19 results on '"Liu, Xiao Bing"'
Search Results
2. Synthesis of Magnetically Separable Nanocatalyst CoFe2O4@SiO2@MIL‐53(Fe) for Highly Efficient and Selective Oxidation of Alcohols and Benzylic Compounds with Hydrogen Peroxide.
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Tan, Jin, Liu, Xiao Bing, Chen, Wei Feng, and Hu, Yu Lin
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HYDROGEN peroxide , *ALCOHOL oxidation - Abstract
A new methodology for the highly efficient and atom‐economic oxidation of alcohols and benzylic compounds to the corresponding aldehydes and ketones with environmental‐friendly hydrogen peroxide using a magnetic MOF nanocatalyst has been developed. We demonstrated that the resulting magnetic nanocomposite CoFe2O4@SiO2@MIL‐53(Fe) can show excellent catalytic performances in the highly selective oxidation at room temperature, based on a synergetic effect between iron sites and CoFe2O4@SiO2. The nanocatalyst offers simple operation for recovery and the recycling test showed that it could be reused for successive runs without significant degradation in catalytic activity. [ABSTRACT FROM AUTHOR]
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- 2019
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3. Relationship between paternalistic leadership and employee’s voice behavior based on regression analysis.
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Liu, Hai-Jun and Liu, Xiao-Bing
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EMPLOYEE psychology , *REGRESSION analysis , *INFORMATION economy , *EMPLOYEE participation in management , *SELF-esteem - Abstract
In order to maintain the competitive edge in competitive environment of global integration and rapid development of knowledge economy, organization not only requires its employees to complete their own tasks, but also hopes employees can actively provide ideas or suggestions to the organization to change the current status of the organization, thus to realize the organizational innovation and to keep sustained competitiveness. In tradition Chinese culture, there has convention that subordinate employees give advice to their leaders, so it gradually forms an organizational structure characterized with distinct hierarchy great power gap. The paternalistic leadership is a distinctive leadership style formed under this deep-rooted cultural background. Through the analysis of relative theory, influence factor and significance of paternalistic leadership and employee voice behavior, this paper adopts regression analysis to study the factor of paternalistic leadership to employee voice behavior under the influence of special Confucian culture, discussing the gaining of organizational self-esteem by employees under this leadership style, finally finding the balance relation between leadership style and employee voice behavior and making prospect for the future research. [ABSTRACT FROM PUBLISHER]
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- 2017
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4. Research on Experimental Teaching Platform of Production Management Oriented by Multi-industry Business Simulation.
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BAI Zhao-yang, LIU Xiao-bing, HOU Li-yan, and SHEN Ling-li
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Aiming at the problem that students lack business practice participation in different industries in production management experimental teaching, we put forward a production management experimental teaching platform which integrates multiple industry data sources. The platform separats the system database from multiple business database and constructs a multi-level platform service technology architecture. The platform is constructed by using SaaS (Software as a Service) model. Using the workflow technology to complete templated business process modeling, it implements the whole process simulation of enterprise production management, and involves multiple industries and roles. Finally, we verify the feasibility and applicability of production management experimental teaching platform by taking motor manufacturing industry as an example. [ABSTRACT FROM AUTHOR]
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- 2014
5. Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: Correlation with Jab1 stability and PI3K/Akt pathway.
