1. New-onset diabetes after liver transplantation: a national report from China Liver Transplant Registry.
- Author
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Ling Q, Xu X, Xie H, Wang K, Xiang P, Zhuang R, Shen T, Wu J, Wang W, and Zheng S
- Subjects
- Adult, Blood Glucose analysis, China, Diabetes Complications epidemiology, Diabetes Mellitus drug therapy, Female, Humans, Hypoglycemic Agents therapeutic use, Incidence, Liver physiopathology, Logistic Models, Male, Middle Aged, Registries, Risk Factors, Survival Analysis, Diabetes Mellitus epidemiology, Hyperglycemia epidemiology, Liver Transplantation adverse effects, Postoperative Complications epidemiology
- Abstract
Background/aims: New-onset diabetes after transplantation (NODAT) is a serious complication of liver transplantation (LT). The present study aimed to investigate the risk factors of NODAT by a national survey using the China Liver Transplant Registry database., Patients: A total of 10 204 non-pre-existing diabetic patients undergone primary LT between January 2000 and December 2013 were included. Risk factors were identified by logistic regression analysis., Results: NODAT occurred in 24.3% of liver recipients with a median follow-up time of 2.6 years, and was associated with a significantly lower patient survival. NODAT increased not only diabetes related complications (e.g., infection, kidney failure) but also biliary stricture and cholangitis. NODAT patients who received hypoglycaemic treatment had a worse prognosis and a higher hepatocellular carcinoma recurrence compared with those without treatment. New-onset hyperglycaemia (<30 days) was the major predictor of NODAT. Other risk factors included cold ischaemia time >9 h, recipient age >50 years, body mass index >25 kg/m(2) , other hepatitis (mainly hepatitis C), post-transplant intensive care unit stay >15 days, cytomegalovirus infection and corticosteroid at discharge., Conclusions: The incidence of NODAT in China is similar to that in Western countries. However, the NODAT-related complications are more common and severer in China compared with those in Western countries. The major risk factors are different., (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2016
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