18 results on '"Viard, Maxime"'
Search Results
2. Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design
- Author
-
Wachter, Rolf, Gröschel, Klaus, Wasser, Katrin, Uhe, Tobias, Schäbitz, Wolf-Rüdiger, Köhrmann, Martin, Dichgans, Martin, Gröschel, Sonja, Uphaus, Timo, Hahn, Marianne, Zuhorn, Frederic, Wulff, Leonard, Plümer, Jorge, Kok, Lena, Janz, Marcel, Kitsiou, Alkisti, Gehmeyr, Julian, Dabbagh, Alhuda, Huber, Charlotte, Pelz, Johann, Wartenberg, Katja, Michalski, Dominik, Seidel, Mirko, Flissakowski, Oscar, Goschenhofer, Anna, Hussain, Rabia-Basari, Kim, Ina, Kinze, Stephan, Kroneberger, Christian, Lingnau, Michale, Lischewski, Dennis, Muhn, Florian, Rogge, Witold, Schieffer, Miriam, Setayesh-Roonizi, Anuscheh, Sparenberg, Paul, Schertel, Jill Marie, Ringleb, Peter, Purrucker, Jan, Berberich, Anne, Heyse, Miriam, Ungerer, Matthias, Bauer, Gregor, Reichardt, Christine, Etgen, Thorleif, Ebel, Bernhard, Milanković-Eberl, Dragana, Schwarte, Olav, Höcherl, Constanze, Asch, Eric-Manuel, Bojtschuk, Luisa, Frey, Maximilian, Dlouhy, Tomas, Ertl, Michael, Zickler, Philipp Patrick, Beier, Barbara, Braadt, Lino-Dominic, Gabrielyan, Inessa, Kermer, Pawel, Kaste, Matthias, Anter, Ahmed, Stirbulescu, Corina, Meleshchenco, Nataliia, Burgholte, Friederike, Lüers, Claus, Steiner, Thorsten, Cierpinski, Mari-Carmen, Lichti, Bethke, Florian, Bonowski, Lars, Eid, Hassan Abou, Vajda-Medina, Esteban, Probst, Mareike, Essa, Hisham, Frank, Benedikt, Stolte, Benjamin, Milles, Lennart, Soda, Hassan, Hiermann, Erich, Rascher, Renate Weinhardt Alexandra, Stan, Marius, Kääb, Stefan, Kellert, Lars, Dimitriadis, Konstantinos, Kopczak, Anna, Küster, Bettina, Sinner, Moritz, Steiger, Ignaz, Kaffe, Maria, Clauß, Sebastian, Janowitz, Daniel, Thaler, Raffael, Schellinger, Peter, Glahn, Jörg, Schubert, Jan, Jenniges, Simone, Markmann-Boenke, Silke, Putzer, Anne-Sophie, Straeten, Michael Schwarze Vera, Wiemer, Marcus, Kallmünzer, Bernd, Macha, Kosmas, Haupenthal, David, Balk, Stefanie, Kossel, Clara-Sophie, Häusler, Georg, Lehrieder, Dominik, Cidlinsky, Peter, Hametner, Christian, Vogl, Christine, Fischer, Thomas, Huttelmaier, Moritz, Nordbeck, Octavian Maniuc Peter, von Hardenberg, Albrecht, Jünemann, Martin, Braun, Tobias, Viard, Maxime, Gerner, Stefan, Omar, AlHaj, Genau, Sonja, Olbricht, Linus, Wassenberg, Matthias, Langguth, Niklas, Fräbel, Christian, Baumgart, Romy, Kalra, Love-Preet, Diel, Norma, Hoffmann, Frank, Kraft, Andrea, Schönmuth, Bettine, Giebler, Anja, Weber, Lorenz, Grond, Martin, Birringer, Jan, Lichte-Schneider, Sandra, Hütwohl, Daniela, Krause, Lars Udo, Petersen, Martina, Althaus, Katharina, Kirchmeier, Konstantin, Novikova, Liubov, Müller, Susanne, Schellong, Sebastian, Brudzinski, Mirko, Gerk, Ulrich, Palisch, Holger, Heinzel, Frank