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A recent study conducted by researchers at Moti Lal Nehru Medical College focused on endometrial stromal sarcoma (ESS), a type of cancer. The study found that low-grade ESS typically presents as a solid uterine mass, but in rare cases, it can mimic a cystic ovarian tumor. The researchers presented a case of a 38-year-old woman who initially presented with a cystic ovarian mass, but it was later determined to be a multiloculated cystic mass in the uterine fundus. The histopathological examination confirmed a diagnosis of low-grade ESS. The study highlights the importance of considering ESS as a differential diagnosis for cystic uterine masses, as it has a poorer prognosis compared to benign masses. [Extracted from the article]

A study conducted by researchers at Ain Shams University in Cairo, Egypt, has investigated the diagnostic value of a combined immunohistochemistry (IHC) panel in differentiating endometrial stromal sarcoma (ESS) from other uterine spindle cell lesions. The study included 60 cases and found that the combined panel of BCOR, Cyclin D1, and CD10 was 100% specific in diagnosing high-grade ESS and differentiating it from low-grade ESS and other malignant uterine spindle cell lesions. The research suggests that the combined IHC panel can be a useful tool for pathologists in accurately diagnosing ESS and making appropriate management decisions. [Extracted from the article]

A recent study published in Women's Health Weekly discusses the rare occurrence of retroperitoneal endometrial stromal sarcoma with multiple pulmonary metastases. The study focuses on a 47-year-old woman who presented with fever and was diagnosed with low-grade endometrial stromal sarcoma. The patient underwent various treatments, including tumor resection, hormone therapy, microwave ablation, and chemotherapy, resulting in partial remission. The study emphasizes the challenges in diagnosing and managing this rare disease and calls for further research to establish effective treatment guidelines. For more information, readers can refer to the article published in Medicine. [Extracted from the article]

A recent report from the All India Institute of Medical Sciences (AIIMS) discusses the rare occurrence of low-grade extrauterine endometrial stromal sarcoma arising from vaginal endometriosis. The case study involves a 38-year-old female who presented with symptoms such as dyspareunia, dysmenorrhea, and painful defecation, along with blood-stained vaginal discharge. After initial diagnosis and treatment, the patient experienced a recurrence of the condition, which was identified as a low-grade endometrial stromal sarcoma. The patient underwent surgery and is currently disease-free after a follow-up of 65 months. This research provides valuable insights into the diagnosis and management of this rare condition. [Extracted from the article]

A recent study conducted by Ardabil University of Medical Sciences focused on high-grade endometrial stromal sarcoma, a rare form of cancer. The study aimed to provide a better understanding of the natural course of the disease and develop appropriate diagnostic and treatment strategies. The researchers presented a case of a 69-year-old Iranian woman diagnosed with high-grade endometrial stromal sarcoma involving the myometrium and ovaries. The patient underwent surgery and received adjuvant chemotherapy. This study contributes to the limited body of research on this topic and may be of interest to those studying oncology and women's health. [Extracted from the article]

A clinical trial, NCT06388018, is being conducted to test the effectiveness of tailored therapy in post-surgery patients with low-risk endometrial cancer. The trial will analyze tissue removed during surgery to determine if additional treatments like radiation or chemotherapy should be recommended. Various outcomes, including pelvic recurrence, isolated vaginal recurrence, and overall survival, will be assessed. The trial also aims to evaluate the impact of molecular classification on patient decision-making and fear of recurrence. The document also provides information on different procedures and imaging techniques used in the treatment and diagnosis of various medical conditions, including teletherapy radiation, high-dose-rate vaginal brachytherapy, computed tomography (CT), positron emission tomography (PET), x-ray imaging, and magnetic resonance imaging (MRI). It outlines the study arms and interventions for patients with specific medical conditions. The clinical trial for patients with endometrial carcinoma is currently suspended and is expected to enroll 325 participants, with an estimated completion date of January 9, 2025. The eligibility criteria include having undergone surgery for hysterectomy and bilateral salpingo-oophorectomy, having histologically confirmed stage I to III endometrial carcinoma, and meeting certain age and performance status requirements. The trial is being conducted by NRG Oncology in collaboration with the National Cancer Institute and the Canadian Cancer Trials Group. [Extracted from the article]

