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光与纳米结构的相互作用一直是纳米光子学的重要研究内容之一,核心部件的纳米结构对光子器件的功能和性能具有决定性作用。纳米光子器件的设计存在两种思路:一是从物理原理出发的直观设计;二是根据所需光学响应探索最优结构的逆设计。近年来,逆设计在纳米器件中取得了一系列重要进展,尤其是最近将深度学习方法引入进来,开启了高性能纳米光子器件智能高效设计的新篇章。文章围绕纳米光子器件智能逆设计方法,分析归纳了这一新兴研究方向的产生背景、重要进展和典型应用,对智能逆设计面临的挑战及未来发展方向进行了展望。

中国三北地区电网风电渗透率较高，同时存在高比例燃煤热电联产机组用于满足冬季巨大的采暖需求，导致其灵活调节能力极其有限，弃风问题十分突出。现有研究尚缺乏对各种类型电采暖负荷促进风电消纳的经济性评价研究，尤其是以电力辅助服务市场为背景，对不同调节特性电采暖负荷的经济性分析还鲜有报道。由此，以集中蓄热式电采暖、直热式电采暖和分布式电采暖三种典型电采暖负荷为研究对象，利用时序生产模拟方法，构建基于实时调峰辅助服务的电采暖负荷消纳弃风经济评估模型，以北方地区实际运行的电采暖项目数据为算例，对比几类典型采暖负荷消纳弃风的经济性，并分析了辅助服务价格、弃风水平和采暖负荷运行特性等关键因素对经济性的影响。计算结果显示，与传统火电机组相比，集中蓄热式电采暖和分布式电采暖的可行辅助服务价格在315～460 元/MWh，具有一定的竞争力。

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Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To identify the causative variants in 5 Chinese families with tuberous sclerosis complex (TSC) to provide genetic counseling and prenatal diagnosis. Methods Genetic counseling and clinical diagnosis were performed in 8 patients from five unrelated TSC families by teleconsultation. With informed consent obtained from the participants, 3 to 5 mL peripheral blood samples were collected from the probands and their family members for the extraction of genomic DNA. Candidate pathogenic variants were screened by panel sequencing (PS). The candidate pathogenic variants found in TSC1 and TSC2 by PS were validated by PCR-Sanger sequencing and bioinformatics analysis. Results All the pathogenic mutations were identified in the probands and their available family members. Causative variants in TSC1 or TSC2 were detected in all patients, including three reported variants and two novel variants. The two novel variants, TSC2:c.245G＞ A and TSC2: c.235delG, which were predicted to cause the nonsense variant p.(Trp82*) and the frameshift variant p.(Val79Lysfs27*) respectively was believed to introduce premature stop codons. The analysis of family co-segregation and bioinformatics were identified as very positive factors for pathogenicity. Conclusions This result provides more evidences for the genetic counseling and prenatal diagnosis in these families and expand the spectrum of TSC2 pathogenic variants. [ABSTRACT FROM AUTHOR]

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Copyright of China Mechanical Engineering is the property of Editorial Board of China Mechanical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To study the causal effects of generalized anxiety disorder, major depressive disorder, schizophrenia, sleep disorder, and psoriasis by two -sample Mendelian randomization analysis. Methods The single nucleotide polymorphisms (SNPs) associated with four psychiatric traits and psoriasis were screened from the genome-wide association study (GWAS) data base. The relationships between exposures and outcome were analyzed by inverse variance weighting (IVW) method, weighted median (WM) method, and MR-Egger method. The results were mainly evaluated by P value of IVW, odds ratio (OJ?), and 95% confidence interval (CI). IVW, MR Egger, and MR-PRESSO were used for sensitivity analysis. Results The IVW results showed that there was a causal effect between schizophrenia and the risk of psoriasis (0-5=1.002, 95%CIi 1.000-1.003, P二0.023). In the heterogeneity test, the Cochranes Q test of the IVW method reported P value of 0.104 and T2 of 19.06%, the MR-PRESSO test in the pleiotropy test reported P value of 0.106, and the regression intercept of MR Egger reported P value of 0,272, The sensitivity analysis results were robust, and the results did not show heterogeneity and pleiotropy. No causal relationship was found for generalized anxiety disorder (Oi? =1,000, 95%CI: 0.999-1.001, P=0.791), major depressive disorder (0/1=1,002, 95%CI: 0.998-1,005, P=0.246), sleep disorder (Oi?=0.999, 95%CI: 0.996-1.001, P= 0.614) with psoriasis. Conclusion There is a causal relationship between schizophrenia and the risk of psoriasis. Patients with schizophrenia should strengthen the screening and prevention of psoriasis in order to reduce the risk of psoriasis. [ABSTRACT FROM AUTHOR]

Tumor metastasis is closely related to high mortality rate of cancer. It is well known that glutamine plays an important role in the malignant progression of cancer. Notably, as an important carbon and nitrogen donor, glutamine has been found to be closely related to tumor metastasis in recent years. Glutamine is not only involved in regulating the proliferation of tumor cells, but is also closely related to the migration and invasion of tumor cells. Furthermore, various enzymes along with transporters in the metabolism of glutamine are involved in the process of tumor metastasis through different signaling pathways. This review provided a summary of the role of glutamine in tumor metastasis in recent years and proposed therapeutic targets to provide new strategies for the clinical treatment of tumor metastases. [ABSTRACT FROM AUTHOR]

