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The article focuses on a paper presenting studies on vascular skin responses in atopic dermatitis. A rough psychiatric classification of patients with flexural prurigo would divide them into the extroverted and the introverted. The former give a normal response to intradermal histamine, in the latter the flare fails to appear, but in both the reaction may change under the influence of psychiatric treatment or adventitious emotional stimulus.

The article discusses a paper entitled "Toxic Dermatitis Associated With Prednisone Therapy," by C.D. Bonner and F. Homburger, which was published in the 1957 issue of "New English Journal of Medicine." This paper describes a patient with atopic dermatitis who developed an altogether different erythemato-bullous eruption after taking 30 mg of prednisono daily for three weeks.

The article discusses the paper "Use of Unsaturated Fatty Acids in the Eczemas of Childhood," by J.H.S. Pettit. This paper presents a long overdue assessment of the value of unsaturated fatty acids in the treatment of eczema, particularly in view of their recent popularity. Fifteen cases of infantile and atopic eczema were treated with local and oral unsaturated fatty acids. Twelve were treated with usual remedies.

Dry epidermal density (D.E.D.) is defined and a method for its estimation in humans is described. Estimations of D.E.D. in normals and atopics are detailed and provide normal values as well as indicating a significantly higher D.E.D. in atopics. It is suggested that after exposure to a careinogenic stimulus the ratio of exposed to non-exposed D.E.D. could prove to be an index of carcinogenicity of that stimulus. [ABSTRACT FROM AUTHOR]

cAMP-dependent protein kinase activity has been measured in skin biopsies from atopic patients, psoriatic patients, and from healthy volunteers. No significant differences were observed either in the presence or absence of cAMP. [ABSTRACT FROM AUTHOR]

The article presents information about three studies on vascular reactions in chronically inflamed skin. All the studies were carried out on patients suffering for the most part from atopic dermatitis, disseminated neurodermatitis, psoriatic erythrodermia and mycosis fungoides. The first study describes the white dermographism produced by stroking firmly such inflamed skins. It depends on mechanical stimulation of the skin and is independent of any chemical or neural stimulus; it is found only in the chronically inflamed skin and does not occur in acute conditions.

This article focuses on the paper "Tar and the Skin," by P.D.C. Kinmont. The paper focuses on the purified tar preparation that was found to be cosmetically more acceptable than prepared coal tar. Beneficial results were observed in 81% of all patients treated with the synthetic tar, and in 03% with the prepared coal tar.

This article presents information on the paper "Recurrent Varicelliform Eruption (Kaposi)," by H. Teller. The paper describes that recurrent attacks of this condition have been reported occasionally. A young man of 22, who suffered from atopic eczema, had two attacks of varicelliform eruption, proved by demonstration of the virus.

This article discusses the paper "Atopic Dermatitis: A Study of its Natural Course and of Wool As a Dominant Allergenic Factor," by Earl D. Osborne and Philip F. Murray. Authors are convinced that wool is the dominant allergen in atopic dermatitis. Contact is not only to woollen garments but also to house dust, which they find contains a percentage of wool fibre. If this rises to 2% or over, as occurs when houses are shut up and centrally heated for the winter, the dermatitis becomes worse, and they thus explain the seasonal occurrence or deterioration of atopic dermatitis in the Buffalo area during the cold months of the year and its improvement if the patient moves to a climate such as Florida where windows can be kept open all the year round.

The article focuses on a study related to the investigations on the serum of a case of atopic eczema. Elimination of flour and milk from the diet of an adult atopic patient caused remission of symptoms on two occasions. Relapses followed a return to full diet. Investigations showed hypoglycaemia, hypercholesterolaemia and a low serum lipase.

The distribution pattern of immunoglobulin- or complement-bearing lymphocytes in healthy controls and in patients with contact dermatitis and with atopic dermatitis has been investigated. A significant predominance of IgD- and C3-bearing lymphocytes was found in ten patients with contact dermatitis. In atopic dermatitis patients the number of IgE- and to a lesser extent of C3-bearing lymphocytes was increased. The results indicate induction or stimulation of two distinct classes of immunologically competent lymphoid cell lines, one in contact and the other in atopic dermatitis. The increased number of B-cells in dermatitis indicates a decreased T-cell population and suggests a deficiency or disturbance of the recirculation of this population. [ABSTRACT FROM AUTHOR]

The kinetics of the enzymes hexokinase, glucose-6-phosphate dehydrogenase, and malate dehydrogenase have been determined and compared in pooled isolated sweat glands from normal and atopic subjects. No significant differences could be detected in the kinetic constants Vmax, and Km for any of the substrates or co-factors studied in the two groups of subjects. The results of these experiments are discussed in relation to the current concepts regarding atopy and atopic dermatitis. [ABSTRACT FROM AUTHOR]

This article focuses on the paper "Allergic Contact Dermatitis Caused By Wood Preservatives Containing Chromates," by P. Behrbohm. Report of 15 cases of contact dermatitis due to wood preservatives containing chromates, mostly potassium bichromate.

