1. Iron Embedded Magnetic Nanodiamonds for in vivo MRI Contrast Enhancement
- Author
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C. P. Lee, Huan Niu, Tzung-Yuang Chen, Chun-Hsiang Chang, Fang-Hsin Chen, Chien-Hsu Chen, Srinivasu Kunuku, Yu-Jen Chang, Li Chuan Liao, Bo-Rong Lin, Hung-Kai Yu, and Tung-Yuan Hsiao
- Subjects
Materials science ,Contrast enhancement ,Acoustics and Ultrasonics ,FOS: Physical sciences ,02 engineering and technology ,Image enhancement ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Physics - Medical Physics ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,In vivo ,Biological Physics (physics.bio-ph) ,Drug delivery ,Medical imaging ,Physics - Biological Physics ,Medical Physics (physics.med-ph) ,Mr images ,0210 nano-technology ,Biomedical engineering - Abstract
Although nanodiamonds have long being considered as a potential tool for biomedical research, the practical in vivo application of nanodiamonds remains relatively unexplored. In this paper, we present the first application of in vivo MRI contrast enhancement using only iron embedded magnetic nanodiamonds. MR image enhancement was clearly demonstrated in the rendering of T2-weighted images of mice obtained using an unmodified commercial MRI scanner. The excellent contrast obtained using these nanodiamonds opens the door to the non-invasive in vivo tracking of NDs and image enhancement. In the future, one can apply these magnetic nanodiamonds together with surface modifications to facilitate drug delivery, targeted therapy, localized thermal treatment, and diagnostic imaging., Comment: 19 pages, 6 figures
- Published
- 2019
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