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Wang, Hua, Liu, Xiao-Bing, Chen, Jia-Hui, Wang, Qing-Qing, Chen, Jin-Peng, Xu, Jun-Fei, Sheng, Chen-Yi, and Ni, Qi-Chao
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BREAST cancer prognosis , *GENE expression , *CYTOPLASM , *TUMOR suppressor genes , *KAPLAN-Meier estimator , *CARRIER proteins - Abstract
Objective Jun activation domain-binding protein 1 (Jab1) was overexpressed in breast cancer, which was involved in degradation of the cyclin-dependent kinase inhibitor p27 Kip1 . The objective of this study was to examine the effect of brain specific kinase 1 (BRSK1) expression on Jab1 over-expression and related signaling pathway in breast cancer. Methods Immunohistochemical analysis was performed in 95 human breast carcinoma samples and the data were correlated with clinicopathologic features. Furthermore, Western blot analysis was performed for BRSK1 and Jab1 in breast carcinoma samples and cell lines to evaluate their protein levels and molecular interaction. Results We found that the cytoplasmic BRSK1 expression was inversely associated with Jab1 expression ( P < 0.01) and correlated significantly with histologic grade ( P = 0.006), however nuclear BRSK1 expression couldn't obtain similar results. Kaplan–Meier analysis revealed that survival curves of low versus high expressers of cytoplasmic BRSK1 and Jab1 showed a highly significant separation in breast cancer ( P < 0.01). While in vitro, following release of breast cancer cell lines from serum starvation, the expression of Jab1, phosphor-Akt (p-Akt) was up-regulated, whereas BRSK1 and p27 Kip1 were decreased. Treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 could diminish Jab1 expression but increase BRSK1 expression. In addition, we employed siRNA technique to knock down Jab1 and/or BRSK1 expression and observed their effects on MDA-MB-231 cell growth. Conclusions BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 expression, may involve in the restoring Jab1-induced suppression of p27 Kip1 and may regulate cell cycle through the PI3K/Akt pathway. [ABSTRACT FROM AUTHOR]
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- 2014
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6. Enhancement of cisplatin-based TACE by a hemoglobin-based oxygen carrier in an orthotopic rat HCC model.
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Liu, Xiao-Bing, Cheng, Qiao, Geng, Wei, Ling, Chang-Chun, Liu, Yan, Ng, Kevin Tak-Pan, Yam, Judy Wai-Ping, Guan, Xin-Yuan, Lo, Chung-Mau, and Man, Kwan
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CISPLATIN , *OXYGEN carriers , *THERAPEUTIC embolization , *OXYGENATION (Chemistry) , *LIVER cancer - Abstract
Objective: Hypoxic tumor cells are more resistant to standard chemotherapies. A number of studies indicated that improving oxygenation inside the tumor could serve as a potential strategy to target hypoxia-induced chemoresistance. In this study, we examined whether a hemoglobin-based oxygen carrier (OC89) could increase tumor oxygenation and thus enhance the efficiency of transarterial chemoembolization (TACE) in an orthotopic rat HCC model. Methods: Efficiency of the hemoglobin-based oxygen carrier (OC89) in improving tumor oxygenation was examined by OxyLab pO2. Sensitization of chemotherapy (cisplatin) in TACE by OC89 was evaluated in four different therapeutic regimens including cisplatin (1 mg/kg) + OC89 (0.2 g/kg), cisplatin (1 mg/kg) + OC89 (0.4 g/kg), cisplatin (3 mg/kg) + OC89 (0.2 g/kg), cisplatin (3 mg/kg) + OC89 (0.4 g/kg). For all the therapeutic regimens, a single delivery of OC89 via the tail vein was performed 1 h before TACE. Results: Compared with Ringer's buffer, systemic delivery of OC89 (0.4 g/kg) attenuated tumor hypoxia ( p < 0.05). Additionally, partial pressure of oxygen (pO2) fraction of low readings (0-10 mmHg) inside the tumor decreased from 74.1% to 24.6% after OC89 delivery, while pO2 fraction of high readings (15-25 mmHg) increased from 22.2% to 41.5%. When cisplatin was combined with OC89, regimen cisplatin (3 mg/kg) + OC89 (0.4 g/kg) resulted in a significant inhibition of tumor growth at Day 21 after therapy ( p < 0.05). Further investigation indicated that OC89 delivery influenced anti-apoptotic and pro-apoptotic balance of the UPR pathway in the tumor. Conclusions: Our data suggest that targeting tumor hypoxia with the hemoglobin-based O2 carrier serves as a promising approach to enhance the efficacy of cisplatin-based chemotherapy in HCC. [ABSTRACT FROM AUTHOR]
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- 2014
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7. Elastic and inelastic collisions of the semirational solutions for the coupled Hirota equations in a birefringent fiber.
