1. A Facile and Mild Alkylation Protocol of N H-Diphenyl Sulfondiimines.
- Author
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Xu, Zeyu, Su, Shuaisong, Li, Xue, and Jia, Tiezheng
- Subjects
- *
ORGANIC synthesis , *HALOALKANES , *PHARMACEUTICAL chemistry , *NATURAL products , *ALKYL bromides , *ALKYLATION - Abstract
As a promising pharmacophore, sulfondiimines have drawn increasing attention in recent years, but their uptake in medicinal chemistry is jeopardized by the scarcity of related transformations. Herein, we report a facile and mild N -alkylation protocol of N H-diphenyl sulfondiimines with alkyl halides to prepare a myriad of N -alkylated diphenyl sulfondiimines. Owing to air atmosphere, room temperature, as well as mild reaction conditions, this protocol has exhibited great potential in organic synthesis and medicinal chemistry by the late-stage functionalization of natural products. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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