31 results on '"Weiming Zhu"'
Search Results
2. Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
- Author
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Yibo Xu, Dongyang Wang, Qianqian Lv, Peng Fu, Ying Wang, and Weiming Zhu
- Subjects
General Chemical Engineering ,General Chemistry - Published
- 2022
3. Antibacterial Gilvocarcin-Type Aryl-C-Glycosides from a Soil-Derived Streptomyces Species
- Author
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Rui Ma, Shan Cheng, Jiwen Sun, Weiming Zhu, and Peng Fu
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Pharmacology ,Complementary and alternative medicine ,Organic Chemistry ,Drug Discovery ,Pharmaceutical Science ,Molecular Medicine ,Analytical Chemistry - Published
- 2022
4. A Cyclohexapeptide and Its Rare Glycosides from Marine Sponge-Derived Streptomyces sp. OUCMDZ-4539
- Author
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Shuige Zhao, Yuwei Xia, Haishan Liu, Tongxu Cui, Peng Fu, and Weiming Zhu
- Subjects
Organic Chemistry ,Physical and Theoretical Chemistry ,Biochemistry - Published
- 2022
5. Metasurface Micro/Nano-Optical Sensors: Principles and Applications
- Author
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Jin Qin, Shibin Jiang, Zhanshan Wang, Xinbin Cheng, Baojun Li, Yuzhi Shi, Din Ping Tsai, Ai Qun Liu, Wei Huang, and Weiming Zhu
- Subjects
Optics and Photonics ,Refractometry ,General Engineering ,Reproducibility of Results ,General Physics and Astronomy ,General Materials Science - Abstract
Metasurfaces are 2D artificial materials consisting of arrays of metamolecules, which are exquisitely designed to manipulate light in terms of amplitude, phase, and polarization state with spatial resolutions at the subwavelength scale. Traditional micro/nano-optical sensors (MNOSs) pursue high sensitivity through strongly localized optical fields based on diffractive and refractive optics, microcavities, and interferometers. Although detections of ultra-low concentrations of analytes have already been demonstrated, the label-free sensing and recognition of complex and unknown samples remain challenging, requiring multiple readouts from sensors
- Published
- 2022
6. Superhybrid Mode-Enhanced Optical Torques on Mie-Resonant Particles
- Author
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Yuzhi Shi, Lei-Ming Zhou, Ai Qun Liu, Manuel Nieto-Vesperinas, Tongtong Zhu, Amir Hassanfiroozi, Jingquan Liu, Hui Zhang, Din Ping Tsai, Hang Li, Weiqiang Ding, Weiming Zhu, Ye Feng Yu, Alfredo Mazzulla, Gabriella Cipparrone, Pin Chieh Wu, C. T. Chan, and Cheng-Wei Qiu
- Subjects
Mechanical Engineering ,General Materials Science ,Bioengineering ,General Chemistry ,Condensed Matter Physics - Abstract
Circularly polarized light carries spin angular momentum, so it can exert an optical torque on the polarization-anisotropic particle by the spin momentum transfer. Here, we show that giant positive and negative optical torques on Mie-resonant (gain) particles arise from the emergence of superhybrid modes with magnetic multipoles and electric toroidal moments, excited by linearly polarized beams. Anomalous positive and negative torques on particles (doped with judicious amount of dye molecules) are over 800 and 200 times larger than the ordinary lossy counterparts, respectively. Meanwhile, a rotational motor can be configured by switching the s- and p-polarized beams, exhibiting opposite optical torques. These giant and reversed optical torques are unveiled for the first time in the scattering spectrum, paving another avenue toward exploring unprecedented physics of hybrid and superhybrid multipoles in metaoptics and optical manipulations.
- Published
- 2022
7. Sulfur-Containing Phenolic Compounds from the Cave Soil-Derived Aspergillus fumigatus GZWMJZ-152
- Author
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Yanchao Xu, Wen Liu, Dan Wu, Wenwen He, Mingxing Zuo, Dongyang Wang, Peng Fu, Liping Wang, and Weiming Zhu
- Subjects
Pharmacology ,Complementary and alternative medicine ,Organic Chemistry ,Drug Discovery ,Pharmaceutical Science ,Molecular Medicine ,Analytical Chemistry - Published
- 2022
8. High-Efficiency Synthesis of Carbon-Bridged Dimers via Bioinspired Green Dimerization Involving Aldehydes
- Author
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Zhi Liu, Shupeng Yin, Rongxin Zhang, Weiming Zhu, and Peng Fu
- Subjects
Renewable Energy, Sustainability and the Environment ,General Chemical Engineering ,Environmental Chemistry ,General Chemistry - Published
- 2021
9. Aromatic Polyketides and Hydroxamate Siderophores from a Marine-Algae-Derived Streptomyces Species
- Author
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Hui Luo, Kunyu Xia, Rui Ma, Weiming Zhu, Rongxin Zhang, and Peng Fu
- Subjects
Pharmacology ,Quantum chemical ,Siderophore ,biology ,Stereochemistry ,Chemistry ,Organic Chemistry ,Pharmaceutical Science ,biology.organism_classification ,Streptomyces ,Streptomyces species ,Analytical Chemistry ,Deferoxamine B ,Complementary and alternative medicine ,Algae ,Drug Discovery ,Molecular Medicine ,Moiety ,Fermentation - Abstract
Four new aromatic polyketides, wailupemycins M-P (1-4), and two new hydroxamate siderophores, streptamides A (5) and B (6), together with the previously reported nocardamine (7), were isolated from the marine-algae-derived Streptomyces sp. OUCMDZ-3434. Wailupemycins M-P (1-4), possessing an α-pyrone moiety, were isolated from the extract of a liquid fermentation, and the siderophores (5-7) were isolated from the extract of a solid fermentation. Their structures were assigned based on detailed spectroscopic analysis and quantum chemical calculations. Compounds 5-7 were capable of binding Fe(III). Compound 5 can form a tighter Fe(III) complex than that of deferoxamine B mesylate (DFB).
