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ATLAS (Antimicrobial Testing Leadership and Surveillance) detects trends in multi-drug resistance longitudinally over time. In the present study, the in vitro activity of ceftazidime-avibactam and comparators was analyzed against Escherichia coli (n = 458) and Klebsiella pneumoniae (n = 455) isolates obtained from 9 centers across India. The overall susceptibility to ceftazidime-avibactam was observed to be 72% among K. pneumoniae isolates and 87% among E. coli isolates. Among the tested carbapenem resistant isolates, 51% of CR- K. pneumoniae and 24% of CR- E. coli were susceptible to ceftazidime- avibactam. OXA-48 like was identified in 52% of the K. pneumoniae isolates followed by co-production of NDM with OXA-48 like in 27%. NDM was predominantly identified in 68% of the E. coli isolates followed by OXA-48 like in 24% isolates. The findings suggest that ceftazidime- avibactam is a reasonable alternative to standard therapy for management of carbapenem resistant Enterobacterales infections particularly with K. pneumoniae and E. coli with the OXA-48 like genotype. [ABSTRACT FROM AUTHOR]

This paper presents a BiCMOS voltage amplifier-based high-speed frontend electronics (FEE) chipset, designed in 0. 35 μ m SiGe BiCMOS technology. This chipset comprises two ASICs, namely a quad voltage amplifier ASIC and an octal comparator ASIC. The two-chip FEE is designed for the readout of large area, single-gap, avalanche mode Resistive Plate Chamber (RPC) detectors of the Iron Calorimeter (ICAL) experiment of the India based Neutrino Observatory (INO). The use of a voltage amplifier-based FEE topology along with a separate comparator ASIC resulted in a stable high gain and high-speed FEE operation in the presence of a large number of detector channels. This FEE solution has a total amplifier gain of 74, overall timing precision of 140 ps (RMS), and power consumption of 25 mW/channel. It exhibits pixel-wise detector efficiency larger than 90% along with position- and time-resolution of 1 cm RMS, and 1 ns RMS, respectively, when used with a prototype INO-ICAL RPC detector of size 1.85 m × 1.75 m. Furthermore, the performance of the FEE is not affected by the presence of the magnetic field (1.3 T) used in the experiment. [ABSTRACT FROM AUTHOR]

A design of high-speed comparator ASIC, fabricated in 0. 35 μ m SiGe BiCMOS process is presented. This ASIC is designed as a part of the front-end readout electronics development for Resistive Plate Chamber detector of Iron Calorimeter experiment of India based Neutrino Observatory. The ASIC comprises eight channels of high-speed voltage comparator with LVDS driver. A novel technique is used to implement a small voltage adjustable hysteresis in the comparator without additional power, area and circuit complexity. This ASIC multiplexes input analog signals through an on-chip high-speed 50 Ω cable driver. The analog multiplexer supports daisy and non-daisy modes for access of input signals. The ASIC has power consumption of ∼ 13 mW/channel. The comparator LVDS output rise time is ∼ 900 ps. The measured timing precision of the ASIC is ∼ 40 ps RMS. [ABSTRACT FROM AUTHOR]