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Xie, Xi-Yang and Liu, Xiao-Bing
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INELASTIC collisions , *ROGUE waves , *DARBOUX transformations , *ELASTIC scattering , *BIREFRINGENT optical fibers , *BOUND states , *SEVERE storms - Abstract
Under investigation in this manuscript is the coupled Hirota equations, which describe the propagation of ultrashort optical pulses in a birefringent fiber or collision of the two waves arisen by severe weather in deep ocean. Based on the generalized Darboux transformation derived before, we obtain the semirational solutions, and properties of the solitons are discussed in detail: Elastic collisions between/among the two/three solitons on the zero-intensity background are shown in figures, which means that the solitons propagate with the stable amplitudes and velocities during the collisions. Also, inelastic collisions between/among the two/three solitons are illustrated, and some of the solitons travel with amplitudes changed. Furthermore, the bound states among the three solitons are observed. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Evaluation of Efficacy of Traditional Chinese Medicinal "Burn Therapy" to Treat Pain Induced by Lumbar Intervertebral Disc Herniation in Community.
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Yu Li-ya, Yu Chuan-you, Liu Xiao-bing, Zhang Hui-yan, Wang Yi-jian, Lv Jian-feng, Wang Wei-qin, Sun Guang-jiang, Liu Chuang, and Pan Guo-wei
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HEALTH facilities , *INTERVERTEBRAL disk , *LUMBAR pain , *HERNIA , *PATIENT compliance , *INTERVERTEBRAL disk hernias - Abstract
Objective: To evaluate the safety, efficacy and patient acceptability of burn therapy with Chinese Medicinals in treating pain induced by lumbar intervertebral disc herniation (LDH) in community. Methods: All 684 cases of LDH were provided with Chinese Medicinal burn therapy treatment in this research. The visual analogue scoring (VAS) was applied to evaluate the lumbago and the quality of life of patients before and after treatment. Moreover, logistic regression analysis was applied to analyze the influence factors of curative effect. Results: The total effective rate of analgesia was 77.2%. The total effective rate of patients with severe pain and disease course ≤6 months before the treatment was 91.8 and 90.9%, which was significantly higher than that of patients with mild and moderate pain group (70.7%) with the course of disease >6 months (76.1%). The more severe the lower back pain, the better the curative effect (OR = 4.877), and the shorter the disease course of lumbago, the better (OR = 0.256) the curative effect. The overall effective rate of improvement was 79.7, 80.2 and 80.3%, respectively on the effects of daily life, daily work and walking ability. The incidence of adverse reactions was 3.5%. The patients' satisfaction and approval degree of technical treatment were 84.0 and 86.3%. Conclusions: The treatment with Chinese Medicinal burn therapy to relieve pain induced by LDH was safe and effective. Moreover, patient's compliance was better; the degree of acceptance was high. In addition, the technique is easy to master by doctors in a basic hospital setting, and is suitable for promotion in primary health care institutions. [ABSTRACT FROM AUTHOR]
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- 2020
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9. Copper-doped mesoporous silica supported dual acidic ionic liquid as an efficient and cooperative reusability catalyst for Biginelli reaction.
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Yao, Nan, Lu, Ming, Liu, Xiao Bing, Tan, Jin, and Hu, Yu Lin
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MESOPOROUS silica , *IONIC liquids , *CATALYSTS , *CATALYSIS , *CHEMICAL reactions - Abstract
A series of MCM-41 supported functionalized ionic liquids doped with copper species were prepared, characterized and evaluated as catalysts in the Biginelli reaction. Most of these supported ionic liquids perform well in the reaction, especially the multifunctional copper coordinated MCM-41 supported heterogeneous catalysts (0.5)IL-TiCl 5 @MCM-41@Cu(15) and (0.5)IL-HSO 4 @MCM-41@Cu(15). The catalytic tests revealed that (0.5)IL-HSO 4 @MCM-41@Cu(15) was the best and powerful catalyst in the Biginelli reaction for the preparation of 3,4-dihydropyrimidinones with high to excellent yields. The catalyst can be easily separated from the reaction mixture by filtration and reused in six consecutive cycles without significant loss in catalytic activity. [ABSTRACT FROM AUTHOR]
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- 2018
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10. Predictive Analysis of the Damage to Axial-Flow Pump's Impeller in Sandy Water.
