9 results on '"Nianyu Huang"'
Search Results
2. The application research on Cu-Al@SBA-15 bimetallic synergistic effect in the C-X bond sequential assembly
- Author
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Mengyu Pei, Xianghao Luo, Quan Tang, Nianyu Huang, and Long Wang
- Subjects
History ,Polymers and Plastics ,Process Chemistry and Technology ,General Chemistry ,Business and International Management ,Industrial and Manufacturing Engineering ,Catalysis - Published
- 2022
3. Environmentally benign and economic synthesis of covalent triazine-based frameworks
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Wei-Qiao Deng, Rui-Xia Yang, Ling Zhang, Nianyu Huang, and Xue Liu
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chemistry.chemical_element ,02 engineering and technology ,General Medicine ,Microporous material ,Zinc ,Cyanation ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Monomer ,Adsorption ,chemistry ,Covalent bond ,Organic chemistry ,0210 nano-technology ,Triazine - Abstract
Covalent triazine-based frameworks (CTFs) are important microporous materials with a wide range of applications. Here, we demonstrate an environmentally benign and economic synthetic pathway to CTFs. The monomers used for CTFs, aromatic nitriles, were obtained by cyanation using nontoxic potassium hexacyanoferrate (Ⅱ) in place of commonly used toxic cyanides. Then, the CTFs were synthesized by trimerization of the corresponding cyano monomers in molten zinc chloride. A series of CTFs was synthesized, and the highest Brunauer-Emmett-Teller surface area measured in this series was 2404 m 2 /g. Among the synthesized CTFs, CTF DCP exhibited excellent CO 2 adsorption properties, with a CO 2 uptake of 225 mg/g at 0℃.
- Published
- 2017
4. Estrogenic and anti-estrogenic activities of hispolon from Phellinus lonicerinus (Bond.) Bond. et sing
- Author
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Hua-Jun Luo, Nianyu Huang, Fan Cheng, Luo Youcheng, Junzhi Wang, Fang Hu, Wei-Qiao Deng, Kun Zou, and Zhangshuang Deng
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Models, Molecular ,Agonist ,medicine.medical_specialty ,Phellinus ,medicine.drug_class ,Catechols ,Estrogen receptor ,Endogeny ,Thymus Gland ,Mice ,chemistry.chemical_compound ,Genes, Reporter ,Cell Line, Tumor ,Two-Hybrid System Techniques ,Internal medicine ,Drug Discovery ,medicine ,Animals ,Humans ,Cell Proliferation ,Pharmacology ,biology ,Cell growth ,Basidiomycota ,Hispolon ,Body Weight ,Estrogen Antagonists ,Estrogen Receptor alpha ,Estrogens ,General Medicine ,biology.organism_classification ,Molecular Docking Simulation ,Endocrinology ,chemistry ,Docking (molecular) ,Estrogen ,Female ,Spleen - Abstract
Hispolon was the main antitumor active ingredient in Phellinus sensu lato species. In order to confirm the dual regulating estrogenic ingredient and obtain more effective natural estrogen replacement drugs, hispolon was separated from Phellinus lonicerinus (Bond.) Bond. et sing. Hispolon exhibited significant anti-proliferative effect against estrogen-sensitive ER (+) MCF-7 cells in the absence of estrogen, and exhibits antagonistic effects on 17β-estradiol (E2)-induced MCF-7 cell proliferation when E2 and the different concentrations of hispolon were treated simultaneously. Hispolon also inhibited the proliferation of estrogen-negative ER (−) MDA-MB-231 cells at the concentration of 5.00 × 10− 5 M. The yeast two-hybrid experiments showed that hispolon had strong and non-selective effects on the estrogen receptor (ER) α and ERβ at a concentration of 1.00 × 10− 6 M. The ERβ-binding ability of hispolon was larger than ERα in the concentration range of 1.00 × 10− 9 M and 1.00 × 10− 7 M. Hispolon could increase the body weight coefficient, serum E2 and progesterone contents in immature female mice at dose of 9.10 × 10− 6 mol/kg, and increase coefficient of thymus and spleen in mice. The Gscores of hispolon-ERα and hispolon-ERβ docked complexes were − 7.93 kcal/mol and − 7.79 kcal/mol in docking simulations. Hispolon presented dual regulating estrogenic activities, which showed estrogenic agonist activity at low concentration or lack of endogenous estrogen, and the estrogenic antagonistic effect was stimulated at high concentrations or too much endogenous estrogen. Hispolon could be used for treating the estrogen deficiency-related disease with the benefit of non-toxic to normal cells, good antitumor effects and estrogenic activity.