- Published
- 2021
10. Enhancing the Electrochemical Performance and Structural Stability of Ni-Rich Layered Cathode Materials via Dual-Site Doping
- Author
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Weiming Zhu, Jie Chen, Wenguang Zhao, Tielei Shao, Rui Wang, Mihai Chu, Lunhua He, Chaoqi Wang, Zhongyuan Huang, Yinguo Xiao, and Taolve Zhang
- Subjects
Materials science ,Doping ,Neutron diffraction ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,Cathode ,Lithium-ion battery ,0104 chemical sciences ,Ion ,law.invention ,Lithium ion transport ,chemistry ,Chemical engineering ,law ,General Materials Science ,Lithium ,0210 nano-technology - Abstract
Ni-rich layered cathode materials are considered as promising electrode materials for lithium ion batteries due to their high energy density and low cost. However, the low rate performance and poor electrochemical stability hinder the large-scale application of Ni-rich layered cathodes. In this work, both the rate performance and the structural stability of the Ni-rich layered cathode LiNi0.8Co0.1Mn0.1O2 are significantly improved via the dual-site doping of Nb on both lithium and transition-metal sites, as revealed by neutron diffraction results. The dual-site Nb-doped LiNi0.8Co0.1Mn0.1O2 delivers 202.8 mAh·g-1 with a capacity retention of 81% after 200 electrochemical cycles, which is much higher than that of pristine LiNi0.8Co0.1Mn0.1O2. Moreover, a discharge capacity of 176 mAh·g-1 at 10C rate illustrates its remarkable rate capability. Through in situ X-ray diffraction and electronic transport property measurements, it was demonstrated that the achievement of dual-site doping in the Ni-rich layered cathode can not only suppress the Li/Ni disordering and facilitate the lithium ion transport process but also stabilize the layered structure against local collapse and structural distortion. This work adopts a dual-site-doping approach to enhance the electrochemical performance and structural stability of Ni-rich cathode materials, which could be extended as a universal modification strategy to improve the electrochemical performance of other cathode materials.
- Published
- 2021
11. Cytotoxic p-Terphenyls from a Marine-Derived Nocardiopsis Species
- Author
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Yi Wang, Peng Fu, Yinfeng Ouyang, Dongyang Wang, and Weiming Zhu
- Subjects
Pharmacology ,Strain (chemistry) ,Stereochemistry ,HL60 ,Organic Chemistry ,Nocardiopsis species ,Pharmaceutical Science ,Benzothiazine ,Analytical Chemistry ,chemistry.chemical_compound ,Complementary and alternative medicine ,chemistry ,Benzothiazole ,Cell culture ,Drug Discovery ,Molecular Medicine ,Cytotoxic T cell ,Moiety - Abstract
Three new p-terphenyl derivatives, nocarterphenyls A-C (1-3), along with three known analogues (4-6) were isolated from the marine-derived actinobacterial strain Nocardiopsis sp. OUCMDZ-4936. Their structures were elucidated on the basis of spectroscopic analysis and a single-crystal X-ray diffraction experiment. Compounds 1 and 2 possess a benzothiazole and benzothiazine moiety, respectively, which are rare in the skeleton of p-terphenyls. Nocarterphenyl A (1) showed potent cytotoxic activity against the HL60 and HCC1954 cancer cell lines with the IC50 values of 0.38 and 0.10 μM among 26 human cancer cell lines.
- Published
- 2019
12. Cytotoxic Indolyl Diketopiperazines from the Aspergillus sp. GZWMJZ-258, Endophytic with the Medicinal and Edible Plant Garcinia multiflora
- Author
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Peng Fu, Yanchao Xu, Weiming Zhu, Wenwen He, Liping Wang, Mingxing Zuo, Yangming Jiang, and Wen Liu
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0106 biological sciences ,Indole test ,chemistry.chemical_classification ,Aspergillus ,biology ,Stereochemistry ,010401 analytical chemistry ,Mutant ,General Chemistry ,biology.organism_classification ,Mass spectrometry ,01 natural sciences ,Endophyte ,0104 chemical sciences ,Amino acid ,chemistry ,Cell culture ,General Agricultural and Biological Sciences ,Diketopiperazines ,010606 plant biology & botany - Abstract
Two new indolyl diketopiperazines, gartryprostatins A and B (1 and 2), with an unusual 2,3-furan-fused pyrano[2,3-g]pyrrolo[1″,2″:4',5']pyrazino[1',2':1,5]pyrrolo[2,3-b]indole nucleus, along with a new naturally occurring compound (gartryprostatin C, 3) were isolated from the solid culture of Aspergillus sp. GZWMJZ-258, an endophyte from Garcinia multiflora (Guttiferae). The structures of compounds 1-3 were determined by nuclear magnetic resonance, mass spectrometry, Marfey's analysis of amino acids, and chemical calculation. Compounds 1-3 displayed selective inhibition on human FLT3-ITD mutant AML cell line, MV4-11, with IC50 values of 7.2, 10.0, and 0.22 μM, respectively.
