1. Moringa oleifera Extracts and Praziquantel Combination: Bioavailability in Rats and Cysticidal Activity in a Murine Model
- Author
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Helgi Jung, Guadalupe Palencia Hernández, Iliana González Hernández, Dinora F. González-Esquivel, Guadalupe Concepción Vidal-Cantú, Irma Susana Rojas-Tomé, Nelly Castro, Francisca Pérez-Severiano, Verónica Pérez de la Cruz, and Francisca Palomares-Alonso
- Subjects
Taenia crassiceps ,biology ,Traditional medicine ,010405 organic chemistry ,Chemistry ,Area under the curve ,food and beverages ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Bioavailability ,Moringa ,Praziquantel ,010404 medicinal & biomolecular chemistry ,Oral administration ,In vivo ,Murine model ,parasitic diseases ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,medicine.drug - Abstract
Praziquantel is an anthelmintic drug extensively used that shows a low oral bioavailability. Various approaches have been used in order to increase the plasma levels of praziquantel, including the co-administration with Cytochrome P450 inhibitors. Moringa oleifera Lam., Moringaceae, is an appreciated plant by its nutritional value and is widely used in traditional medicine. It contains a number of potential active compounds including flavonoids and phenolic components that can alter Cytochrome P450 activity. The aim of this work was to evaluate the effect of M. oleifera leaf and seed extracts on the praziquantel bioavailability and assess its in vivo effect on a Taenia crassiceps murine model. A validated method by high-performance liquid chromatography with diode array detection for determination of praziquantel plasma levels was used. The results showed that after the oral administration of praziquantel with M. oleifera, the maximum plasma concentration of praziquantel increased by 2.4- and 5.6-fold with leaf and seed extracts respectively. The area under the curve values from time 0 to 120-min ratios between the combinations and praziquantel alone were 1.8 and 3.6 for leaf and seed extracts, respectively. Cysticidal activity of the combination of praziquantel and seed extract was significantly greater than the administration of praziquantel alone.
- Published
- 2020