- Published
- 2014
5. Efficient fixation of CO2 at mild conditions by a Cr-conjugated microporous polymer
- Author
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Rui-Xia Yang, Yong Xie, Hua-Jun Luo, Nianyu Huang, and Wei-Qiao Deng
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chemistry.chemical_classification ,Energy Engineering and Power Technology ,Homogeneous catalysis ,Polymer ,Cycloaddition ,Catalysis ,Conjugated microporous polymer ,chemistry.chemical_compound ,Fuel Technology ,chemistry ,Polymer chemistry ,Electrochemistry ,Organic chemistry ,Bifunctional ,Energy (miscellaneous) - Abstract
We reported a bifunctional material, Cr-salen implanted conjugated microporous polymer (Cr-CMP), which is able to capture excellent CO2 amounts and has a remarkable catalytic activity towards the cycloaddition reaction of CO2 to epoxides forming cyclic carbonates at mild conditions without additional solvents. This heterogeneous Cr-CMP catalyst has a superior catalytic activity to its related homogeneous catalyst and can be reused more than ten times without a significant decrease in catalytic activity.
- Published
- 2014
6. The H+/K+-ATPase inhibitory activities of Trametenolic acid B from Trametes lactinea (Berk.) Pat, and its effects on gastric cancer cells
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Kun Zou, Mingruo Ding, Wei-Qiao Deng, Nianyu Huang, Hua-Jun Luo, Qiaoyin Zhang, Junzhi Wang, and Haibo He
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Pathology ,medicine.medical_specialty ,ATPase ,Apoptosis ,Mice, Inbred Strains ,Anti-gastric cancer ,Ulcer index ,Gastric Acid ,H(+)-K(+)-Exchanging ATPase ,Mice ,Random Allocation ,Parietal Cells, Gastric ,In vivo ,Stomach Neoplasms ,Cell Line, Tumor ,Trametenolic acid B ,Drug Discovery ,medicine ,Cytotoxic T cell ,Animals ,Stomach Ulcer ,Omeprazole ,H+/K+-ATPase inhibitory activity ,Cell Proliferation ,Trametes ,Pharmacology ,biology ,business.industry ,Plant Extracts ,Stomach ,Proton Pump Inhibitors ,General Medicine ,Anti-Ulcer Agents ,Molecular biology ,Antineoplastic Agents, Phytogenic ,In vitro ,Triterpenes ,Docking simulation ,Cancer cell ,biology.protein ,business ,medicine.drug ,Phytotherapy - Abstract
Trametenolic acid B (TAB), the bioactive component in the Trametes lactinea (Berk.) Pat, was reported to possess cytotoxic activities and thrombin inhibiting effects. This study was performed to investigate the effects of TAB on H(+)/K(+)-ATPase and gastric cancer. The H(+)/K(+)-ATPase inhibitory activity was determined by gastric parietal cells. Compared to the normal control group, TAB (10, 20, 40 and 80 μg/mL) inhibited the H(+)/K(+)-ATPase activity by 15.97, 16.96, 24.86 and 16.25%, respectively. In the study, 36 Kunming mice were randomly divided into six groups: control, model, TAB-L (TAB, 5 mg/kg/day, i.g.), TAB-M (TAB, 20 mg/kg/day, i.g.), TAB-H (TAB, 40 mg/kg/day, i.g.) and omeprazole (OL, 10 mg/kg/day, i.g.). All mice except the control group were administrated with anhydrous alcohol (5.0 mL/kg, i.g.) for induced gastric-ulcer 1h after the 5th day. At the same time, the control mice were given the same volume of physiological saline. After 4h, TAB was evaluated for H(+)/K(+)-ATPase inhibitory activities of ulcerative gaster, gastric ulcer index and ulcer inhibition. In vitro, the anti-proliferation effect of TAB to gastric cancer cell (HGC-27) in acid environment was detected by MTT, and the apoptosis morphological changes were also observed by Hoechst 33258 dye assay. The results indicated that TAB inhibited moderately H(+)/K(+)-ATPase activity in vitro. Compared to the model group, TAB showed anti-ulcer effects in gastric tissue with the dosages of 20 and 5 mg/kg in vivo. Apart from that, TAB could selectively inhibit gastric cancer cell viability and reduce cell apoptosis against HGC-27 cells at low doses in acid environment.