- Published
- 2019
13. Sekgranaticin, a SEK34b-Granaticin Hybrid Polyketide from Streptomyces sp. 166#
- Author
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Peng Fu, Qianqian Lv, Jingxin Zhai, Boping Ye, Ganzheng Tao, Weiming Zhu, and Yaqin Fan
- Subjects
Circular dichroism ,biology ,010405 organic chemistry ,Stereochemistry ,Chemistry ,Organic Chemistry ,Absolute configuration ,Carbon-13 NMR ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,Streptomyces ,0104 chemical sciences ,Polyketide ,Cell culture ,Molecule ,Cytotoxicity - Abstract
Sekgranaticin (1), a novel hybrid polyketide with a complex 6/6/6/6/6/6/6 7-ring system, was isolated together with granaticins A (2) and B (3) and methyl granaticinate (4) from the culture broth of Streptomyces sp. 166#. Its structure was elucidated by spectroscopic analysis. The absolute configuration was determined on the basis of the calculated 13C NMR and electronic circular dichroism data. Compounds 1-4 exhibited potent cytotoxicity against cancer cell lines MCF-7, A549, P6C, and HCT-116 with IC50 values of 0.02-6.77 μM. The biosynthetic pathway of sekgranaticin (1) was proposed.
- Published
- 2019
14. New α-Pyridones with Quorum-Sensing Inhibitory Activity from Diversity-Enhanced Extracts of a Streptomyces sp. Derived from Marine Algae
- Author
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Yuqi Du, Yi Wang, Peng Fu, Qianhong Gong, Jian Sun, and Weiming Zhu
- Subjects
Pyridones ,Chlorophyta ,010402 general chemistry ,medicine.disease_cause ,01 natural sciences ,Streptomyces ,Algae ,Gene expression ,medicine ,Gene ,Molecular Structure ,biology ,010405 organic chemistry ,Chemistry ,Pseudomonas aeruginosa ,Quorum Sensing ,General Chemistry ,biology.organism_classification ,Anti-Bacterial Agents ,0104 chemical sciences ,Quorum sensing ,Biochemistry ,Green algae ,General Agricultural and Biological Sciences - Abstract
Four new α-pyrones (1-4) and eight known analogues (5-12) were identified from the secondary metabolites of Streptomyces sp. OUCMDZ-3436 derived from the marine green algae Enteromorpha prolifera. Seven new α-pyridones (14-20) were constructed by diversity-oriented synthesis, which has been an effective approach to expanding the chemical space of natural-product-like compounds. Compounds 16, 17, 19, and 20 were found to have inhibitory effect on the gene expression controlled by quorum sensing in Pseudomonas aeruginosa QSIS-lasI.
- Published
- 2018
15. Ophiobolins from the Mangrove Fungus Aspergillus ustus
- Author
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Kui Hong, Pawinee Piyachaturawat, Xia Li, Guoliang Zhu, Weiming Zhu, Zhenyu Lu, Arthit Chairoungdua, Liping Wang, Yi Wang, Jie Fan, and Tonghan Zhu
- Subjects
Sesterterpenes ,Stereochemistry ,Ethyl acetate ,Pharmaceutical Science ,HL-60 Cells ,Fungus ,01 natural sciences ,Analytical Chemistry ,Ophiobolins ,Inhibitory Concentration 50 ,chemistry.chemical_compound ,Aspergillus ustus ,Cell Line, Tumor ,Drug Discovery ,Ic50 values ,Humans ,Inhibitory concentration 50 ,Pharmacology ,biology ,010405 organic chemistry ,Organic Chemistry ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Aspergillus ,Complementary and alternative medicine ,chemistry ,A549 Cells ,MCF-7 Cells ,Molecular Medicine ,Mangrove ,Human cancer - Abstract
Seven new ophiobolins (1–5, 12, and 14) along with the 11 known analogues (6–11, 13, 15–18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4–8 and 11–15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60 human cancer cell lines with the IC50 values ranging from 0.6 to 9.5 μM.
