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Your search keyword '"Bulgakov, V. G."' showing total 3 results
Start Over Author "Bulgakov, V. G." Publisher administrativnoia zdaniia minzdrava sssr
3 results on '"Bulgakov, V. G."'

1. [Effect of phospholipids of different compositions on coronary vessel tonus and myocardial contractility].

Author

Bulgakov VG, Morgunov AA, and Bilenko MV

Subjects
Animals, In Vitro Techniques, Phosphatidylcholines pharmacology, Phosphatidylethanolamines pharmacology, Rana temporaria, Rats, Coronary Vessels drug effects, Myocardial Contraction drug effects, Phospholipids pharmacology
Abstract

In experiments on perfused isolated Wistar rat hearts and frog myocardial strips it has been shown that the injection of egg phospholipid liposomes in the perfusion solution leads to a decrease in the volume velocity of the coronary perfusion and to worsening of the contractile myocardial function. Negative inotropic effect of phospholipids on the perfused heart may be linked not only with the decrease in the coronary perfusion but also with their direct inhibitory action on the contractile ability of myocardiocytes.

Published
1987

2. [The state of lipid peroxidation and enzymes of calcium transport system in sarcoplasmic reticulum of ischemic myocardium].

Author

Bulgakov VG and Bilenko MV

Subjects
Animals, Biological Transport, Calcium-Transporting ATPases metabolism, Coronary Disease enzymology, Dogs, Intracellular Membranes enzymology, Intracellular Membranes metabolism, Membrane Lipids metabolism, Myocardium enzymology, Phospholipids metabolism, Sarcoplasmic Reticulum enzymology, Calcium metabolism, Coronary Disease metabolism, Lipid Peroxidation, Myocardium metabolism, Sarcoplasmic Reticulum metabolism
Abstract

In 30 experiments on mongrel dog hearts it was shown that 30 min of total ischemia (37 degrees C) followed by accumulation of MDA in the SR membranes and decrease of their Ca2+-uptake, but had no effect on activity Ca2+-ATPase. After 60-120 min ischemia marked a decrease of Ca2+-uptake and activity Ca2+-ATPase took place, MDA content remained at the increased level. The results show that lipid peroxidation take part in the increase of the permeability of SR membranes for Ca2+ and inhibiting of Ca2+-ATPase.

Published
1988

3. [Disorders of cardiac contractile function in ischemic shock; the protective effect of antioxidants and liposomes made from egg phospholipids].

Author

Bilenko MV, Morgunov AA, Churakova TD, Bulgakov VG, and Komarov PG

Subjects
Animals, Coronary Disease complications, Coronary Disease drug therapy, Coronary Disease mortality, Drug Carriers, Drug Evaluation, Preclinical, Female, Lipid Peroxidation drug effects, Lipid Peroxidation physiology, Liposomes, Myocardial Contraction drug effects, Rats, Rats, Inbred Strains, Shock, Cardiogenic drug therapy, Shock, Cardiogenic etiology, Shock, Cardiogenic mortality, Time Factors, Antioxidants therapeutic use, Coronary Disease physiopathology, Myocardial Contraction physiology, Phospholipids administration & dosage, Shock, Cardiogenic physiopathology
Abstract

Experiments were made on Wistar rats with 6h tourniqueting of the hind limbs to study animal survival rate, myocardial contractile function and protective action of antioxidants and egg phospholipid liposomes during ischemic shock. It has been shown that reperfusion of the limbs leads to a high animal lethality, make lower myocardial contractile function and coronary flow of the hearts isolated from rats following a 6h reperfusion of the limbs. Well-known antioxidant butylated hydroxytoluene and a new antioxidant tetramethylpiperidine derivative bring animal lethality down and improve coronary flow and contractile function of the isolated heart. Phospholipid liposomes increase survival rate moderately but have no any effect on the heart contractile function. It has been deduced that lipid peroxidation takes part in the disturbance of heart contractile function and genesis of the death within ischemic shock.

Published
1989

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