1. C-Reactive Protein Levels and Clinical Prognosis in LAA-Type Stroke Patients: A Prospective Cohort Study
- Author
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Zhipeng Shen, Wen-Bo Zhang, Mark Slevin, Bin-Bin Deng, Yaying Zeng, Baoqiang Guo, and Qingjia Zeng
- Subjects
Male ,medicine.medical_specialty ,Article Subject ,030204 cardiovascular system & hematology ,Logistic regression ,Severity of Illness Index ,General Biochemistry, Genetics and Molecular Biology ,Brain Ischemia ,03 medical and health sciences ,0302 clinical medicine ,Modified Rankin Scale ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Adverse effect ,Stroke ,Aged ,Ischemic Stroke ,General Immunology and Microbiology ,biology ,business.industry ,Incidence (epidemiology) ,C-reactive protein ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Patient Discharge ,Hospitalization ,C-Reactive Protein ,Logistic Models ,Multivariate Analysis ,biology.protein ,Medicine ,Female ,business ,030217 neurology & neurosurgery ,Research Article - Abstract
Background and Purpose. There are increasing evidences that show that the prognosis of patients with acute ischemic stroke (AIS) is closely related to the inflammatory response. In the inflammation caused by AIS, plasma C-reactive protein (CRP) will increase and is associated with prognosis in these patients; few studies have looked at the relationship between CRP and large artery atherosclerosis- (LAA-) type AIS. We aim to investigate the role of CRP in predicting the functional outcome of LAA-type AIS patients. Methods. We prospectively included 200 patients with LAA-type AIS and tested their CRP levels on admission. We followed these patients consecutively. The primary outcome was an adverse event, defined as a modified Rankin Scale score of 2-6 at months 3, 6, and 12 after discharge. A logistic regression model was used to analyze the relationship between CRP and the functional outcome of LAA stroke. Results. We divided 200 patients into 3 groups evenly based on CRP level. After adjustment for gender, age, smoking history, drinking history, history of hyperlipidemia, history of diabetes, lipid levels, and blood glucose levels, logistic regression showed that the incidence of LAA-type AIS poor outcome was positively associated with CRP level at admission, whether it was 3 months, 6 months, or 12 months after discharge, respectively (OR: 2.574, 95% CI: 1.213-5.463; OR: 2.806, 95% CI: 1.298-6.065; OR: 2.492, 95% CI: 1.167-5.321. In the highest tertile vs. the lowest tertile as a reference), and both were statistically different. Conclusions. High CRP level predicts poor functional outcome in LAA-type AIS patients, which provides a strong basis for clinicians to make treatment decisions for these patients.
- Published
- 2021