- Published
- 2017
16. Cyanogramide with a New Spiro[indolinone-pyrroloimidazole] Skeleton from Actinoalloteichus cyanogriseus
- Author
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Peng Fu, Yi Wang, Xia Li, Fandong Kong, and Weiming Zhu
- Subjects
Stereochemistry ,Chemistry ,Alkaloid ,Organic Chemistry ,Antineoplastic Agents ,Marine Biology ,Biochemistry ,Actinoalloteichus cyanogriseus ,KB Cells ,Indole Alkaloids ,Actinobacteria ,chemistry.chemical_compound ,Cyanogramide ,Humans ,Imidazole ,Spiro Compounds ,Drug Screening Assays, Antitumor ,Physical and Theoretical Chemistry ,K562 Cells ,Fermentation broth ,Nuclear Magnetic Resonance, Biomolecular - Abstract
Cyanogramide (1), an unprecedented alkaloid bearing a novel spirocyclic pyrrolo[1,2-c]imidazole skeleton, was identified from the fermentation broth of the marine-derived Actinoalloteichus cyanogriseus WH1-2216-6. The structure was fully determined by spectroscopic analysis, an exciton chirality CD method, and quantum mechanical calculations. Cyanogramide (1) could efficiently reverse the adriamycin-induced resistance of K562/A02 and MCF-7/Adr cells, and the vincristine-induced resistance of KB/VCR cells at a concentration of 5 μM, with the reversal fold values of 15.5, 41.5, and 9.7, respectively.
- Published
- 2014
17. Preparation and Electrochemical Performance of Tungstovanadophosphoric Heteropoly Acid and Its Hybrid Materials
- Author
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Xia Tong, Wen Wu, Weiming Zhu, A. B. Yaroslavtsev, Naiqin Tian, Fahe Cao, Wenfu Yan, and Qingyin Wu
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Materials science ,Polyvinylpyrrolidone ,Inorganic chemistry ,Crystal structure ,Polyethylene glycol ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Dielectric spectroscopy ,Keggin structure ,chemistry.chemical_compound ,General Energy ,chemistry ,PEG ratio ,medicine ,Physical and Theoretical Chemistry ,Hybrid material ,Single crystal ,Nuclear chemistry ,medicine.drug - Abstract
Tungstovanadophosphoric heteropoly acid H6PW9V3O40·(13.81 ± 0.13)H2O (abbreviated as PW9V3) has been synthesized by the stepwise acidification and the stepwise addition of element solutions. The crystal structure was determined from single crystal X-ray diffraction. The complex crystallizes in the space group R3m, with a = 16.4374 (9) A, b = 16.4374 (9) A, c = 25.3866 (14) A, α = 90°, β = 90°, γ = 120°, V = 5940.20 A, and Z = 6. The product possesses Keggin structure, and its conductivity was 1.730 × 10–2 S·cm–1 at 26 °C and 75% relative humidity by electrochemical impedance spectroscopy (EIS) measurement. Two conducting systems were prepared with a mixture of as-synthesized PW9V3 and organic polymers [polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG)] at the weight ratio 80:20. The hybrid materials exhibit high proton conductivities with 7.110 × 10–3 and 1.050 × 10–2 S·cm–1 (PW9V3/PEG) at 26 °C and 75% relative humidity, respectively. Their activation energies of proton conduction are 15.23 and 13...
- Published
- 2013
18. Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase
- Author
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Peng Fu, Jianhua Ju, Haibo Zhang, Qinheng Lin, Changsheng Zhang, Weiming Zhu, Guangtao Zhang, Sumei Li, and Yiguang Zhu
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Pyridines ,Mutant ,Biochemistry ,Amidohydrolases ,Leucine ,Nonribosomal peptide ,Polyketide synthase ,Actinomycetales ,Gene cluster ,Amino Acid Sequence ,Peptide Synthases ,Physical and Theoretical Chemistry ,Gene ,chemistry.chemical_classification ,Molecular Structure ,biology ,Amidohydrolase ,Chemistry ,Organic Chemistry ,Streptomyces coelicolor ,biology.organism_classification ,Genes, Bacterial ,Multigene Family ,biology.protein ,Heterologous expression - Abstract
The biosynthetic gene cluster for caerulomycin A (1) was cloned and characterized from the marine actinomycete Actinoalloteichus cyanogriseus WH1-2216-6, which revealed an unusual hybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) system. The crmL disruption mutant accumulated caerulomycin L (2) with an extended L-leucine at C-7, implicating an amidohydrolase activity for CrmL. The leucine-removing activity was confirmed for crude CrmL enzymes. Heterologous expression of the 1 gene cluster led to 1 production in Streptomyces coelicolor.
- Published
- 2012
19. Streptocarbazoles A and B, Two Novel Indolocarbazoles from the Marine-Derived Actinomycete Strain Streptomyces sp. FMA
- Author
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Chunli Yang, Weiming Zhu, Yi Wang, Lei Xu, Kui Hong, Peng Fu, Peipei Liu, Yiming Ma, and Mingbo Su
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Indole test ,Indoles ,Molecular Structure ,Strain (chemistry) ,biology ,Stereochemistry ,Organic Chemistry ,Carbazoles ,Antineoplastic Agents ,HL-60 Cells ,Marine Biology ,Indolocarbazole ,biology.organism_classification ,Biochemistry ,Streptomyces ,HeLa ,chemistry.chemical_compound ,chemistry ,Humans ,Moiety ,Molecule ,Glycosyl ,Drug Screening Assays, Antitumor ,Physical and Theoretical Chemistry - Abstract
Streptocarbazoles A (1) and B (2), two novel indolocarbazoles featuring unprecedented cyclic N-glycosidic linkages between 1,3-carbon atoms of the glycosyl moiety and two indole nitrogen atoms of the indolocarbazole core, were isolated from the marine-derived actinomycetes strain Streptomyces sp. FMA. Their structures were established by spectroscopic methods, CD spectra, and ECD quantum mechanical calculations. Compound 1 was cytotoxic on HL-60 and A-549 cell lines and could arrest the cell cycle of Hela cells at the G(2)/M phase.