A new report from the Department of Obstetrics and Gynaecology provides fresh data on endometrial stromal sarcoma, a rare form of cancer. The research highlights that endometrial stromal sarcomas are the least common type of uterine sarcomas. They are more commonly found in perimenopausal women between the ages of 45 and 50, with about one-third of cases occurring in postmenopausal women. The most common symptom is abnormal uterine bleeding. The report includes a case study of a 51-year-old patient who underwent radical hysterectomy and received chemotherapy and radiotherapy. For more information, readers can refer to the International Journal of Scientific Research. [Extracted from the article]

A recent study from the National Defense Medical College in Saitama, Japan, discusses the misdiagnosis of low-grade endometrial stromal sarcoma (ESS) as uterine leiomyoma. The study emphasizes the importance of accurate diagnosis, as the treatment strategies for ESS and leiomyoma differ. The researchers present a case of a 51-year-old woman with abnormal uterine bleeding who was initially diagnosed with a leiomyoma based on MRI findings. However, further examination revealed characteristic MRI findings suggestive of low-grade ESS. The patient underwent total hysterectomy and the pathological diagnosis confirmed low-grade ESS. The study highlights the need for radiologists to be familiar with the MRI findings of low-grade ESS to avoid misdiagnosis. [Extracted from the article]

A new study from Washington University discusses the rare occurrence of endometrial stromal sarcoma (ESS) during pregnancy. The study highlights the challenges in diagnosing ESS, as it shares similarities with more common pregnancy conditions. The case presented in the study involved a 36-year-old patient who underwent a hysterectomy and bilateral salpingectomy after extensive counseling. The research emphasizes the importance of evaluating suspicious uterine masses during pregnancy and advocates for safe abortion access. [Extracted from the article]

A recent study conducted by researchers at the University of Pennsylvania has investigated the prevalence of genomic alterations in homologous recombination DNA damage response (HR-DDR) genes among patients with uterine sarcoma. The study analyzed data from the American Association for Cancer Research GENIE v13.0 database and the OncoKB database to identify patients with various types of uterine sarcoma. The results showed that approximately 28.2% of patients with uterine sarcoma had HR-DDR genomic alterations, with the highest incidence observed in patients with leiomyosarcoma, adenosarcoma, and undifferentiated uterine sarcoma. The study highlights the importance of understanding the genetic factors involved in uterine sarcoma and may contribute to the development of targeted therapies. [Extracted from the article]

A recent study conducted at the Cleveland Clinic in Ohio provides new insights into high-grade endometrial stromal sarcoma (ESS). The researchers found that high-grade ESS with ZC3H7B-BCOR fusion is rare and typically located in the endomyometrium. These tumors have distinct morphologic features, including haphazardly arranged spindle cells, abundant myxoid matrix, high mitotic index, and tongue-like/pushing patterns of myometrial invasion. The study emphasizes the importance of molecular analysis in accurately classifying ESS and highlights the need for further research in this area. [Extracted from the article]

A recent study conducted at Peking Union Medical College Hospital in Beijing, China, aimed to improve understanding of low-grade endometrial stromal sarcoma (LG-ESS) with intracaval or intracardiac extension and identify potential risk factors and optimal treatment methods. The study involved a retrospective review of eight LG-ESS patients who underwent treatment between 2012 and 2020. The median age at diagnosis was 44 years, and the most common symptoms were abnormal uterine bleeding, low back discomfort, edema of the lower limbs, abdominal pain, and dyspnea. All patients underwent tumor resection, and some received adjuvant radiotherapy or hormone therapy. No patients died or relapsed during the follow-up period. The study concluded that long-term follow-up is essential due to the high rate of late recurrence. [Extracted from the article]

Cancer, Endometrial Cancer, Female Urogenital Diseases and Conditions, Genetics, Gynecology, Health and Medicine, Oncology, Sarcomas, Uterine Diseases and Conditions, Women's Health, Endometrial Stromal Sarcoma Keywords: Cancer; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Genetics; Gynecology; Health and Medicine; Oncology; Sarcomas; Uterine Diseases and Conditions; Women's Health EN Cancer Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Genetics Gynecology Health and Medicine Oncology Sarcomas Uterine Diseases and Conditions Women's Health 1414 1414 1 11/06/23 20231109 NES 231109 2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on endometrial stromal sarcoma is the subject of a new report. [Extracted from the article]

