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Recent studies have shown promising results in the development of exercise and calorie-restriction mimetics, which are experimental drugs that mimic the effects of exercise and calorie reduction without the need for physical activity or dietary changes. These drugs have been shown to improve body fat levels, blood lipids, muscle power, blood sugar regulation, and heart function in mice. While not yet available for human use, several mimetics have entered human trials with encouraging results. These drugs have the potential to prevent and treat conditions such as muscle loss, diabetes, heart failure, and neurodegenerative disorders. Mimetics may also help with weight management and muscle preservation. CR mimetics aim to extend healthspan by activating health-promoting genes, while exercise mimetics affect mitochondria to encourage the growth of more mitochondria and the burning of fatty acids for fuel. The development of these drugs is still ongoing, and there are concerns about potential misuse and side effects. However, researchers believe that mimetics could provide significant benefits in terms of healthspan and lifespan, especially for individuals who struggle with exercise and dieting. [Extracted from the article]

Weight loss drugs like glucagon-like peptide 1 (GLP-1) agonists have become popular due to their effectiveness in helping patients lose weight. However, studies have shown that when patients stop taking these drugs, they tend to regain most of the weight within a year. Factors such as high costs, supply shortages, and insurance coverage can make ongoing treatment difficult. Patients may also experience side effects or simply not want to take medication indefinitely. To help patients who want to stop taking GLP-1s, healthcare professionals should understand their reasons, avoid bias, educate them about the biology of obesity, prepare them for increased appetite, help their bodies adjust gradually, consider alternative interventions, create a habit template, prescribe exercise, create a supportive microenvironment, involve multidisciplinary expertise, and reassure patients that they will be supported regardless of their choices. [Extracted from the article]

The article focuses on the importance of smoking cessation for patients with diabetes. Topics include the duration of abstinence and its impact on all-cause mortality and macro- and microangiopathic risks, the risk for weight gain after quitting smoking, and the reduction in the risk for diabetes and metabolic syndrome after quitting smoking with similar benefits observed in women with diabetes.

The article provides a snapshot of the finance industry, highlighting the increase in securitization volume in Q1 FY25 and the active participation of banks as originators. It also mentions the potential weight gain of HDFC Bank in the MSCI Standard Index, which could lead to inflows of up to $4 billion from passive funds. Additionally, the article mentions a decline in India's forex reserves by $1.71 billion for the week ending June 28. [Extracted from the article]

The study showed that change in waist circumference (aka abdominal obesity) is regulated by a separate pathway from overall obesity during weight regain, the researchers report in their paper, published in Diabetes. Genetic effects on abdominal obesity may be more pronounced than those on general obesity during weight regain, a new study suggests. [Extracted from the article]

By the end of the study, those on the TRE regimen had an average reduction in their hemoglobin A1c from baseline that was 0.88 percentage points greater than among the controls, and the TRE arm had also lost an average of nearly 2.15 kg more from baseline than the controls. Time-restricted eating (TRE) can be a practical, easy-to-follow way for some people to control their daily food intake and lose weight. "To maximize the effects [of TRE] people should use the eating window that best fits their life", agreed Kelsey Gabel, PhD, who also gave a TRE talk during the meeting. [Extracted from the article]

According to research presented at the annual meeting of the Endocrine Society, approximately 20% of breast cancer survivors will gain more than 10% of their body weight in the six years following their diagnosis. Younger age and lower weight at diagnosis were found to be the strongest predictors of excessive weight gain over time. This weight gain can increase the risk of breast cancer recurrence, mortality, cardiovascular disease, and all-cause mortality. Lifestyle interventions, such as changes in diet and regular exercise, are recommended to mitigate these weight gains. [Extracted from the article]

The article focuses on the challenge of determining whether weight loss is a consistent trend or just temporary fluctuations. Topics include the frustration of tracking weight changes that do not follow a steady decline, the use of averaging to analyze weight loss patterns, and the concept of monotonic functions in understanding changes in weight over time.