R., Fett, Jana, Suntha, Avinash, Burian, Katja, Schmitz, Bettina, Gutwinski, Anna, Angermüller, Veronika, Alhammoud, Tameem, Cakiroglu, Hüsniye, Bach, Ullrich, Nabavi, Darius, Offermann, Jens, Crome, Olaf, Dimitrijeski, Boris, Meincke, Carsten, Hamann, Gerhard, Alber, Burkhard, Müller, Robert, Pallesen, Lars-Peder, Pütz, Volker, Hartmann, Christian, Berrouschot, Jörg, Stoll, Anett, Keilitz, Janina, Klunk, Dietrich, Voigt, Roman, Kastrup, Andreas, Schröter, Andreas, Schmucker, Johannes, Pfeilschifter, Waltraud, Krämer, Christoffer, Wiemers, Milena, Simon, Micha, Finke, Alexander, Weiß, Christian, Hobohm, Carsten, Naupold, Katrin, Bley-Renning, Karen, Winter, Sabrina, Poli, Sven, Mengel, Annerose, Poli, Khouloud, Expósito, Alexandra Gómez, Mbroh, Joshua, Tieck, Maria, Rosenkranz, Michael, Boskamp, Stefan, Ritter, Nicolas, Seibel, Lena, Schöps, Christian, Ketzler, Rebecca, Nägele, Herbert, Sydow, Karsten, Kurka, Natalia, Schäfer, Jan Hendrik, Charisse, Daniel, Gruber, Katharina, Kohlhase, Konstantin, Lieschke, Franziska, Operhalski, Felix, Seiler, Alexander, Petzold, Gabor, Bode, Felix Jürgen, Stösser, Sebastian, Meißner, Julius, Ebrahimi, Taraneh, Nordsiek, Julia, Beckonert, Niklas, Weissenborn, Karin, Große, Gerrit Maximilian, Worthmann, Hans, Hennemann, Ann-Katrin, Jochmann, Svenja, Gründahl, Julius, Al-Ayoubi, Jana, Ernst, Johanna, Bähr, Oliver, Gruber, Herbert, Benesch, Sonka, Pollinger, Thomas, Alachkar, Nawar, Busch, Sonia, Butz, Steffi, Forkmann, Mathias, Mahnkopf, Christian, Mischke, Thomas, Schnupp, Steffen, Thomalla, Götz, Deb-Chatterji, Milani, Cheng, Bastian, Gelderblom, Mathias, Hoppe, Julia, Jensen, Märit, Schell, Maximilian, Schlemm, Eckhard, Marquardt, Lars, Kazarians, Haiko, Rheingans, Pia Franziska, Hötzer, Kai, Rose, Dietmar, Neumann-Haefelin, Tobias, Berthel, Jörg, Alijaj, Lirim, Krug, Joachim, Niethammer, Margit, Szöllösi, Géza-Attila, Obermann, Marc, Adochitei, Nicoletta, Strik, Herwig, Lenz, Arne, Steigerwald, Frank, Müller, Jörg, Honermann, Martin, Burgstaller, Marian Christoph, Kollmar, Rainer, Rashid, Maryam, Ganai, Ahmad Ajaz, Ossendorf, Saric, Majda, Tischer, Karl-Heinz, Toluli, Adela, Wollenweber, Frank Arne, Rahban, Laya, Silva, Thais Portugal, Lee, Miri, Grosch, Matthias Julius, Minnerup, Jens, Liman, Jan, Nückel, Martin, Böhm, Magdalena, Weber-Krüger, Mark, Brachmann, Johannes, Laufs, Ulrich, Gelbrich, Götz, Petroff, David, Prettin, Christiane, Schellinger, Peter D., Hamann, Gerhard F., Mende, Meinhard, and Wagner, Marcus
- Published
- 2023
- Full Text
- View/download PDF
3. Neuromuscular sonography detects changes in muscle echotexture and nerve diameter in ICU patients within 24 h
- Author
-
Bulinski, Catherine, Viard, Maxime, Vlazak, Alexander, Habig, Kathrin, Juenemann, Martin, Best, Christoph, Schirotzek, Ingo, Kaps, Manfred, and Krämer, Heidrun H.