Keywords: Cancer; Cardiology; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Gynecology; Health and Medicine; Intracardiac; Leiomyomas; Oncology; Sarcomas; Uterine Diseases and Conditions; Women's Health EN Cancer Cardiology Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Gynecology Health and Medicine Intracardiac Leiomyomas Oncology Sarcomas Uterine Diseases and Conditions Women's Health 208 208 1 10/30/23 20231103 NES 231103 2023 OCT 30 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Current study results on endometrial stromal sarcoma have been published. Cancer, Cardiology, Endometrial Cancer, Endometrial Stromal Sarcoma, Female Urogenital Diseases and Conditions, Gynecology, Health and Medicine, Intracardiac, Leiomyomas, Oncology, Sarcomas, Uterine Diseases and Conditions, Women's Health. [Extracted from the article]

"Prior immunohistochemistry characterization of BCOR-mutated uterine sarcomas suggests that activation of the CDK4 kinase complex occurs in this rare subset of uterine sarcomas, which may be therapeutically relevant as specific CDK4 inhibitor drugs are clinically available and currently FDA-approved in estrogen receptor-positive breast cancer (de Duenas E. M. et al. (2018) Clin. In some embodiments of any of the above embodiments, the targeted therapeutic is selected from the group consisting of a CDK inhibitor, an MDM2 inhibitor, a tyrosine kinase inhibitor, a MEK inhibitor, an mTOR inhibitor, and a Hh inhibitor. BCOR-rearranged uterine sarcomas were found to exhibit frequent genomic alterations leading to CDK4 activation, suggesting that most BCOR-mutated uterine sarcoma patients may be eligible for clinical trials with CDK4 or MDM2 inhibitors and the like, including without limitation palbociclib. In contrast, activity of the CDK4 kinase is inhibited by p16 (also known as p16 SP INK4a sp and/or cyclin-dependent kinase inhibitor 2A, encoded by the CDKN2A gene), which binds to the cyclin D1-CDK4 complex and inhibits CDK4 kinase activity (Serrano, M. (1997) Exp. [Extracted from the article]

Keywords: Cancer; Diagnostics and Screening; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Gynecology; Health and Medicine; Hysterectomy; Leiomyomas; Oncology; Sarcomas; Surgery; Uterine Diseases and Conditions; Women's Health EN Cancer Diagnostics and Screening Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Gynecology Health and Medicine Hysterectomy Leiomyomas Oncology Sarcomas Surgery Uterine Diseases and Conditions Women's Health 1417 1417 1 10/09/23 20231013 NES 231013 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on endometrial stromal sarcoma. Cancer, Diagnostics and Screening, Endometrial Cancer, Endometrial Stromal Sarcoma, Female Urogenital Diseases and Conditions, Gynecology, Health and Medicine, Hysterectomy, Leiomyomas, Oncology, Sarcomas, Surgery, Uterine Diseases and Conditions, Women's Health. [Extracted from the article]

Some uterine tumors have also been reported to harbor MDM2 amplification, including a proportion of Mullerian adenosarcomas, BCOR fusion-positive high-grade endometrial stromal sarcoma, BCORL1-altered high-grade endometrial stromal sarcoma, rare JAZF1 fusion-positive low-grade endometrial stromal sarcoma, rare undifferentiated uterine sarcoma, and a single case of MEIS1-NCOA2 fusion sarcoma. Keywords: Dallas; State:Texas; United States; North and Central America; Cancer; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Genetics; Gynecology; Health and Medicine; Oncology; Sarcomas; Uterine Diseases and Conditions; Women's Health EN Dallas State:Texas United States North and Central America Cancer Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Genetics Gynecology Health and Medicine Oncology Sarcomas Uterine Diseases and Conditions Women's Health 1486 1486 1 09/19/23 20230922 NES 230922 2023 SEP 18 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on Oncology - Endometrial Stromal Sarcoma is the subject of a report. [Extracted from the article]

Keywords: Algorithms; Biomarkers; Cancer; Diagnostics and Screening; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Gynecology; Health and Medicine; Leiomyosarcoma; Oncology; Sarcomas; Urology; Uterine Diseases and Conditions; Women's Health EN Algorithms Biomarkers Cancer Diagnostics and Screening Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Gynecology Health and Medicine Leiomyosarcoma Oncology Sarcomas Urology Uterine Diseases and Conditions Women's Health 576 576 1 08/14/23 20230815 NES 230815 2023 AUG 14 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- A new study on endometrial stromal sarcoma is now available. Algorithms, Biomarkers, Cancer, Diagnostics and Screening, Endometrial Cancer, Endometrial Stromal Sarcoma, Female Urogenital Diseases and Conditions, Gynecology, Health and Medicine, Leiomyosarcoma, Oncology, Sarcomas, Urology, Uterine Diseases and Conditions, Women's Health. [Extracted from the article]