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Hua HONG, Zhang ZHI-ZHONG, Liu XIAO-BING, Zeng YONG-ZHONG, and Wang HUI-YAN
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TURBULENCE , *COMPUTATIONAL fluid dynamics , *AXIAL flow pumps , *IMPELLERS , *MULTIPHASE flow - Abstract
With the use of RNG k-ε turbulence model, SIMPLEC algorithm and CFD software, the turbulent flow in an axial flow impeller was numerically simulated in the clear water (single-phase) and the sandy water (solid-liquid twophase) conditions. The distributions of solid concentration, velocity and pressure on the impeller of an axial flow pump were analyzed at the same particle diameter but different volume concentrations in sandy water. And these distributions were comparatively analyzed under the clear water and the sandy water conditions. According to the simulation results, the axial pump impeller will be damaged more easily and quickly in sandy water than in clear water. And the area more prone to damage on the axial flow impeller is predicated. The predicted vulnerable parts in an axial flow impeller are consistent with that in actual projects. This study shows that the numerical simulation results are the same as the actual situation, and it has guiding significance for the wear design of the axial flow pump. [ABSTRACT FROM AUTHOR]
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- 2018
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11. Highly Robust Reentrant Superconductivity in CsV3Sb5 under Pressure.
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Chen, Xu, Zhan, Xinhui, Wang, Xiaojun, Deng, Jun, Liu, Xiao-Bing, Chen, Xin, Guo, Jian-Gang, and Chen, Xiaolong
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FERMI surfaces , *SUPERCONDUCTIVITY , *CARRIER density , *ELECTRONIC structure , *PRESSURE - Abstract
We present the superconducting (SC) property and high-robustness of structural stability of kagome CsV3Sb5 under in situ high pressures. For the initial SC-I phase, its Tc is quickly enhanced from 3.5 K to 7.6 K and then totally suppressed at P ∼ 10 GPa. With further increasing pressure, an SC-II phase emerges at P ∼ 15 GPa and persists up to 100 GPa. The Tc rapidly increases to the maximal value of 5.2 K at P = 53.6 GPa and slowly decreases to 4.7 K at P = 100 GPa. A two-dome-like variation of Tc in CsV3Sb5 is concluded here. The Raman measurements demonstrate that weakening of E2g mode and strengthening of E1g mode occur without phase transition in the SC-II phase, which is supported by the results of phonon spectra calculations. Electronic structure calculations reveal that exertion of pressure may bridge the gap of topological surface nontrivial states near EF, i.e., disappearance of Z2 invariant. Meanwhile, the Fermi surface enlarges significantly, consistent with the increased carrier density. The findings here suggest that the change of electronic structure and strengthened electron-phonon coupling should be responsible for the pressure-induced reentrant SC. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Novel Superconducting Electrides in Ca–S System under High Pressures.
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Liu, Yun-Xian, Wang, Chao, Han, Shuai, Chen, Xin, Sun, Hai-Rui, and Liu, Xiao-Bing
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SUPERCONDUCTING transition temperature , *CALCIUM compounds , *STOICHIOMETRY , *SUPERCONDUCTORS , *CRYSTAL structure - Abstract
Due to their unique structure properties, most of the electrides that possess extra electrons locating in interstitial regions as anions are insulators. Metallic and superconducting electrides are very rare under ambient conditions. We systematically search possible compounds in Ca–S systems stabilized under various pressures up to 200 GPa, and investigate their crystal structures and properties using first-principles calculations. We predict a series of novel stoichiometries in Ca–S systems as potential superconductors, including P21/m Ca3S, P4mbm Ca3S, Pnma Ca2S, Cmcm Ca2S, Fddd CaS2, Immm CaS3 and C2/c CaS4. The P4mbm Ca3S phase exhibits a maximum Tc value of ∼20 K. It is interesting to notice that the P21/m Ca3S and Pnma Ca2S stabilized at 60 and 50 GPa behave as superconducting electrides with critical temperatures Tc of 7.04 K and 0.26 K, respectively. More importantly, our results demonstrate that P21/m Ca3S and Pnma Ca2S are dynamically stable at 5 GPa and 0 GPa, respectively, indicating a high possibility to be quenched to ambient condition or synthesized using the large volume press. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Andrographolide inhibits secretagogue-induced pseudo-allergic reaction.