- Published
- 2012
20. Cyclic Bipyridine Glycosides from the Marine-Derived Actinomycete Actinoalloteichus cyanogriseus WH1-2216-6
- Author
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Peng Fu, Kui Hong, Weiming Zhu, Xia Li, Peipei Liu, Yi Wang, and Shuxia Wang
- Subjects
Models, Molecular ,chemistry.chemical_classification ,Anomer ,Molecular Structure ,Pyridines ,Chemistry ,Stereochemistry ,Organic Chemistry ,Glycoside ,Glycosidic bond ,Crystallography, X-Ray ,Biochemistry ,Actinoalloteichus cyanogriseus ,Bipyridine ,chemistry.chemical_compound ,Aglycone ,Cyclization ,Actinomycetales ,Molecule ,Glycosides ,Physical and Theoretical Chemistry ,Vicinal - Abstract
Cyanogrisides A-D (1-4), four new glycosidic derivatives of bipyridine featuring a novel cyclic glycoside generated by vicinal hydroxyl groups of an aglycone with both the anomeric center and the adjacent carbonyl of a keto sugar, were isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. The structures of 1-4 were elucidated by spectroscopic analysis, X-ray single crystal diffraction, CD spectra, and chemical methods.
- Published
- 2011
21. α-Pyrones and Diketopiperazine Derivatives from the Marine-Derived Actinomycete Nocardiopsis dassonvillei HR10-5
- Author
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Jing Li, Yi Wang, Dian-Feng Chen, Hui Wang, Weiming Zhu, Peipei Liu, Peng Fu, and Hai-Jun Qu
- Subjects
Stereochemistry ,Pharmaceutical Science ,Marine Biology ,Diketopiperazines ,Microbial Sensitivity Tests ,Bacillus subtilis ,Oxazoline ,Biology ,Analytical Chemistry ,chemistry.chemical_compound ,Drug Discovery ,Oxazoles ,Pharmacology ,Molecular Structure ,Nocardiopsis dassonvillei ,Organic Chemistry ,Antimicrobial ,biology.organism_classification ,Anti-Bacterial Agents ,Actinobacteria ,Complementary and alternative medicine ,chemistry ,Pyrones ,Mic values ,Molecular Medicine ,Drug Screening Assays, Antitumor - Abstract
Three new α-pyrones, nocapyrones E-G (1-3), and three new diketopiperazine derivatives, nocazines A-C (4-6), together with a new oxazoline compound, nocazoline A (7), were isolated from the marine-derived actinomycete Nocardiopsis dassonvillei HR10-5. The new structures of 1-7 were determined by spectroscopic analysis, X-ray single-crystal diffraction, CD spectra, and modified Mosher and Marfey methods. Compounds 1-3 showed modest antimicrobial activity against Bacillus subtilis with MIC values of 26, 14, and 12 μM, respectively.
- Published
- 2011
22. Anti-influenza Virus Polyketides from the Acid-Tolerant Fungus Penicillium purpurogenum JS03-21
- Author
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Weiming Zhu, Wei Wang, Hui Wang, Yi Wang, Peng Fu, and Peipei Liu
- Subjects
China ,Stereochemistry ,Ethyl acetate ,Penicillium purpurogenum ,Pharmaceutical Science ,Fungus ,medicine.disease_cause ,Antiviral Agents ,Orsellinic acid ,Virus ,Analytical Chemistry ,Inhibitory Concentration 50 ,chemistry.chemical_compound ,Influenza A Virus, H1N1 Subtype ,Drug Discovery ,Influenza A virus ,medicine ,Humans ,Pharmacology ,Molecular Structure ,biology ,Organic Chemistry ,Penicillium ,Hydrogen-Ion Concentration ,biology.organism_classification ,Complementary and alternative medicine ,chemistry ,Polyketides ,Molecular Medicine ,Two-dimensional nuclear magnetic resonance spectroscopy - Abstract
Fractionation of the ethyl acetate extract of an acid-tolerant fungus, Penicillium purpurogenum JS03-21, resulted in the isolation of six new compounds, purpurquinones A-C (1-3), purpuresters A and B (4 and 5), and 2,6,7-trihydroxy-3-methylnaphthalene-1,4-dione (6), together with three known compounds, TAN-931 (7), (-)-mitorubrin (8), and orsellinic acid. The structures of 1-6 were elucidated primarily by NMR experiments. The absolute configurations of 1-4 were assigned on the basis of CD and NOESY data. Compounds 2-4 and 7 exhibited significant antiviral activity against H1N1, with IC50 values of 61.3, 64.0, 85.3, and 58.6 μM, respectively.