- Published
- 2022
- Full Text
- View/download PDF
4. Age-related changes in oral sensitivity, taste and smell
- Author
-
Braun, Tobias, Doerr, Johanna M., Peters, Laura, Viard, Maxime, Reuter, Iris, Prosiegel, Mario, Weber, Susanne, Yeniguen, Mesut, Tschernatsch, Marlene, Gerriets, Tibo, Juenemann, Martin, Huttner, Hagen B., and Hamzic, Samra
- Published
- 2022
- Full Text
- View/download PDF
5. Superficial siderosis as a rare cause of visual and auditory pseudohallucinations: a case report
- Author
-
Braun, Tobias, Viard, Maxime, Struffert, Tobias, AlhajOmar, Omar, Yeniguen, Mesut, and Juenemann, Martin
- Published
- 2021
- Full Text
- View/download PDF
6. Facilitation of oral sensitivity by electrical stimulation of the faucial pillars
- Author
-
Braun, Tobias, Hamzic, Samra, Doerr, Johanna M., Peters, Laura, Viard, Maxime, Reuter, Iris, Prosiegel, Mario, Weber, Susanne, Yenigün, Mesut, Tschernatsch, Marlene, Gerriets, Tibo, and Juenemann, Martin
- Published
- 2021
- Full Text
- View/download PDF
7. Adjustment of oral diet based on flexible endoscopic evaluation of swallowing (FEES) in acute stroke patients: a cross-sectional hospital-based registry study
- Author
-
Braun, Tobias, Juenemann, Martin, Viard, Maxime, Meyer, Marco, Reuter, Iris, Prosiegel, Mario, Kaps, Manfred, and Tanislav, Christian
- Published
- 2019
- Full Text
- View/download PDF
8. Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
- Author
-
Braun, Tobias, Viard, Maxime, Juenemann, Martin, Struffert, Tobias, Schwarm, Frank, Huttner, Hagen B., and Roessler, Florian C.
- Subjects
Neurology ,Covid-19-vaccination ,ChAdOx1 nCoV-19 vaccine ,Case Report ,cerebral venous thrombosis ,Neurology (clinical) ,vaccine-induced thrombotic thrombocytopenia ,Neurology. Diseases of the nervous system ,RC346-429 ,thrombotic thrombocytopenia syndrome - Abstract
We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time of emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after the onset of the symptom, the first MR-angiography provided no evidence of CVST. Follow-up imaging, performed upon headache refractory to nonsteroidal pain medication verified CVST 2–10 days after initial negative MRI. Both the patients received combined treatment with intravenous immunoglobulins and parenteral anticoagulation leading to an increase of platelet concentration in both the individuals and resolution of the occluded cerebral sinus in one patient.
- Published
- 2021
9. Neuromuscular sonography detects changes in muscle echotexture and nerve diameter in ICU patients within 24 h
- Author
-
Bulinski, Catherine, primary, Viard, Maxime, additional, Vlazak, Alexander, additional, Habig, Kathrin, additional, Juenemann, Martin, additional, Best, Christoph, additional, Schirotzek, Ingo, additional, Kaps, Manfred, additional, and Krämer, Heidrun H., additional
- Published
- 2021
- Full Text
- View/download PDF
10. Case Report: A Well-Hidden Cause for Myelopathy
- Author
-
Braun, Tobias, Schulz, Eva, Viard, Maxime, AlhajOmar, Omar, Struffert, Tobias, Gattenlöhner, Stefan, Yenigün, Mesut, Juenemann, Martin, and Justus Liebig University Giessen
- Subjects
spinal cord syndrome ,ddc:610 ,neurosarcoidosis ,myelopathy ,bone marrow sarcoidosis ,case report ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Introduction: Sarcoidosis is a rare, systemic inflammatory disease and can involve multiple organs, especially the lungs and lymph nodes. The nervous system is affected in
- Published
- 2021
11. Facilitation of Oral Sensitivity by Electrical Stimulation of the Faucial Pillars
- Author
-
Braun, Tobias, primary, Hamzic, Samra, additional, Doerr, Johanna, additional, Peters, Laura, additional, Viard, Maxime, additional, Reuter, Iris, additional, Prosiegel, Mario, additional, Weber, Susanne, additional, Yenigün, Mesut, additional, Tschernatsch, Marlene, additional, Gerriets, Tibo, additional, and Juenemann, Martin, additional
- Published
- 2021
- Full Text
- View/download PDF
12. Flexible endoscopic evaluation of swallowing (FEES) to determine neurological intensive care patients’ oral diet
- Author
-
Braun, Tobias, primary, Juenemann, Martin, additional, Viard, Maxime, additional, Meyer, Marco, additional, Reuter, Iris, additional, Mausbach, Stefan, additional, Doerr, Johanna M., additional, Schirotzek, Ingo, additional, Prosiegel, Mario, additional, Schramm, Patrick, additional, Kaps, Manfred, additional, and Tanislav, Christian, additional
- Published
- 2020
- Full Text
- View/download PDF
13. Adjustment of oral diet based on flexible endoscopic evaluation of swallowing (FEES) in acute stroke patients.A cross-sectional hospital-based registry study.
