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Your search keyword '"Yong Wang"' showing total 2 results
Start Over Author "Yong Wang" Topic medical sciences Publication Year Range Last 50 years Publisher american association for the advancement of science
2 results on '"Yong Wang"'

1. DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension.

Author

Yi Yan, Yang-Yang He, Xin Jiang, Yong Wang, Ji-Wang Chen, Jun-Han Zhao, Jue Ye, Tian-Yu Lian, Xu Zhang, Ru-Jiao Zhang, Dan Lu, Shan-Shan Guo, Xi-Qi Xu, Kai Sun, Su-Qi Li, Lian-Feng Zhang, Xue Zhang, Shu-Yang Zhang, and Zhi-Cheng Jing

Subjects
*BONE morphogenetic protein receptors, *DNA methyltransferases, *MEDICAL sciences, *PULMONARY hypertension, *VASCULAR endothelial growth factor receptors, *VASCULAR remodeling
Abstract

The article discusses the critical role of DNA methylation in the vascular pathology of pulmonary hypertension (PH). Topics include a study which showed that global DNA methylation in the lungs of PH rat models following monocrotaline administration or hypobaric hypoxia exposure, the up-regulation of DNA methyl-transferase 3B (DNMT3B), and the migration of pulmonary artery smooth muscle cells (PASMC).

Published
2020
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2. Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.

Author

Xiao Ma, Ping Zhu, Yonghe Ding, Hong Zhang, Qi Qiu, Dvornikov, Alexey V., Zheng Wang, Maengjo Kim, Yong Wang, Lowerison, Matthew, Yue Yu, Norton, Nadine, Herrmann, Joerg, Ekker, Stephen C., Hsiai, Tzung K., Xueying Lin, and Xiaolei Xu

Subjects
*ANTHRACYCLINES, *RETINOID X receptors, *MEDICAL sciences, *TIGHT junctions, *CARDIOTOXICITY, *RETINOIC acid receptors, *PHARMACOLOGY, *PLURIPOTENT stem cells
Abstract

The article presents a study on how retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Topics discussed include unrecognized spatiotemporally-predominant mechanism that shall inform future translational efforts; Therapeutic strategies based on these noncardiomyocytes, and remain underexplored; and elucidate the disease mechanisms and to search for potential therapeutic targets, several genetic strategies.

Published
2020
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