- Published
- 2011
23. Application of Cobalt Oxide Nanoflower for Direct Electrochemistry and Electrocatalysis of Hemoglobin with Ionic Liquid as Enhancer
- Author
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Yan Zeng, Xintang Huang, Weiming Zhu, Wei Sun, Xia Li, and Zhihong Zhu
- Subjects
Working electrode ,Chemistry ,Inorganic chemistry ,Nanoflower ,Electrocatalyst ,Electrochemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,Electron transfer ,General Energy ,Nafion ,Ionic liquid ,Physical and Theoretical Chemistry ,Cobalt oxide - Abstract
A composite bionanomaterial was prepared by combining Nafion, flowerlike cobalt oxide (CoO) nanoparticles, hemoglobin (Hb), and ionic liquid (IL) 1-ethyl-3-methylimidazolium tetrafluoroborate. Then it was further applied on the surface of a carbon ionic liquid working electrode fabricated with 1-ethyl-3-methylimidazolium ethylsulfate as the modifier. Ultraviolet–visible and Fourier transform infrared spectroscopic results indicated that Hb molecules in the composite film retained the native structure. Cyclic voltammetric results showed that a pair of well-defined redox peaks appeared in 0.1 mol L–1 pH 4.0 phosphate buffer solution, indicating that the direct electron transfer of Hb with the underlying electrode was realized. The results could be attributed to the synergistic effect of CoO nanoflower and IL in the composite film, which provided a specific microenvironment to keep the native structure of Hb and promoted the electron transfer rate of Hb. The electrochemical parameters of Hb on the modified e...
- Published
- 2011
24. Cyclic Tripeptides from the Halotolerant Fungus Aspergillus sclerotiorum PT06-1
- Author
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Kui Hong, Zhihong Xu, Weiming Zhu, Peipei Liu, Yi Wang, and Jinkai Zheng
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China ,Antifungal Agents ,Stereochemistry ,Ethyl acetate ,Pharmaceutical Science ,Peptide ,Microbial Sensitivity Tests ,Tripeptide ,Sodium Chloride ,Peptides, Cyclic ,Analytical Chemistry ,chemistry.chemical_compound ,Penicillic acid ,Candida albicans ,Drug Discovery ,Amino Acid Sequence ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,biology ,Organic Chemistry ,Stereoisomerism ,biology.organism_classification ,Cyclic peptide ,Aspergillus ,Complementary and alternative medicine ,chemistry ,Halotolerance ,Molecular Medicine ,Fermentation ,Drug Screening Assays, Antitumor - Abstract
Eleven new aspochracin-type cyclic tripeptides, sclerotiotides A-K (1-11), together with three known compounds, JBIR-15 (12), aspochracin (13), and penicillic acid, were isolated from the ethyl acetate extract of the fermentation broth of the halotolerant Aspergillus sclerotiorum PT06-1 in a hypersaline nutrient-rich medium. Their structures were elucidated by spectroscopic analysis and chemical methods. Chemical transformations of 12 and 13 proved that sclerotiotides D-K (4-11) were artifacts probably formed during the fermentation or subsequent isolation steps. All 13 cyclic tripeptides have been evaluated for their antimicrobial and cytotoxic effects. Only sclerotiotides A (1), B (2), F (6), and I (9) and JBIR-15 (12) showed selective antifungal activity against Candida albicans with MIC values of 7.5, 3.8, 30, 6.7, and 30 microM, respectively.
- Published
- 2010
25. Sesquiterpenoids and Benzofuranoids from the Marine-Derived Fungus Aspergillus ustus 094102
- Author
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Kui Hong, Yi Wang, Zhenyu Lu, Weiming Zhu, Peipei Liu, and Chengdu Miao
- Subjects
Stereochemistry ,Pharmaceutical Science ,HL-60 Cells ,Marine Biology ,Sesquiterpene ,Analytical Chemistry ,Inhibitory Concentration 50 ,chemistry.chemical_compound ,Aspergillus ustus ,Drug Discovery ,Humans ,Chromans ,Cytotoxicity ,Nuclear Magnetic Resonance, Biomolecular ,Benzofurans ,Polycyclic Sesquiterpenes ,Pharmacology ,A549 cell ,chemistry.chemical_classification ,Molecular Structure ,Chemistry ,Organic Chemistry ,Stereoisomerism ,Biological activity ,Antineoplastic Agents, Phytogenic ,Terpenoid ,Aspergillus ,Complementary and alternative medicine ,Cell culture ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Sesquiterpenes ,Lactone - Abstract
Eight drimane sesquiterpenes (1-8), six isochromane derivatives (9-14), and three known compounds, daldinin B (15), 9alpha-hydroxy-6beta-[(2E,4E,6E)-octa-2,4,6-trienoyloxy]-5alpha-drim-7-en-11,12-olide (16), and pergillin (17), were isolated from the EtOAc extract of the marine-derived fungus Aspergillus ustus 094102. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxic effects on A549 and HL-60 cell lines were evaluated by SRB and MTT methods. Ustusorane E (13) showed significant cytotoxicity against HL-60 cells with an IC50 value of 0.13 microM. Ustusolates C (6) and E (8) exhibited moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 microM, respectively, and ustusolate A (4) showed weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 microM, respectively.