The article presents information on several research articles related to the field of dermatology that were published in the year 1955. A research paper titled "Histochemical Evidence for Human Eccrine Sweat Duct Activity," by Walter C. Lobitz, John B. Holyoke, and Doris Brophy, presents evidence, which indicates that the cells lining the sweat ducts are metabolically active. In a study titled "Occurrence of Cataracts and Keratoconus With Atopic Dermatitis," by Louis A. Bruksting, William B. Reed and Hugo L. Blair, keratoconus was found in 6 patients with atopic dermatitis, 3 of whom also had minor lenticular opacities.

The article focuses on a paper that presents observations on peripheral circulation in various dermatoses. Additional evidence of a vascular dysfunction in patients with scleroderma, psoriasis and lupus erythematosus is seen abnormal photoelectric plethysmograms of the fingers in these diseases compared with normal subjects and patients suffering from a variety of dermatoses including atopic dermatitis.

The judicious use of steroid preparations under polythene film has revolutionized the treatment of chronic psoriasis and other intractable genodermatoses such as atopic eczema. However, occlusive therapy can be tedious and many patients who have established satisfactory control with occlusion become neglectful in its use and suffer disappointing recurrences. There is no suitable alternative treatment for those patients, who must persist with occlusion in order to maintain maximal control of their dermatoses, other than methotrexate and/or oral steroids. It would indeed be ideal if a relatively inexpensive topical steroid could be presented In a base so penetrating that it would obviate the need for occlusion in the management of persistent recurring dermatoses. [ABSTRACT FROM AUTHOR]

The application of a continuous fluorimetric assay technique to carboxylic ester hydrolases (including the cholinesterases) in skin is described. The kinetic properties of guinea-pig skin preparations from different anatomical sites are reported. The in vitro and in vivo effects of propranolol and some other pharmacological compounds on carboxylic ester hydrolases from guinea-pig skin are described. The results are discussed in relation to atopy. [ABSTRACT FROM AUTHOR]

The cutaneous reactions produced by the irritant compounds o-chlorobenzylidenemalononitrile, and ω-chloroacetophenone, have been studied on human subjects. ω-Chloroacetophenone has been shown to present a far greater cutaneous hazard than o-chlorobenzylidenemalononitrile when applied directly to the skin. The cutaneous reactions produced are worse when the irritant is moistened. [ABSTRACT FROM AUTHOR]

Six cases of allergic reactions to green algae are recorded. Five patients had atopic dermatitis in which exacerbations were provoked both by inhalation and by direct contact with algae. These patients also reacted to lichens, which contain algae in symbiosis with fungi. Five of the patients had allergic rhinitis or asthma, often very mild in relation to the severity of the skin symptoms. Three of the patients also had a delayed hypersensitivity contact dermatitis from lichens, but not from algae. It is important to investigate patients with suspected sensitivities to lichens and algae both by patch testing and by prick testing as specific desensitization may help those patients with immediate weal reactions. [ABSTRACT FROM AUTHOR]

In 16 months contact dermatitis from an optical whitener, Tinopal CH 3566, was diagnosed in 167 patients at the Finsen Institute. The dermatitis presented as a textile dermatitis. Since ‘Tinopal’ covers a wide range of chemically unrelated optical whiteners, the designation ‘CPY’ is introduced for the particular pyrazoline derivative implicated in this dermatitis. This product sensitized 16 of 20 animals in the guinea-pig maximization test: this rates this optical whitener as a strong sensitizer. The result of patch testing in some of the patients with a number of pyrazoline derivatives points to the 4-position in the pyrazoline ring and the para-position in the 1-benzyl-ring as key positions. Benzylsalicylate evoked a positive reaction in 16 of 88 patients. Seven of 13 patients showed a positive patch test to ‘Nylon’ washed in a detergent containing the brightener. [ABSTRACT FROM AUTHOR]

The article focuses on some of the case studies of skin diseases that were presented at the West of England Dermatological Society. A girl aged 9 years had Staphylococcal infection of right arm aged 6 days, broncho-pneumonia aged 6 weeks, atopic eczema of face and scalp aged 6 months, measles aged 4 years, massive pyodermia of left arm aged 5 years for which she was admitted to hospital. A man aged 30 had a hoarse voice and his facial skin bruises after shaving. There is no history of repeated skin infection, but about twice yearly he has ulceration of the mouth associated with upper respiratory infections. There is no history of epilepsy.

The incidence of atopy in 37 cases of proven nickel contact dermatitis is given. Eleven per cent had both a personal and a family history of atopy, 14 % had a personal history only and 19 % had a family history only. This incidence is probably no greater than that of atopy in the general population. The literature on the subject is reviewed and it is concluded that nickel sensitivity and atopy unrelated. [ABSTRACT FROM AUTHOR]

The article reports on abnormal vascular reactions in atopic eczema. Although reaginic antibodies are very frequently detectable in patients with atopic eczema, they are probably not concerned in the initiation of the eczema and in only a minority of cases do they determine the exacerbations and relapses. The vasoconstriction of large vessels is shown by the low temperature of the fingers, more rapid fall in skin temperature on cooling and has been confirmed by plethysmography. The same occurs in atopic eczema but after an interval of one half to five minutes an area of blanching spreads out from the edge of the wheal and slowly replaces the flare.