Copyright of Multipurpose Utilization of Mineral Resources / Kuangchan Zonghe Liyong is the property of Multipurpose Utilization of Mineral Resources Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective This study aimed to investigate the causal relationship between saturated fatty acids (SFA) and cardiovascular disease (CVD). Methods A two-sample Mendelian randomization (MR) design was adopted, using genetic variants associated with SFA as instrumental variables, and extracting coronary heart disease, atrial fibrillation, heart failure, ischemic stroke, and 10 cardiovascular risk factors as main outcome indicators from GWAS datasets. The inverse-variance weighted method (IVW) was used as the primary analytical approach, and sensitivity analyses including heterogeneity test, horizontal pleiotropy test, and leave-one-out test were performed to assess the robustness of the MR findings. Results Our results revealed a significant causal association between SFA and coronary heart disease (OR：1.30, 95%CI: 1.15-1.46, P=1.46×10-5), total cholesterol (OR:2.02, 95%CI:1.86-2.18, P=6.71×10-67), low-density lipoprotein cholesterol (OR:1.46, 95%CI:1.39-1.54, P=2.29×10-46) and triglycerides (OR:2.22, 95%CI:2.03-2.42, P=4.43×10-72). However, we did not observe any significant causal effects between SFA and other cardiovascular or risk factors. Conclusion SFA has a causal relationship with coronary heart disease and blood lipid levels, which provides evidence for the dietary prevention of cardiovascular disease by SFA. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aimed at the problem that valve regulated lead-acid (VRLA) battery aging threatening power supply reliability in cloud data centers, a method of an online battery state prediction method based on machine learning algorithms was proposed. Predicting battery status through classic machine learning algorithm models, comparative experiments were conducted on the prediction accuracy between models without extracted feature values and models with extracted feature values. Compare the prediction accuracy of the model using unrefined feature values with the model extracting feature values. The prediction accuracy of the model without extracted feature values ranges from 71. 72% to 81. 82%, and after extracting feature values, the prediction accuracy has improved by 10. 10% to 20. 20%, extracting feature values can improve prediction accuracy. The prediction model based on linear SVM method for extracting feature values is superior to other algorithms, with an accuracy of 96. 46%. Experiment results show that machine learning algorithm based prediction models can be used for online VRLA battery state prediction in cloud data centers. [ABSTRACT FROM AUTHOR]

Objective To investigate whether neutrophils extracellular traps (NETs) treated with microcystin-LR may promote the migration of colorectal cancer cell. Methods Isobaric tags for relative and absolute quantification (iTRAQ) technology was used to detect the secreted proteins in colorectal cancer cell culture supernatant after MC-LR exposure, and Gene Ontology (GO) functional enrichment analysis was performed to analyze in which pathway the differentially expressed proteins were enriched. The quantity of neutrophils in MC-LR-treated tumor tissue of xenograft nude mice was detected by flow cytometry. The expressions of CD11b, neutrophil elastase (NE) and citrulline histones 3 (citH3) in colorectal cancer tissues of BALB/c mice treated with MC-LR were detected by immunohistochemistry. The effect of NETs treated with MC-LR on colorectal cancer cell migration was determined by Transwell migration assay. Results Eleven differentially expressed proteins treated with MC-LR were screened out after MC-LR exposure(P＜0.05), and the differentially expressed proteins were enriched in the way of leukocyte migration. MC-LR increased the counting of neutrophils in colorectal cancer tissue of nude mice (P＜0.05). The expression of CD11b, NE and citH3 in orthotopic colorectal cancer tissues of BALB/c mice was increased after MC-LR administration compared with those in control group (P＜0.05). NETs treated with MC-LR enhanced the migration of colorectal cancer cell (P＜0.05). Conclusions MC-LR may promote migration of colorectal cancer cell by inducing the formation of NETs in the tumor microenvironment (TME). [ABSTRACT FROM AUTHOR]

The magnetic nickel-iron spinel carrier NiFe2O4 is prepared by hydrothermal calcination, and then Ru/NiFe2O4 is prepared by impregnation reduction method by loading Ru nanoparticles on the carriers. The catalyst is characterized by X-ray diffraction （XRD), N2 adsorption-desorption （BET), NH3 programmed temperature desorption （NH3-TPD), H2 programmed temperature reduction （H2-TPR), X-ray photoelectron spectroscopy （XPS） and inductively coupled plasma optical-emission spectrometry （ICP-OES). The results show that the surface oxygen species of Ru/NiFe2O4 catalyst are abundant, and compared with the carriers, the specific surface area and acid amount of the catalyst increases after loading Ru, and Ru interacts with the support, which may be the key to the high activity and stability of the catalyst. The catalyst is used for the selective oxidation of 5-hydroxymethylfurfural （HMF), and the experimental results show that the catalytic activity of the catalyst is significantly increased after loading Ru. The reaction conditions are optimized, when 0. 08 g of KHCO3 is added, the oxidant O2 pressure is 1 MPa, the reaction temperature is 80 ℃, and 0. 1 g of Ru/NiFe2O4 catalyst is used, HMF could be completely converted in water solution for 12 h, and the yield of 2, 5-furandicarboxylic acid （FDCA） is 98. 1%. Ru/NiFe2O4 can still maintain high activity after 5 cycles, and the active component Ru on the catalyst is not easy to leach. The catalyst has magnetic performance, which is convenient for separation from the reaction solution. The research provides valuable reference for the future industrialization of the highly efficient selective oxidation of HMF to synthesize FDCA. [ABSTRACT FROM AUTHOR]

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