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The article reports that YP-P10, a novel, patented synthetic peptide from Yuyu Pharma, is being evaluated for safety, tolerability and efficacy for the treatment of patients diagnosed with dry eye diseases in the phase 2 clinical trial ICECAP 1, as of May 2023. Topics covered include growth in peptide research, the challenges of developing dry eye therapeutics and the results of studies conducted in animal models of dry eye.

Direct sample analysis coupled to high-resolution time-of-flight mass spectrometry (TOFMS) may be effective at analyzing synthetic cathinones, especially for qualitative analysis, because it does not require potentially tedious sample preparation. This technique will allow for a more rapid and simplistic analysis of synthetic drugs and increase laboratory throughput, as evidenced by the work of other researchers with different instrumentation for different compound classes. [ABSTRACT FROM AUTHOR]

Direct sample analysis coupled to high-resolution time-of-flight mass spectrometry (TOFMS) may be effective at analyzing synthetic cathinones, especially for qualitative analysis, because it does not require potentially tedious sample preparation. This technique will allow for a more rapid and simplistic analysis of synthetic drugs and increase laboratory throughput, as evidenced by the work of other researchers with different instrumentation for different compound classes. [ABSTRACT FROM AUTHOR]

Focuses on ways to measure and document accuracy for typical pharmaceutical formulations including synthetic drugs and bioanalytical samples. Significance of the determination of the method's accuracy as an integral part of validating any quantitative method; Requirement of a knowledge of the level of analyte present in stimulated drug products to have an accurate measurement; Possibility for accuracy to be measured.

The article focuses on flakka, a synthetic drug similar to ecstasy and bath salts sometimes called as gravel, which serves as a new challenge for emergency medical services (EMS). It states that symptoms of flakka include insomnia, psychosis, and paranoia. Information about various medications for drug-induced disorder are mentioned including midazolam, lorazepam, and haloperidol.

The article discusses the aspects of organized crime in the Asia-Pacific region which has begun to move away from the mono-ethnic behavior at the end of the Cold War. It mentions that the main adaptation towards the change in organized crime were globalization, technology, the transnational nature of organized crime and the development of new markets. It also highlights the emergence of synthetic drugs in 1990, particularly in Japan, which fell into the hand of the organized Japanese criminals.

The article focuses on the means for many scientists to find ways to prevent or delay cancer by using natural products instead of synthetic drugs. It is stated that chemoprevention drugs sometimes stemmed from epidemiological observations about a cancer prevention trend. A team funded by the National Cancer Institute (NCI) combines experts in natural product isolation, organic synthesis and structural biology.

The article discusses the growth of China's foreign trade in synthetic drugs for the year 2015 which contributed to the further narrowing of its foreign trade balance. Topics include the increase in synthetic drugs exported by China with India remaining as the top export destination and active pharmaceutical ingredients (APIs) as the main variety for export. It also discusses the increase in import volume for synthetic drugs with Europe as the main source of imported drugs followed by Asia.

The article discusses a synthetic approach developed by Harvard University chemist Andrew G. Myers and colleagues which appeared in a 2016 issue of the journal "Nature," allowing them to construct macrolides in a modular way. Topics mentioned include the characteristics of macrolide antibiotics, the synthetic platform created by Myers and colleagues, and how Macrolide Pharmaceuticals, a company Myers cofounded, will work toward making clinical antibiotic candidates.

The article informs that a synthetic opioid developed by Canadian researchers in the early 1980s will be released as a street drug in Canada and the European Union (EU).

The article offers the author's insights on his experience as a firefighter and responding to an incident where a man fell out of a third-floor window. It mentioned the assessment of the medical condition of the victim by the paramedics and their operation in shaky railings, missing balusters, and broken wood stairs. Also mentioned was the spring fever experienced by the victim from the use of synthetic drugs.

The author claims that China has become a major supplier of anabolic steroids, synthetics and counterfeit medications in the U.S., with Chinese drug traffickers allegedly saturating the country with drugs that can ultimately kill. He notes the U.S. law enforcement's inability to pursue the traffickers in their country which is said to condone the practice. He narrates how undercover agents were able to expose several anabolic steroid operations that catered to body builders and weight lifters.

The article reports on the collaboration between LEO Pharma and Scripps Research Institute for the development of practical synthetic routes to complex natural products for skin diseases.

The article reports on the results of a study on the capability of the Forster reaction to devise a synthetic route to the hyperparathyroidism drug cinacalcet hydrochloride, referencing a study that was published by researcher Vijayavitthal T. Mathad and colleagues in a previous issue of the journal "Organic Process Research & Development."

The article reports on research which was conducted on 150 users of the synthetic stimulant drug mephedrone which was conducted by researchers in London, England and found that legislation which was passed in April of 2010 and resulted in the reclassification of mephedrone as a class B drug has had a limited effect in controlling its availability and use.

The article reports that a more possible efficient synthetic route to polyunsaturated fatty acids, antibiotics and antifungal drugs can be performed through the creation of skipped polyenes such as 1,4-dienes and their higher homologs.

Reports on the design completion by a public-private partnership of a synthetic ozonide compound with antimalarial properties. Claim of the drug's cost effectiveness as an alternative to other malaria drugs; Use of the chemical artemisinin extracted from the bark of the wormwood tree; Limitations of plant-based extracts as drug materials due to the poor synthesis of analogs; Design of the endoperoxide-containing OZ277 ozide drug to overcome limitations.

Reports on the use of combination regiment of clarithromycin and a fourth-generation fluoroquinolone in treating keratitis due to non-tuberculous Mycobacteria. Minimum inhibitory concentrations. INSET: Take-Home Message.

Focuses on the synthesis of norzoanthamine, a hepatacyclic marine alkaloid first isolated from Zoanthus sp. anemones. Characterization of norzoanthamine; Advancement in the study of norzoanthamine as a therapeutic drug; Development of the route of norzoanthamine.