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Lu, Zhi-Fang, Min, Jie, Wu, Xu-Cai, Dong, Bu-Huai, Ye, Jiu-Min, Liu, Xiao-Bing, Zhang, Li, Guo, Bin, and Gao, Zi-Jun
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ALLERGIES , *ANIMAL experimentation , *BIOLOGICAL assay , *BIOLOGICAL models , *BIOLOGICAL products , *CELL lines , *MAST cells , *MICE , *MOLECULAR structure , *RESEARCH funding , *TERPENES , *WESTERN immunoblotting , *PLANT extracts , *DATA analysis software , *DESCRIPTIVE statistics , *IN vitro studies , *IN vivo studies ,THERAPEUTIC use of plant extracts - Abstract
Many kinds of drugs induce pseudo-allergic reactions due to activation of mast cells. We investigated the anti-pseudo-allergic effect of andrographolide (Andro). The effects of Andro on pseudo-allergic reactions were investigated in vivo and in vitro. Andro suppressed compound 48/80 (C48/80) induced pseudo-allergic reactions in mice in a dose-dependent manner. Andro also inhibited C48/80-induced local inflammatory reactions in mice. In vitro studies revealed that Andro reduced C48/80-induced mast cells degranulation. Human phospho-kinase array kit and western blotting showed that Andro could inhibit pseudo-allergic responses via the calcium signaling pathway. [ABSTRACT FROM AUTHOR]
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- 2020
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14. Responses of Labile Organic Nitrogen Fractions and Enzyme Activities in eroded Mollisols After 8-year Manure Amendment.
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Chen, Yi-min, Xu, Xin, Jiao, Xiao-guang, Sui, Yue-yu, Liu, Xiao-bing, Zhang, Jin-yuan, Zhou, Ke, and Zhang, Jiu-ming
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- 2018
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15. Bacterial communities incorporating plant-derived carbon in the soybean rhizosphere in Mollisols that differ in soil organic carbon content.
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Lian, Teng-Xiang, Wang, Guang-Hua, Yu, Zhen-Hua, Li, Yan-Sheng, Liu, Xiao-Bing, Zhang, Shao-Qing, Herbert, Stephen James, and Jin, Jian
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MOLLISOLS , *RHIZOSPHERE microbiology , *SOYBEAN , *PYROSEQUENCING , *SOIL mechanics , *PHYSIOLOGY - Abstract
A primary factor regulating the composition of the microbial community in the rhizosphere is carbon (C) efflux from root systems, which fundamentally influences microbial functions in the rhizosphere, such as biodegradation, plant growth, and rhizosphere signalling. However, information regarding the incorporation of plant-C by the bacterial community in the rhizosphere is limited, particularly in soybean. Soybean plants were grown in rhizo-boxes containing low- or high-organic C (C org ) Mollisols and labelled with 13 CO 2 at the flowering stage. After soil DNA was extracted from the rhizosphere, 13 C-DNA was separated from 12 C-DNA using the stable isotope probing method, followed by pyrosequencing analysis. Between soils, significant differences in the abundance of genera incorporating 13 C in the rhizosphere were observed, with Aquincola , Dechloromonas , Massilia , Amycolatopsis , Delftia , Magnetospirillum , Psychrobacter , Ochrobactrum , Pseudoxanthomonas and Niastella showing greater relative abundances in low-C org soil ( p < 0.05) compared to high-C org soil. However, the opposite trend was observed for Enhydrobacter , Flavisolibacter , Propionibacterium and Staphylococcus. Correspondingly, the number of operational taxonomic units in each genus varied between soils. Soil type greatly affected the flow of plant-C into rhizospheric bacterial community. The plant-C metabolizing bacteria may contribute to the transformation of rhizodeposits in the soil and soil C sequestration. [ABSTRACT FROM AUTHOR]
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- 2017
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16. LOW HEAD TURBINE ON-CAM CHARACTER AND OPERATING CONDITION OPTIMIZING APPLICATION.
