/ACC signaling pathway. [Extracted from the article]

A new study conducted by researchers at Harbin Sport University in China has found that moderate-intensity aerobic exercise can improve memory function in mice with Alzheimer's disease. The study involved a 12-week treadmill running program for both transgenic mice and wild-type mice. The results showed that the exercise group had better memory function, lower levels of amyloid beta, and less phosphorylation of tau and glycogen synthase kinase-3 (GSK3) compared to the sedentary group. The researchers concluded that exercise may improve memory function through the modulation of GSK3 phosphorylation in the cortex and hippocampus. [Extracted from the article]

A recent study conducted by researchers at Hebrew University of Jerusalem has found that rasagiline, a selective monoamine oxidase B (MAO-B) inhibitor, has neuroprotective effects in the treatment of Parkinson's disease (PD). The study investigated the signaling pathways of rasagiline in neuronal cultures exposed to oxygen-glucose deprivation (OGD) and reoxygenation, and found that rasagiline provided neuroprotection by inhibiting cell death and increasing antioxidant enzymes through the Akt/Nrf2 redox-signaling pathway. These findings have potential implications for the development of neuroprotective drugs for PD and stroke therapy. [Extracted from the article]