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Objective To investigate the bone complicated index, bone density and fracture in male patients with abnormal bone mass with different diseases. Methods A retrospective study was conducted on 928 male patients with abnormal bone mass who were admitted to the department of endocrinology of the first people's hospital of Shanghai from January 2006 to December 2017. According to different research purposes, the patients were divided into groups with or without diabetes, with or without chronic liver disease, with or without chronic kidney disease, with or without chronic stomach disease, with or without cardiovascular disease, and with or without bone mass loss and osteoporosis according to the study purpose. Observe the difference of various indicators in each group respectively. Results Univariate regression analysis suggested that the patients' age, weight,L1-4 BMD, femoral neck BMD, total hip BMD, myo-ctx, chronic gastric disease and osteoporosis were the influencing factors of fracture history, the differences were statistically significant (P<0.05), and fracture history was positively correlated with patients' age, myo-ctx, chronic gastric disease and osteoporosis.It was negatively correlated with body weight, L1-4 BMD, femoral neck BMD and total hip BMD. The multivariate regression analysis suggested that age, BALP, type 2 diabetes and osteoporosis were the risk factors for fractures, while the level of 25OHD was a protective factor for fractures. Conclusion Among the male patients with abnormal bone mass, it is necessary to focus on those older patients with higher levels of β-CTX and BALP, combined with chronic gastropathy and type 2 diabetes, and to carry out active anti-osteoporosis intervention and treatment to reduce the incidence of fractures in these patients. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective This study aimed to evaluate the ability of lumbar spine trabecular bone score (TBS) to assess bone quality in T2DM patients. Methods In this retrospective cross-sectional study, bone mineral density (BMD) of the lumbar spine was measured in 128 T2DM patients and 64 non-T2DM patients using DXA. TBS was calculated by examining pixel variations within the DXA images using TBS iNsight software. The differences of BMD and TBS between the two groups were analyzed. The correlation between TBS and BMD, age, and body weight was also analyzed. Results Compared with that in patients without T2DM, lumbar spine BMD increased (0.9103 ± 0.1742 vs 0.8382 ± 0.1422, P=0.005), and lumbar spine TBS decreased (1.2787 ± 0.122 vs 1.3166 ± 0.1016, P=0.033) in patients with T2DM. After adjusting data for BMI, age, and BMD, a significant difference was also observed in lumbar spine TBS (P<0.001). Results of correlation analyses showed that TBS was negatively correlated with age (r=-0.395, P<0.001) and BMI (r=-0.270, P<0.001), but was positively correlated with BMD. The association was weaker in T2DM patients than in non-T2DM patients (r=0.563, P<0.001 vs r=0.766, P<0.001). Conclusion The decreased lumbar spine TBS in T2DM patients is consistent with the high fracture risk in these patients. TBS may assist the assessment of the bone quality in T2DM patients. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the clinical characteristics of idiopathic osteoporosis among premenopausal women． Methods 28 idiopathic osteoporosis patients，15 secondary osteoporosis patients and 56 normal cases were selected from 1043 premenopausal women according to the inclusion criteria in Shanghai First People’s hospital between September 2005 and December 2016． Subjects were divided into three groups: idiopathic osteoporosis group，secondary osteoporosis group and control group． Ｒetrospective statistical analyses were performed for basic clinical characteristics，bone turnover markers，bone mineral density ( BMD) and fracture data． Ｒesults BMD of the lumbar spine，femoral neck and hip in the idiopathic osteoporosis group were significantly lower than that of the control group ( t = － 3. 794，P ＜ 0. 01; t = － 4. 080，P ＜ 0. 01; t = － 5. 632，P ＜ 0. 01) ． There were no significant differences in the levels of calcium，phosphorus and vitamin D between the idiopathic osteoporosis group and the control group ( t = 0. 120，P ＞ 0. 05; t = 0. 121，P ＞ 0. 05; t = 0. 004，P ＞ 0. 05) ． There was a trend of lower levels of OC and β-CTX in the idiopathic osteoporosis group than that of the control group，but the differences were not statistically significant ( t = 1. 605，P ＞ 0. 05; t = 1. 543，P ＞ 0. 05) ． BMD of the lumbar spine in the secondary osteoporosis group was significantly lower than that in the idiopathic osteoporosis group ( P = 0. 035) ． However，there were no significant differences in BMD of the femoral neck and hip between the secondary osteoporosis group and the idiopathic osteoporosis group ( P = 0. 298，0. 223) ． The levels of OC and β-CTX in the secondary osteoporosis group were higher than that in control group ( P = 0. 020，P ＜ 0. 01 ) ． There was no significant difference in the level of OC between the secondary osteoporosis group and the idiopathic osteoporosis group ( P ＞ 0. 05) ． The level of β-CTX in the secondary osteoporosis group was higher than that in the idiopathic osteoporosis group ( P ＜ 0. 01) ． Conclusion The pathogenesis of idiopathic osteoporosis in premenopausal women may not be related to the levels of Ca，P and 25OHD，and the high turnover of bone metabolism might be the main cause of the disease．11 [ABSTRACT FROM AUTHOR]