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Your search keyword '"Stavudine -- Physiological aspects"' showing total 12 results
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12 results on '"Stavudine -- Physiological aspects"'

1. Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: a randomized controlled study

Author

McComsey, g.A., Lo Re, V., III, Walker, U.A., Lebrecht, D., Baron, E., Mounzer, K., and Frank, I.

Subjects
Stavudine -- Dosage and administration, Stavudine -- Complications and side effects, Stavudine -- Physiological aspects, Stavudine -- Research, HIV infection -- Drug therapy, Mitochondrial diseases -- Development and progression, Mitochondrial diseases -- Research, Biological markers -- Research, Body composition -- Physiological aspects, Body composition -- Research, Bones -- Density, Bones -- Physiological aspects, Bones -- Research, Health, Health care industry
Published
2008

2. Upregulatory mechanisms compensate for mitochondrial DNA depletion in asymptomatic individuals receiving stavudine plus didnosine

Author

Miro, Oscar, Marinez, Esteban, Giralt, Marta, Vilarroya, Francesc, Casademont, Jordi, Concepcion, Marisa Rodriguez de la, Lopez, Sonia, Gsttsbou, Gloria, Pedrol, Enric, Gatell, Josep M., and Cardellach, Francesc

Subjects
Stavudine -- Physiological aspects, Stavudine -- Chemical properties, Mitochondrial DNA -- Research, Antiviral agents -- Analysis, Antiviral agents -- Physiological aspects, Health
Abstract

The certainty that the homeostatic mechanisms are able to compensate for this mtDNA depletion in patients receiving stavudine plus didnosine(d4T+ ddI), an antiretroviral combination with great in vitro and in vivo capacity to decrease mtDNA is determined. The study concludes that treatment with ddT=ddI is associated with decreased mitochondrial mass and mtDNA content but that cytochrome c oxidase subnit II (COX-II) expression and COX activity remain unaltered.

Published
2004

3. Results of a phase 2 clinical trial at 48 weeks (AI424-007): a dose-ranging, safety, and efficacy comparative trial of atazanavir at three doses in combination with didanosine and stavudine in antiretroviral-naive subjects

Author

Sanne, Ian, Piliero, Peter, Squires, Kathleen, Thirty, Alexandra, and Schnittman, Steven

Subjects
Clinical trials -- Comparative analysis, Stavudine -- Dosage and administration, Stavudine -- Physiological aspects, Didanosine -- Dosage and administration, Didanosine -- Physiological aspects, Drug therapy -- Analysis, Drug therapy -- Usage, Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Drug therapy, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Prevention, HIV infection -- Research, HIV infection -- Health aspects, Antiviral agents -- Dosage and administration, Antiviral agents -- Physiological aspects, AIDS (Disease) -- Research, Health
Abstract

Research has been conducted on protease inhibitor atazanavir. The dose levels of this medication have been compared with those of nelfinavir as a monotherapy and in combination with didanosine and stavudine, and the results of this clinical trial carried out to compare safety, tolerability and antiretroviral efficacy of these three doses are reported.

Published
2003

4. Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine or stavudine, each in combination with lamivudine and indinavir

Author

Descamps, Diane, Flandre, Philippe, Joly, Veronique, Meiffredy, Vincent, Peytavin, Gilles, Izopet, Jacques, Tamalet, Catherine, Ai-Feng Zeng, Harel, Marine, Lastere, Stephane, Aboulker, Jean-Pierre, Yeni, Patrick, and Brun-Vezinet, Francoise

Subjects
Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Drug therapy, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Prevention, HIV infection -- Genetic aspects, HIV infection -- Health aspects, Gene mutations -- Physiological aspects, Drug therapy -- Health aspects, Drug therapy -- Analysis, Zidovudine -- Genetic aspects, Zidovudine -- Physiological aspects, Stavudine -- Physiological aspects, Lamivudine -- Physiological aspects, Indinavir -- Physiological aspects, AIDS (Disease) -- Research, Health
Abstract

Research has been conducted on zidovudine resistance mutations. The role of these mutations in virologic response to treatment with zidovudine or stavudine in combination with lamivudine and indinavir has been investigated, and the results demonstrate that zidovudine resistance mutations do not preclude a durable response to treatment with a three-drug regimen in the patients.

Published
2002

5. Antiviral activity of enteric-coated didanosine, stavudine, and nelfinavir versus zidovudine plus lamivudine and nelfinavir

Author

Gathe, Joseph, Jr., Badaro, Roberto, Grimwood, Ashraf, Abrams, Lori, Klesczewski, Ken, Cross, Anne, and McLaren, Colin

Subjects
Didanosine -- Physiological aspects, Stavudine -- Physiological aspects, Zidovudine -- Physiological aspects, Lamivudine -- Physiological aspects, Nelfinavir -- Physiological aspects, Enteric-coated tablets -- Physiological aspects, Enteric-coated tablets -- Usage, Epidemiology -- Research, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Health aspects, HIV infection -- Research, HIV infection -- Prevention, Antiviral agents -- Composition, Antiviral agents -- Physiological aspects, Antiviral agents -- Research, AIDS (Disease) -- Research, Health
Abstract

Research has been conducted on enteric-coated didanosine beadlets administered once daily. The activity and safety of the capsules which contain these beadlets have been compared with stavudine and nelfinavir, and the results are reported.