- Author
-
Braun, Tobias, primary, Juenemann, Martin, additional, Viard, Maxime, additional, Meyer, Marco, additional, Reuter, Iris, additional, Prosiegel, Mario, additional, Kaps, Manfred, additional, and Tanislav, Christian, additional
- Published
- 2019
- Full Text
- View/download PDF
14. MOESM1 of Adjustment of oral diet based on flexible endoscopic evaluation of swallowing (FEES) in acute stroke patients: a cross-sectional hospital-based registry study
- Author
-
Braun, Tobias, Juenemann, Martin, Viard, Maxime, Meyer, Marco, Reuter, Iris, Prosiegel, Mario, Kaps, Manfred, and Tanislav, Christian
- Subjects
cardiovascular diseases - Abstract
Additional file 1: Table S1. Differences in baseline characteristics between patients with normal swallowing function versus those with clinically relevant dysphagia in the subgroup of patients with ischemic stroke. Table S2. Differences in baseline characteristics between stroke patients with and without change in oral diet in the subgroup of patients with ischemic stroke. Table S3. Binaryl logistic regression analysis for pneumonia in ischemic stroke patients. Table S4. Binary logistic regression analysis for intubation in ischemic stroke patients.
- Published
- 2019
- Full Text
- View/download PDF
15. Flexible endoscopic evaluation of swallowing (FEES) to determine neurological intensive care patients' oral diet.
- Author
-
Braun, Tobias, Juenemann, Martin, Viard, Maxime, Meyer, Marco, Reuter, Iris, Mausbach, Stefan, Doerr, Johanna M., Schirotzek, Ingo, Prosiegel, Mario, Schramm, Patrick, Kaps, Manfred, and Tanislav, Christian
- Subjects
PNEUMONIA ,LENGTH of stay in hospitals ,TRACHEOTOMY ,NEUROLOGICAL disorders ,STROKE ,CRITICALLY ill ,RESPIRATORY aspiration ,PATIENTS ,DEGLUTITION disorders ,DIET ,INGESTION ,MANN Whitney U Test ,NIH Stroke Scale ,ARTIFICIAL respiration ,FEEDING tubes ,SEVERITY of illness index ,DISABILITIES ,FOOD ,CHI-squared test ,DESCRIPTIVE statistics ,DATA analysis software ,ENDOSCOPY - Abstract
Dysphagia is common in critically ill neurological patients and is associated with a high mortality and morbidity. Data on the usefulness of flexible endoscopic examination of swallowing (FEES) in neurological intensive care unit (ICU) patients are lacking, raising the need for evaluation. FEES was performed in neurological intensive care patients suspected of dysphagia. We correlated findings with baseline data, disability status, pneumonia and duration of hospitalisation, as well as a need for mechanical ventilation or tracheotomy. This analysis consisted of 125 patients with suspected dysphagia. Most of the patients (81; 64,8%) suffered from acute stroke. Dysphagia was diagnosed using FEES in 90 patients (72%). FEES results led to dietary modifications in 80 patients (64%). The outcome at discharge was worse in dysphagic stroke patients diagnosed by FEES as compared to non-dysphagic stroke patients (p = 0.009). Patients without oral diet had higher need for intubation (p = 0.007), tracheotomy (p = 0.032) and higher mortality (p < 0.001) in comparison to patients with at least small amounts of oral intake. As the clinical assessment of the patients often classified the dysphagia incorrectly, the broad use of FEES in ICU patients might help to adequately adjust patients' oral diet. This knowledge might contribute to lower mortality and morbidity. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
16. What is the value of fibre-endoscopic evaluation of swallowing (FEES) in neurological patients? A cross-sectional hospital-based registry study