Seniors are missing out on the benefits of weight-loss drugs like Ozempic and Wegovy due to insurance hurdles and concerns about muscle loss. These medications can improve mobility, balance, mood, and overall health for older individuals. However, seniors face challenges in getting insurance coverage for these drugs and need to be cautious about potential muscle loss and interactions with other medications. Medicare typically does not cover weight-loss medications for seniors, which can be costly. Despite these obstacles, doctors encourage seniors to consider the potential health improvements that these drugs can offer. [Extracted from the article]

This article discusses the challenges that healthcare professionals face in maintaining a healthy diet due to the demands of their work. The ubiquity of junk food in clinical settings, the use of food as a reward or stress reliever, and the lack of time for self-care are all factors that contribute to unhealthy eating habits among healthcare professionals. The article provides practical tips for healthcare professionals to eat healthily, such as making sure to eat something, bringing healthy snacks to work, meal prepping, automating healthy snacks, and considering meal delivery services. It also emphasizes the importance of hydration and advocating for healthier options in the workplace. The article concludes by encouraging healthcare professionals to be tenacious about making positive changes to their diet and lifestyle. [Extracted from the article]

A recent study conducted in South Korea found that a triple combination therapy of metformin, dapagliflozin, and saxagliptin is an effective and safe treatment option for drug-naive patients with type 2 diabetes (T2D). The study compared this triple therapy with stepwise add-on therapy and found that a higher proportion of patients in the triple therapy group achieved the primary outcome of A1c levels < 6.5% without hypoglycemia, weight gain, or discontinuation of drugs due to adverse events. The authors suggest that this combination therapy could be a novel strategy for initial combination therapy in newly diagnosed T2D patients. However, it is important to note that the study had limitations, such as a small sample size and a relatively short trial duration. The study was funded by AstraZeneca, and some authors reported financial ties with pharmaceutical and medical device companies. [Extracted from the article]

The article focuses on the relationship between rapid weight gain (RWG) in infants and maternal prepregnancy overweight, and their combined effect on the risk of childhood obesity.

The article delves into the painful struggles families face in diagnosing cystic fibrosis, especially among non-white children, highlighting missed screenings and systemic biases despite advances in genetic testing and newborn screenings.

According to a recent article in Pediatric News, there is a complex relationship between obesity and cancer. While about 42% of cancers are considered obesity-related, only about 8% of incident cancers are attributed to excess body weight. The article highlights that the link between excess fat and cancer is not as clear-cut as it is with tobacco. The timing of weight gain also appears to be a factor, with studies showing that weight gain at any point after age 18 is associated with an increased risk of postmenopausal breast cancer and colorectal and gastrointestinal cancers. The article also discusses the limited evidence on whether weight loss can reduce the risk of obesity-related cancers. It emphasizes the importance of considering individual circumstances and setting realistic expectations when addressing obesity and cancer risk. [Extracted from the article]

A study presented at the annual clinical and scientific meeting of the American College of Obstetricians and Gynecologists found that only half of initial prenatal visits involved a discussion of gestational weight gain. The discussion was most often initiated by the healthcare provider. The researchers analyzed audio-recorded visits and found that ACOG guidelines on gestational weight gain were only mentioned in 8% of visits where weight was discussed. The study highlights the importance of counseling patients on weight gain during pregnancy, as it is related to maternal and neonatal outcomes. Future research will explore the association between patient race or BMI and the frequency and content of these conversations. [Extracted from the article]

This article discusses the potential loss of lean mass that can occur during successful weight loss interventions, particularly with the use of anti-obesity drugs. While the loss of lean mass is a normal part of the weight loss process, it is important for clinicians to be aware of this potential side effect and to educate patients on strategies to offset the loss, such as strength training and proper nutrition. The article emphasizes that the benefits of significant fat mass reduction outweigh the drawbacks of lean mass loss, as excess adiposity is what contributes to health issues. Special considerations are also discussed for older patients, who are more vulnerable to lean mass loss. Overall, the article provides insights into the complexities of weight loss interventions and the importance of addressing body composition. [Extracted from the article]

Eating within 3 hours of bedtime at least 4 days a week may increase the risk of developing colorectal cancer, according to a study presented at the annual Digestive Disease Week. The study surveyed 664 people undergoing colonoscopies, with 42% identifying as late eaters. Late eaters were 46% more likely to have an adenoma found during colonoscopy, which can become cancerous over time. The study suggests that late eating may disrupt the body's circadian rhythm, potentially leading to unwanted weight gain and negatively impacting the gut microbiome. However, the study is observational and relies on self-reported dietary recall, so further research is needed to confirm these findings. [Extracted from the article]