Published
2002

6. Subtle decreases in stavudine phenotypic susceptibility predict poor virologic response to stavudine monotherapy zidovudine-experienced patients

Author

Shulman, Nancy S., Hughes, Michael D., Winters, Mark A., Shafer, Robert W., Zolopa, Andrew R., Hellmann, Nicholas S., Bates, Michael, Whitcomb, Jeannette M., and Katzenstein, David A.

Subjects
Immunological deficiency syndromes -- Research, Stavudine -- Physiological aspects, Stavudine -- Usage, Virology -- Research, Drug resistance -- Research, Drug resistance -- Health aspects, Drug resistance -- Physiological aspects, Zidovudine -- Usage, Zidovudine -- Physiological aspects, AIDS patients -- Drug therapy, AIDS patients -- Health aspects, AIDS patients -- Care and treatment, Phenotype -- Research, Health
Abstract

Research has been conducted on stavudine. The study of the phenotypic susceptibility level of this drug associated with a diminished virologic response to stavudine therapy has been carried out via phenotyping, performed on the baseline HIV isolates from the patients who received stavudine monotherapy, and the details are reported.

Published
2002

7. Abnormalities of body fat distribution in HIV-infected persons treated with antiretroviral drugs

Author

Bernasconi, Enos, Boubaker, Karim, Junghans, Cornelia, Flepp, Markus, Furrer, Hans-Jakob, Haensel, Alexander, Boggian, Katia, Chave, Jean-Philippe, Opravil, Milos, Weber, Rainer, Rickenbach, Martin, Telenti, Amalio, and Hirschel, Bernard

Subjects
Epidemiology -- Research, HIV infection -- Care and treatment, HIV infection -- Prevention, HIV infection -- Health aspects, HIV patients -- Drug therapy, HIV patients -- Physiological aspects, HIV patients -- Health aspects, Stavudine -- Health aspects, Stavudine -- Physiological aspects, Lipodystrophy -- Health aspects, Lipodystrophy -- Causes of, Health
Abstract

Research has been conducted on the abnormal body fat distribution in HIV-infected persons. Results demonstrate that the prevalence of lipodystrophy is higher among the patients treated with stavudine for a longer period of time.

Published
2002

8. Simple entry to 3'-substituted analogues to anti-HIV agent stavudine based on an anionic O (approaches) C stannyl migration

Author

Kumamoto, Hiroki and Tanaka, Hiromichi

Subjects
Chemistry, Organic -- Research, Stavudine -- Physiological aspects, Anti-HIV agents -- Physiological aspects, Anions -- Physiological aspects, Oxygen -- Physiological aspects, Carbon -- Physiological aspects, Lithium -- Physiological aspects, Chemical reactions -- Analysis, Biological sciences, Chemistry
Abstract

Research has been conducted on the anti-HIV agent stavudine. The reaction of the 5'-O-protected derivative of this agent with LTMP has been investigated in the presence of HMPA in an attempt to lithiate vinylic hydrogens and the results indicate that the reaction has triggered anionic silyl migration to produce 3'-C-silylated product.

Published
2002

9. Susceptibility of human T cell leukemia virus type I to nucleoside reverse transcriptase inhibitors

Author

Hill, Shawn A., Lloyd, Patricia A., McDonald, Shannon, Wykoff, Jennifer, and Derse, David

Subjects
Zidovudine -- Physiological aspects, Stavudine -- Physiological aspects, Zalcitabine -- Physiological aspects, Lamivudine -- Physiological aspects, Abacavir -- Physiological aspects, Tenofovir -- Physiological aspects, Antiviral agents -- Physiological aspects, Antiviral agents -- Genetic aspects, T cells -- Physiological aspects, T cells -- Genetic aspects, Nucleosides -- Physiological aspects, Nucleosides -- Genetic aspects, Leukemia -- Health aspects, Leukemia -- Care and treatment, Leukemia -- Prevention, Cancer patients -- Health aspects, Cancer patients -- Care and treatment, Airborne infection -- Research, Airborne infection -- Causes of, Health
Published
2003

10. Selection of zidovudine resistance mutations and escape of human immunodeficiency virus type 1 from antiretroviral pressure in stavudine-treated pediatric patients

Author

Maxeiner, Horst-Guenter, Keulen, Wilco, Schuurman, Rob, Bijen, Marc, Graaf, Loek De, Wijk, Albert Van, Back, Nicole, Kline, Mark W., Boucher, Charles A.B., and Nijhuis, Monique

Subjects
Stavudine -- Physiological aspects, HIV infection in children -- Drug therapy, Anti-HIV agents -- Evaluation, Zidovudine -- Physiological aspects, Health
Published
2002

11. Inhibition of Purified Recombinant Reverse Transcriptase from Wild-Type and Zidovudine-Resistant Clinical Isolates of Human Immunodeficiency Virus Type 1 by Zidovudine, Stavudine, and Lamivudine Triphosphates. (Concise Communication)

Author

Duan, Chengying, Poticha, David, Stoeckli, Thomas C., Petropoulos, Christos J., Whitcomb, Jeannette M., McHenry, Charles S., and Kuritzkes, Daniel R.

Subjects
Drug resistance in microorganisms, Zidovudine -- Physiological aspects, Stavudine -- Physiological aspects, Lamivudine -- Physiological aspects, HIV infection, Health
Published
2001

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