- Author
-
Braun, Tobias, primary, Juenemann, Martin, additional, Viard, Maxime, additional, Meyer, Marco, additional, Fuest, Sven, additional, Reuter, Iris, additional, Kaps, Manfred, additional, Prosiegel, Mario, additional, and Tanislav, Christian, additional
- Published
- 2018
- Full Text
- View/download PDF
17. PTPIP51 ein multifunktionales Protein im Gehirn
- Author
-
Viard, Maxime Jean and Justus Liebig University Giessen
- Subjects
ddc:610 ,PTPIP51 ,brain ,glioblastoma ,PTP1B ,Gehirn ,14.3.3 beta ,Glioblastom - Abstract
PTPIP51 wird in mehreren spezifischen Gehirnarealen wie dem Kleinhirn, demHippocampus, dem Nucleus paraventrikularis, dem Nucleus supraopticus, demNucleus accumbens, dem piriformen Kortex, den Colliculi superiores, den Peduncullicerebelli inferiores, dem Genu nervi facialis, dem spinalen Trigeminaltrakt und in derNeurohypophyse exprimiert. Diese lokal differente Expression ermöglicht dieBeteiligung an einer Vielzahl von funktionellen Prozessen wie zum Beispiel optischenReflexen, Lernprozessen, Gedächtnisbildung, Emotionen, Gleichgewicht,Orientierung, Hyposmie bei Morbus Parkinson. Schizophrenie und Depression.Auf zellulärer und subzellulärer Ebene zeigt sich ebenfalls ein sehr heterogenesExpressionsmuster des PTPIP51. Das PTPIP51 interagiert mit der PTP1B, dem 14-3-3beta und dem Neurophysin II. Durch diese Interaktionen greift PTPIP51 inzahlreiche essentielle Signalwege wie den MAPK-, den CNTF- und den NGF- Signalwegein. Deshalb ist eine der Hauptfunktionen des PTPIP51 im Nervengewebewohl die Regulation von Proliferation, Differenzierung, Migration und desVesikeltransports. Neben diesen Funktionen kann dem PTPIP51 bedingt durch seineInvolvierung in diesen Signalwegen eine wichtige Rolle in der Pathogenese vonErkrankungen wie zum Beispiel dem Glioblastom und anderen Hirntumoren, derAlzheimer-Demenz und dem Morbus Parkinson zukommen. Dies macht dasPTPIP51 nicht nur für die Grundlagenforschung, sondern auch für die Klinikinteressant.Die heterogene PTPIP51-Expression und dessen Funktionen lassen sich mit derExistenz möglicher Isoformen des PTPIP51 erklären und wird durch dieunterschiedliche Verteilung mit peptidspezifischen Antikörpern nachgewiesenerFormen gezeigt.Auf Grund seiner weit gefächerten Funktionen im ZNS kann man das PTPIP51 auchals ein multifunktionales Protein des Nervengewebes bezeichnen.Diese Arbeiten stellen die Basis für weitere interessante Studien des PTPIP51 imZNS dar.So laufen bereits weitere Versuche mit kultivierten Glioblastomzellen, die dieWirkung von Chemotherapeutika (PD98059, Gefitinib, Cetuximab) auf die PTPIP51-Expression analysieren. Außerdem wird untersucht, ob die Expressionsrate desPTPIP51 in Ependymomen als möglicher Marker für verschiedene Stadien etabliertwerden kann. Die Rolle von PTPIP51 bei der erhöhten Ausschüttung von Oxytocin inweiblichen Ammenratten soll weiteren Aufschluss über die Funktion im axonalenTransport geben.Zusammenfassend kann man sagen, dass diese Arbeit eine wichtige Grundlage fürviele weitere sehr interessante Projekte bezüglich des PTPIP51 im ZNS darstellt. Diekommenden Projekte werden nun das PTPIP51 in Relation zu Erkrankungen undmögliche Nutzung für Diagnose und Therapie stellen., PTPIP51 is expressed in several specific brain areas: the cerebellum, thehippocampus, the paraventricular nucleus, the supraoptic nucleus, the nucleusaccumbens, the piriformal cortex, the superior colliculus, the inferior cerebellarpeduncle, the