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Aims: Present report describes the in vitro antimalarial activity and docking analysis of seven 4-aminoquinoline-clubbed 1,3,5-triazine derivatives on pf-DHFR-TS. Methods and Results: The antimalarial activity was evaluated in vitro against chloroquine-sensitive 3D7 strain of Plasmodium falciparum. Compounds were docked onto the active site of pf-DHFR-TS using docking server to explicate necessary structural requirements for antimalarial activity. Conclusion: Title molecules demonstrated considerable bioactivity against the malaria parasite. Docking analysis revealed deep engulfment of the molecules into the inner groove of pf-DHFR-TS active site by making stable ligand-receptor posses. Hydrophobic interaction was identified as the only major interacting force playing a role between ligand-receptor interaction and minor with hydrogen bonds. Significance and Impact of the study: The study provided the novel insight into the necessary structural requirement for rationale-based antimalarial drug discovery. [ABSTRACT FROM AUTHOR]

High-resolution far-infrared observations of a large area of the star-forming complex RCW 106 obtained using the TIFR 1-m balloon-borne telescope are presented. Intensity maps have been obtained simultaneously in two bands centred around 150 and 210 μm. Intensity maps have also been obtained in the four IRAS bands using HIRES-processed IRAS data. From the 150- and 210-μm maps, reliable maps of dust temperature and optical depth have been generated. The star formation in this complex has occurred in five linear sub-clumps. Using the map at 210 μm, which has a spatial resolution superior to that of IRAS at 100 μm, 23 sources have been identified. The spectral energy distribution (SED) and luminosity of these sources have been determined using the associations with the IRAS maps. The luminosity distribution of these sources has been obtained. Assuming these embedded sources to be zero-age main-sequence stars and using the mass–luminosity relation for these, the power-law slope of the initial mass function is found to be -1.73±0.5. This index for this very young complex is about the same as that for more evolved complexes and clusters. Radiation transfer calculations in spherically symmetric geometry have been undertaken to fit the SEDs of 13 sources with fluxes in both the TIFR and the IRAS bands. From this, the r[sup -2] density distribution in the envelopes is ruled out. Finally, a correlation is seen between the luminosity of embedded sources and the computed dust masses of the envelopes. [ABSTRACT FROM AUTHOR]

Compares the effectiveness of the anxiolytics Diazemuls and Midazolam as premedication agents for fiberoptic bronchoscopy in elderly patients. Outcome measures; Reaction of older patients to the procedure; Gender differences in reaction; Basal oxygen saturation and age; Amnesic effects of both drugs; Need for supplemental oxygen with both drugs.

Investigates the effect of vitamin C on blood pressure (BP) in patients with both systolic and essential hypertension. Association between decreased dietary intake of antioxidants and increased risk of hypertension; Similar effects between placebo and vitamin C in lowering BP; Need for longer-term studies of antioxidant therapy; More.

Aim To evaluate the virulence determinants and genetic diversity of Staphylococcus aureus from bovine subclinical mastitis milk. Methods and Results PCR detection of virulence genes was performed for 173 Staph. aureus from bovine subclinical mastitis milk. Further, genetic diversity was analysed by agr and spa typing followed by pulsed field gel electrophoresis ( PFGE) of selected isolates. Screening of virulence genes ( n = 19) showed the adherence genes viz. fnb A, clf A, fnb B and cna in 98·8, 97·1, 68·8 and 28·3 percentage of isolates, respectively, and 80 strains (46·24%) positive for enterotoxin genes were distributed as 23 toxinotypes, of which, 5 genotypes contained a single gene and the rest comprised of multiple toxin genes. Out of agr type-1 (87·3%), 74·2 per cent belonged to the three predominant spa types. Of 27 spa types, 11 were identified for the first time. The predominant spa types were t267 ( N =44), t359 ( N = 42) and t6877 ( N =29), which together accounts to 66·5 per cent of isolates. PFGE analysis of isolates ( N = 45) covering all the spa types revealed mostly similar or closely related pulsotypes. Local emergence of spa type t6877 in herd-dependant manner was observed. spa sequence-based phylogenetic analysis suggested t267 as the ancestral clone of t359, t6877 and other spa types except two. Conclusion Heterogenous virulence profile of the isolates had no significant association with the genotype. High prevalence of agr group I reaffirms their association with persistent subclinical mastitis. The spa type t267 appears to be the ancestral clone endemic in the region causing subclinical mastitis. In addition, few new spa types have emerged in the geographic region. Significance and Impact of Study Gives an insight into the genetic and evolutionary behaviour of Staph. aureus associated with bovine subclinical mastitis in India. The study would pave the way for devising effective control strategy for bovine mastitis in Indian context. [ABSTRACT FROM AUTHOR]