Eight patients with atopic eczema have been studied. All experiments have been performed on skin overlying the middle third of the anterior surface of the tibia using polythene as the rubbing agent. Three of these patients, although the skin over the anterior surface of the tibia appeared clinically normal, appeared to be abnormally resistant to friction in that they did not produce blisters until they had received several times the amount of friction necessary to produce blisters in a group of normal subjects. Possible mechanisms of this are discussed. Owing to this abnormal resistance to friction it was possible to administer daily to the same site on such a patient, without producing a blister, several times the number of rubs needed to produce a blister in a normal person. The skin reacted to this by producing a patch of lichenification. No comparable change could be produced in a normal person. [ABSTRACT FROM AUTHOR]

Positive skin tests occurred in two-thirds of the children with atopic eczema while all the children in the control group were negative to these tests. Over 80% of the children tested gave virtually the same results six months later. Reactions to egg were the predominant positive result in the first three years of life ; older children were more often positive to pollens. Asthma occurred in 17% of the children and of these 80% were positive to pollens and 20% to egg. Elimination of egg from the diet of egg-sensitive children did not influence their eczema although some produced immediate urticarial reactions when given egg. Skin tests may be of some diagnostic significance hut in this group of children were not related to the severity of the skin disorder. [ABSTRACT FROM AUTHOR]

Presents list of medical cases relating to skin diseases. "Pituitary-adrenocortical functioning in patients with atopic dermatitis," by T. H. Sternberg, P. Butler and M. C. Zimmermann; "Peripheral neuritis in systemic lupus erythematous," by R. H. Heptinstall and G. S. C. Sowry; "Histoplasmosis," by G. Scott; "A case of acanthosis nigricans," by V. Resta

A Statistical study of 102 patients with lichen simplex lesions and a large group of controls shows a significant association between this disease and a personal and family history of atopic disorders. This communication compares the prevalence of a personal and family history of atopy in patients with lichen simplex with that in a control group. [ABSTRACT FROM AUTHOR]

Four cases of cataract with keratoconus are reported in patients suffering from atopic dermatitis. [ABSTRACT FROM AUTHOR]

Two adult patients with both dominant ichthyosis vulgaris and a past history of atopic eczema, who developed recurrent attacks of eczema herpeticum, are described. [ABSTRACT FROM AUTHOR]

Adenyl cyclase activity was measured in biopsy specimens from the lesions of atopic dermatitis, from atopic "uninvolved" skin, and from the skin of healthy controls. No decrease in the level of this enzyme was found in the atopic. [ABSTRACT FROM AUTHOR]

The article discusses a case of a patient suffering from a disease that has occurred due to reaction from green tattoo. On examination he had confluent dermatitis of the ankles, wrists, sides of the neck and popliteal fossa with scattered lesions over the remainder of the body. There was a tender mass in the site of each of four green portions of the tattoo on his left forearm. There is extensive inflammation throughout the cutis, consisting mostly of lymphocytes and a few eosinophils. The inflammatory infiltrate is mostly perivascular in arrangement and does not seem to be particularly aggravated around the foreign-body material in the cutis. There is small erosion at one point. Spectrographic analysis of a portion of the specimen showed considerable amounts of chromium.

The article presents news related to the dermatology field. The Northern Ireland Hospitals Authority has announced the appointment of Col. Donald Gill as Consultant Dermatologist at hospitals managed by the Mid-Antrim, North Antrim, Mid-Ulster and Coleraine and Portrush Hospital Management Committees. Professor Alfred Marchionini, Director of the University Skin Clinic, Munich, has been elected President of the International Society of Tropical Dermatology. The French Society of Allergy is organizing a Réunion on atopic eczema that will be held on June 26, 1965 in Lille.

This article presents an outline of a previously published clinical study which focuses on occupational dermatoses in Finland. An analysis of the causes of 1752 cases of occupational dermatitis, is made in the study.

The article focuses on the after effect of anti-eczematous measures on atopic dermatitis. One half of the body of a patient was treated with active medicaments, the other side served as control. Relapse occurred earlier on the control side. Tar in the form of "liantral" paste was most effective, chrysarobin (tolerated better than in psoriasis) next, sulphur on the other hand seemed to predispose to earlier relapse.

The article presents information on disseminated eczematoid microbides. When a localized focus of eczema, usually on the lower limb, is treated with unsuitable medicaments and a secondary ide eruption results on other parts of the body this is often the result of the development of a sensitization to skin organisms, usually staphylococci.

The article presents information on chrondrodermatitis nodularis ghronica helicis. A report of ninety-four cases and survey of literature was presented, with emphasis upon pathogenesis and treatment.

The article presents information on low incidence of dermographism in subacute and chronic urticaria. Dermographism was present in 5 out of 100 dermatological patients with no urticaria and in 6 out of 100 with urticaria.