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LI ZHENG GUI, WANG BO, ZHANG JIA RONG, YANG FENG YU, REN MING YUE, WANG SHI SONG, and LIU XIAO BING
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TURBINE blades , *HYDRAULICS , *SIMULATION methods & models , *SINGLE frequency network , *FLUCTUATIONS (Physics) - Abstract
In application, it is vitally important to study the characteristics of unit generating capacity and stability within on-cam zone of the low head turbine. According to the actual position of the guide vane and blade. This paper performed theoretical analysis of hydraulic loss and stability. Experimentally, we investigated this topic with the numerical simulation and test the theoretic value in the real instruments. We found out that the greater the deviation from the on-cam point, the more complex the draft tube vortex structure, and the larger area the vortex core occupied, the lower efficiency of the system. Within the on-cam zone, the farther it is from the on-cam point, the more are the flow separation vortexes. At the same time, it appears a rule that the vortex core frequency evolves from a single frequency doubling to guild vane frequency multiplier (×16), finally to runner frequency multiplier (×4). It also appears a rule that with the vortex core evolving with time, the pressure fluctuation is increasing, and at the on-cam point, the percentage of deviation in the guide vane opening and percentage increase in pressure fluctuation is approximately linearly distributed. [ABSTRACT FROM AUTHOR]
- Published
- 2016
17. CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation.
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Li, Chang Xian, Ling, Chang Chun, Shao, Yan, Xu, Aimin, Li, Xiang Cheng, Ng, Kevin Tak-Pan, Liu, Xiao Bing, Ma, Yuen Yuen, Qi, Xiang, Liu, Hui, Liu, Jiang, Yeung, Oscar Wai Ho, Yang, Xin Xiang, Liu, Qing Sheng, Lam, Yin Fan, Zhai, Yuan, Lo, Chung Mau, and Man, Kwan
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T cells , *LIVER tumors , *TUMOR treatment , *CANCER relapse , *LIVER cancer , *LIVER transplantation , *LABORATORY rats - Abstract
Background & Aims Liver graft injury and tumor recurrence are the major challenges of liver transplantation for the patients with hepatocellular carcinoma (HCC). Here, we aimed to explore the role and mechanism of liver graft injury mobilizing regulatory T cells (Tregs), which lead to late phase tumor recurrence after liver transplantation. Methods The correlation among tumor recurrence, liver graft injury and Tregs mobilization were studied in 257 liver transplant recipients with HCC and orthotopic rat liver transplantation models. The direct roles of CXCL10/CXCR3 signaling on Tregs mobilization and tumor recurrence were investigated in CXCL10 −/− and CXCR3 −/− mice models with hepatic IR injury. Results Clinically, patients received the graft with graft weight ratio (GWR) <60% had higher HCC recurrence after liver transplantation than the recipients with GWR ⩾60% graft. More circulating Tregs and higher intragraft TLR4/CXCL10/CXCR3 levels were detected in recipients with GWR <60% graft. These results were further validated in rat transplantation model. Foxp3 + cells and expressions of TLR4, CXCL10, TGFβ, CTLA-4 and CD274 were increased in rat liver tumor tissues from small-for-size graft group. In mouse model, the mobilization and recruitment of Tregs were decreased in TLR4 −/− , CXCL10 −/− and CXCR3 −/− mice compared to wild-type mice. Moreover, less CXCR3 + Tregs were recruited into liver in CXCL10 −/− mice after hepatic IR injury. The knockout of CXCL10 and depletion of Tregs inhibited tumor recurrence after hepatic IR injury. Conclusion CXCL10/CXCR3 signaling upregulated at liver graft injury directly induced the mobilization and intragraft recruitment of Tregs, which further promoted HCC recurrence after transplantation. Lay summary There were positive correlation among tumor recurrence, circulating Tregs and liver graft injury after human transplantation for HCC patients. The knockout of CXCL10 decreased hepatic recruitment of CXCR3 + Tregs and late phase tumor recurrence after hepatic IR injury. [ABSTRACT FROM AUTHOR]
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- 2016
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18. Regulatory B cells accelerate hepatocellular carcinoma progression via CD40/CD154 signaling pathway.