- Published
- 2013
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7. 3-Acyl-5-hydroxybenzofuran derivatives as potential anti-estrogen breast cancer agents: A combined experimental and theoretical investigation
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Bi-Feng He, Hua-Jun Luo, Nianyu Huang, Wei-Qiao Deng, and Xiao Yan Li
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Antineoplastic Agents, Hormonal ,Stereochemistry ,Clinical Biochemistry ,Pharmaceutical Science ,Anti estrogen ,Breast Neoplasms ,Hydroxylation ,Biochemistry ,symbols.namesake ,Breast cancer ,Cell Line, Tumor ,Drug Discovery ,medicine ,Humans ,Molecular Biology ,IC50 ,Benzofurans ,Cell Proliferation ,Molecular Structure ,Hydrogen bond ,Chemistry ,Organic Chemistry ,Estrogen Receptor alpha ,medicine.disease ,Docking (molecular) ,MCF-7 Cells ,symbols ,Quantum Theory ,Molecular Medicine ,Female ,van der Waals force ,Estrogen receptor alpha ,Human breast - Abstract
we first report the application of 3-acyl-5-hydroxybenzofurans as a scaffold to develop potential drugs for breast cancer. seven novel derivative compounds were synthesized by using a microwave-assisted synthesis method. those compounds exhibited different antiproliferation against human breast cancer mcf-7 cells, with the best activity of ic50=43.08 mu m for compound 1. a quantum mechanics polarized ligand docking (qpld) study was carried out to investigate the binding interactions between these compounds and estrogen receptor alpha (er alpha). the simulation results showed that the trend of receptor-ligand binding interactions was same as that of their antiproliferative activities. a detailed analysis indicated that compound 1 possesses the highest van der waals and hydrogen bond interactions compared to the other six compounds and better inhibitors are achievable by enhancing the hydrogen bond interactions. based on these results, we addressed that 3-acyl-5-hydroxybenzofuran is an attractive scaffold for designing drugs against breast cancer. (c) 2013 elsevier ltd. all rights reserved.
- Published
- 2013
8. Efficient synthesis of solid-emissive Boron–Fluorine derivatives
- Author
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Qiong Cao, Zhangshuang Deng, Sa Wang, Kun Zou, Xiaohong Chen, Shuzhang Xiao, and Nianyu Huang
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chemistry.chemical_classification ,Organic Chemistry ,Alkyne ,Aromaticity ,Conjugated system ,Photochemistry ,Biochemistry ,Fluorescence ,symbols.namesake ,chemistry ,Stokes shift ,Drug Discovery ,symbols ,Molecule ,Absorption (chemistry) ,Single crystal - Abstract
A highly solid-emissive Boron–Fluorine scaffold with two conjugated alkyne groups ( BOPIM-S ) is facilely synthesized, which shows enhanced fluorescent intensity compared to the BOPIM dye without alkyne units. According to X-ray single crystal analysis, the terminal alkyne groups interact with atoms B, F, C and N on neighbouring molecules, producing a rigid rectangular structure, which helps to avoid energy loss via non-irradiative decay. Furthermore, BOPIM-S can undergo copper catalysed alkyne–azide-cycloaddition (CuAAC) chemistry with aromatic azides to produce conjugated molecules with high yields. According to absorption and fluorescent measurements, all these compounds synthesized by CuAAC emit large Stokes shift (over 100 nm) both in solution and in solid state. But the electronic environments of terminal aromatic rings slightly affect their photophysical properties.
