1. Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects
- Author
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Yoshifumi Tamura, Toshio Yanagiya, Ruriko Suzuki, Daisuke Sugimoto, Satoshi Kadowaki, Ryuzo Kawamori, Yasuhiko Furukawa, Keisuke Watanabe, Yuki Someya, Hirotaka Watada, Hideyoshi Kaga, Takashi Funayama, Kageumi Takeno, Saori Kakehi, Toshiyuki Kurihara, and Hiroaki Eshima
- Subjects
medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Non-obese ,Isometric exercise ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Risk factor ,Muscle strength ,business.industry ,Brief Report ,Insulin sensitivity ,Type 2 Diabetes Mellitus ,musculoskeletal system ,medicine.disease ,Clamp ,Endocrinology ,business - Abstract
Introduction Reduced muscle strength is a high risk factor for type 2 diabetes mellitus, and this association is especially strong in non-obese male individuals. However, it remains unclear how reduced muscle strength affects susceptibility to diabetes. We have examined whether lower limb muscle strength is associated with insulin resistance in non-obese Japanese male subjects. Methods Measurements from 64 non-diabetic, non-obese, middle-aged Japanese men were analyzed. Insulin sensitivity in muscle was measured using the hyperinsulinemic-euglycemic clamp. Isometric muscle strength of the knee extensor and flexor muscles was evaluated using a dynameter. Results Lower muscle strength of knee flexors, but not knee extensors, was associated with impaired muscle insulin sensitivity (knee flexor muscles: low, medium, and high strength was 6.6 ± 2.2, 7.3 ± 2.0, and 8.8 ± 2.2 mg/kg per minute, respectively, p for trend
- Published
- 2020