genu of the facial nerve, the spinal trigeminal tract, theneurohypophysis. This locally restricted different expression allows PTPIP51 to takepart in a multitude of functions e.g. optical reflexes, learning, forming of memories,emotions, equilibrium, orientation, hyposmy in morbus Parkinson, schizophrenia anddepression.On cellular and sub- cellular level PTPIP51 displayed a heterogeneous expression.In brain PTPIP51 interacts with PTP1B,14-3-3 beta and neurophysin II. By theseinteractions PTPIP51 is involved in many essential pathways such as MAPK, CNTFand NGF. Therefore one of the main functions of PTPIP51 in nervous tissue seemsto be the regulation of proliferation, differentiation, migration and vesicle transport.Besides these functions PTPIP51 plays a central role in the genesis of glioblastoma,Alzheimer disease and morbus Parkinson. This stresses the importance of basic andclinical research on PTPIP51.The heterogeneous expression and function of PTPIP51 can be explained bypossible isoforms. This subject was investigated by peptide specific antibodies.Based on the broad spectrum of functions in the CNS PTPIP51 is a real multifunctional protein .The presented manuscript is the basis for many interesting studies of PTPIP51 inCNS.A current study with cultured glioblastoma cells investigates the effects ofchemotherapeutics (PD98059, Gefitinib, Cetuximab) on the expression of PTPIP51.Another study tests whether the grade of PTPIP51- expression in ependymoma is apossible marker for its staging. The role of PTPIP51 in axonal transport is furtherinvestigated in nurse rats using their increased productions of oxytocin as a trigger.In summary this PHD thesis is an important basis for many consecutive studies ofPTPIP51 in CNS in relation to diseases and possibly for the use in diagnosis andtherapy.
- Published
- 2011
- Full Text
- View/download PDF
18. PTPIP51 ein multifunktionales Protein im Gehirn
- Author
-
Viard, Maxime Jean and Institut für Anatomie und Zellbiologie
- Subjects
PTPIP51 ,brain ,glioblastoma ,PTP1B ,ddc:610 ,Gehirn ,14.3.3 beta ,Glioblastom ,Medical sciences Medicine - Abstract
PTPIP51 wird in mehreren spezifischen Gehirnarealen wie dem Kleinhirn, dem Hippocampus, dem Nucleus paraventrikularis, dem Nucleus supraopticus, dem Nucleus accumbens, dem piriformen Kortex, den Colliculi superiores, den Pedunculli cerebelli inferiores, dem Genu nervi facialis, dem spinalen Trigeminaltrakt und in der Neurohypophyse exprimiert. Diese lokal differente Expression ermöglicht die Beteiligung an einer Vielzahl von funktionellen Prozessen wie zum Beispiel optischen Reflexen, Lernprozessen, Gedächtnisbildung, Emotionen, Gleichgewicht, Orientierung, Hyposmie bei Morbus Parkinson. Schizophrenie und Depression. Auf zellulärer und subzellulärer Ebene zeigt sich ebenfalls ein sehr heterogenes Expressionsmuster des PTPIP51. Das PTPIP51 interagiert mit der PTP1B, dem 14- 3-3beta und dem Neurophysin II. Durch diese Interaktionen greift PTPIP51 in zahlreiche essentielle Signalwege wie den MAPK-, den CNTF- und den NGF- Signalweg ein. Deshalb ist eine der Hauptfunktionen des PTPIP51 im Nervengewebe wohl die Regulation von Proliferation, Differenzierung, Migration und des Vesikeltransports. Neben diesen Funktionen kann dem PTPIP51 bedingt durch seine Involvierung in diesen Signalwegen eine wichtige Rolle in der Pathogenese von Erkrankungen wie zum Beispiel dem Glioblastom und anderen Hirntumoren, der Alzheimer-Demenz und dem Morbus Parkinson zukommen. Dies macht