Picky eating can be a problem for some children, as it can limit their growth and nutrition, as well as their social interactions. However, about 18% of young children and 7% of older children and adolescents are picky eaters, and most of them get adequate nutrition and grow fine without intervention. There are practical strategies that parents can use to address picky eating, such as providing healthy food in reasonable amounts, allowing children to feed themselves, and modeling eating a variety of foods. In severe cases, medical problems may be a potential cause, and specialized feeding programs or medical intervention may be necessary. It is important for parents to understand potential contributing factors and seek appropriate support and guidance. [Extracted from the article]

A recent study has found that high-dose valproate, a medication commonly used to treat psychiatric conditions, is associated with significant weight gain in patients. The study analyzed data from two longitudinal studies conducted between 2007 and 2022, involving 215 patients diagnosed with bipolar disorder, schizoaffective disorders, schizophrenia, or other conditions. The researchers found that each 500-mg increase in valproate dose was associated with a weight increase of 0.52% per month over a year. The greatest weight gain was observed in patients receiving doses of 1300 mg/d or higher. The study highlights the importance of closely monitoring patients on valproate for weight gain and prescribing the lowest effective doses. However, it is important to note that the study only demonstrates an association, not causation, and did not consider lifestyle factors that could affect weight gain. [Extracted from the article]

Byline: Tim Benz Jun. 8During Tuesday's minicamp interview sessions, Pittsburgh Steelers running back Najee Harris certainly gave the impression that he thought the media was overreacting to his alleged weight [...]

The article focuses on the underrepresented genre of qawwali in the British music scene and praises the Chand Ali Khan and group as the best British qawwali ensemble, highlighting their recent performances and contributions to the genre.

Glucagon-like peptide 1 receptor agonists (GLP-1 RAs), such as semaglutide and tirzepatide, have shown potential therapeutic effects beyond their current use for type 2 diabetes and obesity. Recent studies suggest that GLP-1 RAs may improve male fertility by addressing the hormonal disruptions and other factors associated with obesity. Animal studies and small trials have indicated that GLP-1 RAs can improve sperm parameters and erectile dysfunction. However, more research is needed to determine the direct effects of GLP-1 RAs on male fertility and the potential effects on offspring. While GLP-1 RAs may offer additional options for treating fertility in men with obesity, further evidence is required before they can be widely prescribed. [Extracted from the article]

This article discusses the relationship between metabolism and weight gain or loss. It explains that as we age, our metabolism slows down, which can contribute to weight regain after attempting to lose weight. The article also explores the effects of weight loss or gain on metabolism, with a particular focus on the role of muscle mass. It suggests that increasing muscle work and muscle mass can help alter or increase metabolism. Additionally, the article emphasizes the importance of protein intake and resistance exercise training in boosting metabolism. It concludes by providing tips for incorporating cardio and resistance exercise into a routine and mentioning potential future treatments for obesity. [Extracted from the article]

The article discusses the importance of gut health in relation to weight loss. While injectable weight loss drugs have gained attention, focusing on the gut microbiome can be an alternative approach. The gut microbiome, which consists of trillions of microbes, plays a crucial role in turning fiber from food into substances that the body needs. Research has linked problems in the gut microbiome to various health conditions, including inflammatory bowel disease, autoimmune diseases, metabolic diseases, cardiovascular disease, asthma, and autism. Consuming a diet that supports a healthy gut microbiome, such as foods rich in fiber, phenols, fermented foods, and healthy fats, can have positive effects on gut health and potentially aid in weight loss. However, it is important to prioritize overall health rather than solely focusing on weight loss. [Extracted from the article]

Glucagon-like peptide 1 (GLP-1) agonists are effective in treating obesity, but studies have shown that once patients stop taking these drugs, they regain most of the weight they lost. Additionally, patients who continue on the drug eventually reach a plateau where their body refuses to lose more weight. This plateau occurs because the body resists going below its set point and activates hunger hormones. Strategies to break through the plateau include trying multiple weight loss agents, tapering the GLP-1 dose, and emphasizing lifestyle changes. It is important to manage patients' expectations and provide behavioral health support throughout their weight loss journey. [Extracted from the article]

