26 results on '"Schuberth I"'
Search Results
2. A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivatives from nontoxic prodrugs
3. Syntheses and biological evaluation of new glyco-modified angucyclin-antibiotics
4. ChemInform Abstract: Prodrugs of the Cytostatic CC-1065 That Can be Activated in a Tumor- Selective Manner.
5. The two faces of potent antitumor duocarmycin-based drugs: a structural dissection reveals disparate motifs for DNA versus aldehyde dehydrogenase 1 affinity.
6. Photoactivatable prodrugs of highly potent duocarmycin analogues for a selective cancer therapy.
7. Synthesis, biological evaluation, and live cell imaging of novel fluorescent duocarmycin analogs.
8. Synthesis and biological evaluation of prodrugs based on the natural antibiotic duocarmycin for use in ADEPT and PMT.
9. Glycosidic prodrugs of highly potent bifunctional duocarmycin derivatives for selective treatment of cancer.
10. Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity.
11. Determination of the biological activity and structure activity relationships of drugs based on the highly cytotoxic duocarmycins and CC-1065.
12. CD-spectroscopy as a powerful tool for investigating the mode of action of unmodified drugs in live cells.
13. A comprehensive view on 4-methyl-2-quinazolinamine, a new microbial alkaloid from Streptomyces of TCM plant origin.
14. Synthesis and biological studies of different duocarmycin based glycosidic prodrugs for their use in the antibody-directed enzyme prodrug therapy.
15. Asymmetric synthesis and biological evaluation of glycosidic prodrugs for a selective cancer therapy.
16. Duocarmycin-based prodrugs for cancer prodrug monotherapy.
17. Synthesis and biological evaluation of a novel pentagastrin-toxin conjugate designed for a targeted prodrug mono-therapy of cancer.
18. Novel strategies for the synthesis of anthrapyran antibiotics: discovery of a new antitumor agent and total synthesis of (S)-espicufolin.
19. Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins.
20. Antitumor agents: development of highly potent glycosidic duocarmycin analogues for selective cancer therapy.
21. Investigation of reactivity and selectivity of DNA-alkylating duocarmycin analogues by high-resolution mass spectrometry.
22. Novel carboranyl C-glycosides for the treatment of cancer by boron neutron capture therapy.
23. Proof of principle in the selective treatment of cancer by antibody-directed enzyme prodrug therapy: the development of a highly potent prodrug.
24. Highly selective glycosylated prodrugs of cytostatic CC-1065 analogues for antibody-directed enzyme tumor therapy.
25. A novel approach in drug discovery: synthesis of estrone--talaromycin natural product hybrids.
26. Preparation of a new carboranyl lactoside for the treatment of cancer by boron neutron capture therapy: synthesis and toxicity of fluoro carboranyl glycosides for in vivo 19F-NMR spectroscopy.
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