das PTPIP51 nicht nur für die Grundlagenforschung, sondern auch für die Klinik interessant. Die heterogene PTPIP51-Expression und dessen Funktionen lassen sich mit der Existenz möglicher Isoformen des PTPIP51 erklären und wird durch die unterschiedliche Verteilung mit peptidspezifischen Antikörpern nachgewiesener Formen gezeigt. Auf Grund seiner weit gefächerten Funktionen im ZNS kann man das PTPIP51 auch als ein multifunktionales Protein des Nervengewebes bezeichnen. Diese Arbeiten stellen die Basis für weitere interessante Studien des PTPIP51 im ZNS dar. So laufen bereits weitere Versuche mit kultivierten Glioblastomzellen, die die Wirkung von Chemotherapeutika (PD98059, Gefitinib, Cetuximab) auf die PTPIP51- Expression analysieren. Außerdem wird untersucht, ob die Expressionsrate des PTPIP51 in Ependymomen als möglicher Marker für verschiedene Stadien etabliert werden kann. Die Rolle von PTPIP51 bei der erhöhten Ausschüttung von Oxytocin in weiblichen Ammenratten soll weiteren Aufschluss über die Funktion im axonalen Transport geben. Zusammenfassend kann man sagen, dass diese Arbeit eine wichtige Grundlage für viele weitere sehr interessante Projekte bezüglich des PTPIP51 im ZNS darstellt. Die kommenden Projekte werden nun das PTPIP51 in Relation zu Erkrankungen und mögliche Nutzung für Diagnose und Therapie stellen. PTPIP51 is expressed in several specific brain areas: the cerebellum, the hippocampus, the paraventricular nucleus, the supraoptic nucleus, the nucleus accumbens, the piriformal cortex, the superior colliculus, the inferior cerebellar peduncle, the genu of the facial nerve, the spinal trigeminal tract, the neurohypophysis. This locally restricted different expression allows PTPIP51 to take part in a multitude of functions e.g. optical reflexes, learning, forming of memories, emotions, equilibrium, orientation, hyposmy in morbus Parkinson, schizophrenia and depression. On cellular and sub- cellular level PTPIP51 displayed a heterogeneous expression. In brain PTPIP51 interacts with PTP1B,14-3-3 beta and neurophysin II. By these interactions PTPIP51 is involved in many essential pathways such as MAPK, CNTF and NGF. Therefore one of the main functions of PTPIP51 in nervous tissue seems to be the regulation of proliferation, differentiation, migration and vesicle transport. Besides these functions PTPIP51 plays a central role in the genesis of glioblastoma, Alzheimer disease and morbus Parkinson. This stresses the importance of basic and clinical research on PTPIP51. The heterogeneous expression and function of PTPIP51 can be explained by possible isoforms. This subject was investigated by peptide specific antibodies. Based on the broad spectrum of functions in the CNS PTPIP51 is a real multifunctional protein. The presented manuscript is the basis for many interesting studies of PTPIP51 in CNS. A current study with cultured glioblastoma cells investigates the effects of chemotherapeutics (PD98059, Gefitinib, Cetuximab) on the expression of PTPIP51. Another study tests whether the grade of PTPIP51- expression in ependymoma is a possible marker for its staging. The role of PTPIP51 in axonal transport is further investigated in nurse rats using their increased productions of oxytocin as a trigger. In summary this PHD thesis is an important basis for many consecutive studies of PTPIP51 in CNS in relation to diseases and possibly for the use in diagnosis and therapy.
- Published
- 2011
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.