- Published
- 2009
26. Resin Glycoside Constituents of Ipomoea pes-caprae (Beach Morning Glory)
- Author
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Weiming Zhu, Qianqun Gu, Jinggen Liu, Jian Ding, Xiao-Jiang Hao, Hongwen Tao, and Yuchun Fang
- Subjects
Antifungal ,Chemical transformation ,medicine.drug_class ,Receptors, Opioid, mu ,Pharmaceutical Science ,HL-60 Cells ,Microbial Sensitivity Tests ,Ipomoea pes-caprae ,Analytical Chemistry ,Mice ,Drug Discovery ,medicine ,Animals ,Humans ,Organic chemistry ,Glycosides ,Nuclear Magnetic Resonance, Biomolecular ,Morning ,Pharmacology ,chemistry.chemical_classification ,Plants, Medicinal ,Molecular Structure ,biology ,Traditional medicine ,Leukemia P388 ,Chemistry ,Fatty Acids ,Organic Chemistry ,Glycoside ,biology.organism_classification ,Carbohydrate Sequence ,Complementary and alternative medicine ,Molecular Medicine ,Ipomoea ,Drug Screening Assays, Antitumor ,Cancer cell lines ,Resins, Plant ,Drugs, Chinese Herbal - Abstract
Eight new resin glycosides, pescapreins X-XVII (1-8), were isolated from a lipophilic fraction of an ethanol extract of the entire plant of beach morning glory, Ipomoea pes-caprae. Their structures were elucidated by spectroscopic data analysis and by chemical transformation. These compounds were evaluated biologically in terms of cancer cell line cytotoxicity, antibacterial and antifungal activity, and effects on the mu-opioid receptor.
- Published
- 2008
27. Cytotoxic Alkaloids and Antibiotic Nordammarane Triterpenoids from the Marine-Derived Fungus Aspergillus sydowi
- Author
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Yuchun Fang, Wen-Liang Wang, Qianqun Gu, Min Zhang, Tianjiao Zhu, and Weiming Zhu
- Subjects
Stereochemistry ,Ethyl acetate ,Pharmaceutical Science ,Micrococcus ,Antineoplastic Agents ,HL-60 Cells ,Microbial Sensitivity Tests ,Bacillus subtilis ,Indole Alkaloids ,Analytical Chemistry ,chemistry.chemical_compound ,Triterpene ,Drug Discovery ,Escherichia coli ,Humans ,Spiro Compounds ,Antibacterial agent ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,biology ,Alkaloid ,Organic Chemistry ,biology.organism_classification ,Antimicrobial ,Triterpenes ,Anti-Bacterial Agents ,Aspergillus ,Complementary and alternative medicine ,chemistry ,Lactam ,Molecular Medicine ,Drug Screening Assays, Antitumor - Abstract
Three new diketopiperazine alkaloids, 6-methoxyspirotryprostatin B (1), 18-oxotryprostatin A (2), and 14-hydroxyterezine D (3), with an oxaspiro[4.4]lactam moiety, 14-norpseurotin A (4), and the 29-nordammarane triterpenoid 6beta,16beta-diacetoxy-25-hydroxy-3,7-dioxy-29-nordammara-1,17(20)-dien-21-oic acid (5), as well as 12 known compounds (6- 17), were isolated from the ethyl acetate extract of a marine-derived fungal strain, Aspergillus sydowi PFW1-13. The structures of compounds 1- 5 were elucidated by comprehensive spectroscopic analysis. Compounds 1- 3 exhibit weak cytotoxicity against A-549 cells, with IC 50 values of 8.29, 1.28, and 7.31 microM, respectively. Compound 1 also shows slight cytotoxicity against HL-60 cells, with an IC 50 value of 9.71 microM. Compounds 4 and 5 display significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM and 10.65, 5.33, and 10.65 microM, respectively.
- Published
- 2008
28. Gentisyl Alcohol Derivatives from the Marine-Derived Fungus Penicillium terrestre
- Author
-
Qianqun Gu, Weiming Zhu, Yuchun Fang, Tianjiao Zhu, and Li Chen
- Subjects
China ,Antioxidant ,Stereochemistry ,DPPH ,medicine.medical_treatment ,Dimer ,Pharmaceutical Science ,Antineoplastic Agents ,Marine Biology ,Trimer ,Ether ,Analytical Chemistry ,Inhibitory Concentration 50 ,chemistry.chemical_compound ,Picrates ,Drug Discovery ,medicine ,Humans ,Phenols ,Benzyl Alcohols ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,Biphenyl Compounds ,Organic Chemistry ,Penicillium ,Biological activity ,Free Radical Scavengers ,Vascular Endothelial Growth Factor Receptor-2 ,src-Family Kinases ,Enzyme ,Complementary and alternative medicine ,chemistry ,Molecular Medicine ,Drug Screening Assays, Antitumor - Abstract
Nine new gentisyl alcohol derivatives, namely, the trimeric terrestrol A (8), dimeric terrestrols B-H (1-7), and a monomeric derivative (12), together with four known analogues (9-11, 13) were isolated from the marine-derived fungus Penicillium terrestre. The structures of the new compounds were elucidated by spectroscopic methods including one- and two-dimensional NMR as well as low- and high-resolution mass spectrometric analysis. These new compounds (1-8, 12) showed cytotoxic effects on HL-60, MOLT-4, BEL-7402, and A-549 cell lines with IC50 values in the range 5-65 microM. Compound 6 also showed moderate inhibitory activity against protein tyrosine kinases (Src and KDR). Furthermore, all new compounds exhibited moderate radical scavenging activity against DPPH with IC50 values in the range 2.6-8.5 microM.