A study conducted in Hong Kong found that very few patients with type 2 diabetes (T2D) achieve and sustain diabetes remission through weight loss alone. Only 6% of the more than 37,000 participants achieved and maintained diabetes remission solely through weight loss up to 8 years after diagnosis. The study also found that those who lost the most weight in the first year after diagnosis were most likely to sustain remission. The study suggests that early weight management interventions should be implemented for individuals diagnosed with T2D. [Extracted from the article]

A recent study published in Pediatric News found that the quality of a low-carbohydrate diet (LCD) can impact weight gain. The study included 123,332 participants and categorized their diets into different types of LCDs. Participants who followed a high-quality LCD, rich in plant-based proteins and healthy fats, experienced slower weight gain, while those who followed a lower-quality LCD had the opposite effect. The study suggests that the quality of nutrients in a diet is important for maintaining a healthy body weight, rather than solely focusing on macronutrient quantity. However, it is important to note that the study had limitations, such as self-reported data and a predominantly White population of health professionals. [Extracted from the article]

New data suggests that women with a history of gastric bypass or sleeve gastrectomy have lower pregnancy weight gain compared to those without such a history, especially when the time between surgery and conception is shorter. The study, conducted in Sweden, analyzed 12,776 pregnancies and found that women with a history of bariatric surgery had lower pregnancy weight gain across all early-pregnancy BMI categories. The difference in weight gain was largest for women with normal weight or overweight early-pregnancy BMI status. The study suggests that clinical attention should be given to women with a history of bariatric surgery and a normal weight status in early pregnancy. [Extracted from the article]

The article focuses on women experiencing menopausal weight gain, turning to drugs like Ozempic and Wegovy to combat the issue, with individuals expressing concerns about body changes during menopause and the desire for effective weight loss solutions.

The article focuses on a study published in The Lancet journal, which reveals that pregnant women who gain more weight than recommended face a higher risk of later-life mortality from heart disease and diabetes, irrespective of their pre-pregnancy weight status.

The article reports that scientists have discovered how working night shifts can disrupt the body's biological clock, leading to changes in hormones that regulate appetite and potentially resulting in weight gain, with implications for those working night shifts to maintain daylight exposure,.

The article focuses on the prevalence of anxiety and mental health issues among college-aged women, despite the cultural influences of empowerment and confidence.

The article focuses on the impact of COVID-19 on infants exposed in the womb. Topics include lower birth weight of the infants but experience greater weight gain in their first year of life, potentially indicating a catch-up response to prenatal growth deficit; this accelerated growth raises concerns about the development of obesity, diabetes or cardiovascular disease in the future; and need for further research with larger sample sizes and longer follow-up.

The article focuses on the benefits of smoking cessation in diabetes. It highlighting three topics: the similar benefits for both sexes; the increased weight gain in women after quitting smoking; and the risks of smoking during pregnancy, including pregnancy-related complications and the risk of type 2 diabetes in newborns; and also emphasizes the importance of helping family members of pregnant women quit smoking to reduce these risks.

An interview with a Pakistani actress, Ramsha Khan is presented who appeared in several notable serials including "Mah-e-Tamaam," "Khud Parast," "Kaisa Hai Naseeban," "Ishqiya," "Ghisi Piti Mohabbat" and "Hum Tum, " discusses on "Hum Tum," secret behind her success, future hopes, acting, inspirations and what she would love to master. When asked about characters is closest to heart, she refers to e "Samiya" from "Ghisi Piti Mohabbat" because that character sort of changed her as a person.

Byline: DAVID EDDIE Lead DAMAGE CONTROL The question My brother-in-law hadn't seen my son for some time. He asked him how much he weighed. My son politely answered, but my [...]

The article discusses gaining weight has often a gradual process; happens over the years as a result of modern-day life and the odd unhealthy habit.

Frozen vegetables (or fruit) can contain just as many nutrients as fresh, if not more, as they are frozen rapidly after harvesting, so lock in the nutrients. IMPROVE YOUR NUTRITION AND LOSE THE POUNDS BY MAKING SMALL CHANGES TO YOUR DIET www.easterneye.eu Promotional feature March 12, 2021 • Twitter.com/easterneye Facebook.com/easterneye 16 This is the time to move towards a better and healthier 2021 W E KNOW that the last year has been tough on all of us, but there has never been a better time to have a go at some new healthier habits. 1 Vary your vegetables Vegetables are packed with nutrients such as vitamins, minerals, fibre, and antioxidants. [Extracted from the article]