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Researchers from Shanghai Jiao Tong University School of Medicine conducted a study on the associations between choline metabolites and incident heart failure (HF) in 245,072 participants from the UK Biobank. The study found that total choline and phosphatidylcholine were positively associated with HF risk, while glycine showed an inverse association. High polygenic risk score and high choline metabolites increased HF risk, while low polygenic risk score and high glycine reduced risk. The study suggests that targeting the choline metabolic pathway may be a potential strategy for improving heart health, but further validation is needed. [Extracted from the article]

A recent study conducted by Instituto Politecnico Nacional in Oaxaca, Mexico, focused on the development of a nondestructive 1H NMR sensor for characterizing organic and inorganic materials. The sensor, inspired by the NMR MOUSE, utilizes a permanent magnet array and RF coil tuned to 11.71 MHz to monitor proton spins of liquid molecules during various processes. The research demonstrated the sensor's ability to achieve a 1 mm spatial resolution and detect differences in materials such as erasers, cement pastes, avocado fruit, and beef steak. The findings suggest that the sensor can provide valuable insights into material composition without causing damage, offering potential applications in diagnostics and screening within the health and medicine field. [Extracted from the article]

The article discusses the issuance of a patent to Wuxi Marvel Stone Healthcare Co. Ltd. for a nuclear magnetic resonance (NMR) measurement system aimed at non-invasive quantitative detection of organs. The system addresses limitations of traditional detection methods like ultrasonic and NMR detection, providing a cost-effective and portable solution for accurate organ fat detection. The patent outlines the components and functionality of the NMR measurement system, emphasizing its ability to generate a static magnetic field in a detection region and conduct safe quantitative detection of organ fat. [Extracted from the article]

A recent report from the University of Almeria in Spain discusses the development of an Earth-Field Nuclear Magnetic Resonance (EFNMR) spectrometer. The researchers highlight the limitations of high-field NMR devices, which are expensive and require specialized personnel. In contrast, EFNMR devices use magnetic fields induced by ordinary conductors or the Earth's magnetic field, making them more affordable and accessible for educational purposes. The report provides a detailed explanation of the design, construction, and software development for these spectrometers, paving the way for AI-enhanced low-field NMR technology. [Extracted from the article]

A patent application has been filed for a device based on ensemble nitrogen-vacancy (NV) centers, which have been shown to have advantages in magnetic field detection. The device utilizes a layered diamond with ensemble NV centers, a dichroic parabolic condensing lens, a Lenz lens, and a microwave coil to polarize and collect fluorescence signals from the NV centers. The device has potential applications in magnetic signal detection, including nuclear magnetic signal detection, and offers advantages in terms of size and robustness compared to traditional architectures. [Extracted from the article]

A recent study conducted by researchers at Henan University of Technology in China examined the effect of sorghum flour particle size on the storage quality of leavened pancakes. The study found that the particle size of sorghum flour significantly influenced the quality of the pancakes during storage. Pancakes made with smaller particle sizes of sorghum flour exhibited delayed aging, enhanced water holding capacity, and reduced retrogradation enthalpy and crystallinity compared to pancakes made with wheat flour. The study concluded that using sorghum flour with smaller particle sizes can improve the stability and quality of pancakes during storage. [Extracted from the article]

A recent study conducted by researchers at Changchun University of Science and Technology in China focuses on improving the quality of magnetic resonance spectrometers. The study highlights the importance of highly homogeneous magnetic fields for chemical structure analysis and kinetic information. The researchers developed a high-precision, high-stability, low-ripple active shimming power supply system for magnetic resonance spectrometers, which significantly improved the magnetic field homogeneity. This work contributes to the integration of compact nuclear magnetic resonance spectrometer systems and the applications related to active shimming. [Extracted from the article]

A study conducted by researchers at the National Taiwan University of Science and Technology has found that curcumin, a natural compound with antioxidant and anti-inflammatory properties, could potentially be used in the treatment of glaucoma. The researchers developed methacrylated hydroxypropyl methylcellulose (HPMC-MA) hydrogels for curcumin delivery, which showed sustained drug release and mucoadhesive properties. The study concluded that these hydrogels have the potential to overcome the challenges of low ocular bioavailability and high dosing frequency associated with conventional eye drops. The research has been peer-reviewed and published in the Journal of Drug Delivery Science and Technology. [Extracted from the article]

A patent has been issued for a syringe pump module developed by Chemyx Inc. The module features a non-decoupling drive mechanism and includes a housing, a motor, and a motor actuation mechanism. The drive mechanism consists of a screw rod and a full nut push plate assembly, which allows for more secure engagement and avoids common problems associated with half-nut transmission push plates. The module also includes a syringe support and is designed to be used with removable syringes. The motor actuation mechanism controls the movement of the drive mechanism bidirectionally and can be operated using buttons or a knob. The patent also includes a method for preparing an injection using the syringe pump module. [Extracted from the article]

A recent study from Changchun University of Science and Technology discusses the development and validation of a portable zero-field NMR spectrometer based on a compact atomic magnetometer. This spectrometer offers an alternative to traditional high-field NMR techniques, which require advanced superconducting technology and large, expensive magnets. The zero-field NMR spectrometer has a main magnetic field strength of less than 1 nT and can achieve high-resolution J-spectrum under zero-field conditions. The researchers conducted experiments to calibrate the magnetic field coils and validate the performance of the spectrometer. This research provides valuable insights into the field of magnetic resonance and its potential applications in diagnostics and screening. [Extracted from the article]