Keywords: Bordeaux; France; Europe; Cancer; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Gynecology; Health and Medicine; Oncology; Sarcomas; Uterine Diseases and Conditions; Women's Health EN Bordeaux France Europe Cancer Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Gynecology Health and Medicine Oncology Sarcomas Uterine Diseases and Conditions Women's Health 594 594 1 08/07/23 20230808 NES 230808 2023 AUG 7 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Research findings on Oncology - Endometrial Stromal Sarcoma are discussed in a new report. Keywords for this news article include: Bordeaux, France, Europe, Cancer, Endometrial Cancer, Endometrial Stromal Sarcoma, Female Urogenital Diseases and Conditions, Gynecology, Health and Medicine, Oncology, Sarcomas, Uterine Diseases and Conditions, Women's Health, Institute Bergonie. [Extracted from the article]

Keywords: Salt Lake City; State:Utah; United States; North and Central America; Adenosarcomas; Cancer; Chemotherapy; Drugs and Therapies; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Gynecology; Health and Medicine; Histology; Information Technology; Leiomyosarcoma; Oncology; Pharmaceuticals; Radiation Therapy; Sarcomas; Surgery; Urology; Uterine Diseases and Conditions; Women's Health EN Salt Lake City State:Utah United States North and Central America Adenosarcomas Cancer Chemotherapy Drugs and Therapies Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Gynecology Health and Medicine Histology Information Technology Leiomyosarcoma Oncology Pharmaceuticals Radiation Therapy Sarcomas Surgery Urology Uterine Diseases and Conditions Women's Health 252 252 1 06/26/23 20230627 NES 230627 2023 JUN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on Oncology - Endometrial Stromal Sarcoma is the subject of a report. We examined patterns of care for leiomyosarcomas (LMS), endometrial stromal sarcomas (ESS), adenosarcomas (AS), and mixed uterine sarcomas and assessed the utilization of adjuvant therapy for each histology.". [Extracted from the article]

Cancer, Endometrial Cancer, Endometrial Stromal Sarcoma, Female Urogenital Diseases and Conditions, Gynecology, Health and Medicine, Leiomyomas, Oncology, Sarcomas, Uterine Diseases and Conditions, Women's Health Keywords: Cancer; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Gynecology; Health and Medicine; Leiomyomas; Oncology; Sarcomas; Uterine Diseases and Conditions; Women's Health EN Cancer Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Gynecology Health and Medicine Leiomyomas Oncology Sarcomas Uterine Diseases and Conditions Women's Health 1008 1008 1 06/05/23 20230606 NES 230606 2023 JUN 5 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New study results on endometrial stromal sarcoma have been published. [Extracted from the article]

Keywords: Cancer; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Gynecology; Health and Medicine; Oncology; Sarcomas; Uterine Diseases and Conditions; Women's Health EN Cancer Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Gynecology Health and Medicine Oncology Sarcomas Uterine Diseases and Conditions Women's Health 1051 1051 1 05/15/23 20230516 NES 230516 2023 MAY 15 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on endometrial stromal sarcoma. Cancer, Endometrial Cancer, Endometrial Stromal Sarcoma, Female Urogenital Diseases and Conditions, Gynecology, Health and Medicine, Oncology, Sarcomas, Uterine Diseases and Conditions, Women's Health. [Extracted from the article]

Cancer, Chemotherapy, Diagnostics and Screening, Drugs and Therapies, Endometrial Cancer, Female Urogenital Diseases and Conditions, Gynecology, Health and Medicine, Nanotechnology, Oncology, Sarcomas, Uterine Diseases and Conditions, Women's Health, Endometrial Stromal Sarcoma Keywords: Cancer; Chemotherapy; Diagnostics and Screening; Drugs and Therapies; Endometrial Cancer; Endometrial Stromal Sarcoma; Female Urogenital Diseases and Conditions; Gynecology; Health and Medicine; Nanotechnology; Oncology; Sarcomas; Uterine Diseases and Conditions; Women's Health EN Cancer Chemotherapy Diagnostics and Screening Drugs and Therapies Endometrial Cancer Endometrial Stromal Sarcoma Female Urogenital Diseases and Conditions Gynecology Health and Medicine Nanotechnology Oncology Sarcomas Uterine Diseases and Conditions Women's Health 1242 1242 1 05/15/23 20230516 NES 230516 2023 MAY 15 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Data detailed on endometrial stromal sarcoma have been presented. [Extracted from the article]