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Shao, Yan, Lo, Chung Mau, Ling, Chang Chun, Liu, Xiao Bing, Ng, Kevin Tak-Pan, Chu, Andrew Chi Yuen, Ma, Yuen Yuen, Li, Chang Xian, Fan, Sheung Tat, and Man, Kwan
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B cells , *LIVER cancer , *CANCER invasiveness , *CD40 antigen , *CELLULAR signal transduction , *TUMOR growth , *PROGNOSIS - Abstract
Human hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide with a poor prognosis of limited survival. The role of regulatory B cell (Breg), a new important B cell subset, in HCC progression remains unclear. We firstly found that the percentage of B cells at tumor margin was significantly higher than that in tumor and non-tumor regions. Especially, increased intrahepatic B cells at tumor margin were positively associated with tumor invasive features and more tumor recurrence. Besides, HCC patients had a significantly higher percentage of circulating Bregs than healthy people. Increased circulating Bregs were correlated with advanced tumor staging, tumor multiplicity and venous infiltration. Next, we firstly revealed that human Bregs promoted HCC tumor growth independent of Tregs in SCID mice. The migration of Bregs from blood into tumor was also confirmed in mice. Finally, we further explored the molecular mechanism of Bregs promoting proliferation and migration of HCC cells in vitro . Bregs promoted HCC growth and invasiveness by directly interacting with liver cancer cells through the CD40/CD154 signaling pathway. [ABSTRACT FROM AUTHOR]
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- 2014
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19. Prediction of enhanced thermoelectric performance in two-dimensional black phosphorus nanosheets.
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Cui, Yang-Fan, Duan, Shuai, Chen, Xin, Yang, Man-Man, Yang, Bing-Chao, Yi, Wen-Cai, and Liu, Xiao-Bing
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FORECASTING , *THERMOELECTRIC materials , *TRANSPORT theory , *PHOSPHORUS , *THERMAL conductivity - Abstract
Because of the unique layered structure, black phosphorus (BP) provides a possibility of relatively independent control in electrical and thermal conductivity for thermoelectrical applications. It is therefore of great interest to realize high-performance BP-based thermoelectrics as flexible non-toxic and ultralight devices in spite of the low energy conversion efficiency and structural instability of the bulk BP. In this work, we systematically study the thermoelectric properties for the two-dimensional BP from mono-layer up to quad-layer by first-principles calculations and Boltzmann transport theory. It can be concluded from the calculations that the thermoelectric performance of BP nanosheets can be effectively optimized by tuning the layer thickness. We reveal that the maximum ZT values at 300 and 500 K can reach up to 0.45 and 0.90 in p -type bi-layer BP along armchair direction, respectively, around 5 times higher than that of the bulk at room temperature. The high performance in bi-layer BP is mainly attributed to its highly anisotropic and degenerate carrier pockets. Accordingly, we further propose that the formation of BP/h-BN heterostructure can enhance ZT up to 1.2 at 500 K, which facilitates the real application of thin BP for flexible and eco-friendly thermoelectrics. • Black phosphorus (BP) nanosheets can be effectively optimized by tuning the layer thickness. • An obviously improved ZT of around 1.0 is predicted in bi-layer BP, compared with the bulk counterpart. • High ZT of bi-layer BP is mainly attributed to its unique anisotropic and highly degenerate band structure. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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