1. Metabotropic Glutamate Receptors at the Aged Mossy Fiber – CA3 Synapse of the Hippocampus
- Author
-
Ernesto Griego and Emilio J. Galván
- Subjects
0301 basic medicine ,Mossy fiber (hippocampus) ,animal structures ,Hippocampus ,Hippocampal formation ,Neurotransmission ,Receptors, Metabotropic Glutamate ,Synaptic Transmission ,Synapse ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,Humans ,Chemistry ,musculoskeletal, neural, and ocular physiology ,General Neuroscience ,CA3 Region, Hippocampal ,nervous system diseases ,Electrophysiology ,030104 developmental biology ,nervous system ,Metabotropic glutamate receptor ,Mossy Fibers, Hippocampal ,Synapses ,Excitatory postsynaptic potential ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Metabotropic glutamate receptors (mGluRs) are a group of G-protein-coupled receptors that exert a broad array of modulatory actions at excitatory synapses of the central nervous system. In the hippocampus, the selective activation of the different mGluRs modulates the intrinsic excitability, the strength of synaptic transmission, and induces multiple forms of long-term plasticity. Despite the relevance of mGluRs in the normal function of the hippocampus, we know very little about the changes that mGluRs functionality undergoes during the non-pathological aging. Here, we review data concerning the physiological actions of mGluRs, with particular emphasis on hippocampal area CA3. Later, we examine changes in the expression and functionality of mGluRs during the aging process. We complement this review with original data showing an array of electrophysiological modifications observed in the synaptic transmission and intrinsic excitability of aged CA3 pyramidal cells in response to the pharmacological stimulation of the different mGluRs.
- Published
- 2021