- Published
- 2007
29. Isoechinulin-type Alkaloids, Variecolorins A–L, from Halotolerant Aspergillus variecolor
- Author
-
Wen-Liang Wang, Qianqun Gu, Hongwen Tao, Yuchun Fang, Tianjiao Zhu, Zhenyu Lu, and Weiming Zhu
- Subjects
China ,Salinity ,DPPH ,Stereochemistry ,Pharmaceutical Science ,Analytical Chemistry ,Inhibitory Concentration 50 ,chemistry.chemical_compound ,Alkaloids ,Picrates ,Drug Discovery ,Animals ,Pharmacology ,chemistry.chemical_classification ,Aspergillus ,Dipeptide ,Molecular Structure ,biology ,Chemistry ,Alkaloid ,Biphenyl Compounds ,Organic Chemistry ,Biological activity ,Free Radical Scavengers ,Fungi imperfecti ,biology.organism_classification ,Cyclic peptide ,Complementary and alternative medicine ,Halotolerance ,Molecular Medicine ,Drug Screening Assays, Antitumor - Abstract
Twelve new compounds, variecolorins A-L ( 1- 12), together with eleven known analogues ( 13- 23) were isolated from the broth of a halotolerant fungus, Aspergillus variecolor. The structures of compounds 1- 12 were determined by chemical and spectroscopic methods. Compounds 1- 11, 13- 15, and 20- 23 exhibited weak radical scavenging activity against DPPH, with IC 50 values from 43 to 103 microM. The new compounds 1- 12 all were essentially nontoxic against the P388, HL-60, BEL-7402, and A-549 cell lines with IC 50 values from 70 to 260 microM.
- Published
- 2007
30. Sulfated Alkenes from the Echinus Temnopleurus hardwickii
- Author
-
Hongbing Liu, Tianjiao Zhu, Yuchun Fang, Xiaodong Luo, Weiming Zhu, Hongping He, Li Chen, and Qianqun Gu
- Subjects
China ,Stereochemistry ,Pharmaceutical Science ,Antineoplastic Agents ,Echinus ,Alkenes ,Sulfuric Acid Esters ,Animal origin ,Analytical Chemistry ,Inhibitory Concentration 50 ,Mice ,Sulfation ,Temnopleurus hardwickii ,Drug Discovery ,Animals ,Humans ,Inhibitory concentration 50 ,Spectral analysis ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,Molecular Structure ,biology ,Leukemia P388 ,Chemistry ,Organic Chemistry ,biology.organism_classification ,Complementary and alternative medicine ,Echinoderm ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Aliphatic compound ,Echinodermata - Abstract
Three new sulfated alkenes (1-3), trimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, dimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, and 2'-methyl-4'-oxobutan-2-ylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, were isolated from an echinoderm, Temnopleurus hardwickii. Their structures were elucidated by spectral analysis and chemical degradation methods.
- Published
- 2006
31. Oxidation of alkenes with aqueous potassium peroxymonosulfate and no organic solvent
- Author
-
Weiming Zhu and Warren T. Ford
- Subjects
chemistry.chemical_classification ,chemistry.chemical_compound ,Aqueous solution ,chemistry ,Cyclooctene ,Alkene ,Organic Chemistry ,Cyclohexene ,Cationic polymerization ,Epoxide ,Organic chemistry ,Potassium peroxymonosulfate ,Styrene - Abstract
Aqueous potassium peroxymonosulfate oxidizes water-immiscible alkenes at room temperature in the absence of organic solvent. Acidic (pH I 1.7) solutions of 2KHS05-KHS04.K2S04 in water produced the epoxide from cyclooctene and diols from all other reactive alkenes investigated. Adjustment of initial pH to 1 6.7 with NaHC03 enabled selective epoxidations of 2,3-dimethyl-2-butene, 1-methylcyclohexene, cyclohexene, styrene, and 8methylstyrene. The order of decreasing reactivity of alkenes was: 2,3-dimethyl-2-butene > 1-methylcyclohexene 2 cyclohexene > cyclooctene,> a-methylstyrene 1 @-methylstyrene > styrene > p-methylstyrene > allylbenzene. 1-Octene and tetrachloroethylene did not react. Phaset rader catalysts, a colloidal cationic polymer, and a cationic surfactant microemulsion had little effect on the reaction.
- Published
- 1991
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