Researchers at Fudan University in Shanghai, China have developed a sensitive and rapid method for detecting amino compounds in mixtures using nuclear magnetic resonance (NMR) spectroscopy. The method, called PRISE-NUS-HSQC, combines probe-induced sensitivity enhancement and nonuniform-sampling-based H-1-C-13 HSQC 2D-NMR. By introducing (CH3)-C-13 tags for each analyte, the researchers were able to increase the H-1 and C-13 abundances, enabling the detection of analytes at concentrations as low as 0.4-0.8 mu M in just 5 minutes. The method has shown good accuracy, precision, and applicability in various biological matrices, making it a valuable tool for quantitative analysis in chemistry, medicine, metabolomics, and other fields. [Extracted from the article]

Researchers at the Karlsruhe Institute of Technology (KIT) have conducted a study on the integration of micro process chemistry into an NMR spectrometer. The study highlights the benefits of miniaturization in the fields of micro process engineering, gas-based hyperpolarization, and small-scale bioreactors. The researchers discuss the compatible materials and manufacturing options for these applications, emphasizing the potential for expanding the application space of NMR through miniaturization. The study has been peer-reviewed and provides valuable insights into the advancements in analytical characterization technologies. [Extracted from the article]

A recent report discusses research conducted at the New Jersey Institute of Technology on drug delivery systems. The researchers designed far-red BODIPY-based oxime esters that can release molecules of interest using low power red LED light. They studied the mechanism and kinetics of the uncaging procedure using a 1H NMR spectrometer and tested the drug delivery strategy in vitro to induce apoptosis in tumor cells. The research concluded that this far-red light sensitive photo-uncaging system could effectively release pro-drugs for cancer treatment. The study was funded by the New Jersey Health Foundation and the National Institute of General Medical Sciences. [Extracted from the article]

A patent application has been published for a new nuclear magnetic resonance (NMR) measurement system that aims to improve the accuracy of organ detection. The system, developed by inventors from Chengdu, China and assigned to Wuxi Marvel Stone Healthcare Co. Ltd., utilizes regional selective excitation to detect fat in organs. It is lightweight, convenient, and economically beneficial, offering operator-independent and streamlined measurement processes. The system includes a radio frequency (RF) subsystem and a magnet that generates a static magnetic field, with the RF subsystem consisting of an NMR spectrometer, RF power amplifier, pre-amplifier, transmit/receive switch, and RF coil group. The system aims to achieve regional selective excitation and accurate positioning for non-invasive organ detection. [Extracted from the article]

Keywords: Thousand Oaks; State:California; United States; North and Central America; Amgen Inc.; Biopharmaceutical Companies; Business; Chemistry; Data Acquisition; Diagnostics and Screening; Health and Medicine; Healthcare Biotechnology Companies; Information Technology; Nuclear Magnetic Resonance EN Thousand Oaks State:California United States North and Central America Amgen Inc. Biopharmaceutical Companies Business Chemistry Data Acquisition Diagnostics and Screening Health and Medicine Healthcare Biotechnology Companies Information Technology Nuclear Magnetic Resonance 2263 2263 1 09/04/23 20230908 NES 230908 2023 SEP 8 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Information Technology - Data Acquisition is the subject of a report. According to the news editors, the research concluded: "The accuracy of measurement of the anisotropic NMR data with the HTS magnet spectrometer is evaluated through the CASE-3D fitting protocol, as implemented in the Mestrenova-StereoFitter software program.". [Extracted from the article]

"In some aspects, the syringe pump module comprises: a housing; a non-decoupling drive mechanism on the outside of the housing; a motor coupled to the non-decoupling drive mechanism; and a motor actuation mechanism connected to the motor and configured to move the non-decoupling drive mechanism bidirectionally. The method may comprise: providing a syringe pump module; placing a syringe on the syringe support; and moving the non-decoupling drive mechanism bidirectionally using the motor actuation mechanism. A syringe pump module comprising: a housing; a non-decoupling drive mechanism on the outside of the housing; a motor coupled to the non-decoupling drive mechanism; and a motor actuation mechanism connected to the motor and configured to move the non-decoupling drive mechanism bidirectionally. [Extracted from the article]

Keywords: Antimetabolites; Antineoplastics; Antipsoriatics; Antirheumatics; Arthritis; Autoimmune Diseases and Conditions; Biotechnology; Drug Delivery; Drug Delivery Systems; Drugs and Therapies; Emerging Technologies; Glycyrrhizic Acid; Health and Medicine; Hydrocarbons; Joint Diseases and Conditions; Methotrexate Therapy; Musculoskeletal Diseases and Conditions; Nanodrugs; Nanopharmaceuticals; Nanotechnology; Organic Chemicals; Pentacyclic Triterpenes; Pharmaceuticals; Rheumatoid Arthritis; Transdermal; Transdermal Delivery EN Antimetabolites Antineoplastics Antipsoriatics Antirheumatics Arthritis Autoimmune Diseases and Conditions Biotechnology Drug Delivery Drug Delivery Systems Drugs and Therapies Emerging Technologies Glycyrrhizic Acid Health and Medicine Hydrocarbons Joint Diseases and Conditions Methotrexate Therapy Musculoskeletal Diseases and Conditions Nanodrugs Nanopharmaceuticals Nanotechnology Organic Chemicals Pentacyclic Triterpenes Pharmaceuticals Rheumatoid Arthritis Transdermal Transdermal Delivery 1555 1555 1 06/05/23 20230609 NES 230609 2023 JUN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- A new study on rheumatoid arthritis is now available. Methotrexate is one of the most effective drugs for rheumatoid arthritis, but the adverse reactions caused by oral methotrexate greatly limit its clinical application.". [Extracted from the article]

Keywords: Technology EN Technology 7805 7805 1 03/23/23 20230317 NES 230317 2023 MAR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in technology. Derived shale oil is primarily made of aliphatic compounds that are dominated by n-alkanes and alkenes (comprising more than 70%). [Extracted from the article]