- Published
- 2013
9. Double directional adjusting estrogenic effect of naringin from Rhizoma drynariae (Gusuibu)
- Author
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Dongyan Guo, Xingqin Wang, Nianyu Huang, Hua-Jun Luo, Hongqi Zhang, Junzhi Wang, Lei Chen, and Dan Cao
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Models, Molecular ,Agonist ,Naringenin ,medicine.drug_class ,Estrogen receptor ,Pharmacology ,Mice ,chemistry.chemical_compound ,Polypodiaceae ,Two-Hybrid System Techniques ,Drug Discovery ,medicine ,Animals ,Humans ,Receptor ,Naringin ,Cell Proliferation ,Dose-Response Relationship, Drug ,Uterus ,food and beverages ,Estrogens ,Hydrogen Bonding ,Organ Size ,chemistry ,Nuclear receptor ,Estrogen ,Docking (molecular) ,Flavanones ,MCF-7 Cells ,Female ,hormones, hormone substitutes, and hormone antagonists - Abstract
Ethnopharmacological relevance Chinese traditional medicine Rhizoma drynariae (Gusuibu) is widely used for clinically treating osteoporosis and bone non-union. Naringin and its active metabolite naringenin are the main active ingredients of Rhizoma drynariae total flavonoids. Aim of the study The purpose of this paper is to confirm estrogenic and anti-estrogenic activity of naringin and naringenin, and provide the basic data to further study for the dose–effect relationship and the mechanism for Rhizoma drynariae in treatment of osteoporosis and other estrogen deficiency-related diseases. Materials and methods Naringin was extracted from Rhizoma drynariae. Naringin and its metabolin naringenin were tested estrogenic and anti-estrogenic activities through the experiment of cell proliferation and uterus weight gain in mice. Their estrogen-receptor binding abilities were tested by yeast two-hybrid experiment and nuclear receptor cofactor assays (RCAS) experiment, and their possible binding sites for ERβ were performed by computer aided molecular docking technology. Results Naringin and naringenin showed significant effects on the proliferation of estrogen-sensitive ER(+) MCF-7 cells in the absence of estrogen. Induction increased proliferation as the drug concentration, and the strongest proliferation appeared at a concentration of 8.6 × 10−5 M. When estradiol (10−10 M) and the different concentrations of naringin or naringenin were treated at the same time, naringin and naringenin could result in antagonistic effects on estradiol-induced MCF-7 cell proliferation, but they did not significantly affect proliferation of estrogen-insensitive ER(−) MDA-MB-231 cells. Naringin and naringenin exhibited higher binding capacity to estrogen receptor β (ERβ) than estrogen receptor α (ERα) in yeast two-hybrid experiments and nuclear receptor cofactor assays (RCAS) experiment. Docking simulation between naringin/naringenin and ERβ were performed, and the corresponding binding free energies of naringin–receptor and naringenin–receptor docked complexes were −7.95 and −10.45 kcal/mol. Hydrogen bonds were found between naringin and the amino acid residues Lys304 and His308. The oxygen atom (O11) of naringenin formed hydrogen bond to Arg346, and there may be hydrophobic space interactions between phenyl group (C13–C18) of naringenin and the amino acid residues Leu298, Met336, Met340, Phe356, Ile376 and Leu380. Conclusions Naringin and naringenin revealed a double directional adjusting function of estrogenic and anti-estrogenic activities. Both of them showed estrogenic agonist activity at low concentration or lack of endogenous estrogen. On the other hand, they also acted as estrogenic antagonists at high concentrations or too much endogenous estrogen. They produced estrogenic and anti-estrogenic effects primarily through selectively binding with ERβ, which could prevent and treat osteoporosis with the mechanism of estrogenic receptor agitation. This paper confirmed the estrogenic and anti-estrogenic activity of naringin and naringenin, and further studies were still essential to study their dose–effect relationship and the anti-osteoporosis mechanism for Rhizoma drynariae in the treatment of osteoporosis and other estrogen deficiency-related diseases.
- Published
- 2011
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